CN213642164U

CN213642164U - Multilayer dripping pill equipment

Info

Publication number: CN213642164U
Application number: CN202022474863.6U
Authority: CN
Inventors: 黄维佳; 陈志涛; 马俊; 柯百胜
Original assignee: SHENZHEN WANHE PHARMACEUTICAL CO Ltd
Current assignee: SHENZHEN WANHE PHARMACEUTICAL CO Ltd
Priority date: 2020-10-31
Filing date: 2020-10-31
Publication date: 2021-07-09
Anticipated expiration: 2030-10-31

Abstract

The application relates to multilayer dripping pill equipment, it includes: the device comprises a dripper, a material supply pipeline, a material supply tank, a temperature control system, a dripping pill receiving device and a drying cylinder, wherein the upper part of the dripping pill receiving device is a cooling barrel, and the lower part of the dripping pill receiving device is a receiving part; the diameter of the top of the cooling barrel is gradually contracted to form an upper opening and allow the main body of the dripper to extend into the cooling barrel, and a plurality of first air nozzles, second air nozzles and third air nozzles are annularly arranged on the inner wall of the cooling barrel; the bottom of the cooling barrel is provided with a cooling disc, and the lower opening of the cooling disc is downwards connected with the receiving part; the receiving part is a bent pipe with the inner diameter gradually reduced from top to bottom, dripping pills coming out of the dripping pill receiving device enter a drying cylinder for drying, the drying cylinder comprises a roller, dust screens are installed at two ends of the roller, an air blower is arranged at one end of the roller, a discharge hole is formed in one end of the air blower in the roller, a feed inlet is formed in the other end of the air blower in the roller, and a guide plate is arranged on the inner wall of the roller. The multilayer dripping pill equipment of this application can the rapid production dripping pill.

Description

Multilayer dripping pill equipment

Technical Field

The application relates to the field of mechanical equipment, in particular to the field of pharmaceutical mechanical equipment, more particularly to equipment for preparing multilayer dripping pills and key parts thereof, and even more particularly to equipment capable of preparing three-layer dripping pills or key parts thereof, wherein the equipment or key parts can realize rapid production of the three-layer dripping pills.

Background

The dripping pill is a high-end preparation formulation in the field of pharmacy, and can endow the medicament with special performance due to the special structure of the dripping pill. The drop pill is a pellet preparation prepared by heating, melting and mixing solid or liquid medicine and proper substances (generally called as matrix), dropping into immiscible condensate, and shrinking and condensing, and is mainly used for oral administration. From the composition and preparation method of the dripping pill, the dripping pill has the following characteristics: 1. the equipment is simple, the operation is convenient, the labor protection is facilitated, the process period is short, and the productivity is high; 2. the process conditions are easy to control, the quality is stable, the dosage is accurate, the heating time is short, and the stability of the medicine can be improved after the medicine which is easy to oxidize and has volatility is dissolved in a matrix; 3. the matrix has large amount of liquid medicine, so that the liquid medicine can be solidified, such as Ruta graveolens oil dripping pill with oil content of 83.5%; 4. the dripping pill prepared by solid dispersion technology has the characteristics of rapid absorption and high bioavailability, such as the griseofulvin dripping pill has effective dose of 1/4 of 100 mesh fine powder and 1/2 of micro powder (the particle size is less than 5 microns); 5. new formulations for ear and eye administration are developed, and the five sense organs preparation is mostly liquid or semisolid, has short action time, and can be prepared into dripping pills to achieve the effect of prolonging.

The dripping pill has the advantages of three effects, namely quick effect, high efficiency and long effect. Most of the dripping pills are sublingual buccal, and the medicine is directly absorbed through sublingual mucosa and enters blood circulation, so that the first pass effect of liver caused by swallowing and the degradation loss of the medicine in stomach are avoided, so that the medicine reaches a target organ at high concentration and takes effect rapidly. Generally, the medicine can take effect after being taken for 5 to 15 minutes, and the maximum time is not more than 30 minutes. And a slow release agent is also added, so that the half-life period of the medicament can be obviously prolonged, and the aim of long acting is fulfilled. When needed, the medicine is taken orally.

