CN213877245U

CN213877245U - In-vitro simulation device for pharmacokinetics

Info

Publication number: CN213877245U
Application number: CN202023024093.1U
Authority: CN
Inventors: 顾哲明; 董凌云
Original assignee: Value Pharmaceutical Services Co ltd
Current assignee: Value Pharmaceutical Services Co ltd
Priority date: 2020-12-15
Filing date: 2020-12-15
Publication date: 2021-08-03
Anticipated expiration: 2030-12-15

Abstract

The utility model relates to an analogue means technical field, and an external analogue means of pharmacokinetics is disclosed, including the analogue means body, the analogue means body includes the peristaltic pump, peristaltic pump fixed connection is at the last lateral wall of analogue means body, the equal fixedly connected with cross section of the lateral wall of the peristaltic pump left and right sides is the carriage of type of falling L structure, the spread groove has all been seted up to the lateral wall of the peristaltic pump left and right sides, the water hole has been seted up to the lateral wall of spread groove, it is the joint of type of falling L structure to peg graft the cross section in the spread groove, the lower extreme fixedly connected with of joint manages outward, the lower extreme of outer pipe and the fixed intercommunication of the last lateral wall of analogue means body, the lateral wall of carriage rotates through the bearing and is connected with a thread section of thick bamboo, the inner wall thread bush of a thread section of thick bamboo is equipped with the threaded rod. The utility model discloses can be under the condition that need not use ring flange and bolt convenient quick fixed connection pipe and other equipment, improved operating personnel's work efficiency.

Description

In-vitro simulation device for pharmacokinetics

Technical Field

The utility model relates to an analogue means technical field especially relates to an external analogue means of pharmacokinetics.

Background

When the drug is combined, the in vivo metabolic kinetic processes and parameters (such as absorption, distribution, metabolism and excretion) of the drug are changed, and the processes are mainly expressed as follows: effect on drug absorption: the change of the pH value of the digestive juice directly influences the dissociation degree of the medicine, the medicine for promoting or inhibiting the secretion of the digestive juice influences the absorption of other medicines, the acidic medicines such as phenylbutazone, vitamin C and the like can be better absorbed when the pH value is lower, for example, the absorption is influenced by combining alkaline medicines such as sodium bicarbonate and the like or anticholinergic medicines, H2 receptor blocking agents, omeprazole and other medicines for inhibiting the secretion of gastric acid, and on the contrary, the absorption is reduced when weakly alkaline medicines such as aminophylline and the like and the acidic medicines are combined.

In an in vitro device for simulating pharmacokinetic properties of a multicomponent combination for administration as set forth in patent publication No. CN102097026B, the device comprises: the multi-element variable-speed liquid conveying unit is used for conveying each component stock solution and the blank solution at a preset speed respectively; wherein, the predetermined rate of each component stock solution is that the characteristic of a delivery speed-time curve of each component stock solution is consistent with the characteristic of a blood concentration-time curve of the component in a human body or an animal body; moreover, the sum of the predetermined rate of each component stock solution and the predetermined rate of the blank solution is in a constant state; also, the ratio between the delivery rates of the component stock solutions. The connecting pipe is more in this patent, and the connecting pipe passes through the ring flange and the bolt is connected with other equipment, because the connecting pipe is more, uses ring flange and bolt fastening connection pipe can influence operating personnel's work efficiency.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving prior art well connecting pipe more, the connecting pipe passes through the ring flange and the bolt is connected with other equipment, because the connecting pipe is more, uses ring flange and bolt fastening connecting pipe can influence operating personnel work efficiency's problem, and the external analogue means of a pharmacokinetics that proposes.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

an in vitro simulation device of pharmacokinetics comprises a simulation device body, wherein the simulation device body comprises a peristaltic pump, the peristaltic pump is fixedly connected with the upper side wall of the simulation device body, the side walls of the left side and the right side of the peristaltic pump are fixedly connected with a connecting frame with an inverted L-shaped cross section, the side walls of the left side and the right side of the peristaltic pump are respectively provided with a connecting groove, the side walls of the connecting grooves are respectively provided with a water hole, a joint with an inverted L-shaped cross section is inserted in each connecting groove, the lower end of the joint is fixedly connected with an external connecting pipe, the lower end of the external connecting pipe is fixedly communicated with the upper side wall of the simulation device body, the side wall of the connecting frame is rotatably connected with a threaded cylinder through a bearing, the inner wall of the threaded cylinder is sleeved with a threaded rod, the right end of the threaded rod is fixedly connected with a top plate, and the outer wall of the threaded cylinder is fixedly sleeved with a gear ring, the side wall fixedly connected with diaphragm goes up of carriage, spacing hole has been seted up to the lateral wall of diaphragm, it has the spacer pin to peg graft in the spacing perforation, the lower extreme fixedly connected with clamp of spacer pin, a plurality of spacing teeth of inner wall fixedly connected with of clamp, the upper end fixedly connected with connecting plate of spacer pin, the same root cover of lateral wall fixedly connected with between connecting plate and the diaphragm is established at the outer first spring of spacer pin.

