CN213519856U - Mass spectrum detection system and ion source device - Google Patents
Mass spectrum detection system and ion source device Download PDFInfo
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- CN213519856U CN213519856U CN202022624447.XU CN202022624447U CN213519856U CN 213519856 U CN213519856 U CN 213519856U CN 202022624447 U CN202022624447 U CN 202022624447U CN 213519856 U CN213519856 U CN 213519856U
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Abstract
The utility model relates to a mass spectrum detecting system and ion source device, ion source device include casing, focus orifice plate, spraying capillary, gas circuit subassembly and advance kind of subassembly. The shell is provided with an ionization chamber, and is also provided with a sample inlet, a sample outlet and a gas inlet which are communicated with the ionization chamber. The sample outlet and the gas inlet are respectively positioned at two opposite ends of the shell. The focusing orifice plate is connected with the shell and is provided with a through hole. The through hole is communicated with the sample outlet and is also used for being communicated with a mass spectrum inlet of a mass spectrometer. The spray capillary penetrates through the shell and extends into the ionization chamber, the spray end of the spray capillary faces the through hole, and the formed spray area covers the through hole. The air path component is provided with a first air blowing end which is communicated with the air inlet, and auxiliary air at the first air blowing end enters the ionization cavity through the air inlet. The output end of the sample feeding assembly is communicated with the sample feeding port, and the input end of the sample feeding assembly is used for introducing a sample to be detected. Therefore, the ion source device can improve the ionization efficiency and ensure the detection effect.
Description
Technical Field
The utility model relates to a mass spectrometry detects technical field, especially relates to a mass spectrometry detecting system and ion source device.
Background
With the development of mass spectrometry, Electrospray ionization (ESI) and Secondary Electrospray ionization (SESI) have been developed. In this case, ESI is generally performed by dissolving a sample to be detected in a solvent and spraying the solution in an electrospray manner, so that the sample is ionized to form charged ions. SESI is a novel Mass Spectrometry (MS) ionization technique derived based on ESI, and its ionization process can be summarized as that a high-purity solution without a sample is passed through ESI to form charged micro-droplets, and these charged micro-droplets are ejected and contacted with a sample (including gas-phase molecules or aerosol particles (solid or liquid)) to ionize the sample to form charged ions. However, the ionization efficiency of the conventional SESI to the sample is low, resulting in poor sample detection effect.
SUMMERY OF THE UTILITY MODEL
Therefore, it is necessary to overcome the defects of the prior art and provide a mass spectrometry detection system and an ion source apparatus, which can improve ionization efficiency and ensure detection effect.
The technical scheme is as follows: an ion source apparatus, comprising: the device comprises a shell and a focusing orifice plate, wherein the shell is provided with an ionization chamber, and is also provided with a sample inlet, a sample outlet and a gas inlet which are communicated with the ionization chamber, the sample outlet and the gas inlet are respectively positioned at two opposite ends of the shell, the focusing orifice plate is connected with the shell, the focusing orifice plate is provided with a through hole, the through hole is communicated with the sample outlet, and the through hole is also used for being communicated with a mass spectrum inlet of a mass spectrometer; the spray capillary penetrates through the shell and extends into the ionization chamber, the spray end of the spray capillary faces the through hole, and a spray area is formed to cover the through hole; the air path assembly is provided with a first air blowing end, the first air blowing end is communicated with the air inlet, and auxiliary air at the first air blowing end enters the ionization chamber through the air inlet; and the output end of the sample injection assembly is communicated with the sample injection port, and the input end of the sample injection assembly is used for introducing a sample to be detected.