The current dropping pills mainly have the following types: quick-acting high-efficiency dripping pills: the dripping pill is prepared by using a solid dispersion technology. When the matrix is dissolved, the medicine in vivo is released in the form of fine crystal, amorphous particle or molecule, so the dissolution is fast, the absorption is fast, the effect is fast, and the bioavailability is high. Typical examples of such products are fast acting heartburn drop pills. Sustained-release controlled-release dropping pills: the slow release is to ensure that the medicine in the dropping pill is slowly dissolved out in a longer time to achieve long-acting effect; controlled release is to dissolve the drug in the drop pills at a constant rate, and the effect can reach more than several days, such as chloramphenicol controlled release eye pills. Solution dropping pill: since many of the lubricants and disintegrants used in tablets are water-insoluble, it is not usually possible to prepare a clear solution in a tablet. The dripping pill can be prepared with water soluble matrix, and can be disintegrated into clear solution in water, such as chlorhexidine dripping pill for drinking water disinfection. Suppository dropping pills: the dripping pill can be dissolved by body fluid when used in cavity, and can be used as water soluble matrix such as polyethylene glycol like water soluble suppository. Such as dripping pills for norfloxacin ear, dripping pills for metronidazole tooth, etc. The dripping pill can be applied to rectum, can be absorbed by rectum to directly act on whole body, and has the advantages of high bioavailability and quick action. Hard capsule dropping pills: the hard capsule can be filled with dripping pills with different dissolution rates to form sustained-release pellet capsules with the required dissolution rates, such as bifendate hard capsule dripping pills. Coating the dripping pills: the tablet and pill can be coated with sugar or film, such as bifendate dripping pill. Liposome dropping pill: the liposome is suspension liquid, and can be made into solid dosage form with polyethylene glycol by adding liposome into molten polyethylene glycol 4000 under stirring to form suspension, pouring into a mold, and condensing to form. Enteric-coated dripping pills: a matrix insoluble in stomach, such as AlK pill, is prepared by making pill with gelatin solution, treating with formaldehyde to make the amino group of gelatin insoluble in gastric juice and soluble in intestine. Dry pressing the coated dripping pills: the dripping pill is used as the center, and a coating layer consisting of other medicines is pressed on the dripping pill, so that the advantages of two dosage forms, such as cough relieving and phlegm eliminating potassium chloride dry-pressed coated tablets, are combined. The former is dripping pill and the latter is coating layer.

However, in some cases, some substances are absorbed in a specific part of the digestive tract, such as the small intestine or even the large intestine, when being prepared into a dripping pill, and cannot be contacted with the acidic gastric juice in the stomach. The dripping pill process can realize the production of dripping pills with uniform components and high roundness, can ensure that the medicine is uniformly released, has long release time and is convenient to carry and store. At present, most of the domestic dripping pill processes are single-component preparations, and effective components cannot be coated by substances with protective effect, so that the aim of multilayer coating is fulfilled. Particularly, if multilayer dripping pill equipment and the process thereof are successfully researched, the effective components can be completely wrapped and protected by gastric acid resistant substances and directly reach small intestines or even large intestines to be released, so that the effect is maximized. For example, probiotics go directly to the large intestine. Has obvious effects of improving the intestinal function and promoting the balance of intestinal flora. The technology can also be used for developing a novel medicinal preparation, so that the acid-afraid medicament is sent into the large intestine by avoiding gastric acid and is absorbed by the human body, and the treatment effect of the medicament is improved. Or a plurality of layers of sustained-release medicines are developed to ensure that the medicines in each layer exert effects in turn, and the like, thereby providing a practical and feasible way for the newly prepared medicines or foods.

The classic dropping pills are not layered, the dropping pills are uniform mixtures from inside to outside, and the development of multilayer dropping pills (such as three-layer dropping pills) presents strong requirements along with the development requirement of preparations. The process for preparing these multi-layered dripping pills, e.g., bi-layered dripping pills, is distinguished from soft capsules produced by the dripping method in that the contents of the soft capsule are liquid, whereas the inner components of the multi-layered dripping pills, e.g., tri-layered dripping pills, are substantially solid at ordinary temperature. Therefore, the soft capsule production equipment/process cannot be applied to multi-layer dropping pills (e.g., three-layer dropping pills).

