CN213984645U

CN213984645U - High-efficient condensing equipment of clozapine cyclization reaction

Info

Publication number: CN213984645U
Application number: CN202022653407.8U
Authority: CN
Inventors: 高政; 戴晓阳; 谭进; 王宇; 吴卫征; 张伟; 魏征; 汪池; 耿炎
Original assignee: Jiangsu Cixing Pharmaceutical Co ltd
Current assignee: Jiangsu Cixing Pharmaceutical Co ltd
Priority date: 2020-11-16
Filing date: 2020-11-16
Publication date: 2021-08-17
Anticipated expiration: 2030-11-16

Abstract

The utility model discloses a high-efficient condensing equipment of clozapine cyclization reaction belongs to the reation kettle field. The device mainly comprises a kettle body, a heat conduction oil heating device, a first condenser and a second condenser; double spiral pipes are wound on the outer surface of the kettle body and respectively comprise a heat conduction oil pipe and a condensate pipe; the heat conduction oil pipe is connected with the heat conduction oil heating device and the first condenser; a first extraction pump is arranged on the main path of the oil inlet pipe of the heat conduction oil pipe; the condensate pipe is connected with the second condenser, and a second throttle valve and a second extraction pump are arranged at a water outlet pipe of the second condenser. The utility model discloses a two condenser parallel operation, the condenser firstly cools off the conduction oil cooling cauldron body after the rethread cooling to the conduction oil earlier, and two directness of condenser cool off the cauldron body through the condensation salt solution, and two condensers fully cooperate, have shortened the cool time greatly, have promoted cooling efficiency.

Description

High-efficient condensing equipment of clozapine cyclization reaction

Technical Field

The utility model belongs to the technical field of reation kettle, concretely relates to high-efficient condensing equipment of clozapine cyclization reaction.

Background

In clozapine cyclization reaction, after the high temperature reaction of materials in a reaction kettle, the materials need to be rapidly cooled, the reaction kettle adopts heat conducting oil to cool, the temperature of the heat conducting oil reaches 130 ℃ during heating, the materials need to be cooled to 10 ℃ in a short time, cold salt water with the temperature of minus 7 ℃ is generally adopted to cool the heat conducting oil in an oil tank, and then the reaction kettle is cooled, so that the cooling time is long, and the efficiency is low. The original condenser has limited condensation effect, and long time is needed for cooling, thereby influencing the clozapine reaction effect.

SUMMERY OF THE UTILITY MODEL

The utility model provides a technical problem: the utility model provides a high-efficient condensing equipment of clozapine cyclization reaction can effectively shorten the cooling time to the processing of cooling down of conduction oil and reation kettle body simultaneously, and work is more high-efficient.

The technical scheme is as follows: in order to solve the technical problem, the utility model discloses a technical scheme as follows:

a clozapine cyclization reaction efficient condensing device comprises a kettle body, a heat conduction oil heating device, a first condenser and a second condenser; the upper end of the kettle body is provided with a motor port, a rotating shaft is arranged in the motor port, a motor is arranged on the rotating shaft, the rotating shaft penetrates through the motor, and the rotating shaft extends into the kettle body and is connected with a stirrer; double spiral pipes are wound on the outer surface of the kettle body and respectively comprise a heat conduction oil pipe and a condensate pipe; the end head of the main path of the oil inlet pipe of the heat conduction oil pipe is provided with two branches which are respectively connected with an oil discharge pipe of the heat conduction oil heating device and an outlet of the first condenser, and each branch is provided with a first throttle valve; the end head of the main path of the oil outlet pipe of the heat conduction oil pipe is provided with two branches which are respectively connected with a return pipe of the heat conduction oil heating device and an inlet of the first condenser; a first extraction pump is arranged on the main path of the oil inlet pipe of the heat conduction oil pipe; the condensate pipe is connected with the second condenser, and a second throttle valve and a second extraction pump are arranged at a water outlet pipe of the second condenser.

Further, the kettle body further comprises a controller, and the heat conduction oil heating device, the first condenser, the second condenser, the first throttle valve, the second throttle valve, the first extraction pump and the second extraction pump are all connected with the controller.

Further, the inner sides of the heat conduction oil pipe and the condensate pipe are flat.

Furthermore, a vertical decompression pipe and a horizontal overflow pipe communicated with the lower part of the decompression pipe are arranged at the upper part of the heat-conducting oil heating device.

Furthermore, the pipeline of the overflow pipe is arranged horizontally, and the upper part of the decompression pipe is opened.

Furthermore, a pressure sensor is arranged on the oil inlet pipe main path of the heat conduction oil pipe and connected with the controller.

Further, a shell is arranged outside the kettle body, and a heat conduction oil pipe and a condensate pipe are arranged in a cavity between the shell and the kettle body.

Further, the controller is arranged in the control box and is provided with an operation panel.

Further, the controller is a PLC controller.

