CN213596289U

CN213596289U - Biochip for diagnosing and detecting lung cancer

Info

Publication number: CN213596289U
Application number: CN202022106164.6U
Authority: CN
Inventors: 陀晓宇; 赵华君; 潘国庆; 王智园; 舒然; 赵晓玮
Original assignee: First Affiliated Hospital of Kunming Medical University
Current assignee: First Affiliated Hospital of Kunming Medical University
Priority date: 2020-09-23
Filing date: 2020-09-23
Publication date: 2021-07-02
Anticipated expiration: 2030-09-23

Abstract

The utility model relates to the technical field of biology, in particular to a biochip for lung cancer diagnosis and detection, which comprises a supporting box, wherein a placing plate is connected inside the supporting box in a sliding manner, a biochip carrier is arranged at the top of the placing plate, biological probe molecules are arranged at the top of the biochip carrier, and a drainage plate is arranged at the top of the supporting box; the utility model discloses a setting of standing groove, the user can obtain multiunit data simultaneously, improve the accuracy that detects, help the user to improve detection efficiency, collect the box through setting up, can collect the waste liquid after finishing detecting, prevent the waste liquid polluted environment, it can only gather a set of data once to have solved current partial biochip detection, a set of data is not accurate enough, can influence doctor's judgement, the waste liquid after finishing detecting simultaneously is difficult for collecting, cause the pollution easily, the demand that satisfies the user that can not be fine.

Description

Biochip for diagnosing and detecting lung cancer

Technical Field

The utility model relates to the field of biotechnology, specifically be a biochip for lung cancer diagnosis and detection.

Background

Biochips, also called protein chips or gene chips, originate from crystallization combining DNA hybridization probe technology with semiconductor industry technology, in which a large number of probe molecules are immobilized on a support and then hybridized with DNA or other sample molecules with fluorescent labels, and the number and sequence information of the sample molecules is obtained by detecting the hybridization signal intensity of each probe molecule.

Present part biochip detects once can only gather a set of data, and a set of data is accurate inadequately, may influence doctor's judgement, and the waste liquid after finishing detecting simultaneously is difficult for collecting, causes the pollution easily, the demand that satisfies the user that can not be fine.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a biochip for lung cancer diagnoses and detects, it can obtain multiunit data simultaneously to possess the user, improve the accuracy that detects, can carry out the advantage of collecting to the waste liquid after detecting simultaneously, it can only gather a set of data once to have solved current partial biochip and detected, a set of data is not accurate enough, can influence doctor's judgement, the waste liquid after finishing detecting simultaneously is difficult for collecting, cause the pollution easily, the problem of the demand of satisfying the user that can not be fine.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a biochip for lung cancer diagnosis and detection, includes the support box, the inside sliding connection of support box has places the board, the top of placing the board is provided with the biochip carrier, the top of biochip carrier is provided with the biological probe molecule, the top of support box is provided with the drainage board, the top of drainage board is provided with the pellicle, the waste liquid hole has been seted up to the bottom of support box, the four corners of support box bottom all is provided with first support column, the outside sliding connection of first support column has the collection box, the inside of support box is provided with the infiltration paper.

Preferably, the bottom of the supporting box is communicated with the top of the collecting box through a waste liquid hole, a drainage hole is formed in the drainage plate, and a drainage tube is communicated with the bottom of the drainage hole.

Preferably, the bottom of the drainage plate is communicated with the top of the support box through the drainage tube, the four corners of the bottom of the drainage plate are fixedly provided with second support columns, a first cavity matched with the second support columns for use is formed in the support box, and the outer side of each second support column is connected with the inner wall of the corresponding first cavity in a sliding mode.

Preferably, a second cavity is formed in the supporting box, a first spring is fixedly mounted at the bottom of an inner cavity of the second cavity, and one end, far away from the bottom of the inner cavity of the second cavity, of the first spring is fixedly mounted at the bottom of the placing plate.

Preferably, the placing plate is internally provided with a placing groove, the two sides of the placing plate are fixedly provided with sliding blocks, a sliding groove matched with the sliding blocks for use is formed in the supporting box, and the outer side of the sliding block is connected with the inner wall of the sliding groove in a sliding mode.

Preferably, a third cavity is formed in the collecting box, and a second spring is fixedly mounted at the bottom of an inner cavity of the third cavity.

Preferably, both sides of the collecting box are slidably connected with push-pull rods, a fourth cavity matched with the push-pull rods for use is formed in the first supporting column, and the outer sides of the push-pull rods are slidably connected with the inner part of the collecting box and the inner wall of the fourth cavity.

Compared with the prior art, the beneficial effects of the utility model are as follows:

1. the utility model discloses a setting of standing groove, the user can obtain multiunit data simultaneously, improve the accuracy that detects, help the user to improve detection efficiency, collect the box through setting up, can collect the waste liquid after finishing detecting, prevent the waste liquid polluted environment, through setting up first support column and push-and-pull rod, can carry out zonulae occludens to collecting the box and supporting box, the better collects the waste liquid, it once can only gather a set of data to have solved current partial biochip detection, a set of data is not accurate enough, the judgement that probably influences the doctor, detect the waste liquid after finishing simultaneously and be difficult for collecting, cause the pollution easily, can not be fine user's demand of satisfying.