The applicant is dedicated to the development and mechanical design of multilayer dripping pills for a long time, for example, chinese patent ZL2016101875809 developed by the applicant relates to multilayer dripping pill equipment, parts thereof and a process for preparing multilayer dripping pills, the provided dripping head for preparing multilayer dripping pills is a detachable and assembled combined structure, which comprises: the connecting component comprises an inner-layer material lead-in component, a middle-layer material lead-in component, an outer-layer material lead-in component and a connecting component, wherein the inner-layer material lead-in component, the middle-layer material lead-in component, the outer-layer material lead-in component and the connecting component are generally in a barrel shape, and a first interface, a second interface and a third interface are sequentially arranged in the connecting component from top to bottom and are respectively used for being connected with the inner-layer material lead-in component, the middle-layer material lead-in component and. For another example, chinese patent ZL2016210586095 discloses a method for improving a multilayer dripping pill structure and an apparatus used thereof, and relates to a dripper for preparing a multilayer dripping pill, which is a detachable and assembled combined structure, comprising: the upper part of the dripper is connected with a vibration device, and the vibration device enables the dripper to vibrate up and down in a reciprocating manner. The invention also relates to multilayer dripping pill equipment, a method for preparing the multilayer dripping pills and a vibrating device for preparing the multilayer dripping pills. The multilayer dripping pill with excellent and uniform structure can be prepared by the invention. For another example, chinese patent 2019202634724 relates to a method for preparing highly uniform dripping pills and an apparatus used therein, the apparatus for preparing multi-layer dripping pills comprises a dripper, a material supply pipe connected to the dripper, a material supply tank, a temperature control system for providing temperature control to the material supply tank, the material supply pipe and the dripper, and a pill receiving apparatus; the pill receiving device comprises a cylindrical pill cooling part and an inverted cone-shaped pill recovery part connected to the lower part of the cylindrical pill cooling part, and is filled with cooling liquid when the multilayer pill equipment works; the dropping nozzle is positioned below the liquid level, an isolation circular plate comprising a central circular hole and a small hole is coaxially arranged in the middle of the barrel-shaped dropping pill cooling part, the dropping pills dropping from the dropping nozzle pass through the central circular hole to descend to enter the dropping pill recovery part in the sinking process, and a stirring paddle is also arranged to stir the cooling liquid and enable the dropping pills to be dispersed and settled respectively after entering the lower part of the isolation circular plate. The pills obtained by the method have very high roundness and uniformity. The entire contents of these patent documents are incorporated herein by reference.

In the field of pharmaceutical industry, in the production process of dripping pills, the dripping speed is the bottleneck process of dripping pill preparation. However, in the existing methods for preparing multilayer dripping pills, the dripping pills are all dropped into cooling liquid and are formed and solidified in the cooling liquid, and the forming and solidifying method greatly restricts the production efficiency of the multilayer dripping pills and becomes another bottleneck process for preparing the dripping pills. The reason is that the cooling liquid usually adopts liquid paraffin, the dropping pills walk slowly in the cooling liquid, and after being filtered out from the cooling liquid, the dropping pills are subjected to complex and time-consuming processes of dewaxing and cleaning, and the difficulty of subsequent drying is greatly increased. In addition, since trilayer dropping pills are generally smaller than conventional dropping pills, for example, the diameter is generally smaller than 3mm, for example, smaller than 2mm, for example, smaller than 1.5 mm. Such small drops, which have a large surface area, are difficult to remove from the cooling fluid.

Therefore, overcoming the problem of low production efficiency in the cooling process of the multi-layer dropping pill is a problem which is urgently desired to be solved by the technical personnel in the field.

Disclosure of Invention

The object of the present application is to provide an apparatus capable of being dripped into multilayer, in particular trilayer, dripping pills. It has been unexpectedly found that the apparatus and/or components thereof having three-layered pills having the structural features of the present application can achieve unexpected technical results. The present application has thus been completed.

For this reason, this application first aspect provides a multilayer dripping pill equipment, and it includes:

(i) a dripper with a dripping nozzle facing downwards for dripping multiple layers of dripping pills (such as three layers of dripping pills);

(ii) the material supply pipeline is connected with the dripper;

(iii) a material supply tank;

(iv) a temperature control system for providing temperature control for the material supply tank, the material supply pipeline and the dripper;

(v) a drop pill receiving device for receiving drop pills dropping from the dropping head and promoting the drop pills to be shaped, cooled and solidified; and

(vi) a drying cylinder is arranged in the drying cylinder,

it is characterized in that the preparation method is characterized in that,

the upper part of the pill receiving device is a cylindrical cooling barrel, and the lower part of the pill receiving device is a receiving part;

the diameter of the top of the cooling barrel is gradually shrunk to form an upper opening, the upper opening can allow the main body of the dripper to extend into the cooling barrel, and the airflow in the cooling barrel is allowed to overflow outwards;

the dripping mouth of the dripper faces downwards to enable dripping pills to fall into the cooling barrel in a free falling mode;

a plurality of first air nozzles are uniformly and annularly arranged on the inner wall of the cooling barrel and positioned at the height of the drip nozzle;

the inner wall of the cooling barrel is located at a height of 40-50 cm below the first air nozzle, and a plurality of second air nozzles are uniformly and annularly arranged;

