CN213878022U - Quadrupole rod electrode system for quadrupole mass spectrometry - Google Patents

Abstract

The utility model relates to a quadrupole rod electrode system for quadrupole mass spectrum, its characterized in that: having at least two sets of adjacently positioned quadrupole electrodes and planar foil electrodes; the four-pole rod electrodes are all composed of 4 identical electrodes, and all groups of four-pole rod electrodes are coaxially arranged; the flat sheet electrodes are arranged between two groups of adjacent quadrupole rod electrodes and are coaxially arranged with the quadrupole rod electrodes. The utility model discloses a set up the dull and stereotyped thin slice electrode of specific shape between adjacent two sets of electrode poles, can produce continuous quadrupole electric field distribution, avoid the marginal field effect that current structure leads to, prevent that the ion from running out and arousing the ion loss to can make the ion pass through along the axial completely when two-stage or multistage mass analysis, improve the transmission efficiency of ion.

Description

Quadrupole rod electrode system for quadrupole mass spectrometry

Technical Field

The utility model relates to a mass spectrometry instrument technical field, concretely relates to quadrupole rod electrode system for quadrupole mass spectrum.

Background

The mass spectrometry technology is a means for ionizing a sample in different ionization modes to form charged molecular ions and fragment ions, sequentially arranging the charged particles according to the ratio of mass m to charge z by a mass analyzer, and detecting by a detector to obtain the target mass number information. The mass spectrometer has the advantages of wide application range, high sensitivity, less sample consumption, high analysis speed, high mass resolution and the like, can realize the determination of the relative molecular weight and the atomic weight of an object to be detected, the structural analysis of organic compounds, the analysis of inorganic elements, the analysis of isotopes and the like, and is widely applied to the fields of food safety, environmental protection, life science, aerospace, biochemistry, medical science and the like.

Mass spectrometer development has been over a hundred years old, mass spectrometry technology has matured considerably, and various powerful commercial instruments have emerged during the last decades, and a complete mass spectrometer system includes: ion source, ion optics, mass analyzer, detector, and vacuum system, with the mass analyzer being the most critical part of a mass spectrometer. Mass spectrometers are generally named by the class of mass analyzers, and at present, the more common mass spectrometers are: sector magnetic mass spectrometry, quadrupole ion trap mass spectrometry, time-of-flight mass spectrometry, fourier transform ion cyclotron resonance mass spectrometry, orbital ion trap mass spectrometry, and the like. Different types of mass spectrometers have their own features and fields of application.

In addition to using a single mass analyzer, more and more commercial mass spectrometers are now using a plurality of mass analyzers in series, which can effectively extend the range of mass spectrometers, so-called tandem mass spectrometry, and the more common tandem mass spectrometry includes: triple quadrupole mass spectrometry (QQQ), matrix assisted laser desorption-time-of-flight mass spectrometry (MALDI-TOF-TOF), quadrupole linear ion trap mass spectrometry (Q-Q-LIT), quadrupole time-of-flight mass spectrometry (Q-TOF), quadrupole ion trap-time-of-flight mass spectrometry (IT-TOF), quadrupole Fourier transform ion cyclotron resonance mass spectrometry (Q-FTICFTR), linear ion trap-Fourier transform ion cyclotron resonance mass spectrometry (LIT-FTICR), and the like. The triple quadrupole mass spectrometer has the advantages of simple structure and low price, and can perform fragment ion analysis on macromolecular substances, so that the triple quadrupole mass spectrometer becomes the most common tandem mass spectrometer.

Fig. 1 is a schematic diagram of a conventional triple quadrupole mass spectrometer, in which a sample to be measured is ionized by an ion source to become charged particles, and after being transmitted and focused by an ion funnel, the charged particles firstly reach a triple quadrupole mass analyzer Q1 (1 in fig. 1), parent ions to be measured are selected according to mass-to-charge ratio, and secondly pass through a flat sheet electrode to reach a triple quadrupole mass analyzer Q2 (3 in fig. 1), namely a so-called quadrupole ion collision cell, and accelerated parent ions are dissociated in the ion collision cell by colliding with buffer gas molecules such as argon and helium molecules. The dissociated fragment ions enter a third quadrupole mass system Q3 (at 5 in fig. 1) from the collision cell, all the fragment ions are subjected to mass analysis by the third quadrupole mass spectrometer to obtain information of the fragment ions, and then the composition and molecular structure of the parent ions can be deduced according to the information of the fragment ions.