Preferably, the last lateral wall fixedly connected with location hoop of connecting plate, the last lateral wall fixedly connected with riser of diaphragm, the locating hole has been seted up to the lateral wall of riser, it has the locating pin to peg graft in the locating hole, the right-hand member fixedly connected with arm-tie of locating pin, the same root cover of lateral wall fixedly connected with between arm-tie and the riser is established the second spring outside the locating pin.

Preferably, the inner wall of the connecting frame is symmetrically and fixedly connected with two sliding rods with cross sections of inverted L-shaped structures, and the rod wall of the threaded rod is symmetrically provided with two sliding grooves matched with the sliding rods.

Preferably, the right end fixedly connected with sealing washer that connects, the seal groove that matches each other with the sealing washer is seted up to the lateral wall of spread groove.

Preferably, the left end of the threaded cylinder is fixedly connected with a rotating plate.

Preferably, the outer sleeve of the external connecting pipe is provided with a protective sleeve.

Compared with the prior art, the utility model provides an external analogue means of pharmacokinetics possesses following beneficial effect:

this external analogue means of pharmacokinetics through analogue means body, peristaltic pump, carriage, spread groove, water hole, joint, external pipe, threaded cylinder, threaded rod, roof, ring gear, diaphragm, spacing hole, spacer pin, clamp, spacing tooth, connecting plate and the first spring that sets up, can be under the condition that need not use ring flange and bolt convenient quick fixed connection pipe and other equipment, improved operating personnel's work efficiency.

And the part that does not relate to among the device all is the same with prior art or can adopt prior art to realize, the utility model discloses can be under the condition that need not use ring flange and bolt convenient quick fixed connection pipe and other equipment, improved operating personnel's work efficiency.

Drawings

Fig. 1 is a schematic structural diagram of an in vitro pharmacokinetic simulation device according to the present invention;

FIG. 2 is an enlarged view of portion A of FIG. 1;

fig. 3 is a schematic diagram of the shape structure of the hoop in the pharmacokinetic in vitro simulation device of the present invention.

In the figure: the device comprises a simulation device body 1, a peristaltic pump 2, a connecting frame 3, a connecting groove 4, a water hole 5, a joint 6, an external connecting pipe 7, a threaded cylinder 8, a threaded rod 9, a top plate 10, a gear ring 11, a transverse plate 12, a limiting hole 13, a limiting pin 14, a clamping hoop 15, a limiting tooth 16, a connecting plate 17, a first spring 18, a positioning hoop 19, a vertical plate 20, a positioning hole 21, a positioning pin 22, a pulling plate 23, a second spring 24, a sliding rod 25, a sliding groove 26, a sealing ring 27, a sealing groove 28, a rotating plate 29 and a protective sleeve 30.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Referring to fig. 1-3, an in vitro simulator of pharmacokinetics comprises a simulator body 1, the simulator body 1 comprises a peristaltic pump 2, the peristaltic pump 2 is fixedly connected to the upper side wall of the simulator body 1, the side walls of the left and right sides of the peristaltic pump 2 are fixedly connected with a connecting frame 3 with an inverted L-shaped cross section, the side walls of the left and right sides of the peristaltic pump 2 are respectively provided with a connecting groove 4, the side wall of the connecting groove 4 is provided with a water hole 5, a joint 6 with an inverted L-shaped cross section is inserted into the connecting groove 4, the lower end of the joint 6 is fixedly connected with an external connecting pipe 7, the lower end of the external connecting pipe 7 is fixedly communicated with the upper side wall of the simulator body 1, the side wall of the connecting frame 3 is rotatably connected with a threaded cylinder 8 through a bearing, the inner wall of the threaded cylinder 8 is threaded with a threaded rod 9, the right end of the threaded rod 9 is fixedly connected with a top plate 10, and the outer wall of the threaded cylinder 8 is fixedly sleeved with a gear ring 11, the upper side wall fixedly connected with diaphragm 12 of connecting frame 3, spacing hole 13 has been seted up to the lateral wall of diaphragm 12, and spacing round pin 14 has been pegged graft in spacing hole 13, and the lower extreme fixedly connected with clamp 15 of spacing round pin 14, a plurality of spacing teeth 16 of the inner wall fixedly connected with of clamp 15, the upper end fixedly connected with connecting plate 17 of spacing round pin 16, the same root cover of lateral wall fixedly connected with between connecting plate 17 and diaphragm 12 is established at first spring 18 outside the spacing round pin 14.

The upper side wall fixedly connected with of connecting plate 17 fixes a position hoop 19, the upper side wall fixedly connected with riser 20 of diaphragm 12, locating hole 21 has been seted up to riser 20's lateral wall, and locating pin 22 has been pegged graft in the locating hole 21, and the right-hand member fixedly connected with arm-tie 23 of locating pin 22, the same root cover of lateral wall fixedly connected with between arm-tie 23 and the riser 20 is established and is established second spring 24 outside locating pin 22, can fix connecting plate 17.

