CN214232866U - Column chromatography separation device - Google Patents
Column chromatography separation device Download PDFInfo
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- CN214232866U CN214232866U CN202023113187.6U CN202023113187U CN214232866U CN 214232866 U CN214232866 U CN 214232866U CN 202023113187 U CN202023113187 U CN 202023113187U CN 214232866 U CN214232866 U CN 214232866U
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Abstract
The utility model discloses a column chromatography separator, including the device base, the device base is cuboid, its top from a left side to the right side and is equipped with chromatography mechanism, fixed establishment and telescopic machanism in proper order, fixed establishment controls respectively fixed connection chromatography mechanism and telescopic machanism, and fixed establishment and telescopic machanism's bottom is all fixed at device base upside. This device provides a column chromatography separator convenient to fix and installation are used, utilizes telescopic machanism and fixed establishment effectively to fix the chromatographic mechanism after will assembling, is favorable to improving separation efficiency, reduces elution mobile phase's quantity, reduces the material separation cost, and this device simple structure, reasonable in design, the laboratory operation of being convenient for are applicable to extensive application and popularization simultaneously.
Description
Technical Field
The utility model relates to a chemistry experiment instrument technical field, concretely relates to column chromatography separator.
Background
The chromatography is a separation technology established by utilizing the difference of physical and chemical properties of different substances, and all chromatography systems consist of a stationary phase and a mobile elution phase. When the mixture to be separated passes through the fixed phase along with the mobile phase, the mixture shows different distribution proportions in the mobile elution phase and the fixed phase due to the difference of the physicochemical properties of the components in the mixture, the mixture moves along with the flow of the mobile elution phase to ensure that the components are continuously redistributed in the two phases, and effluent is respectively collected according to different outflow time of the components, so that the aim of separating the components is fulfilled. Most of the existing chromatographic devices are of integrated columnar structures, so that the retention time of effective separation components in the device is prolonged, the usage amount of a mobile elution phase solvent is increased, and the yield of a target collected product is reduced, so that the working efficiency of column chromatography separation is reduced, and the separation cost is increased.
With the increasing requirements on chromatographic separation, the improvement on chromatographic columns is increasing, for example, CN203154873U, CN207101967U and CN207085404U all disclose chromatographic columns capable of being freely combined, but these patents only disclose chromatographic columns, and do not provide a fixed structure used in combination with the chromatographic columns, so that the device cannot be well applied in practical tests, and is not convenient for popularization.
Therefore, there is a strong need for a chromatography column device that can be freely combined and can be stably fixed to solve the above problems.
SUMMERY OF THE UTILITY MODEL
The utility model aims at overcoming the not enough of above-mentioned prior art, provide a column chromatography separator, can realize the high-efficient separation of mixing material, effectively reduce the separation cost, utilize the fixed establishment that this device provided simultaneously, can guarantee the holistic stability of device, be convenient for in-service use and extensive popularization.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
column chromatography separator, including the device base, the device base is cuboid, its top from a left side to the right side and is equipped with chromatographic mechanism, fixed establishment and telescopic machanism in proper order, fixed establishment is fixed connection chromatographic mechanism and telescopic machanism respectively about the fixed establishment, and fixed establishment and telescopic machanism's bottom is all fixed at the device base upside.
The chromatography mechanism comprises a feeding section, a chromatography column section and a discharging section which are sequentially connected from top to bottom, wherein the feeding section is a first chromatography column with a column diameter being a frosted opening; the chromatographic column section comprises at least one section of second identical chromatographic column; the discharge section is a third chromatographic column with a funnel-shaped column shoulder and a liquid discharge port connected below.
The lower ports of the first chromatographic column and the second chromatographic column are in a cone shape folded inwards, and the outer wall of the bent part is a frosted surface; the upper ports of the second chromatographic column and the third chromatographic column are provided with grooves, the shapes of the grooves are matched with the shapes of the lower ports of the first chromatographic column and the second chromatographic column, and the outer walls of the grooves are frosted surfaces, so that no gap is generated when the upper and lower adjacent sections of chromatographic columns are spliced, and the experimental effect is ensured.