Furthermore, heat insulation layers are arranged on the surfaces of the first condenser and the second condenser, and the heat insulation layers are heat insulation cotton or foam layers.

Has the advantages that: compared with the prior art, the utility model has the advantages of it is following:

the utility model discloses a two condenser parallel operation, the condenser firstly cools off the conduction oil cooling cauldron body after the rethread cooling to the conduction oil earlier, and two directness of condenser cool off the cauldron body through the condensation salt solution, and two condensers fully cooperate, have shortened the cool time greatly, have promoted cooling efficiency.

The utility model discloses set up the relief pipe that communicates with the atmosphere and communicate the overflow pipe of this relief pipe at conduction oil heating device's top for the inside conduction oil of heating jar accessible relief pipe and overflow pipe carry out the pressure release after the boiling, prevent that the too big explosion of production of heating jar internal pressure from overflowing the accident, guarantee reation kettle's security.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Detailed Description

The present invention will be further clarified by the following embodiments, which are implemented on the premise of the technical solution of the present invention, with reference to the attached drawings, and it should be understood that these embodiments are only used for illustrating the present invention and are not used for limiting the scope of the present invention.

As shown in fig. 1, the efficient condensing device for clozapine cyclization reaction comprises a kettle body 1, a heat-conducting oil heating device 7, a first condenser 8 and a second condenser 9; the upper end of the kettle body 1 is provided with a motor port, a rotating shaft 5 is arranged in the motor port, a motor 4 is arranged on the rotating shaft 5, the rotating shaft 5 penetrates through the motor 4, and the rotating shaft 5 extends into the kettle body 1 and is connected with a stirrer 6; double spiral pipes, namely a heat conducting oil pipe 11 and a condensate pipe 12, are wound on the outer surface of the kettle body 1; the end head of the main path of the oil inlet pipe of the heat conduction oil pipe 11 is provided with two branches which are respectively connected with an oil discharge pipe of the heat conduction oil heating device 7 and an outlet of a first condenser 8, and each branch is provided with a first throttle valve 13; the end head of the main oil outlet pipe of the heat conduction oil pipe 11 is provided with two branches which are respectively connected with the return pipe of the heat conduction oil heating device 7 and the inlet of the condenser I8; a first extraction pump 14 is arranged on the main oil inlet pipe path of the heat conduction oil pipe 11; in addition, the condensate pipe 12 is connected with the second condenser 9, and a second throttle valve 15 and a second extraction pump 16 are arranged at a water outlet pipe of the second condenser 9. The first condenser 8 cools the conduction oil firstly and then cools the kettle body 1 through the cooled conduction oil, and the second condenser 9 directly cools the kettle body 1 through condensed brine.

For realizing the intelligent control of whole reation kettle conduction oil heating and condenser cooling, the utility model discloses still include controller 3, above-mentioned conduction oil heating device 7, condenser 8, condenser two 9, choke valve 13, choke valve two 15, extraction pump 14 and extraction pump two 16 all are connected with controller 3.

The inner sides of the heat conduction oil pipe 11 and the condensate pipe 12 are flat, and can be better attached to the surface of the reaction kettle.

A vertical decompression pipe 71 and a horizontal overflow pipe 72 communicated with the lower part of the decompression pipe 71 are arranged at the upper part of the heat-conducting oil heating device 7. The pipe line of the overflow pipe 72 is set horizontally, and the upper part of the decompression pipe 71 is opened. When the heat conducting oil in the heat conducting oil heating device 7 is boiled, the boiling heat conducting oil can rise along the pressure reducing pipe 71 under the action of the pressure in the heat conducting oil heating device 7, and can be communicated with the atmosphere through the opening at the top of the pressure reducing pipe 71 to release partial pressure, so that excessive pressure generated in the heat conducting oil heating device 7 is avoided, meanwhile, the heat conducting oil rising into the pressure reducing pipe 71 can also enter the overflow pipe 72 at the lower end of the pressure reducing pipe 71, and the overflow pipe 72 is connected into a transfer container for temporarily storing the heat conducting oil overflowing from the overflow pipe 72. Prevent that the excessive explosion of 7 internal pressure of conduction oil heating device from producing and spill over the accident, guarantee reation kettle's security.

And a pressure sensor 17 is also arranged on the oil inlet pipe main path of the heat conduction oil pipe 11 and used for sensing the pressure of heat conduction oil, and the pressure sensor 17 is connected with the controller 3 and used for collecting a pressure signal of the heat conduction oil so as to facilitate the controller 3 to adjust the flow of the throttle valve 13. The heat conducting oil is ensured to work under safe pressure.

Set up shell 2 outside the cauldron body 1, with heat conduction oil pipe 11 and condensate pipe 12 as for in the cavity between shell 2 and the cauldron body 1, the outward appearance is clean and tidy on the one hand, and on the other hand prevents to scald and takes place to guarantee operating personnel's safety.