When the ion source device works, a sample to be detected (comprising gas phase molecules or aerosol particles (solid or liquid)) enters the sample injection assembly through the input end of the sample injection assembly, enters the ionization cavity from the output end of the sample injection assembly through the sample injection port, electrospray agent forms electrospray through the spray capillary and is sprayed into the ionization cavity, the sample to be detected is ionized to form charged ions when the electrospray contacts the sample to be detected, meanwhile, auxiliary gas at the first blowing end of the gas circuit assembly enters the ionization cavity through the gas inlet and flows towards the through hole, on one hand, the auxiliary gas and the charged ions can enter a mass spectrum inlet of a mass spectrometer through the through hole of the focusing orifice plate, and the mass spectrometer performs mass spectrum detection and analysis on the charged ions to obtain the composition components of the sample to be detected; on the other hand, the auxiliary gas flows to the focusing orifice plate from the end of the shell far away from the focusing orifice plate, so that the auxiliary gas can concentrate a sample to be detected to the side of the focusing orifice plate, the sample to be detected can be prevented from colliding and remaining on the inner wall of the shell to cause pollution, the protection effect is achieved, and the ionization efficiency of the sample to be detected can be improved. In addition, the spraying end of the spraying capillary tube is opposite to the through hole, and the formed spraying area covers the through hole, so that a sample to be detected entering the through hole can be contacted with the electrospray and sent for ionization, and the ionization efficiency of the sample to be detected can be improved. In addition, under the action of the focusing orifice plate, charged ions can be focused and enter the mass spectrometer. Therefore, the ionization efficiency can be improved, and the detection effect is ensured. And secondly, the contact ionization of the electrospray and the sample to be detected is carried out in an ionization cavity with better sealing property, and the air outside the shell can enter the ion cavity and the mass spectrometer, so that the reduction of the sensitivity of the method caused by the generation of background interference can be avoided.
In one embodiment, the ion source device further comprises an ultraviolet lamp and/or a corona discharge needle; when the ion source device comprises the ultraviolet lamp, a light-transmitting part opposite to the spraying area is arranged on the shell, and the ultraviolet lamp transmits ultraviolet light to the spraying area through the light-transmitting part; when the ion source device includes when the corona discharge needle, the corona discharge needle runs through the casing stretches into in the ionization chamber, just the discharge end of corona discharge needle is located spray region.
In one embodiment, the ion source apparatus further comprises a first heating member for heating the housing.
In one embodiment, the first heating member is a plurality of first heating members, and the plurality of first heating members are arranged on the housing at regular intervals.
In one embodiment, the spray capillary is a fused silica capillary.
In one embodiment, the shell is further provided with a flow equalizing chamber and a flow equalizing plate for separating the ionization chamber from the flow equalizing chamber, the flow equalizing plate is provided with a plurality of flow equalizing holes, the flow equalizing chamber is communicated with the ionization chamber through the flow equalizing holes, and the air inlet is arranged on the shell wall of the flow equalizing chamber and is communicated with the flow equalizing chamber.
In one embodiment, the casing further comprises a filling block, one side surface of the filling block is connected with the middle part of the flow equalizing plate, the other opposite side surface of the filling block is connected with the casing, the flow equalizing chamber is an annular chamber arranged around the filling block in the circumferential direction, and the flow equalizing holes are arranged on the flow equalizing plate in a spaced mode.
In one embodiment, the spray capillary tube penetrates through the shell, the filling block and the flow equalizing plate and then extends into the ionization chamber, so that the spray capillary tube is positioned in the middle part of the ionization chamber and the spray end of the spray capillary tube faces the through hole.
In one embodiment, the gas path assembly is further provided with a second blowing end, the side surface of the focusing orifice plate, which is away from the ionization chamber, and the end surface of the sample injection end of the mass spectrometer are provided with gas flow intervals, the gas flow intervals are communicated with the through holes, and the second blowing end is communicated with the gas flow intervals.
In one embodiment, the through hole comprises a conical section and a through section, wherein the aperture of the conical section gradually increases from the side of the focusing orifice plate facing the ionization cavity to the side facing away from the ionization cavity, and the through section is communicated with the conical section; the through hole can be arranged at the sample introduction end of the mass spectrometer, the hole wall of the conical section is used for forming an airflow interval with the end face of the sample introduction end of the mass spectrometer, and the inner wall of the straight-through section is used for being in sealing fit with the side wall of the sample introduction end of the mass spectrometer; the air path assembly is also provided with a second air blowing end, and the second air blowing end is communicated with the air flow at intervals.
In one embodiment, the air path assembly includes a first air inlet pipe, a second air inlet pipe and a third air inlet pipe, one end of the first air inlet pipe is used for introducing the auxiliary air, the other end of the first air inlet pipe is respectively communicated with one end of the second air inlet pipe and one end of the third air inlet pipe, the other end of the second air inlet pipe is the first blowing end, and the other end of the third air inlet pipe is the second blowing end.