And sand core filter plates are arranged in the first chromatographic column, the second chromatographic column and the third chromatographic column close to the outlet end at the bottom, so that each section of chromatographic column can be operated as an independent chromatographic unit.
The fixing mechanism comprises at least three vertically connected identical connecting blocks, the connecting blocks are provided with vertical and horizontal circular through holes, the horizontal through holes are communicated in the connecting blocks along the left and right sides, the two through holes are intersected at the central point of the connecting blocks, fastening bolts are arranged on the front sides of the connecting blocks, and the fastening bolts penetrate through the front sides of the connecting blocks and are inserted into the vertical through holes; a connecting rod is fixed at two ends of the transverse through hole of the connecting block respectively, a fixing rod is fixed at the vertical through hole of the connecting block, and the top end of the fixing rod is fixed at the intersection of the two through holes and the bottom end of the fixing rod extends out of the connecting block.
The two connecting rods at the transverse through hole of the connecting block are respectively a first connecting rod at the left side and a second connecting rod at the right side, the first connecting rod is a three-jaw clamp, and the right end of the first connecting rod is a circular tube and is inserted into the transverse through hole of the connecting rod; the second connecting rod is the pipe, and the left end of second connecting rod is fixed in the horizontal through-hole of connecting block, and the right-hand member is fixed in telescopic machanism department, utilizes the connecting block to fix each section chromatography post in telescopic machanism department, strengthens the holistic stability of device.
The telescopic mechanism comprises at least four vertically connected identical telescopic pipes, the telescopic pipes are respectively a first telescopic pipe positioned at the lowest end and a second telescopic pipe positioned above the first telescopic pipe, the first telescopic pipe and the second telescopic pipe respectively comprise an outer rod and an inner rod, the outer rod is a cylinder with an open lower end, the inner rod is a circular pipe, the inner rod is fixed on the upper side of the outer rod, the outer diameter of the inner rod is smaller than the inner diameter of the outer rod, and the inner rod can be axially drawn up and down along the outer rod in the outer rod.
The bottom end of the outer rod of the first telescopic pipe is fixed on the upper side of the device base, and the telescopic mechanism and the device base are fixed.
The side surface of the outer rod of the second telescopic pipe is vertically provided with at least three positioning holes which are round through holes, a space is reserved between every two adjacent positioning holes, the side surfaces of the inner rods of the first telescopic pipe and the second telescopic pipe are respectively provided with an elastic positioning bead matched with the positioning holes for use, and the height of each section of chromatographic column can be conveniently adjusted by utilizing the matching use of the elastic positioning beads and the positioning holes.
The right side of a second connecting rod of the connecting block at the bottommost end is fixed at the outer rod of a second telescopic pipe located at the bottommost end in the telescopic mechanism, and a gap is reserved between the chromatographic mechanism and the device base by utilizing the first telescopic pipe, so that liquid flowing out from the liquid discharging opening can be conveniently collected.
The utility model has the advantages that:
this device provides a column chromatography separator convenient to fix and installation are used, utilizes telescopic machanism and fixed establishment effectively to fix the chromatographic mechanism after will assembling, is favorable to improving separation efficiency, reduces elution mobile phase's quantity, reduces the material separation cost, and this device simple structure, reasonable in design, the laboratory operation of being convenient for are applicable to extensive application and popularization simultaneously.
Drawings
FIG. 1 is a schematic view of the structure of the apparatus;
wherein, 1, a device base; 21. a first chromatography column; 22. a second chromatography column; 23. a third chromatography column; 31 connecting blocks; 32. fixing the rod; 33. a first connecting rod; 34. a second connecting rod; 35. fastening a bolt; 41. a first telescopic tube; 42. a second telescopic tube; 401. an outer rod; 402. an inner rod; 403. positioning holes; 404. an elastic positioning bead.