The inner wall symmetry fixedly connected with of connection frame 3 two cross sections are for the slide bar 25 of type of falling L structure, and two spouts 26 that match each other with slide bar 25 are seted up to the pole wall symmetry of threaded rod 9, avoid threaded rod 9 rotatory through mutually supporting of slide bar 25 and spout 26, make threaded rod 19 only can remove about the horizontal direction.

The right-hand member fixedly connected with sealing washer 27 of joint 6, the seal groove 28 of mutually supporting with sealing washer 27 has been seted up to the lateral wall of spread groove 4, has increased the leakproofness between joint 6 and the spread groove 4.

The left end of the thread cylinder 8 is fixedly connected with a rotating plate 29, so that the thread cylinder 8 can be conveniently rotated.

The outer sleeve of the external pipe 7 is provided with a protective sleeve 30 which can protect the external pipe 7.

The utility model discloses in, during the use, to connect 6 inserts in spread groove 4, then rotatory commentaries on classics board 29, it is rotatory that commentaries on classics board 29 drives a screw thread section of thick bamboo 8, it moves right suitable position together to drive threaded rod 9 and roof 10 through screw-thread fit, fix joint 6, then to the direction pulling arm-tie 23 of keeping away from riser 20, make arm-tie 23 drive locating pin 22 break away from location hoop 19, connecting plate 17 drives spacer pin 14 and hoop 15 suitable position of moving down under the pulling force of first spring 18, mutually support through hoop 15 and ring gear 11 and fix a screw thread section of thick bamboo 8, reverse operation can take out joint 6, the device can be under the condition that need not use ring flange and bolt convenient quick fixed connection pipe and other equipment, operating personnel's work efficiency has been improved.

The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.

Claims

1. The in vitro simulation device of pharmacokinetics comprises a simulation device body (1) and is characterized in that the simulation device body (1) comprises a peristaltic pump (2), the peristaltic pump (2) is fixedly connected with the upper side wall of the simulation device body (1), the side walls of the left side and the right side of the peristaltic pump (2) are fixedly connected with a connecting frame (3) with an inverted L-shaped cross section, the side walls of the left side and the right side of the peristaltic pump (2) are respectively provided with a connecting groove (4), the side walls of the connecting grooves (4) are respectively provided with a water hole (5), a joint (6) with an inverted L-shaped cross section is inserted into the connecting grooves (4), the lower end of the joint (6) is fixedly connected with an external connecting pipe (7), the lower end of the external connecting pipe (7) is fixedly communicated with the upper side wall of the simulation device body (1), and the side wall of the connecting frame (3) is rotatably connected with a threaded barrel (8) through a bearing, the inner wall thread bush of screw thread section of thick bamboo (8) is equipped with threaded rod (9), right-hand member fixedly connected with roof (10) of threaded rod (9), the outer wall fixed cover of screw thread section of thick bamboo (8) is equipped with ring gear (11), go up lateral wall fixedly connected with diaphragm (12) of connecting frame (3), spacing hole (13) have been seted up to the lateral wall of diaphragm (12), it has spacer pin (14) to peg graft in spacing hole (13), the lower extreme fixedly connected with clamp (15) of spacer pin (14), a plurality of spacing teeth (16) of inner wall fixedly connected with of clamp (15), the upper end fixedly connected with connecting plate (17) of spacer pin (14), the same root cover of lateral wall fixedly connected with between connecting plate (17) and diaphragm (12) is established first spring (18) outside spacer pin (14).

2. The pharmacokinetics in vitro simulator of claim 1, wherein the upper side wall of the connecting plate (17) is fixedly connected with a positioning hoop (19), the upper side wall of the transverse plate (12) is fixedly connected with a vertical plate (20), the side wall of the vertical plate (20) is provided with a positioning hole (21), the positioning hole (21) is internally inserted with a positioning pin (22), the right end of the positioning pin (22) is fixedly connected with a pulling plate (23), and the side wall between the pulling plate (23) and the vertical plate (20) is fixedly connected with a second spring (24) which is sleeved outside the positioning pin (22).

3. The pharmacokinetic in vitro simulation device according to claim 1, wherein the inner wall of the connection frame (3) is symmetrically and fixedly connected with two sliding bars (25) with an inverted L-shaped cross section, and the bar wall of the threaded bar (9) is symmetrically provided with two sliding grooves (26) matched with the sliding bars (25).

4. The pharmacokinetic in vitro simulation device according to claim 1, wherein a sealing ring (27) is fixedly connected to the right end of the joint (6), and a sealing groove (28) matched with the sealing ring (27) is formed in the side wall of the connecting groove (4).

5. A pharmacokinetic in vitro simulation device according to claim 1, characterized in that a rotating plate (29) is fixedly connected to the left end of the threaded cylinder (8).

6. A pharmacokinetic in vitro simulation device according to claim 1, wherein the extension tube (7) is externally sheathed with a protective sheath (30).