CN213762193U - Entecavir preparation is with high-efficient jet milling equipment - Google Patents

Entecavir preparation is with high-efficient jet milling equipment Download PDF

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Publication number
CN213762193U
CN213762193U CN202022069835.6U CN202022069835U CN213762193U CN 213762193 U CN213762193 U CN 213762193U CN 202022069835 U CN202022069835 U CN 202022069835U CN 213762193 U CN213762193 U CN 213762193U
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China
Prior art keywords
connecting plate
plate
positioning
jet mill
dust box
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CN202022069835.6U
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Chinese (zh)
Inventor
冯学彬
马国栋
孙秋颖
李贵千
车美玲
曹烁久
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Shandong Zibo Haiya Pharmaceutical Co.,Ltd.
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Shandong Haiya Pharmaceutical Technology Co ltd
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Abstract

The utility model provides a high-efficient jet milling equipment is used in entecavir preparation, including the jet mill, cushion location chassis structure, exhaust tube, aspiration pump, waste material are led and are fallen collection frame structure, dust box, stainless steel mesh, motor, rotary impeller, blast pipe, arc, dust exhaust pipe, valve and shock attenuation buffer frame structure, exhaust tube one end and jet mill's upper portion switch-on, the other end and the left side switch-on of aspiration pump; the waste material guiding and collecting frame structure is arranged on the right side of the upper part of the buffering and positioning underframe structure; the stainless steel mesh bolt is arranged at the upper part of the inner side of the dust box. The rubber anti-skid pad is arranged on the bottom screw of the bottom anti-skid plate, so that the anti-skid effect of the bottom anti-skid plate when contacting with the ground can be increased when the anti-skid plate is used; buffer spring cup joints in the outside of locating lever, sets up the lower part at the upside connecting plate simultaneously, is favorable to when using conveniently playing buffering shock-absorbing function to the upside connecting plate.