Detailed Description
The present invention will be further explained with reference to the drawings and examples.
The structure, ratio, size and the like shown in the drawings attached to the present specification are only used for matching with the content disclosed in the specification, so as to be known and read by people familiar with the technology, and are not used for limiting the limit conditions which can be implemented by the present invention, so that the present invention does not have the substantial significance in the technology, and any structure modification, ratio relationship change or size adjustment should still fall within the scope covered by the technical content disclosed by the present invention without affecting the function and the achievable purpose of the present invention. Meanwhile, the terms such as "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for convenience of description, and are not intended to limit the scope of the present invention, and changes or adjustments of the relative relationship thereof may be made without substantial technical changes, and the present invention is also regarded as the scope of the present invention.
As shown in fig. 1, the column chromatography separation device comprises a device base 1, wherein the device base 1 is a cuboid, a chromatography mechanism, a fixing mechanism and a telescopic mechanism are sequentially arranged from left to right above the cuboid, the fixing mechanism is fixedly connected with the chromatography mechanism and the telescopic mechanism from left to right, and the bottom ends of the fixing mechanism and the telescopic mechanism are fixed on the upper side of the device base 1. The chromatographic mechanism comprises a feeding section, a chromatographic column section and a discharging section which are sequentially connected from top to bottom, wherein the feeding section is a first chromatographic column 21 with a frosted opening in column diameter, the chromatographic column section comprises at least one section of second chromatographic column 22 which is completely the same, the discharging section is a third chromatographic column 23 with a funnel-shaped column shoulder and a drainage opening connected below, the lower ports of the first chromatographic column 21 and the second chromatographic column 22 are in a cone shape folded inwards, and the outer wall of the bending part is a frosted surface; the upper port department of second chromatography column 22 and third chromatography column 23 is equipped with the recess, and the shape of recess matches with the lower port shape of first, second chromatography column, and the recess outer wall is the frosting, does not produce the gap when guaranteeing adjacent chromatography column concatenation from top to bottom, ensures the experiment effect. The sand core filter plates are arranged in the first chromatographic column 21, the second chromatographic column 22 and the third chromatographic column 23 close to the outlet end at the bottom, so that each section of chromatographic column can be used as an independent chromatographic unit for operation.
The fixing mechanism comprises at least three vertically-connected identical connecting blocks 31, the connecting blocks 31 are provided with vertical and horizontal circular through holes, the horizontal through holes are communicated in the connecting blocks 31 along the left and right sides, the two through holes are intersected at the central point of the connecting blocks 31, two ends of the horizontal through holes of the connecting blocks 31 are respectively fixed with a connecting rod, the connecting rods are respectively a first connecting rod 33 on the left side and a second connecting rod 34 on the right side, the first connecting rod 33 is a three-jaw clamp, the right end of the first connecting rod is a circular tube and is inserted into the horizontal through hole of the connecting blocks 31, the second connecting rod 34 is a circular tube, the left end of the second connecting rod 34 is fixed in the horizontal through hole of the connecting blocks 31, and the right end of the second connecting rod 34 is fixed at the telescopic mechanism; the fixing rod 32 is fixed at the vertical through hole of the connecting block 31, the top end of the fixing rod 32 is fixed at the intersection of the two through holes, and the bottom end of the fixing rod extends out of the connecting block 31, the front side of the connecting block 31 is further provided with a fastening bolt 35, and the fastening bolt 35 penetrates through the front side of the connecting block 31 and is inserted into the vertical through hole to fasten the fixing rod 32.