2. The utility model discloses a setting of drainage tube, the user pours blood into the drainage plate in, blood gets into the drainage tube through the drainage hole, can be rapid shunt blood, be convenient for detect it, through the setting of second support column, can prevent that the drainage plate from droing with the support box zonulae occludens, cause the influence to the testing result, through the setting of first spring, the elasticity of first spring is acting on placing the board, can assist the removal of placing the board, make simultaneously to place the board more stable.

3. The utility model discloses a setting of slider and spout, when placing the board and remove, drive the slider at spout internal movement, make to place the more stable that the board removed, setting through the second spring, the elastic action of second spring is on first support column, when the collection box is taken off to needs, the elasticity of second spring accelerates the motion of collecting the box, convenient to use person is to the dismouting of collecting the box, setting through the push-and-pull rod, the push-and-pull rod is at the inside motion of fourth cavity and third cavity, make to collect box and first support column connection inseparabler, prevent to collect the box and drop.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic structural view of the drainage plate of the present invention;

fig. 3 is a schematic structural view of the placing plate of the present invention;

fig. 4 is an enlarged schematic structural view of a portion a shown in fig. 1 according to the present invention.

In the figure: 1. a support box; 2. placing the plate; 3. a biochip carrier; 4. a biological probe molecule; 5. a drainage plate; 6. a semi-permeable membrane; 7. a waste liquid hole; 8. a first support column; 9. a collection box; 10. a drainage hole; 11. a drainage tube; 12. a second support column; 13. a first cavity; 14. a second cavity; 15. a first spring; 16. a placement groove; 17. a slider; 18. a chute; 19. a third cavity; 20. a second spring; 21. a push-pull rod; 22. a fourth cavity; 23. and (4) permeating the paper.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, a biochip for lung cancer diagnosis and detection comprises a supporting box 1, a placing plate 2 is connected to the inside of the supporting box 1 in a sliding manner, a biochip carrier 3 is arranged on the top of the placing plate 2, biological probe molecules 4 are arranged on the top of the biochip carrier 3, a drainage plate 5 is arranged on the top of the supporting box 1, a semipermeable membrane 6 is arranged on the top of the drainage plate 5, a waste liquid hole 7 is formed in the bottom of the supporting box 1, first supporting columns 8 are arranged at four corners of the bottom of the supporting box 1, a collecting box 9 is connected to the outer sides of the first supporting columns 8 in a sliding manner, and permeable paper 23 is arranged inside the supporting box 1.

In this embodiment, specific, the bottom of supporting box 1 is through waste liquid hole 7 and the top intercommunication of collecting box 9, and drainage hole 10 has been seted up to the inside of drainage plate 5, and the bottom intercommunication in drainage hole 10 has drainage tube 11, and through the setting of drainage tube 11, the user pours blood into drainage plate 5 into, and blood gets into drainage tube 11 through drainage hole 10, can be rapid with blood reposition of redundant personnel, be convenient for detect it.

In this embodiment, it is concrete, drainage tube 11 is passed through to the bottom of drainage plate 5 and the top intercommunication that supports box 1, and the equal fixed mounting in four corners of drainage plate 5 bottom has second support column 12, supports the inside of box 1 and offers the first cavity 13 that uses with the cooperation of second support column 12, the outside of second support column 12 and the inner wall sliding connection of first cavity 13, through the setting of second support column 12, can be with drainage plate 5 and support box 1 zonulae occludens, prevent that drainage plate 5 from droing, cause the influence to the testing result.

In this embodiment, specifically, the second cavity 14 has been seted up to the inside of supporting box 1, and the bottom fixed mounting of the 14 inner chambers of second cavity has first spring 15, and the one end that first spring 15 kept away from the 14 inner chambers of second cavity bottom and the bottom fixed mounting who places board 2, through the setting of first spring 15, the elasticity of first spring 15 is used in placing board 2, can assist the removal of placing board 2, makes simultaneously to place board 2 more stable.

In this embodiment, it is concrete, the inside of placing board 2 is provided with standing groove 16, the equal fixed mounting in both sides of placing board 2 has slider 17, support the inside of box 1 and offer the spout 18 that uses with slider 17 cooperation, the outside of slider 17 and the inner wall sliding connection of spout 18, through the setting of slider 17 and spout 18, when placing board 2 and removing, drive slider 17 at 18 internal motion of spout for it is more stable to place board 2 and remove.

In this embodiment, specifically, third cavity 19 has been seted up to the inside of collecting box 9, and the bottom fixed mounting of the 19 inner chamber of third cavity has second spring 20, and through the setting of second spring 20, the elasticity of second spring 20 is used on first support column 8, and when collecting box 9 was taken off to needs, the motion of collecting box 9 was accelerated to the elasticity of second spring 20, and convenient to use person is to the dismouting of collecting box 9.