the inner wall of the cooling barrel is located at a height of 40-50 cm below the second air nozzles, and a plurality of third air nozzles are uniformly and annularly arranged;

a cooling disc is arranged at the bottom of the cooling barrel and is positioned at a height of 30-40 cm below the third air nozzle, a lower opening is arranged at the center of the cooling disc, and the dropping pills are allowed to continuously fall into the receiving part from the lower opening;

the lower opening of the cooling plate is downwards connected with the receiving part;

the receiving part is a bent pipe with the inner diameter gradually reduced from top to bottom, the bending radius R of the bent pipe is 50-60 cm, and a dropping pill outlet is formed from the lower end of the bent pipe to a position close to the horizontal position;

the dropping pill from the dropping pill outlet of the dropping pill receiving device enters the drying cylinder for drying, the drying cylinder comprises a cylindrical roller, dust screens are arranged at the two ends of the roller, an air blower is arranged at one end of the roller, a discharge port is arranged at one end of the air blower in the roller, a feed port is arranged at the other end of the air blower, and a guide plate is arranged on the inner wall of the roller.

The multilayer dripping pill equipment of the first aspect of this application, wherein the internal diameter of cooling barrel is 20~30cm, for example 20~25 cm.

The multilayer dripping pill equipment of the first aspect of this application, wherein the internal diameter of two of bottom outlet and return bend upper end is 5~12cm, for example 6~10 cm.

The multilayer dripping pill equipment of the first aspect of the application is characterized in that the inner diameter of the lower end of the elbow is 1-2 cm, such as 1-1.5 cm.

Multilayer dripping pill equipment according to this application first aspect, characterized in that, the even annular overall arrangement of first tuyere is provided with 6~12, for example 6~ 10.

Multilayer dripping pill equipment according to this application first aspect, characterized in that, the even cyclic annular overall arrangement of second air cock is provided with 6~12, for example 6~ 10.

Multilayer dripping pill equipment according to this application first aspect, characterized in that, the even cyclic annular overall arrangement of third air cock is provided with 6~12, for example 6~ 10.

According to the multilayer dripping pill equipment of this application first aspect, its characterized in that, first air cock is with personally submitting 30~45 oblique ascending orientation of angle with the horizontal plane and blows to the cooling barrel is middle.

According to the multilayer dripping pill equipment of this application first aspect, its characterized in that, the second air cock is with personally submitting 30~45 oblique ascending orientation of angle with the horizontal plane and blows to the cooling barrel is middle.

According to the multilayer dripping pill equipment of this application first aspect, its characterized in that, the third air cock is with personally submitting 30~45 oblique ascending orientation of angle with the horizontal plane and blowing in the middle of the cooling barrel.

Multilayer dripping pill equipment according to this application first aspect, characterized in that, at the during operation, first tuyere is used for blowing in the air that the temperature is 35~45 ℃ into to the cooling barrel.

Multilayer dripping pill equipment according to this application first aspect, its characterized in that, at the during operation, the second air cock is used for blowing in the air that the temperature is 15~25 ℃ into to the cooling barrel.

Multilayer dripping pill equipment according to this application first aspect, its characterized in that, at the during operation, the third air cock is used for blowing in the air that the temperature is 0~5 ℃ into to the cooling barrel.

Multilayer dripping pill equipment according to the first aspect of this application, characterized in that, in operation, the cooling dish is used for placing dry ice to cool the dripping pill that falls by oneself.

Multilayer dripping pill equipment according to this application first aspect, its characterized in that, at the during operation, first air cock, second air cock and third air cock are respectively independently blown at 50~500 ml/min's flow. The air velocity of each air nozzle can be adjusted according to factors such as the type of the dropping pill material, the thickness of the outer layer, the forming speed and the like.

Further, the second aspect of the present application provides a pill receiving device for preparing a multilayer dripping pill, which is characterized in that the device comprises a cooling barrel with a cylindrical upper part and a receiving part at a lower part; wherein,

the receiving part is a bent pipe with the inner diameter gradually reduced from top to bottom, the bending radius R of the bent pipe is 50-60 cm, and a dropping pill outlet is formed from the lower end of the bent pipe to a position close to the horizontal position.

The pill receiving device according to the second aspect of the present application, wherein the cooling barrel has an inner diameter of 20 to 30cm, for example 20 to 25 cm.

The pill receiving device according to the second aspect of the present application, wherein the inner diameter of both the lower opening and the upper end of the elbow is 5 to 12cm, for example 6 to 10 cm.