In one embodiment, a first flow regulating valve and a first filter are arranged on the first air inlet pipe.
In one embodiment, the gas path assembly further comprises an exhaust pipe, the other end of the first gas inlet pipe is further connected with the exhaust pipe, and a second flow regulating valve is arranged on the exhaust pipe.
In one embodiment, the sample injection assembly comprises a first sample injection tube and a second sample injection tube; one end of the first sample inlet pipe is communicated with the sample inlet, and the other end of the first sample inlet pipe is used for introducing the sample to be detected; one end of the second sample inlet pipe is used for being communicated with the sample inlet, and the other end of the second sample inlet pipe is used for introducing the sample to be detected.
In one embodiment, the sample injection assembly further comprises a second filter and a second heating element, the second filter is used for filtering out particulate matters in the sample to be detected entering the first sample injection pipe, and the second heating element is used for heating the sample to be detected.
In one embodiment, the sample injection assembly further comprises a third filter, and the third filter is used for filtering out volatile organic compounds in the sample to be measured entering the second sample injection pipe.
The mass spectrum detection system comprises the ion source device and a mass spectrometer, wherein a mass spectrum inlet of the mass spectrometer is communicated with the through hole.
In the mass spectrometry detection system, a sample to be detected (including gas phase molecules or aerosol particles (solid or liquid)) enters the sample injection assembly through the input end of the sample injection assembly, enters the ionization cavity through the output end of the sample injection assembly through the sample injection port, electrospray agent forms electrospray through the spray capillary and is sprayed into the ionization cavity, the sample to be detected is ionized to form charged ions when the electrospray contacts the sample to be detected, meanwhile, auxiliary gas at the first blowing end of the gas circuit assembly enters the ionization cavity through the gas inlet and flows towards the through hole, on one hand, the auxiliary gas and the charged ions can enter the mass spectrometry inlet of the mass spectrometer through the through hole of the focusing orifice plate, and the mass spectrometer performs mass spectrometry detection analysis on the charged ions to obtain the composition components of the sample to be detected; on the other hand, the auxiliary gas flows to the focusing orifice plate from the end of the shell far away from the focusing orifice plate, so that the auxiliary gas can concentrate a sample to be detected to the side of the focusing orifice plate, the sample to be detected can be prevented from colliding and remaining on the inner wall of the shell to cause pollution, the protection effect is achieved, and the ionization efficiency of the sample to be detected can be improved. In addition, the spraying end of the spraying capillary tube is opposite to the through hole, and the formed spraying area covers the through hole, so that a sample to be detected entering the through hole can be contacted with the electrospray and sent for ionization, and the ionization efficiency of the sample to be detected can be improved. In addition, under the action of the focusing orifice plate, charged ions can be focused and enter the mass spectrometer. Therefore, the ionization efficiency can be improved, and the detection effect is ensured. And secondly, the contact ionization of the electrospray and the sample to be detected is carried out in an ionization cavity with better sealing property, and the air outside the shell can enter the ion cavity and the mass spectrometer, so that the reduction of the sensitivity of the method caused by the generation of background interference can be avoided.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification.
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
Fig. 1 is a schematic structural diagram of an ion source apparatus according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a gas circuit assembly of an ion source apparatus according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of an ion source apparatus according to another embodiment of the present invention;
fig. 4 is a schematic structural diagram of a gas circuit assembly of an ion source apparatus according to another embodiment of the present invention.
10. A housing; 11. an ionization chamber; 12. a sample inlet; 13. a sample outlet; 14. an air inlet; 15. a flow equalizing chamber; 16. a flow equalizing plate; 161. a flow equalizing hole; 17. filling blocks; 20. a focusing aperture plate; 21. a through hole; 211. a tapered section; 212. a straight-through section; 22. air flow spacing; 23. an annular sleeve; 24. a seal ring; 30. spraying a capillary tube; 31. a spray area; 40. a gas circuit component; 41. a first blowing end; 42. a second blowing end; 43. a first intake pipe; 44. a second intake pipe; 45. a third intake pipe; 46. a first flow regulating valve; 47. a first filter; 48. an exhaust pipe; 49. a second flow regulating valve; 50. a sample introduction assembly; 51. a first sample introduction pipe; 52. a second sample injection pipe; 53. a second filter; 54. a second heating member; 55. a third filter; 60. a mass spectrometer; 61. a mass spectrometry inlet; 62. a sample introduction end; 70. an ultraviolet lamp; 80. corona discharge needles; 90. a first heating member; 100. a charged ion.
