CN213995458U - A separator for polypeptide - Google Patents
A separator for polypeptide Download PDFInfo
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- CN213995458U CN213995458U CN202022442967.9U CN202022442967U CN213995458U CN 213995458 U CN213995458 U CN 213995458U CN 202022442967 U CN202022442967 U CN 202022442967U CN 213995458 U CN213995458 U CN 213995458U
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Abstract
The utility model discloses a separation device for polypeptide, which comprises a raw material tank, a connecting plate, a separation tank, a cover plate, an inlet pipe and a separation column, wherein the lower end of the raw material tank is detachably connected with one end of the inlet pipe, the interior of the raw material tank is communicated with the inlet pipe, the other end of the inlet pipe is fixedly connected with the connecting plate, the separation tank is provided with a cavity with an upward opening, the opening end surface of the cavity is detachably connected with the cover plate, the bottom of the cover plate is fixedly connected with the top of the separation column, the separation column is arranged in the cavity, the separation column is provided with a separation chamber with an upward opening, the cover plate is provided with a through hole communicated with the separation chamber, one end of the inlet pipe, which is far away from the raw material tank, penetrates through the connecting plate and is arranged in the separation chamber, the inner wall of the separation column is provided with a separation membrane, the separation membrane is used for filtering out the polypeptide into the cavity, the technical problems in the prior art are solved, such as: the separation chamber and the separation membrane are inconvenient to clean and replace.
Description
Technical Field
The utility model relates to a polypeptide separation field is a separator who is used for polypeptide particularly.
Background
Peptides are compounds of alpha-amino acids linked together by peptide bonds, which are intermediates in the hydrolysis of proteins. The compounds obtained by dehydration condensation of two amino acid molecules are called dipeptides, and similarly, tripeptides, tetrapeptides, pentapeptides, and the like are also included. Generally, a compound formed by dehydration condensation of 10 to 100 amino acid molecules is called a polypeptide, such as cytokine mimetic peptide, antibacterial active peptide and other medicinal small peptides.
In polypeptide production, a membrane separation technology is often adopted to separate and purify a polypeptide raw material, the membrane separation technology refers to a technology for realizing selective separation when a mixture of molecules with different particle sizes passes through a semipermeable membrane, the semipermeable membrane is also called a separation membrane or a filter membrane, small holes are distributed on the membrane wall, and the separation can be divided into the following steps according to the pore size: microfiltration Membrane (MF), milipore filter (UF), receive filter membrane (NF), reverse osmosis membrane (RO) etc, polypeptide separator among the prior art often sets up the separation membrane in the knockout drum and separates, but because its separation essence is physical separation, so can produce a large amount of accumulations in membrane surface and separation chamber after long-time, cause the jam with influence separation efficiency and quality, the deposit in prior art to the knockout drum is cleared up or is changed the water pipe that the separation membrane need demolish the knockout drum top, a flange, a plurality of parts such as seal assembly, it exists: the separation chamber and the separation membrane are inconvenient to clean and replace.
SUMMERY OF THE UTILITY MODEL
In view of the above-mentioned shortcomings of the prior art, the present invention is directed to: provided is a separation device for polypeptide, which is used for solving the technical problems existing in the prior art, such as: the separation chamber and the separation membrane are inconvenient to clean and replace.
In order to realize the purpose of the utility model, the utility model provides a following technical scheme:
a separation device for polypeptide comprises a raw material tank, a connecting plate, a separation tank, a cover plate, a feeding pipe and a separation column, the lower end of the raw material tank is detachably connected with one end of the feeding pipe, the interior of the raw material tank is communicated with the feeding pipe, the other end of the feeding pipe is fixedly connected with the connecting plate, the separating tank is provided with a cavity with an upward opening, the end surface of the opening of the cavity is detachably connected with the cover plate, the bottom of the cover plate is fixedly connected with the top of the separation column, the separation column is arranged in the cavity and is provided with a separation chamber with an upward opening, the cover plate is provided with a through hole communicated with the separation chamber, one end of the feed pipe, which is far away from the raw material tank, penetrates through the connecting plate and is arranged in the separation chamber, the side surface of the separation column is provided with a plurality of filtering holes, the inner wall of the separation column is provided with a separation membrane, and the separation membrane is used for filtering polypeptide into the cavity.