As shown in fig. 1, in a conventional triple quadrupole mass spectrometer, two adjacent quadrupole electrodes 1 and 3 and 5 are separated by metal plate thin electrodes 2 and 4, respectively, and an ion beam enters the next quadrupole electrode system from one quadrupole electrode system and needs to pass through a small hole on the plate thin electrode. The flat plate electrode has two uses, namely, the two quadrupole electrode systems are separated to play a role of differential vacuum; and secondly, under necessary conditions, voltage can be loaded on the ion source to play a role of ion focusing. Fig. 2 is a schematic diagram of ions passing from a front quadrupole to a rear quadrupole through a plate foil electrode, and the plate electrode between the two quadrupole electrodes has two disadvantages, namely, the small hole on the plate foil electrode limits the transmission of the ion beam, and after the charged ion beam 6 passes through a front mass spectrum, part of the charged ions collide with the plate foil electrode 8 to cause ion loss; secondly, the existence of the plate electrode can cause the change of the quadrupole electric field distribution generated by the power supply on the quadrupole rod, so-called 'fringe field effect' is generated, and the movement of the ions is completely dependent on the distribution of the electric field, so that the constraint of the quadrupole electric field on the ions is destroyed by the 'fringe field' distribution, the movement track of part of the ions 8 after leaving the quadrupole rod electrode system is dispersed, a large amount of ions are lost, and finally the sensitivity of mass spectrometry is influenced.

SUMMERY OF THE UTILITY MODEL

The utility model aims at overcoming the defect that prior art exists, provide one kind and can make the ion pass through along the axial completely when two-stage or multistage mass analysis, improve the transmission efficiency's of ion quadrupole rod electrode system for quadrupole mass spectrum.

Realize the utility model discloses the technical scheme of purpose is: a quadrupole electrode system for quadrupole mass spectrometry having at least two sets of adjacently positioned quadrupole electrodes and plate foil electrodes; the four-pole rod electrodes are all composed of 4 identical electrodes, and all groups of four-pole rod electrodes are coaxially arranged; the flat sheet electrodes are arranged between two groups of adjacent quadrupole rod electrodes and are coaxially arranged with the quadrupole rod electrodes.

The cross section of the flat sheet electrode in the technical scheme is in a double-T shape, a double-L shape or a double-T shape with an oblique angle.

According to the technical scheme, the horizontal distance that two axial end parts of the flat sheet electrode penetrate into two adjacent quadrupole rod electrodes is 5-20 mm, and the radial metal plate of the flat sheet electrode is placed at the symmetrical center of the two adjacent quadrupole rod electrodes.

According to the technical scheme, when the cross section of the flat sheet electrode is in a double-T shape with a certain oblique angle, the angle range of the oblique angle and the horizontal plane is 0-30 degrees.

According to the technical scheme, each quadrupole rod electrode is composed of 4 identical electrodes.

The cross section of each electrode in the technical scheme is in a hyperbolic surface shape or a circular or rectangular shape.

The two groups of quadrupole rod electrodes in the technical scheme are respectively one of quadrupole ion guide, a quadrupole mass analyzer or a quadrupole ion collision cell.

After the technical scheme is adopted, the utility model discloses following positive effect has:

(1) the utility model discloses a set up the dull and stereotyped thin slice electrode of specific shape between adjacent two sets of electrode poles, can produce continuous quadrupole electric field distribution, avoid the marginal field effect that current structure leads to, prevent that the ion from running out and arousing the ion loss to can make the ion pass through along the axial completely when two-stage or multistage mass analysis, improve the transmission efficiency of ion.