The telescopic mechanism comprises at least four vertically connected identical telescopic pipes, the telescopic pipes are respectively a first telescopic pipe 41 positioned at the lowest end and a second telescopic pipe 42 positioned above the first telescopic pipe 41, the first telescopic pipe 41 and the second telescopic pipe 42 both comprise an inner rod 401 and an outer rod 402, the outer rod 401 is a cylinder with an open lower end, the inner rod 402 is a circular pipe, the inner rod 402 is fixed on the upper side of the outer rod 401, the outer diameter of the inner rod 402 is smaller than the inner diameter of the outer rod 401, and the inner rod 402 can be axially drawn up and down along the outer rod 401 in the outer rod 401. The bottom end of the outer rod 401 of the first extension tube 41 is fixed to the upper side of the apparatus base 1, and the extension mechanism is fixed to the apparatus base 1. At least three positioning holes 403 are vertically formed in the side face of the outer rod 401 of the second telescopic tube 42, the positioning holes 403 are circular through holes, a space is reserved between every two adjacent positioning holes 403, elastic positioning beads 404 matched with the positioning holes 403 are arranged on the side faces of the inner rod 402 of the first telescopic tube 41 and the inner rod 402 of the second telescopic tube 42, and the heights of all sections of chromatographic columns can be conveniently adjusted by means of matching of the elastic positioning beads 404 and the positioning holes 403. The right side of the second connecting rod 34 of the connecting block 31 at the bottommost end is fixed at the outer rod 401 of the second telescopic tube 42 at the bottommost end in the telescopic mechanism, and a gap is reserved between the chromatographic mechanism and the device base 1 by using the first telescopic tube 41, so that the liquid flowing out from the liquid discharging port can be conveniently collected.
When the device is used specifically, the number of the corresponding connecting blocks 31 and the number of the corresponding second telescopic tubes 42 are increased or decreased according to the number of the second chromatographic columns 22 which are shown in the figure and specifically needed to be used, the stationary phase is filled in the chromatographic columns, each chromatographic column is adjusted to a proper position by utilizing the matching of the outer rod 401 and the inner rod 402, the operation is carried out according to the experimental flow, when one section of chromatographic column needs to be extracted independently, the elastic positioning beads 404 at the second telescopic tubes 42 corresponding to the section of chromatographic column are pressed, the height of the outer rod 401 is increased, and the chromatographic column can be taken down for replacement or other operations. The device can utilize a plurality of combined same chromatographic column units to form a separation chromatographic column, thereby improving the separation efficiency, reducing the consumption of eluting mobile phase and lowering the separation and purification cost of materials; the inlet and outlet sections of each chromatographic column unit are all arranged as frosted openings, so that a seamless compaction state is kept between all levels of stationary phases as far as possible.
Although the present invention has been described with reference to the accompanying drawings, it is not intended to limit the scope of the present invention, and those skilled in the art should understand that various modifications or variations that can be made by those skilled in the art without inventive work are still within the scope of the present invention.
Claims (10)
1. The utility model provides a column chromatography separator, includes the device base, characterized by, the device base is cuboid, its top from a left side to the right side and is equipped with chromatography mechanism, fixed establishment and telescopic machanism in proper order, fixed establishment controls respectively fixed connection chromatography mechanism and telescopic machanism, and fixed establishment and telescopic machanism's bottom is all fixed at device base upside.
2. The column chromatography separation device of claim 1, wherein the chromatography mechanism comprises a feeding section, a chromatography column section and a discharging section which are sequentially connected from top to bottom, and the feeding section is a first chromatography column with a frosted opening; the chromatographic column section comprises at least one section of second identical chromatographic column; the discharge section is a third chromatographic column with a funnel-shaped column shoulder and a liquid discharge port connected below.
3. The column chromatography separation device of claim 2, wherein the lower ports of the first and second chromatography columns are in a cone shape folded inwards, and the outer wall of the bent part is a frosted surface; the upper ports of the second chromatographic column and the third chromatographic column are provided with grooves, the shapes of the grooves are matched with the shapes of the lower ports of the first chromatographic column and the second chromatographic column, and the outer walls of the grooves are frosted surfaces.