Detailed Description
In order to make the above objects, features and advantages of the present invention more comprehensible, embodiments of the present invention are described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein, as those skilled in the art will be able to make similar modifications without departing from the spirit and scope of the present invention.
Referring to fig. 1 and 2, fig. 1 illustrates a schematic structural diagram of an ion source device according to an embodiment of the present invention, and fig. 2 illustrates a schematic structural diagram of a gas circuit assembly 40 of an ion source device according to an embodiment of the present invention. An embodiment of the present invention provides an ion source device, which includes a housing 10, a focusing hole plate 20, a spray capillary 30, a gas circuit assembly 40 and a sample introduction assembly 50.
The shell 10 is provided with an ionization chamber 11, and the shell 10 is further provided with a sample inlet 12, a sample outlet 13 and a gas inlet 14 which are communicated with the ionization chamber 11. The sample outlet 13 and the gas inlet 14 are located at opposite ends of the housing 10, respectively. The focus orifice plate 20 is connected to the housing 10, and the focus orifice plate 20 is provided with a through hole 21. The through hole 21 is communicated with the sample outlet 13, and the through hole 21 is also used for being communicated with a mass spectrum inlet 61 of the mass spectrometer 60. The spray capillary 30 extends through the housing 10 into the interior of the ionization chamber 11, the spray end of the spray capillary 30 facing the through-opening 21 and forming a spray area 31 covering the through-opening 21. The air path assembly 40 is provided with a first blowing end 41, the first blowing end 41 is communicated with the air inlet 14, and the auxiliary air of the first blowing end 41 enters the ionization chamber 11 through the air inlet 14. The output end of the sample feeding assembly 50 is communicated with the sample feeding port 12, and the input end of the sample feeding assembly 50 is used for introducing a sample to be detected.
When the ion source device works, a sample to be detected (including gas-phase molecules or aerosol particles (solid or liquid)) enters the sample injection assembly 50 through the input end of the sample injection assembly 50, enters the ionization chamber 11 through the output end of the sample injection assembly 50 through the sample injection port 12, an electrospray agent forms electrospray through the spray capillary 30 and is sprayed into the ionization chamber 11, the sample to be detected is ionized to form charged ions 100 when the electrospray contacts the sample to be detected, meanwhile, auxiliary gas at the first gas blowing end 41 of the gas circuit assembly 40 enters the ionization chamber 11 through the gas inlet 14 and flows towards the through holes 21, on one hand, the auxiliary gas and the charged ions 100 can enter the mass spectrum inlet 61 of the mass spectrometer 60 through the through holes 21 of the focusing orifice plate 20, and the mass spectrometer 60 performs mass spectrum detection analysis on the charged ions 100 to obtain composition components of the sample to be detected; on the other hand, the auxiliary gas flows to the focusing hole plate 20 from the end of the casing 10 far away from the focusing hole plate 20, so that the auxiliary gas can concentrate the sample to be detected to the side of the focusing hole plate 20, thereby not only preventing the sample to be detected from colliding and remaining on the inner wall of the casing 10 to cause pollution, but also playing a role in protection and improving the ionization efficiency of the sample to be detected. In addition, the spraying end of the spray capillary 30 faces the through hole 21 and the formed spraying area 31 covers the through hole 21, so that the sample to be tested just entering the through hole 21 is contacted with the electrospray and sends ionization, thereby improving the ionization efficiency of the sample to be tested. In addition, under the action of the focusing orifice 20, the charged ions 100 can be focused and enter the mass spectrometer 60. Therefore, the ionization efficiency can be improved, and the detection effect is ensured. Secondly, the contact ionization of the electrospray and the sample to be detected is carried out in the ionization chamber 11 with better sealing performance, and the air outside the shell 10 can enter the ionization chamber and the mass spectrometer 60, so that the reduction of the sensitivity of the method caused by the generation of background interference can be avoided.
Specific examples of the auxiliary gas include nitrogen, helium, hydrogen, or other inert gases that do not participate in the chemical reaction, and are not limited herein and may be provided according to actual needs.