Description

Entecavir preparation is with high-efficient jet milling equipment
Technical Field
The utility model belongs to the technical field of the medicine processing, especially, relate to a high-efficient jet milling equipment is used in entecavir preparation.
Background
Entecavir (Entecavir) is cyclopentyl guanosine analogue, is an oral anti-HBV drug capable of selectively inhibiting the replication of Hepatitis B Virus (HBV) in the liver. It can be used for treating adult chronic hepatitis B patients with active virus replication, continuously increased serum transaminase (ALT) or active pathological changes due to liver histology.
But current jet mill equipment has the antiskid effect to the bottom poor, does not possess to this equipment play shock-absorbing function and inconvenient to the problem that leads to the dust down.
Therefore, the invention of the high-efficiency airflow crushing equipment for preparing the entecavir is very necessary.
SUMMERY OF THE UTILITY MODEL
In order to solve the technical problem, the utility model provides an entecavir preparation is with high-efficient jet milling equipment to it is poor to the anti-skidding effect of bottom to solve current jet milling equipment existence, does not possess to play shock-absorbing function and inconvenient to lead the problem that falls to the dust line down to this equipment. A high-efficiency airflow crushing device for preparing entecavir comprises an airflow crusher, a buffering and positioning underframe structure, an exhaust pipe, an exhaust pump, a waste material guide and collection frame structure, a dust box, a stainless steel mesh, a motor, a rotary impeller, an exhaust pipe, an arc-shaped plate, a dust exhaust pipe, a valve and a damping and buffering frame structure, wherein one end of the exhaust pipe is communicated with the upper part of the airflow crusher, and the other end of the exhaust pipe is communicated with the left side of the exhaust pump; the waste material guiding and collecting frame structure is arranged on the right side of the upper part of the buffering and positioning underframe structure; the stainless steel mesh bolt is arranged at the upper part of the inner side of the dust box; the motor bolt is arranged in the middle of the stainless steel net; the rotary impeller is arranged at the lower part of the dust box, and meanwhile, the bolt is arranged on an output shaft of the motor; the exhaust pipe is inserted at the upper part of the dust box; the arc-shaped plate screw is arranged in the middle of the dust box; the dust exhaust pipe is inserted at the right side of the dust box; the valve is in threaded connection with the right side of the dust exhaust pipe; the damping and buffering frame structure is arranged on the upper side of the buffering and positioning underframe structure; the buffering and positioning underframe structure comprises a bottom antiskid plate, an upper side connecting plate, an I-shaped rubber buffer seat, a positioning hole and a silica gel sleeve, wherein the bottom antiskid plate is arranged at the lower part of the upper side connecting plate; the I-shaped rubber buffer seat is glued to the inner sides of the bottom antiskid plate and the upper side connecting plate; the positioning holes are respectively formed in the upper side connecting plate; the jet mill is arranged on the left side of the upper part of the upper side connecting plate.
Preferably, the damping buffer frame structure comprises a transverse positioning plate, a positioning rod, a locking nut, a buffer spring and a rubber protective sleeve, wherein the locking nut is in threaded connection with the upper part of the outer side of the positioning rod; the transverse positioning plate is embedded in the upper part of the bottom antiskid plate.
Preferably, the waste material guiding and collecting frame structure comprises a collecting frame, a collecting hopper, a handle, a fixing pipe and a material guiding hopper, wherein the collecting frame is mounted at the right side position of the upper part of the upper side connecting plate through a bolt; the collecting hopper is inserted at the lower part of the inner side of the collecting frame; the handle screw is arranged in the middle of the front side of the collecting hopper; the fixed pipe is welded at the upper part of the collecting frame; the material guide hopper is welded on the upper part of the fixed pipe; the air suction pump is mounted on the left side of the fixed pipe through a bolt; the dust box is arranged on the upper part of the material guide hopper through a bolt.
Preferably, the bottom screw of the bottom antiskid plate is provided with a rubber antiskid pad.
Preferably, the buffer spring is sleeved outside the positioning rod and is arranged at the lower part of the upper connecting plate.
Preferably, the locating rod is welded at the middle upper part of the transverse locating plate and is inserted into the inner side of the locating hole.
Preferably, the inner wall of the material guide hopper inclines towards the middle lower part.
Preferably, the rubber protective sleeve is sleeved on the outer side of the locking nut and is arranged on the upper portion of the upper side connecting plate.
Preferably, the silica gel sleeve is glued at the joint of the outer sides of the upper side connecting plate and the bottom antiskid plate.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the utility model discloses in, the bottom screw of bottom antiskid ribbed tile install the rubber slipmat, be favorable to increasing the antiskid effect when bottom antiskid ribbed tile and ground contact when using.
2. The utility model discloses in, buffer spring cup joint in the outside of locating lever, set up the lower part at the upside connecting plate simultaneously, be favorable to when the use conveniently play buffering shock-absorbing function to the upside connecting plate.
3. The utility model discloses in, the locating lever welding in the well upper portion of transverse orientation board, peg graft in the inboard of locating hole simultaneously, be favorable to locating lever from the locating hole internalization when using to play locate function to upside connecting plate and bottom antiskid ribbed tile, and avoid upside connecting plate to rock about from the bottom antiskid ribbed tile.
4. The utility model discloses in, the slope of guide fill inner wall to well lower part, be favorable to conveniently leading the inside material thing of dust box downwards when using to avoid the gathering of material sediment in the edge of the lower part of dust box.
5. The utility model discloses in, rubber lag cup joint in lock nut's the outside, set up on the upper portion of upside connecting plate simultaneously, be favorable to conveniently playing the guard action along with lock nut when using to can avoid lock nut to wet the damage.
6. The utility model discloses in, silica gel cover glue joint in the outside junction of upside connecting plate and bottom antiskid ribbed tile, be favorable to avoiding dust debris to enter into the gap department of upside connecting plate and bottom antiskid ribbed tile when using.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic structural view of the buffering and positioning underframe structure of the present invention.