(2) The utility model discloses a diaxon of dull and stereotyped thin slice electrode is deepened the horizontal distance of two adjacent quadrupole pole electrodes to the tip and is 5 ~ 20 millimeters, and the radial metal sheet of dull and stereotyped thin slice electrode is placed in double-phase adjacent quadrupole pole electrode symmetry center department, can prevent that the ion from running out well and arousing the ion loss, does not influence adjacent electrode system's performance simultaneously again.

Drawings

In order that the present invention may be more readily and clearly understood, the following detailed description of the present invention is given in conjunction with the accompanying drawings, in which

FIG. 1 is a schematic diagram of a conventional triple quadrupole mass spectrometer;

FIG. 2 is a schematic diagram of the movement of charged particles in a conventional quadrupole rod electrode system;

FIG. 3 is a three-dimensional model of a flat sheet electrode;

FIG. 4 is a schematic diagram of a double T-section flat sheet electrode for a quadrupole rod electrode system according to the present invention;

FIG. 5 is a three-dimensional model diagram of a double T-section flat sheet electrode according to the present invention;

FIG. 6 is a schematic view of a double T-section flat sheet electrode with a bevel angle for implementing a quadrupole rod two electrode system of the present invention;

FIG. 7 is a three-dimensional model of a double T-section flat sheet electrode with a bevel according to the present invention;

fig. 8 is a schematic diagram of a double L-shaped cross-section flat sheet electrode for implementing a three-center quadrupole rod electrode system according to the present invention;

fig. 9 is a three-dimensional model diagram of a double-L-shaped cross-section flat sheet electrode according to the present invention.

Detailed Description

As shown in fig. 4, the present invention includes at least two sets of first quadrupole rods 7 and second quadrupole rods 10 and intermediate flat sheet electrodes 11, which are adjacently disposed. Two groups of adjacent first quadrupole electrodes 7 and second quadrupole electrodes 10 are arranged in a horizontal axis superposition mode, and the flat sheet electrode 11 is arranged between the two adjacent quadrupole electrodes.

As shown in fig. 5, the cross-sectional shape of the flat sheet electrode 11 is a double T shape, and can be regarded as consisting of a round metal sheet with small holes and a metal cylinder, wherein the inner diameters of the small holes of the round metal sheet and the metal cylinder are equal and perpendicular to each other. The round metal sheet is vertically arranged on the symmetry axis of the two adjacent quadrupole rod electrode groups, and the metal cylinder and the quadrupole rod electrode are arranged in parallel. The distance from the horizontal metal cylinder of the double-T-shaped section flat sheet electrode 11 to the quadrupole rod electrode is 5 mm to 20 mm, so that charged particles are bound between the double-T-shaped section flat sheet electrodes 11 before entering the gap between two adjacent quadrupole rod electrodes, the effect of improving the ion transmission efficiency is achieved, the normal work of a quadrupole rod electrode group is not influenced, and meanwhile, the effect of differential vacuum can be achieved.

The two sets of adjacent quadrupole electrode systems may each be selected from one of a quadrupole ion guide, a quadrupole mass analyser and a quadrupole ion collision cell.

The cross sections of two groups of adjacent quadrupole rod electrode systems are completely the same, and the cross section can be hyperbolic surface shape, circular or rectangular.

(example 2)

As shown in fig. 6, a quadrupole rod electrode system for improving ion transmission efficiency in tandem mass spectrometry has a structure substantially the same as that of embodiment 1, except that: in the embodiment, the cross section of the horizontal electrode of the middle flat sheet electrode 11 is changed to have a certain inclination, the angle between the horizontal electrode and the horizontal plane is controlled to be 0-30 degrees, the specific shape is as shown in fig. 7, the diameter of one side close to the metal disc sheet is smaller than that of one side close to the quadrupole rods, the metal disc sheet is symmetrically arranged on two sides, and the horizontal distance penetrating into the quadrupole rod electrode groups on the two sides is also controlled to be 5-20 mm.