The utility model discloses a controller 3 sets up in the control box to set up the operating panel and be convenient for operating personnel operation and control. In addition, the controller 3 selects the existing Siemens or Mitsubishi brand PLC controller, and has stable and reliable performance and long service life.

In order to prevent the surface of the condenser from frosting, heat insulation layers are arranged on the surfaces of the first condenser 8 and the second condenser 9, and the heat insulation layers are heat insulation cotton or foam layers.

The utility model discloses a theory of operation: at the initial stage of the reaction, the reaction kettle needs to be heated, the first throttling valve 13 connected with the first condenser 8 on the branch of the heat conduction oil pipe 11 is closed, the first throttling valve 13 connected with the heat conduction oil heating device 7 is opened, and the two condensers are closed. And starting the heat conduction oil heating device 7 and the first extraction pump 14 to perform heating operation, and after the material reaction is finished. Closing a first throttling valve 13 connected with the heat-conducting oil heating device 7 on the branch of the heat-conducting oil heating device 7 and the heat-conducting oil pipe 11, opening the first throttling valve 13 connected with a first condenser 8, starting two condensers, two extraction pumps and a second throttling valve 15, and allowing high-temperature heat-conducting oil to enter the first condenser 8 for rapid cooling treatment so as to cool the kettle body 1, wherein the cooling time is long; and the second condenser 9 directly utilizes the subzero cooling salt water to cool the kettle body 1, the cooling is rapid, the time is short, the whole kettle body 1 is cooled by the sufficient matched heat conduction oil, the cooling time is greatly shortened, and the cooling efficiency is improved.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. The utility model provides a high-efficient condensing equipment of clozapine cyclization reaction which characterized in that: comprises a kettle body (1), a heat-conducting oil heating device (7), a first condenser (8) and a second condenser (9); a motor port is formed in the upper end of the kettle body (1), a rotating shaft (5) is arranged in the motor port, a motor (4) is arranged on the rotating shaft (5), the rotating shaft (5) penetrates through the motor (4), and the rotating shaft (5) extends into the kettle body (1) and is connected with a stirrer (6); double spiral pipes are wound on the outer surface of the kettle body (1) and respectively comprise a heat conduction oil pipe (11) and a condensate pipe (12); the end of the main path of the oil inlet pipe of the heat conduction oil pipe (11) is provided with two branches which are respectively connected with the oil discharge pipe of the heat conduction oil heating device (7) and the outlet of the condenser I (8), and each branch is provided with a throttle valve I (13); the end head of the main oil outlet pipe path of the heat conduction oil pipe (11) is provided with two branches which are respectively connected with a return pipe of the heat conduction oil heating device (7) and an inlet of the condenser I (8); a first extraction pump (14) is arranged on the main path of the oil inlet pipe of the heat-conducting oil pipe (11); the condensate pipe (12) is connected with the second condenser (9), and a second throttle valve (15) and a second extraction pump (16) are arranged at a water outlet pipe of the second condenser (9).

2. The clozapine cyclization reaction high efficiency condensing unit of claim 1, wherein: the kettle body (1) further comprises a controller (3), and the heat conduction oil heating device (7), the first condenser (8), the second condenser (9), the first throttle valve (13), the second throttle valve (15), the first extraction pump (14) and the second extraction pump (16) are all connected with the controller (3).

3. The clozapine cyclization reaction high efficiency condensing unit of claim 1, wherein: the inner sides of the heat-conducting oil pipe (11) and the condensate pipe (12) are flat.

4. The clozapine cyclization reaction high efficiency condensing unit of claim 1, wherein: and a vertical decompression pipe (71) and a horizontal overflow pipe (72) communicated with the lower part of the decompression pipe (71) are arranged at the upper part of the heat-conducting oil heating device (7).

5. The clozapine cyclization reaction high efficiency condensing unit of claim 4, wherein: the pipe of the overflow pipe (72) is arranged horizontally, and the upper part of the decompression pipe (71) is opened.

6. The clozapine cyclization reaction high efficiency condensing unit of claim 2, wherein: and a pressure sensor (17) is also arranged on the oil inlet pipe main path of the heat-conducting oil pipe (11), and the pressure sensor (17) is connected with the controller (3).

7. The clozapine cyclization reaction high efficiency condensing unit of claim 1, wherein: a shell (2) is arranged outside the kettle body (1), and a heat conducting oil pipe (11) and a condensate pipe (12) are arranged in a cavity between the shell (2) and the kettle body (1).

8. The clozapine cyclization reaction high efficiency condensing unit of claim 2, wherein: the controller (3) is arranged in the control box and is provided with an operation panel.

9. The clozapine cyclization reaction high efficiency condensing unit of claim 8, wherein: the controller (3) is a PLC controller.

10. The clozapine cyclization reaction high efficiency condensing unit of claim 1, wherein: and heat insulation layers are arranged on the surfaces of the first condenser (8) and the second condenser (9), and the heat insulation layers are heat insulation cotton or foam layers.