Fig. 3 is a schematic structural view of the waste material guide collecting rack structure of the present invention.
Fig. 4 is a schematic structural view of the shock absorbing and buffering frame structure of the present invention.
In the figure:
1. a jet mill; 2. a buffer positioning underframe structure; 21. a bottom cleat; 22. an upper side connecting plate; 23. an I-shaped rubber buffer seat; 24. positioning holes; 25. a silica gel sleeve; 3. an air exhaust pipe; 4. an air pump; 5. a waste material guide and collection frame structure; 51. a collection frame; 52. a collecting hopper; 53. a handle; 54. a fixed tube; 55. a material guide hopper; 6. a dust box; 7. a stainless steel mesh; 8. a motor; 9. rotating the impeller; 10. an exhaust pipe; 11. an arc-shaped plate; 12. a dust exhaust pipe; 13. a valve; 14. a shock absorbing and buffering frame structure; 141. a transverse positioning plate; 142. positioning a rod; 143. locking the nut; 144. a buffer spring; 145. a rubber protective sleeve.
Detailed Description
The invention is further described below with reference to the accompanying drawings:
example (b):
as shown in figures 1 and 2
The utility model provides a high-efficient jet mill equipment is used in entecavir preparation, including jet mill 1, buffering location chassis structure 2, exhaust tube 3, aspiration pump 4, waste material are led and are fallen collection frame structure 5, dust box 6, stainless steel net 7, motor 8, rotary impeller 9, blast pipe 10, arc 11, dust exhaust pipe 12, valve 13 and shock attenuation buffer frame structure 14, exhaust tube 3 one end and jet mill 1's upper portion switch-on, the other end and jet mill 4's left side switch-on; the waste material guiding and collecting frame structure 5 is arranged on the right side of the upper part of the buffering and positioning underframe structure 2; the stainless steel net 7 is mounted on the upper part of the inner side of the dust box 6 through bolts; the motor 8 is mounted in the middle of the stainless steel net 7 through bolts; the rotary impeller 9 is arranged at the lower part of the dust box 6, and a bolt is arranged on an output shaft of the motor 8; the exhaust pipe 10 is inserted at the upper part of the dust box 6; the arc-shaped plate 11 is arranged in the middle of the dust box 6 through a screw; the dust exhaust pipe 12 is inserted at the right side of the dust box 6; the valve 13 is connected to the right side of the dust exhaust pipe 12 in a threaded manner; the damping and buffering frame structure 14 is arranged on the upper side of the buffering and positioning underframe structure 2; the buffering and positioning underframe structure 2 comprises a bottom antiskid plate 21, an upper side connecting plate 22, an I-shaped rubber buffer seat 23, a positioning hole 24 and a silica gel sleeve 25, wherein the bottom antiskid plate 21 is arranged at the lower part of the upper side connecting plate 22; the I-shaped rubber buffer seat 23 is glued on the inner sides of the bottom antiskid plate 21 and the upper side connecting plate 22; the positioning holes 24 are respectively arranged on the upper side connecting plate 22; the jet mill 1 is arranged on the left side of the upper part of the upper side connecting plate 22; the bottom screw of bottom antiskid ribbed tile 21 install the rubber slipmat, antiskid effect when can increase bottom antiskid ribbed tile 21 and ground contact when using, silica gel cover 25 splice in the outside junction of upside connecting plate 22 and bottom antiskid ribbed tile 21, can avoid dust debris to enter into the gap department of upside connecting plate 22 and bottom antiskid ribbed tile 21 when using.
As shown in fig. 4, in the above embodiment, specifically, the shock absorbing and buffering frame structure 14 includes a transverse positioning plate 141, a positioning rod 142, a lock nut 143, a buffering spring 144 and a rubber protecting sleeve 145, wherein the lock nut 143 is screwed on the upper portion of the outer side of the positioning rod 142; the transverse positioning plate 141 is embedded in the upper part of the bottom antiskid plate 21; buffer spring 144 cup joint in the outside of locating lever 142, set up the lower part at upside connecting plate 22 simultaneously, conveniently play buffering shock-absorbing function to upside connecting plate 22 when using, locating lever 142 weld in the well upper portion of horizontal locating plate 141, peg graft in the inboard of locating hole 24 simultaneously, locating lever 142 from locating hole 24 internalization when using to play locate function to upside connecting plate 22 and bottom antiskid ribbed tile 21, and avoid upside connecting plate 22 to rock from the bottom antiskid ribbed tile 21 about following, rubber lag 145 cup joint in lock nut 143's the outside, set up the upper portion at upside connecting plate 22 simultaneously, conveniently play the guard action along with lock nut 143 when using, thereby can avoid lock nut 143 to wet the damage.
In the above embodiment, as shown in fig. 3, specifically, the waste material guiding and collecting frame structure 5 includes a collecting frame 51, a collecting bucket 52, a handle 53, a fixing pipe 54 and a material guiding bucket 55, wherein the collecting frame 51 is mounted at the upper right position of the upper connecting plate 22 by bolts; the collecting hopper 52 is inserted at the lower part of the inner side of the collecting frame 51; the handle 53 is mounted at the middle position of the front side of the collecting bucket 52 through a screw; the fixed pipe 54 is welded on the upper part of the collecting frame 51; the material guide hopper 55 is welded on the upper part of the fixed pipe 54; the air suction pump 4 is installed on the left side of the fixed pipe 54 through bolts; the dust box 6 is arranged at the upper part of the material guide hopper 55 through bolts; the inner wall of the material guiding hopper 55 is inclined towards the middle lower part, so that materials in the dust box 6 can be conveniently guided downwards when the dust box is used, and therefore, the phenomenon that the materials are accumulated at the corners of the lower part of the dust box 6 is avoided.
Principle of operation
The utility model discloses in the course of the work, usable fluid energy mill 1 smashes the material thing during use, then utilize exhaust tube 3 to extract via aspiration pump 4, then enter into fixed pipe 54 in, it is rotatory to utilize motor 8 to drive rotatory impeller 9 simultaneously, and the dust is discharged through the dust exhaust pipe 12 outside, dust in the dust box 6 enters into fixed pipe 54 through guide hopper 55 simultaneously, then fall to the collection in the collection frame 51 fill 52 in store, utilize buffer spring 144 and I shape rubber buffer seat 23 to play the shock attenuation buffer function to this equipment simultaneously.
Utilize technical scheme, or technical personnel in the field are in the utility model discloses under technical scheme's the inspiration, design similar technical scheme, and reach above-mentioned technological effect, all fall into the utility model discloses a protection scope.