(example 3)

As shown in fig. 8, a quadrupole rod electrode system for improving ion transmission efficiency in tandem mass spectrometry has a structure substantially the same as that of embodiment 1, except that: in this embodiment, the cross-sectional shape of the middle plate thin electrode 11 is changed from double T shape to double L shape, and the horizontal distance from the horizontal electrode to the next quadrupole rod electrode group is controlled between 5 mm and 20 mm. Fig. 9 is a model view of the present example, and it can be seen that the inner diameter of the vertical metal disk electrode is equal to the inner diameter of the horizontal tubular electrode, the vertical metal disk of the flat sheet electrode 13 is placed at the vertical symmetry axis of the first quadrupole electrode 7 and the second quadrupole electrode 10, and the horizontal tubular electrode axis of the flat sheet electrode 13 coincides with the axes of the two sets of the first quadrupole electrode 7 and the second quadrupole electrode 10.

(example 4)

A method of series connection of quadrupole rod electrode systems, comprising the steps of:

two sets of quadrupole rods electrodes that adjacent placed around arbitrary selection in two sets of and above quadrupole rods electrode system are as adjacent quadrupole rods electrode group, place in their centre the utility model discloses dull and stereotyped thin slice electrode 11.

In three groups and above quadrupole rod electrode system, set up at one or more adjacent quadrupole rod electrode group the utility model discloses dull and stereotyped thin slice electrode 11, every two sets of adjacent quadrupole rods click the shape of dull and stereotyped thin slice electrode 11 between the group can be the same also can be different.

The utility model discloses a quadrupole rod electrode system and series connection method thereof, through set up the dull and stereotyped thin slice electrode 11 of different shapes between adjacent two sets of electrode pole electrodes, not only can the differential vacuum, produce continuous quadrupole electric field distribution, can also avoid the marginal field effect that current structure leads to, prevent that the ion from running out and arousing the ion loss to can make the ion pass through along the axial completely when two-stage or multistage mass analysis, improve the transmission efficiency of ion.

The above-mentioned embodiments, further detailed description of the objects, technical solutions and advantages of the present invention, it should be understood that the above-mentioned embodiments are only specific embodiments of the present invention, and are not intended to limit the present invention, and any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (7)

1. A quadrupole electrode system for quadrupole mass spectrometry, comprising: having at least two sets of adjacently positioned quadrupole electrodes and planar foil electrodes; the four-pole rod electrodes are all composed of 4 identical electrodes, and all groups of four-pole rod electrodes are coaxially arranged; the flat sheet electrodes are arranged between two groups of adjacent quadrupole rod electrodes and are coaxially arranged with the quadrupole rod electrodes.

2. The quadrupole rod electrode system for quadrupole mass spectrometry of claim 1, wherein: the cross section of the flat sheet electrode is in a double-T shape or double-L shape or double-T shape with an oblique angle.

3. Quadrupole rod electrode system for quadrupole mass spectrometry according to claim 1 or 2, wherein: the horizontal distance that two axial ends of dull and stereotyped flake electrode go deep into two adjacent quadrupole rods electrode is 5 ~ 20 millimeters, and the radial metal sheet of dull and stereotyped flake electrode is placed in two adjacent quadrupole rods electrode symmetry center department.

4. Quadrupole rod electrode system for quadrupole mass spectrometry according to claim 1 or 2, wherein: when the cross section of the flat sheet electrode is in a double-T shape with a certain oblique angle, the angle range of the oblique edge and the horizontal plane is 0-30 degrees.

5. The quadrupole rod electrode system for quadrupole mass spectrometry of claim 1, wherein: each quadrupole rod electrode consists of 4 identical electrodes.

6. The quadrupole rod electrode system for quadrupole mass spectrometry of claim 5, wherein: the cross section of each electrode is in the shape of a hyperboloid or a circle or a rectangle.

7. The quadrupole rod electrode system for quadrupole mass spectrometry of claim 1, wherein: the two groups of quadrupole rod electrodes are respectively one of quadrupole ion guide, quadrupole mass analyzer or quadrupole ion collision cell.

Images