The pill receiving device according to the second aspect of the present application, wherein the inner diameter of the lower end of the elbow is 1-2 cm, such as 1-1.5 cm.

The pill receiving device according to the second aspect of the present application, wherein the first nozzles are uniformly arranged in an annular arrangement with 6-12, for example, 6-10.

The pill receiving device according to the second aspect of the present application, wherein the second air nozzles are uniformly arranged in an annular layout of 6-12, for example, 6-10.

The pill receiving device according to the second aspect of the present application, wherein the third air nozzles are uniformly arranged in an annular layout with 6-12, for example, 6-10.

The pill receiving device according to a second aspect of the present application, wherein the first air nozzle blows air into the middle of the cooling barrel in an obliquely upward direction forming an angle of 30 to 45 degrees with the horizontal plane.

The pill receiving device according to a second aspect of the present application, wherein the second air nozzle blows air into the middle of the cooling barrel in an obliquely upward direction forming an angle of 30 to 45 degrees with the horizontal plane.

The pill receiving device according to a second aspect of the present application, wherein the third air nozzle blows air into the middle of the cooling barrel in an obliquely upward direction forming an angle of 30 to 45 degrees with the horizontal plane.

The pill receiving device according to the second aspect of the present application, wherein the first air nozzle is configured to blow air at a temperature of 35 to 45 ℃ into the cooling tub during operation.

The pill receiving device according to a second aspect of the present application, wherein the second air nozzle is configured to blow air at a temperature of 15 to 25 ℃ into the cooling barrel during operation.

The pill receiving device according to the second aspect of the present application, wherein the third air nozzle is configured to blow air at a temperature of 0 to 5 ℃ into the cooling barrel during operation.

A pill receiving device according to the second aspect of the present application, characterized in that, in operation, the cooling tray is used for placing dry ice to cool a pill falling by itself.

The pill receiving device according to the second aspect of the present application is characterized in that, in operation, the first air nozzle, the second air nozzle and the third air nozzle blow air at a flow rate of 50-500 ml/min independently from each other. The air velocity of each air nozzle can be adjusted according to factors such as the type of the dropping pill material, the thickness of the outer layer, the forming speed and the like.

In describing the method steps herein, although specific steps are described in some detail or language different from the steps described in the examples of the embodiments section herein, those skilled in the art can still fully appreciate the above-described method steps from the detailed disclosure throughout the application.

Any embodiment of any aspect of the present application may be combined with other embodiments, as long as they do not contradict. Furthermore, in any embodiment of any aspect of the present application, any feature may be applicable to that feature in other embodiments, as long as they do not contradict.

The present application is further described below.

All documents cited in this application are incorporated herein by reference in their entirety and to the extent that the meaning of such documents is inconsistent with this application, the express disclosure of this application controls. Further, the various terms and phrases used herein have the ordinary meaning as is known to those skilled in the art, and even so, it is intended that the present application be more fully described and interpreted herein, to the extent that such terms and phrases are not inconsistent with this known meaning and from the context in which such terms and phrases are expressed.

The equipment and the process provide a more advanced and reliable medicine wrapping technology, compared with capsule filling and coating technologies, the multi-layer dropping pill has better sealing performance and more comprehensive and reliable wrapping. It is believed that economic and social benefits will be significant after industrialization. Researchers of the present application have been devoted to studying the principle of the multilayer dropping pill process and the implementation method thereof; the researchers designed and manufactured three-layer pill dropping equipment which can be used for industrialization.

The multilayer dripping pill device and the process thereof can industrially produce spherical multilayer medicaments or food preparations with different components, and can be dripped into two layers, three layers and four layers as far as the required layers. Schematic representations of trilayer dropping pills are depicted, for example, in fig. 1 of chinese patent No. ZL2016202539660 or chinese patent application No. 2016101875809, or, for example, in fig. 2 of chinese patent No. ZL2016210586095 or chinese patent application No. 2016108267433.

The equipment and the method can realize rapid cooling and molding of the dropping pill, overcome the bottleneck problem caused by the production efficiency of the dropping pill due to the condensation molding process, and avoid the trouble of additional treatment process caused by the condensate liquid to the dropping pill process.

Drawings

Fig. 1 is a schematic view of a pill receiving apparatus of the present application.

Fig. 2 is a schematic view of a pill drying cylinder of the present application.

Some reference numbers of the various plant devices of the present application are summarized below: the device comprises a cooling barrel 1, a receiving part 2, an upper opening 3, a first air nozzle 4, a second air nozzle 5, a third air nozzle 6, a cooling disc 7, a lower opening 8, a bent pipe 9, a dropping pill outlet 10, dry ice 11, a dripper 21, a dripping nozzle 22, a roller 31, a feeding hole 32, a discharging hole 33, a blower 34, a material guiding plate 35 and a dustproof net 36.