Claims (9)

1. The efficient airflow crushing equipment for preparing the entecavir is characterized by comprising an airflow crusher (1), a buffering and positioning chassis structure (2), an air suction pipe (3), an air suction pump (4), a waste guide and collection frame structure (5), a dust box (6), a stainless steel net (7), a motor (8), a rotary impeller (9), an exhaust pipe (10), an arc-shaped plate (11), a dust exhaust pipe (12), a valve (13) and a damping and buffering frame structure (14), wherein one end of the air suction pipe (3) is communicated with the upper part of the airflow crusher (1), and the other end of the air suction pipe is communicated with the left side of the air suction pump (4); the waste material guiding and collecting frame structure (5) is arranged on the right side of the upper part of the buffering and positioning underframe structure (2); the stainless steel net (7) is arranged at the upper part of the inner side of the dust box (6) by bolts; the motor (8) is arranged in the middle of the stainless steel net (7) through a bolt; the rotary impeller (9) is arranged at the lower part of the dust box (6), and meanwhile, a bolt is arranged on an output shaft of the motor (8); the exhaust pipe (10) is inserted at the upper part of the dust box (6); the arc-shaped plate (11) is arranged in the middle of the dust box (6) through a screw; the dust exhaust pipe (12) is inserted at the right side of the dust box (6); the valve (13) is in threaded connection with the right side of the dust exhaust pipe (12); the damping and buffering frame structure (14) is arranged on the upper side of the buffering and positioning underframe structure (2); the buffer positioning underframe structure (2) comprises a bottom antiskid plate (21), an upper side connecting plate (22), an I-shaped rubber buffer seat (23), a positioning hole (24) and a silica gel sleeve (25), wherein the bottom antiskid plate (21) is arranged at the lower part of the upper side connecting plate (22); the I-shaped rubber buffer seat (23) is glued on the inner sides of the bottom antiskid plate (21) and the upper side connecting plate (22); the positioning holes (24) are respectively formed in the upper side connecting plate (22); the jet mill (1) is arranged on the left side of the upper part of the upper side connecting plate (22).
2. The entecavir preparation high-efficiency jet mill device according to claim 1, wherein the shock-absorbing buffer frame structure (14) comprises a transverse positioning plate (141), a positioning rod (142), a locking nut (143), a buffer spring (144) and a rubber protecting sleeve (145), wherein the locking nut (143) is screwed on the upper part of the outer side of the positioning rod (142); the transverse positioning plate (141) is embedded in the upper part of the bottom antiskid plate (21).
3. The efficient jet mill for entecavir preparation according to claim 1, wherein the trash guide and collection frame structure (5) comprises a collection frame (51), a collection hopper (52), a handle (53), a fixed pipe (54) and a guide hopper (55), the collection frame (51) is bolted to the upper right position of the upper connecting plate (22); the collecting hopper (52) is inserted at the lower part of the inner side of the collecting frame (51); the handle (53) is arranged at the middle position of the front side of the collecting hopper (52) through a screw; the fixed pipe (54) is welded on the upper part of the collecting frame (51); the material guide hopper (55) is welded at the upper part of the fixed pipe (54); the air suction pump (4) is arranged on the left side of the fixed pipe (54) through a bolt; the dust box (6) is arranged on the upper part of the material guide hopper (55) through bolts.
4. The efficient jet mill for preparing entecavir according to claim 1, characterized in that a rubber anti-skid pad is installed on the bottom screw of the bottom anti-skid plate (21).
5. The entecavir preparation high-efficiency jet mill device according to claim 2, wherein the buffer spring (144) is sleeved on the outer side of the positioning rod (142) and is arranged at the lower part of the upper connecting plate (22).
6. The efficient jet mill apparatus for preparing entecavir according to claim 2, wherein the positioning rod (142) is welded to the middle upper portion of the transverse positioning plate (141) and inserted into the inner side of the positioning hole (24).
7. The efficient jet mill apparatus for preparing entecavir according to claim 3, wherein the inner wall of the guide hopper (55) is inclined toward the middle and lower portion.
8. The entecavir preparation high-efficiency jet mill device according to claim 2, wherein the rubber protecting jacket (145) is sleeved on the outer side of the locking nut (143) and is arranged on the upper portion of the upper connecting plate (22).
9. The efficient airflow crushing device for preparing entecavir according to claim 1, wherein the silica gel sleeve (25) is glued at the joint of the outer sides of the upper connecting plate (22) and the bottom antiskid plate (21).
CN202022069835.6U 2020-09-21 2020-09-21 Entecavir preparation is with high-efficient jet milling equipment Active CN213762193U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202022069835.6U CN213762193U (en) 2020-09-21 2020-09-21 Entecavir preparation is with high-efficient jet milling equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202022069835.6U CN213762193U (en) 2020-09-21 2020-09-21 Entecavir preparation is with high-efficient jet milling equipment