4. The column chromatography separation device of claim 2, wherein the first, second and third chromatographic columns are provided with sand core filter plates near the bottom outlet ends.
5. The column chromatography separation device of claim 1, wherein the fixing mechanism comprises at least three vertically connected identical connecting blocks, each connecting block is provided with two vertical and horizontal circular through holes, the horizontal through holes are communicated in the connecting block along the left and right directions, the two through holes are intersected at the central point of the connecting block, the front side of the connecting block is provided with a fastening bolt, and the fastening bolt penetrates through the front side of the connecting block and is inserted into the vertical through hole; a connecting rod is fixed at two ends of the transverse through hole of the connecting block respectively, a fixing rod is fixed at the vertical through hole of the connecting block, and the top end of the fixing rod is fixed at the intersection of the two through holes and the bottom end of the fixing rod extends out of the connecting block.
6. The column chromatography separation device of claim 5, wherein the two connecting rods at the transverse through hole of the connecting block are respectively a first connecting rod at the left side and a second connecting rod at the right side, the first connecting rod is a three-jaw clamp, the right end of the first connecting rod is a circular tube and is inserted into the transverse through hole of the connecting rod; the second connecting rod is a round pipe, the left end of the second connecting rod is fixed in the transverse through hole of the connecting block, and the right end of the second connecting rod is fixed at the telescopic mechanism.
7. The column chromatography separation device of claim 1, wherein the telescoping mechanism comprises at least four vertically connected identical telescopic pipes, the telescopic pipes are respectively a first telescopic pipe positioned at the lowermost end and a second telescopic pipe positioned above the first telescopic pipe, the first telescopic pipe and the second telescopic pipe both comprise an outer rod and an inner rod, the outer rod is a cylinder with an open lower end, the inner rod is a round pipe, the inner rod is fixed on the upper side of the outer rod, the outer diameter of the inner rod is smaller than the inner diameter of the outer rod, and the inner rod can be drawn up and down in the outer rod along the axial direction of the outer rod.
8. The column chromatography separation device of claim 7, wherein the bottom end of the outer rod of the first telescopic tube is fixed on the upper side of the device base.
9. The column chromatography separation device of claim 7, wherein the side surface of the outer rod of the second extension tube is vertically provided with at least three positioning holes, the positioning holes are circular through holes, a space is reserved between the adjacent positioning holes, and the side surfaces of the inner rods of the first extension tube and the second extension tube are respectively provided with an elastic positioning bead matched with the positioning holes.
10. The column chromatography separation device of claim 5, wherein the right side of the second connecting rod of the connecting block at the lowermost end is fixed at the outer rod of the second telescopic tube at the lowermost end in the telescopic mechanism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023113187.6U CN214232866U (en) | 2020-12-22 | 2020-12-22 | Column chromatography separation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023113187.6U CN214232866U (en) | 2020-12-22 | 2020-12-22 | Column chromatography separation device |
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| Publication Number | Publication Date |
|---|---|
| CN214232866U true CN214232866U (en) | 2021-09-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202023113187.6U Active CN214232866U (en) | 2020-12-22 | 2020-12-22 | Column chromatography separation device |
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|---|---|
| CN (1) | CN214232866U (en) |
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2020
- 2020-12-22 CN CN202023113187.6U patent/CN214232866U/en active Active
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| GR01 | Patent grant | ||
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| CP03 | Change of name, title or address |
Address after: No.1, Shiliquan East Road, Shizhong District, Zaozhuang City, Shandong Province 277100 Patentee after: Shandong Taihe Technology Co.,Ltd. Address before: 277000 No.1, Shiliquan East Road, Shizhong District, Zaozhuang City, Shandong Province Patentee before: SHANDONG TAIHE WATER TREATMENT TECHNOLOGIES Co.,Ltd. |
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