Further, the connecting plate bottom with still be equipped with sealed the pad between the apron top, sealed pad is hollow structure, the inlet pipe is kept away from the one end of head tank passes sealed pad's hollow portion.
Furthermore, the apron is equipped with the installation cavity that the opening is down, separator tank open-top end set up in the installation cavity, the apron side is through the screw connection the separator tank.
Furthermore, a sealing ring is arranged between the cover plate and the top end face of the separation tank.
Further, the connecting plate is connected with the cover plate through screws.
Further, the feeding pipe is a plastic hose.
Further, still include force pump, connection pad, row's material pipe, three-way valve, back flow and discharging pipe, the head tank lower extreme is equipped with the raw materials export, the raw materials export with the inlet pipe is close to the one end of head tank all is equipped with the connection pad, two the connection pad passes through the screw connection, the raw materials export with the inlet pipe intercommunication, be equipped with in the raw materials export the force pump, the knockout drum lower extreme be equipped with the row of cavity intercommunication expects the pipe, it connects to arrange the material union coupling the input of three-way valve, two outputs of three-way valve are connected respectively the discharging pipe with the back flow, the back flow other end is connected the head tank.
Compared with the prior art, the utility model, following beneficial effect has:
1. can dismantle the connection head tank through the inlet pipe to its other end fixed connection connecting plate, the apron is connected to connecting plate detachably again, so pull down the sub-assembly of inlet pipe and connecting plate, can make separation post top terminal surface expose, and because the apron can be dismantled and connect the separation tank, its bottom fixed connection separation top of the column, so take off the apron and can take out the sub-assembly of apron and separation post, reached the beneficial effect of being convenient for change the separating film and rinsing separation post and separation tank.
Drawings
FIG. 1 is a schematic diagram of an overall structure of a separation apparatus for polypeptides according to the present invention;
list of reference numerals
1-raw material tank, 2-connecting plate, 3-separating tank, 4-cover plate, 5-feeding pipe, 6-separating column, 7-sealing gasket, 8-discharging pipe, 9-three-way valve, 10-return pipe, 11-discharging pipe, 12-connecting disc and 13-pressure pump.
Detailed Description
The technical solution of the present invention will be described clearly and completely with reference to fig. 1, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may include, for example, a fixed connection, an integral connection, or a detachable connection; may be communication within two elements; they may be directly connected or indirectly connected through an intermediate, and those skilled in the art can understand the specific meaning of the above terms in the present invention in specific situations.
A separation device for polypeptide comprises a raw material tank 1, a connecting plate 2, a separation tank 3, a cover plate 4, an inlet pipe 5 and a separation column 6, wherein the lower end of the raw material tank 1 is detachably connected with one end of the inlet pipe 5, the raw material tank 1 is internally communicated with the inlet pipe 5, the other end of the inlet pipe 5 is fixedly connected with the connecting plate 2, the separation tank 3 is provided with a cavity with an upward opening, the opening end surface of the cavity is detachably connected with the cover plate 4, the bottom of the cover plate 4 is fixedly connected with the top of the separation column 6, the separation column 6 is arranged in the cavity, the separation column 6 is provided with a separation chamber with an upward opening, the cover plate 4 is provided with a through hole communicated with the separation chamber, one end of the raw material tank 1, which is far away from the raw material tank 5, passes through the connecting plate 2 and is arranged in the separation chamber, the side surface of the inlet pipe 6 is provided with a plurality of filter holes, and a separation membrane is arranged on the inner wall of the separation column 6 and is used for filtering polypeptide into the cavity.