Referring to fig. 1 and 2, the ion source device further includes an ultraviolet lamp 70 and/or a corona discharge needle 80. When the ion source device includes the ultraviolet lamp 70, a light-transmitting portion is provided on the housing 10 to face the spray region 31, and the ultraviolet lamp 70 emits ultraviolet light into the spray region 31 through the light-transmitting portion; when the ion source device includes the corona discharge needle 80, the corona discharge needle 80 protrudes into the ionization chamber 11 through the housing 10, and the discharge end of the corona discharge needle 80 is located in the spray region 31. Thus, the ultraviolet light emitted by the ultraviolet lamp 70 is incident on the spraying area 31, and/or the discharging end of the corona discharge needle 80 discharges in the spraying area 31, so that the ionization capacity is enhanced, and the weak polar substances or the non-polar substances (such as the alkane substances) can be ionized, and the weak polar substances or the non-polar substances can be ionized, so that the weak polar substances or the non-polar substances can be ionized, the types of the ionizable substances are increased, and the product performance is improved.
It should be noted that the ultraviolet lamp 70 and the corona discharge needle 80 may be replaced or combined with other ionization devices according to actual requirements, and the other ionization devices include, but are not limited to, normal pressure ionization devices such as a combination of a flowing afterglow arrester (FA-APGD), a Low Temperature Plasma (LTP), a Microwave Plasma Torch (MPT), and the like, which all can improve the capability of the ion source apparatus to perform desorption ionization on chemical components in the sample to be detected.
It should be noted that the spray capillary 30, the ultraviolet lamp 70, the corona discharge needle 80, and the sample inlet 12 may be changed and adjusted according to actual requirements, and are not limited herein.
Referring to fig. 1 and 2, in one embodiment, the ion source apparatus further includes a first heating member 90. The first heating member 90 is used to heat the housing 10. Therefore, the first heating element 90 heats the shell 10 during operation, so that the temperature of the sample to be tested in the shell 10 is maintained within a preset temperature range (for example, 85 ℃ -95 ℃), and thus, the water vapor carried by the sample to be tested entering the ionization chamber 11 cannot be condensed on the chamber wall of the ionization chamber 11, and the sample to be tested is prevented from being adhered to the chamber wall of the ionization chamber 11, so that the cleanliness of the chamber wall of the ionization chamber 11 can be ensured, and cross contamination caused by residues on the chamber wall of the ionization chamber 11 during different tests can be avoided.
Referring to fig. 1 and 2, in one embodiment, the first heating member 90 is provided in a plurality, and the plurality of first heating members 90 are disposed on the housing 10 at regular intervals. So, a plurality of first heating members 90 carry out the heating during operation, alright be heated comparatively evenly in order to realize each position of casing 10, can realize that each position temperature of ionization chamber 11 is even, avoid vapor condensation on the chamber wall of ionization chamber 11, and avoid the sample that awaits measuring to adhere to on the chamber wall of ionization chamber 11 to can guarantee the cleanliness factor in the chamber wall of ionization chamber 11. Specifically, the first heating member 90 may be a heating wire, a heating rod, a heating plate attached to an outer wall of the casing 10, or the like, and is not limited herein.
Referring to fig. 1 and 2, in one embodiment, the spray capillary 30 is a fused silica capillary. Therefore, the electrospray solvent forms nano-liter electrospray through the fused quartz capillary, the flow of the nano-liter electrospray is small, and the influence on the gas velocity flow field can be ignored, so that the interaction between the primary electrospray and the sample airflow can not be disturbed, the ionization efficiency can be ensured, and the adverse phenomenon that the sample airflow collides and remains on the wall of the ionization cavity 11 caused by the disturbance of the sample airflow can be avoided.
It should be noted that the conventional ESI method generates electrospray, and the flow rate is usually 5ml/min, and the flow rate of the electrospray region 31 is large, which may have a large interference effect on the air flow. The inner diameter of the fused silica capillary tube in the embodiment is usually 20-50 μm, the generated flow is usually 100nL/min, the flow rate is negligible, and the gas flow is not disturbed.
The amorphous state of fused silica, which is a kind of glass, does not mean a molten state. Fused silica is a substance in a glassy state produced by melting natural high purity silica in an electric furnace at a temperature above 1760 ℃ followed by rapid cooling.