Detailed Description

The present application can be further described by the following examples, however, the scope of the present application is not limited to the following examples. Those skilled in the art will appreciate that various changes and modifications can be made to the present application without departing from the spirit and scope of the application. The materials used in the tests and the test methods are generally and/or specifically described herein. Although many materials and methods of operation are known in the art for the purposes of this application, this application is nevertheless described herein in detail as far as possible. The following examples further illustrate the present application without limiting the same.

The design of the present application is described in detail below with reference to the accompanying drawings. Figure 1 depicts a schematic diagram of a pill receiving apparatus of the present application.

As shown in fig. 1, a pill receiving device for preparing multi-layer pills (e.g. three-layer pills) comprises a cooling barrel 1 with a cylindrical upper part and a receiving part 2 with a lower part; wherein,

the diameter of the top of the cooling barrel 1 is gradually contracted to form an upper opening 3, the upper opening 3 can allow the main body of the dripper 21 to extend into the cooling barrel 1, and the airflow in the cooling barrel 1 is allowed to overflow outwards;

the dripping nozzle 22 of the dripper 21 faces downwards to enable dripping pills to fall into the cooling barrel 1 in a free falling mode;

a plurality of first air nozzles 4 are uniformly and annularly arranged on the inner wall of the cooling barrel 1 at the height of the drip nozzles 22;

a plurality of second air nozzles 5 are uniformly and annularly arranged on the inner wall of the cooling barrel 1 and are positioned at a height of 40-50 cm below the first air nozzle 4;

a plurality of third air nozzles 6 are uniformly and annularly arranged on the inner wall of the cooling barrel 1 and are positioned at the height of 40-50 cm below the second air nozzles 5;

a cooling disc 7 is arranged at the bottom of the cooling barrel 1 and is positioned at a height of 30-40 cm below the third air nozzle 6, a lower opening 8 is arranged at the center of the cooling disc 7, and the dropping pills are allowed to continuously descend from the lower opening 8 and fall into the receiving part 2;

the lower opening 8 of the cooling plate 7 is connected downwards with the receiving part 2;

the receiving part 2 is a bent pipe 9 with the inner diameter gradually reduced from top to bottom, the bending radius R of the bent pipe 9 is 50-60 cm, and a dropping pill outlet 10 is formed from the lower end of the bent pipe 9 to a position close to the horizontal position.

The dripper, the material supply pipe connected to the dripper, the material supply tank, the temperature control system for providing temperature control for the material supply tank, the material supply pipe and the dripper, and the like may be of prior art designs, for example, as described in chinese patent No. ZL2016202539660 or chinese patent No. ZL 2016210586095.

According to an embodiment of the present application, the inner diameter of the cooling tub 1 is 20-30 cm, such as 20-25 cm.

According to an embodiment of the present application, the inner diameter of both the lower opening 8 and the upper end of the elbow 9 is 5-12 cm, such as 6-10 cm.

According to an embodiment of the present application, the inner diameter of the lower end of the elbow 9 is 1-2 cm, such as 1-1.5 cm.

According to an embodiment of the present application, the first air nozzles 4 are uniformly arranged in an annular arrangement with 6-12, for example, 6-10.

According to a specific example of the pill receiving device of the present application, the second air nozzles 5 are uniformly arranged in an annular layout of 6 to 12, for example, 6 to 10.

According to a specific example of the pill receiving device of the present application, the third nozzles 6 are uniformly arranged in an annular layout of 6 to 12, for example, 6 to 10.

According to a specific example of the apparatus for receiving pills of the present application, the first air nozzle 4 blows air toward the middle of the cooling tub 1 in an obliquely upward direction at an angle of 30 to 45 ° with respect to the horizontal plane.

According to a specific example of the apparatus for receiving pills of the present application, the second air nozzle 5 blows air in an obliquely upward direction at an angle of 30 to 45 ° from the horizontal plane toward the middle of the cooling tub 1.

According to a specific example of the apparatus for receiving pills of the present application, the third air nozzle 6 blows air in an obliquely upward direction at an angle of 30 to 45 ° from the horizontal plane toward the middle of the cooling tub 1.

According to an embodiment of the apparatus for receiving pills, the first air nozzle 4 is used for blowing air with a temperature of 35-45 ℃ into the cooling barrel 1 during operation.