As shown in FIG. 1, the polypeptide raw material in the raw material tank 1 enters the separation tank 3 through the feeding pipe 5, enters the separation chamber of the separation column 6, is filtered through the separation holes on the separation membrane, and is filtered out from the filter holes on the side surface of the separation column 6, so that impurities or other macromolecules and large colloids are removed. Large particles and the like are accumulated in the separation column 6, and the polypeptide enters a gap between the separation column 6 and the separation tank 3 to complete the purification and separation of the polypeptide.
In the above and prior arts, after a large amount of impurities are accumulated in the separation membrane and the separation chamber, the separation efficiency of the separation membrane becomes low, clogging is easily caused, because the feeding pipe 5 is detachably connected with the raw material tank 1, the other end of the feeding pipe is fixedly connected with the connecting plate 2, the connecting plate 2 is detachably connected with the cover plate 4, therefore, the assembly of the feed pipe 5 and the connecting plate 2 is disassembled, the top end surface of the separation column 6 can be exposed, and the operations such as cleaning or replacing the separation membrane and the like can be carried out in the separation chamber, and further, since the cover plate 4 is detachably connected with the separation tank 3, the bottom thereof is fixedly connected with the top of the separation column 6, therefore, the cover plate 4 is taken down, and the assembly of the cover plate 4 and the separation column 6 can be taken out, and the cavities of the separation column 6 and the separation tank 3 can be cleaned at the moment, so that the beneficial effects of facilitating the replacement of the separation membrane and the cleaning of the separation column 6 and the separation tank 3 are achieved.
Further, 2 bottoms of connecting plate with still be equipped with sealed 7 of filling up between 4 tops of apron, sealed 7 of filling up is hollow structure, inlet pipe 5 is kept away from the one end of head tank 1 is passed the hollow portion of sealed 7 of filling up has played sealed effect.
Further, apron 4 is equipped with the installation cavity that the opening is down, 3 open-top end faces of knockout drum set up in the installation cavity, 4 side of apron pass through the screw connection knockout drum 3.
Furthermore, a sealing ring is arranged between the cover plate 4 and the top end face of the separation tank 3, so that a sealing effect is achieved.
Further, the connecting plate 2 is connected with the cover plate 4 through screws.
Further, the feeding pipe 5 is a plastic hose.
Furtherly, still include force pump 13, connection pad 12, arrange material pipe 8, three-way valve 9, back flow 10 and discharging pipe 11, 1 lower extreme of head tank is equipped with the raw materials export, the raw materials export with inlet pipe 5 is close to the one end of head tank 1 all is equipped with connection pad 12, two connection pad 12 passes through the screw connection, the raw materials export with inlet pipe 5 intercommunication, be equipped with in the raw materials export force pump 13, 3 lower extremes of knockout drum be equipped with the row of cavity intercommunication expects pipe 8, it connects to arrange material pipe 8 the input of three-way valve 9, two outputs of three-way valve 9 are connected respectively discharging pipe 11 with back flow 10, the back flow 10 other end is connected head tank 1.
Its raw materials that passes through force pump 13 with its inside of head tank 1 is carried to inlet pipe 5 in, then carry again to the separation column 6 in, the polypeptide thing that the separation column 6 was separated passes through three-way valve 9 and back flow 10, get back to in head tank 1 once more, carry out secondary or multiple separation, in order to improve separation purity, after the separation is accomplished, control three-way valve 9 closes back flow 10 passageway, open discharging pipe 11 passageway, discharge pure polypeptide thing, in order to accomplish whole technology, still be equipped with corresponding feed inlet on the head tank 1, in order to be used for supplementary raw materials.
The preferred embodiments of the present invention have been described in detail with reference to the accompanying drawings, however, the present invention is not limited to the details of the embodiments in the above description, and the technical concept of the present invention can be within the scope of the present invention, and can be modified to various simple modifications, and these simple modifications all belong to the protection scope of the present invention. It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and in order to avoid unnecessary repetition, the present invention does not need to describe any combination of the features. In addition, various embodiments of the present invention can be combined arbitrarily, and the disclosed content should be regarded as the present invention as long as it does not violate the idea of the present invention.