Referring to fig. 1 and 2, in one embodiment, the housing 10 further has a flow equalizing chamber 15 and a flow equalizing plate 16 for separating the ionization chamber 11 from the flow equalizing chamber 15. The flow equalizing plate 16 is provided with a plurality of flow equalizing holes 161, and the flow equalizing chamber 15 is communicated with the ionization chamber 11 through the flow equalizing holes 161. The gas inlet 14 is arranged on the shell wall of the flow equalizing chamber 15 and is communicated with the flow equalizing chamber 15. Like this, the auxiliary gas of first end 41 of blowing passes through air inlet 14 and enters into flow equalizing chamber 15 earlier, and through flow equalizing chamber 15 after flow equalizing in the flow equalizing chamber again in flow equalizing hole 161 enters into ionization chamber 11, makes the gas that enters into ionization chamber 11 more even like this, is favorable to realizing pushing the sample to be measured to spray region 31.
Referring to fig. 1 and 2, in one embodiment, housing 10 further includes a filler block 17. One side surface of the filling block 17 is connected with the middle part of the flow equalizing plate 16, the other opposite side surface of the filling block 17 is connected with the shell 10, and the flow equalizing chamber 15 is an annular chamber arranged around the circumference of the filling block 17. The flow equalizing holes 161 are spaced around the flow equalizing plate 16. Therefore, the auxiliary gas entering the ionization chamber 11 from the flow equalizing chamber 15 can better prevent the sample to be detected from flowing towards the chamber wall of the ionization chamber 11, so that the sample to be detected can be prevented from colliding with the inner wall of the ionization chamber 11 and remaining in the ionization chamber 11 to cause pollution, the protection effect is achieved, and the ionization efficiency of the sample to be detected can be improved.
In one embodiment, the spray capillary 30 extends into the ionization chamber 11 through the housing 10, the filling block 17, and the flow equalizing plate 16, such that the spray capillary 30 is located in the middle portion of the ionization chamber 11 and the spray end of the spray capillary 30 faces the through hole 21.
Referring to fig. 3 and 4, fig. 3 illustrates a schematic structural diagram of an ion source apparatus according to another embodiment of the present invention, and fig. 4 illustrates a schematic structural diagram of a gas circuit assembly 40 of an ion source apparatus according to another embodiment of the present invention. In one embodiment, the air channel assembly 40 is further provided with a second air blowing end 42, the side of the focusing orifice 20 facing away from the ionization chamber 11 and the end face of the sample injection end 62 of the mass spectrometer 60 are provided with an air flow gap 22, the air flow gap 22 is communicated with the through hole 21, and the second air blowing end 42 is communicated with the air flow gap 22. Wherein, mass spectrum inlet 61 of mass spectrometer 60 is provided on sample introduction end 62 of mass spectrometer 60. Second gas-blowing end 42 feeds auxiliary gas into gas flow space 22 and is drawn into mass spectrometer 60 along gas flow space 22 by mass spectrometer 60. In the process that the auxiliary gas and the charged ions 100 at the through hole 21 enter the mass spectrometer 60 through the mass spectrum inlet 61, the auxiliary gas can prevent the sample ions from colliding and remaining on the opening wall of the mass spectrum inlet 61.
Referring to fig. 3 and 4, in order to further ensure the sealing performance, the air path assembly 40 further includes an annular sleeve 23, the annular sleeve 23 is sleeved outside the sample injection end 62, an inner wall of one end of the annular sleeve 23 is in sealing fit with an outer wall of the sample injection end 62 through a sealing ring 24, an end face of the other end of the annular sleeve 23 is in sealing fit with a side surface of the focusing orifice plate 20 away from the ionization chamber 11, and the annular sleeve 23 is wound around the periphery of the through hole 21, so as to prevent the auxiliary air flow channel from being in the external environment and prevent the external air from entering the mass spectrometer 60 through the air flow gap 22, so that the sealing performance is good, the detection effect is ensured, the contact ionization of the electrospray and the sample to be detected is performed in the ionization chamber 11 with good sealing performance, the air outside the housing 10 can enter the ion chamber and the mass spectrometer 60, and therefore, the reduction of the.