According to an embodiment of the apparatus for receiving pills of the present application, the second air nozzle 5 is used for blowing air with a temperature of 15-25 ℃ into the cooling barrel 1 during operation.

According to a specific example of the pill receiving device of the present application, in operation, the third air nozzle 6 is used for blowing air with a temperature of 0-5 ℃ into the cooling barrel 1.

According to a specific example of the pill receiving device of the present application, the cooling tray 7 is used for placing dry ice 11 to cool the dropping pills which are dropped by themselves during operation.

According to a specific example of the pill receiving device, in operation, the first air nozzle 4, the second air nozzle 5 and the third air nozzle 6 blow air at a flow rate of 50-500 ml/min independently. The air velocity of each air nozzle can be adjusted according to factors such as the type of the dropping pill material, the thickness of the outer layer, the forming speed and the like.

Example a of a pill receiving device of the present application (described in connection with fig. 1): the pill receiving device comprises a cooling barrel 1 with a barrel-shaped upper part and a receiving part 2 with a lower part; wherein, the diameter of the top of the cooling barrel 1 gradually shrinks to form an upper opening 3, the upper opening 3 can allow the main body of the dripper 21 to extend into the cooling barrel 1, and allow the airflow in the cooling barrel 1 to overflow outwards; the dripping nozzle 22 of the dripper 21 faces downwards to enable dripping pills to fall into the cooling barrel 1 in a free falling mode; a plurality of first air nozzles 4 are uniformly and annularly arranged on the inner wall of the cooling barrel 1 at the height of the drip nozzles 22; a plurality of second air nozzles 5 are uniformly and annularly arranged on the inner wall of the cooling barrel 1 at a height of 45cm below the first air nozzles 4; a plurality of third air nozzles 6 are uniformly and annularly arranged on the inner wall of the cooling barrel 1 at a height of 45cm below the second air nozzles 5; a cooling disc 7 is arranged at the bottom of the cooling barrel 1 and is positioned at the height of 35cm below the third air nozzle 6, a lower opening 8 is arranged at the center of the cooling disc 7, and the dropping pills are allowed to continuously descend from the lower opening 8 to fall into the receiving part 2; the lower opening 8 of the cooling plate 7 is connected downwards with the receiving part 2; the receiving part 2 is a bent pipe 9 with gradually reduced inner diameter from top to bottom, the bending radius R of the bent pipe 9 is 55cm, and a dropping pill outlet 10 is formed from the lower end of the bent pipe 9 to a position close to the horizontal position; further:

the inner diameter of the cooling barrel 1 is 25 cm; the inner diameters of the lower opening 8 and the upper end of the elbow 9 are 8 cm; the inner diameter of the lower end of the elbow 9 is 1.5 cm; the number of the first air nozzles 4 is 8 in uniform annular arrangement; the number of the second air nozzles 5 is 8; the third air nozzles 6 are uniformly distributed in an annular shape, and 8 air nozzles are arranged; the first air nozzle 4 blows air to the middle of the cooling barrel 1 in an oblique upward direction forming an angle of 35 degrees with the horizontal plane; the second air nozzle 5 blows air to the middle of the cooling barrel 1 in an oblique upward direction forming an angle of 40 degrees with the horizontal plane; the third air nozzle 6 blows air to the middle of the cooling barrel 1 in an oblique upward direction forming an angle of 40 degrees with the horizontal plane; the first air nozzle 4 is used for blowing air with the temperature of 45 ℃ into the cooling barrel 1; the second air nozzle 5 is used for blowing air with the temperature of 20-22 ℃ into the cooling barrel 1; the third air nozzle 6 is used for blowing air with the temperature of 2-5 ℃ into the cooling barrel 1; the first air nozzle 4, the second air nozzle 5 and the third air nozzle 6 blow air at the flow rates of 100ml/min, 250ml/min and 250ml/min respectively.

Fig. 2 is a schematic view of the drying cylinder of the present application. The drying cylinder comprises a cylindrical roller 31, dust screens 36 are mounted at two ends of the roller 31, an air blower 34 is arranged at one end, a discharge hole 33 is arranged at one end of the air blower 34 in the roller, a feed hole 32 is arranged at the other end of the air blower, and a guide plate 35 is arranged on the inner wall of the roller 31. The dropping pills from the dropping pill outlet 10 of the dropping pill receiving device enter the drying cylinder from the feeding hole 32, the rolling dropping pills move to the end of the discharging hole 33 along with the rotation of the roller and the guiding of the guiding plate 35, and the air driven by the blower 34 enters the roller 31 from the end of the discharging hole 33 of the roller in the direction opposite to the running direction of the dropping pills, thereby completing the drying process of the dropping pills.