In this embodiment, specifically, both sides of the collection box 9 are slidably connected with a push-pull rod 21, a fourth cavity 22 used in cooperation with the push-pull rod 21 is formed in the first support column 8, the outer side of the push-pull rod 21 is slidably connected with the inside of the collection box 9 and the inner wall of the fourth cavity 22, and the push-pull rod 21 moves in the fourth cavity 22 and the third cavity 19 through the arrangement of the push-pull rod 21, so that the connection between the collection box 9 and the first support column 8 is tighter, and the collection box 9 is prevented from falling off.

The working principle is as follows: when the biological chip carrier is used, a user pours blood to be detected into the drainage plate 5, the blood cannot fall under the action of the semipermeable membrane 6, the blood enters the drainage tube 11 through the drainage hole 10, then enters the inside of the support box 1 through the drainage tube 11, the blood can uniformly permeate under the action of the permeation paper 23, falls on the surface of the biological probe molecules 4 and reacts with the biological probe molecules 4, the rest blood which does not react enters the inside of the collection box 9 through the waste liquid hole 7, when the user needs to disassemble and assemble the collection box 9, the push-pull rod 21 is pulled, the push-pull rod 21 slides out from the inside of the fourth cavity 22 and the third cavity 19, under the action of the elastic force of the second spring 20, the elastic force is generated on the first support column 8 to eject the collection box 9, the uniform treatment on waste liquid is convenient for the user, when the user needs to take out the biological chip carrier 3, through the cooperation use of first cavity 13 and second support column 12, take off drainage plate 5, then promote and place board 2, drive the motion of standing groove 16, take out biochip carrier 3, inspect the testing result to record multiunit data.

The control mode of the present application is automatically controlled by a controller, the control circuit of the controller can be realized by simple programming by those skilled in the art, and the present application belongs to the common knowledge in the field, and the present application mainly protects the mechanical device, so the present application does not explain the control mode and the circuit connection in detail.

The standard parts used in the present application document can be purchased from the market, and can be customized according to the description of the specification and the accompanying drawings, the specific connection mode of each part adopts the conventional means of mature bolt, rivet, welding and the like in the prior art, the machinery, parts and equipment adopt the conventional models in the prior art, and the structure and principle of the parts known by the skilled person can be known by the technical manual or by the conventional experimental method.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A biochip for lung cancer diagnosis and detection, comprising a support cassette (1), characterized in that: the inside sliding connection who supports box (1) places board (2), the top of placing board (2) is provided with biochip carrier (3), the top of biochip carrier (3) is provided with biological probe molecule (4), the top of supporting box (1) is provided with drainage plate (5), the top of drainage plate (5) is provided with pellicle (6), waste liquid hole (7) have been seted up to the bottom of supporting box (1), the four corners of supporting box (1) bottom all is provided with first support column (8), the outside sliding connection of first support column (8) has collection box (9), the inside of supporting box (1) is provided with infiltration paper (23).

2. The biochip for diagnosing and detecting lung cancer according to claim 1, wherein: the bottom of the supporting box (1) is communicated with the top of the collecting box (9) through a waste liquid hole (7), a drainage hole (10) is formed in the drainage plate (5), and the bottom of the drainage hole (10) is communicated with a drainage tube (11).

3. The biochip for diagnosing and detecting lung cancer according to claim 2, wherein: the bottom of drainage plate (5) is passed through drainage tube (11) and is communicated with the top that supports box (1), the equal fixed mounting in four corners of drainage plate (5) bottom has second support column (12), support the inside of box (1) and seted up first cavity (13) that use with the cooperation of second support column (12), the outside of second support column (12) and the inner wall sliding connection of first cavity (13).

4. The biochip for diagnosing and detecting lung cancer according to claim 1, wherein: a second cavity (14) is formed in the supporting box (1), a first spring (15) is fixedly mounted at the bottom of an inner cavity of the second cavity (14), and one end, far away from the bottom of the inner cavity of the second cavity (14), of the first spring (15) is fixedly mounted with the bottom of the placing plate (2).

5. The biochip for diagnosing and detecting lung cancer according to claim 4, wherein: the novel multifunctional table is characterized in that a placing groove (16) is formed in the placing plate (2), sliding blocks (17) are fixedly mounted on two sides of the placing plate (2), sliding grooves (18) matched with the sliding blocks (17) are formed in the supporting box (1), and the outer sides of the sliding blocks (17) are connected with the inner walls of the sliding grooves (18) in a sliding mode.

6. The biochip for diagnosing and detecting lung cancer according to claim 1, wherein: a third cavity (19) is formed in the collecting box (9), and a second spring (20) is fixedly mounted at the bottom of the inner cavity of the third cavity (19).

7. The biochip for diagnosing and detecting lung cancer according to claim 1, wherein: the collecting box is characterized in that push-pull rods (21) are connected to two sides of the collecting box (9) in a sliding mode, fourth cavities (22) matched with the push-pull rods (21) for use are formed in the first supporting columns (8), and the outer sides of the push-pull rods (21) are connected with the inner portion of the collecting box (9) and the inner wall of the fourth cavities (22) in a sliding mode.