Referring to fig. 1 and 2 again, in one embodiment, the through hole 21 includes a tapered section 211 whose aperture gradually increases from the side of the focusing aperture plate 20 facing the ionization chamber 11 to the side facing away from the ionization chamber 11, and a through section 212 communicating with the tapered section 211. The through hole 21 can be installed in the sample inlet end 62 of the mass spectrometer 60, the hole wall of the conical section 211 is used for forming the gas flow interval 22 with the end face of the sample inlet end 62 of the mass spectrometer 60, and the inner wall of the straight section 212 is used for being matched with the side wall of the sample inlet end 62 of the mass spectrometer 60 in a sealing mode. The air passage assembly 40 is further provided with a second air blowing end 42, and the second air blowing end 42 is communicated with the air flow space 22. Specifically, the second air blowing end 42 penetrates the focusing hole plate 20 and is communicated with the air flow space 22. In this way, the smaller diameter end of the conical section 211 is formed on the side of the focusing orifice plate 20 facing the ionization chamber 11, so that the diameter of the opening on the side of the focusing orifice plate 20 facing the ionization chamber 11 is smaller, and the focusing function can be achieved; in addition, the hole wall of the conical section 211 is gradually enlarged and can be matched with the end face of the sample introduction end 62 of the mass spectrometer 60 to form the gas flow interval 22, the end with the larger hole diameter of the conical section 211 is communicated with the straight-through section 212, and the straight-through section 212 is matched with the side wall of the sample introduction end 62 in a sealing mode, so that the whole gas tightness is better.
In one embodiment, the shape of the through hole 21 may be designed according to the shape of the end surface of the sample introduction end 62 of the mass spectrometer 60, and when the end surface of the sample introduction end 62 of the mass spectrometer 60 is not a conical surface, the through hole 21 may not need to be designed with the conical section 211, but may be provided with two through sections 212 communicated with each other, wherein the aperture of one through section 212 is relatively small, and the aperture of the other through section 212 is relatively large and is used for sealing fit with the side wall of the sample introduction end 62.
In one embodiment, the number of the focusing orifice plates 20 is at least one, and the focusing orifice plates 20 may be added according to actual requirements, and the specific number is not limited herein. Alternatively, the focusing aperture plate 20 may be provided with or without electrodes, that is, the focusing aperture plate 20 with electrodes may be replaced with the focusing aperture plate 20 without electrodes according to actual requirements. When the focusing orifice plate 20 is provided with the electrodes, the focusing effect of the focusing orifice plate 20 is good due to the provided electrodes, charged sample ions can be focused, so that the charged ions 100 enter the mass spectrum inlet 61, and the sample ions are prevented from colliding or being adsorbed on the wall surface to cause loss.
Referring to fig. 1 and 2, in one embodiment, the air path assembly 40 includes a first air inlet pipe 43, a second air inlet pipe 44 and a third air inlet pipe 45. One end of the first air inlet pipe 43 is used for introducing auxiliary air, the other end of the first air inlet pipe 43 is respectively communicated with one end of the second air inlet pipe 44 and one end of the third air inlet pipe 45, the other end of the second air inlet pipe 44 is a first air blowing end 41, and the other end of the third air inlet pipe 45 is a second air blowing end 42.
Referring to fig. 1 and 2, a first flow rate adjusting valve 46 and a first filter 47 are further disposed on the first air inlet pipe 43. Specifically, the first filter 47 may be, for example, an activated carbon filter for filtering out volatile organic compounds, and the first filter 47 may be another filter, which is not limited herein. The amount of the auxiliary air flow into the first intake pipe 43 can be controlled by the first flow rate adjustment valve 46 so that the amount of the auxiliary air flow into the first intake pipe 43 is within a preset range.
Referring to fig. 1 and 2, further, the air path assembly 40 further includes an exhaust pipe 48. The other end of the first intake pipe 43 is also connected to an exhaust pipe 48, and a second flow rate adjustment valve 49 is provided on the exhaust pipe 48.