Claims (7)
1. The utility model provides a separator for polypeptide, its characterized in that, including head tank (1), connecting plate (2), knockout drum (3), apron (4), inlet pipe (5) and separation post (6), head tank (1) lower extreme detachably connects the one end of inlet pipe (5), head tank (1) inside with inlet pipe (5) intercommunication, inlet pipe (5) other end fixed connection connecting plate (2), knockout drum (3) are equipped with the cavity that opens up, cavity opening terminal surface detachably connects apron (4), apron (4) bottom fixed connection the top of separation post (6), separation post (6) set up in the cavity, separation post (6) are equipped with the separation chamber that opens up, apron (4) be equipped with the through-hole of separation chamber intercommunication, keep away from inlet pipe (5) the one end of head tank (1) is passed connecting plate (2) and set up in the separator chamber, separation column (6) side is equipped with a plurality of filtration pores, separation column (6) inner wall is equipped with the separation membrane, the separation membrane is used for filtering polypeptide extremely in the cavity.
2. The separation device for the polypeptides according to claim 1, characterized in that a sealing gasket (7) is further arranged between the bottom of the connecting plate (2) and the top of the cover plate (4), the sealing gasket (7) is of a hollow structure, and one end of the feeding pipe (5) far away from the raw material tank (1) penetrates through the hollow part of the sealing gasket (7).
3. The separation device for polypeptides according to claim 1, wherein the cover plate (4) is provided with a mounting cavity with an opening facing downwards, the open top end face of the separation tank (3) is arranged in the mounting cavity, and the side face of the cover plate (4) is connected with the separation tank (3) through screws.
4. A separation device for polypeptides according to claim 3, characterized in that a sealing ring is provided between the cover plate (4) and the top end surface of the separation tank (3).
5. The separation device for polypeptides according to claim 1, wherein the connection plate (2) is connected to the cover plate (4) by screws.
6. A separation device for polypeptides according to claim 1, characterized in that the feeding pipe (5) is a plastic hose.
7. The separation device for the polypeptide according to claim 1, further comprising a pressure pump (13), connecting discs (12), a discharging pipe (8), a three-way valve (9), a return pipe (10) and a discharging pipe (11), wherein a raw material outlet is arranged at the lower end of the raw material tank (1), the connecting discs (12) are arranged at the end of the raw material outlet and the end of the feeding pipe (5) close to the raw material tank (1), the two connecting discs (12) are connected through screws, the raw material outlet is communicated with the feeding pipe (5), the pressure pump (13) is arranged on the raw material outlet, a discharging pipe (8) communicated with the cavity is arranged at the lower end of the separation tank (3), the discharging pipe (8) is connected with the input end of the three-way valve (9), and the two output ends of the three-way valve (9) are respectively connected with the discharging pipe (11) and the return pipe (10), the other end of the return pipe (10) is connected with the raw material tank (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022442967.9U CN213995458U (en) | 2020-10-28 | 2020-10-28 | A separator for polypeptide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022442967.9U CN213995458U (en) | 2020-10-28 | 2020-10-28 | A separator for polypeptide |
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| Publication Number | Publication Date |
|---|---|
| CN213995458U true CN213995458U (en) | 2021-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202022442967.9U Active CN213995458U (en) | 2020-10-28 | 2020-10-28 | A separator for polypeptide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116764278A (en) * | 2022-05-19 | 2023-09-19 | 嘉兴碳捕快科技有限公司 | Liquid-liquid phase separation device, liquid-liquid phase automatic separation system and control method thereof |
-
2020
- 2020-10-28 CN CN202022442967.9U patent/CN213995458U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116764278A (en) * | 2022-05-19 | 2023-09-19 | 嘉兴碳捕快科技有限公司 | Liquid-liquid phase separation device, liquid-liquid phase automatic separation system and control method thereof |
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