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CN213762193U true CN213762193U (en) 2021-07-23

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114472440A (en) * 2022-01-20 2022-05-13 青岛国海生物制药有限公司 Dust absorption rubbing crusher for preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114472440A (en) * 2022-01-20 2022-05-13 青岛国海生物制药有限公司 Dust absorption rubbing crusher for preparation

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Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20221201

Address after: 255000 High-tech Zone, Zibo City, Shandong Province, No. 51 Lutai Avenue, Block A, Seven Floors of Polymer Material Industry Innovation Park

Patentee after: Shandong Zibo Haiya Pharmaceutical Co.,Ltd.

Address before: 255000 7 / F, block a, polymer materials Industrial Innovation Park, No. 51, Lutai Avenue, high tech Zone, Zibo City, Shandong Province

Patentee before: Shandong Haiya Pharmaceutical Technology Co.,Ltd.

TR01 Transfer of patent right
PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of utility model: A backup high-efficiency airflow crushing equipment for Entecavir production

Effective date of registration: 20230411

Granted publication date: 20210723

Pledgee: Dongying Bank Co.,Ltd. Zibo Branch

Pledgor: Shandong Zibo Haiya Pharmaceutical Co.,Ltd.

Registration number: Y2023980037757

PE01 Entry into force of the registration of the contract for pledge of patent right
PC01 Cancellation of the registration of the contract for pledge of patent right

Granted publication date: 20210723

Pledgee: Dongying Bank Co.,Ltd. Zibo Branch

Pledgor: Shandong Zibo Haiya Pharmaceutical Co.,Ltd.

Registration number: Y2023980037757

PC01 Cancellation of the registration of the contract for pledge of patent right
PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of utility model: A backup high-efficiency airflow crushing equipment for Entecavir production

Granted publication date: 20210723

Pledgee: Dongying Bank Co.,Ltd. Zibo Branch

Pledgor: Shandong Zibo Haiya Pharmaceutical Co.,Ltd.

Registration number: Y2024980012479

PE01 Entry into force of the registration of the contract for pledge of patent right