Using the multi-layer pill making apparatus of the present application (which includes a dripper, a material supply line connected to the dripper, a material supply tank, a temperature control system for providing temperature control to the material supply tank, the material supply line, and the dripper, a pill receiving apparatus, a drying cylinder), in addition to the pill receiving apparatus and the drying cylinder, other methods, components, apparatus or systems employ the method and apparatus described in our chinese patent application No. 2016101875809, particularly using 2016101875809 of the schematic diagrams of the three-layer dripper and the manufacturing process shown in fig. 2 and 4, using the following inner, middle and outer layers of liquid, the three materials are respectively dripped out of the inner layer, the middle layer and the outer layer of the three-layer dripping pill and then enter the dripping pill receiving device of the application example A to cool and form the dripped three-layer dripping pill, then ventilating and drying at 20 deg.C for 8 hr to obtain three-layer dripping pill with diameter of 5.5 mm. Inner layer liquid: middle layer liquid: the weight ratio of the outer layer liquid is 50: 30: 20, the compositions of the inner layer liquid, the middle layer liquid and the outer layer liquid are respectively as follows: inner layer liquid: dispersing 19 parts by weight of bifidobacterium powder in 81 parts by weight of melted palm stearin (non-hydrogenated oil, melting point 51 ℃) to obtain a mixed inner layer liquid: mixing 93 parts by weight of melted palm stearin (non-hydrogenated oil, melting point 53 ℃) and 7 parts by weight of lecithin to obtain an intermediate solution, an outer solution: an outer layer solution was obtained by mixing and dissolving 18 parts by weight of gelatin (gel strength 280 Bloom), 6 parts by weight of glycerin, 1 part by weight of low-methoxy pectin, and 75 parts by weight of purified water. The roundness of the thus-obtained three-layer dropping pill was measured to be 0.976(n = 6). If the first air tap is eliminated from the pill receiving apparatus of example a, the resulting pill has a roundness of 0.910(n = 6); if the second air tap is eliminated in the pill receiving apparatus of example a, the resulting pill has a roundness of 0.928(n = 6); if the third air tap is eliminated in the pill receiving apparatus of example a, the resulting pill has a roundness of 0.921(n = 6); if the dry ice tray is removed from the pill receiving device of example a, the resulting pill roundness is 0.883(n = 6). The roundness of a dripping pill is the ratio of the shortest diameter to the longest diameter of the dripping pill.

The above-described embodiments are merely preferred embodiments for fully illustrating the present application, and the scope of the present application is not limited thereto. The equivalent substitution or change made by the person skilled in the art on the basis of the present application is within the protection scope of the present application. The protection scope of this application is subject to the claims.

Claims

1. A multilayer dripping pill equipment, it includes:

(i) the dripper is used for dripping a plurality of layers of dripping pills with a downward dripping mouth;

(ii) the material supply pipeline is connected with the dripper;

(iii) a material supply tank;

(vi) a drying cylinder is arranged in the drying cylinder,

it is characterized in that the preparation method is characterized in that,

2. The multilayer dripping pill device of claim 1, wherein the cooling barrel has an internal diameter of 20-30 cm.

3. The multilayer dripping pill device of claim 1 wherein the inner diameter of both the lower opening and the upper end of the elbow is 5-12 cm.

4. The multilayer dripping pill device according to claim 1, wherein the inner diameter of the lower end of the elbow is 1-2 cm.

5. The multilayer dripping pill device of claim 1, wherein there are 6-12 uniform annular arrangements of the first air nozzles.

6. The multilayer dripping pill device according to claim 1, wherein there are 6-12 uniform annular gas nozzles; or 6-12 third air nozzles are uniformly distributed in an annular shape.

7. The multilayer dripping pill device according to claim 1, wherein the first, second and third air nozzles blow air into the middle of the cooling barrel in directions obliquely upward at an angle of 30-45 ° with the horizontal plane.

8. The multilayer dripping pill device as claimed in claim 1, wherein the first air nozzle is used to blow air at 35-45 ℃ into the cooling barrel, the second air nozzle is used to blow air at 15-25 ℃ into the cooling barrel, and the third air nozzle is used to blow air at 0-5 ℃ into the cooling barrel.

9. The multilayer drop pill apparatus of claim 1, wherein the cooling tray is adapted to receive dry ice to cool a self-dropping drop pill.

10. The multilayer dripping pill device according to claim 1 wherein the first, second and third air nozzles blow air at a flow rate of 50-500 ml/min respectively during operation.