Referring to fig. 1 and 2, the sample injection assembly 50 further includes a first sample injection pipe 51 and a second sample injection pipe 52. One end of the first sample inlet pipe 51 is used for being communicated with the sample inlet 12, and the other end of the first sample inlet pipe 51 is used for introducing a sample to be measured. One end of the second sample inlet pipe 52 is used for communicating with the sample inlet 12, and the other end of the second sample inlet pipe 52 is used for introducing a sample to be measured. Thus, when the first sample introduction tube 51 is opened to operate, a sample to be detected, which is a gas, is introduced into the sample inlet 12 through the first sample introduction tube 51 and is sent into the ionization chamber 11, and the second sample introduction tube 52 is closed, that is, the gas detection and analysis operation is performed; when the second sample injection tube 52 is in an open state, a sample to be detected, which is aerosol particles, is introduced into the sample inlet 12 through the second sample injection tube 52 and is sent into the ionization chamber 11, and the first sample injection tube 51 is in a closed state, that is, the detection and analysis of the aerosol particles are performed.
It should be noted that, both the first sample inlet pipe 51 and the second sample inlet pipe 52 are connected to the sample inlet 12 through a tee-joint pipe, or the first sample inlet pipe 51 is connected to the second sample inlet pipe 52, and then the second sample inlet pipe 52 is connected to the sample inlet 12, which is not limited herein.
Referring to fig. 1 and 2, the sample injection assembly 50 further includes a second filter 53 and a second heating element 54. The second filter 53 is used for filtering particulate matters in the sample to be measured entering the first sample inlet pipe 51, and the second heating member 54 is used for heating the sample to be measured.
Specifically, the second filter 53 is, for example, a particle filter, and when the sample to be measured entering the first sample introduction tube 51 is a gas, the particles contained in the gas can be completely filtered out, and the detection effect can be improved.
Referring to fig. 1 and 2, the sample injection assembly 50 further includes a third filter 55. The third filter 55 is used for filtering out volatile organic compounds in the sample to be measured entering the second sample inlet pipe 52. Specifically, the third filter 55 is, for example, an activated carbon filter, and when the sample to be measured entering the second sample inlet pipe 52 is aerosol particles, volatile organic compounds in the sample to be measured can be filtered.
Furthermore, in order to prevent the water vapor contained in the sample to be detected from being condensed on the inner wall of the first sample inlet pipe 51 or the second sample inlet pipe 52, the third heating members are wound on the pipe walls of the first sample inlet pipe 51 and the second sample inlet pipe 52. The third heating member heats the first sample inlet pipe 51 and the second sample inlet pipe 52, so that the first sample inlet pipe 51 and the second sample inlet pipe 52 are maintained within a preset temperature range, and the water vapor contained in the sample to be detected is prevented from being condensed on the inner wall of the first sample inlet pipe 51 or the second sample inlet pipe 52.
Referring to fig. 1 and 2, in one embodiment, a mass spectrometry detection system includes the ion source apparatus of any one of the above embodiments, and further includes a mass spectrometer 60. The mass spectrum inlet 61 of the mass spectrometer 60 communicates with the through hole 21.
In the mass spectrometry detection system, a sample to be detected (including gas phase molecules or aerosol particles (solid or liquid)) enters the sample injection assembly 50 through the input end of the sample injection assembly 50, enters the ionization chamber 11 through the output end of the sample injection assembly 50 through the sample injection port 12, an electrospray agent forms electrospray through the spray capillary 30 and is sprayed into the ionization chamber 11, the sample to be detected is ionized to form charged ions 100 when the electrospray contacts the sample to be detected, meanwhile, auxiliary gas at the first gas blowing end 41 of the gas circuit assembly 40 enters the ionization chamber 11 through the gas inlet 14 and flows towards the through hole 21, on one hand, the auxiliary gas and the charged ions 100 can enter the mass spectrometry inlet 61 of the mass spectrometer 60 through the through hole 21 of the focusing orifice plate 20, and the mass spectrometer 60 performs mass spectrometry detection analysis on the charged ions 100 to obtain the composition components of the sample to be detected; on the other hand, the auxiliary gas flows to the focusing hole plate 20 from the end of the casing 10 far away from the focusing hole plate 20, so that the auxiliary gas can concentrate the sample to be detected to the side of the focusing hole plate 20, thereby not only preventing the sample to be detected from colliding and remaining on the inner wall of the casing 10 to cause pollution, but also playing a role in protection and improving the ionization efficiency of the sample to be detected. In addition, the spraying end of the spray capillary 30 faces the through hole 21 and the formed spraying area 31 covers the through hole 21, so that the sample to be tested just entering the through hole 21 is contacted with the electrospray and sends ionization, thereby improving the ionization efficiency of the sample to be tested. In addition, under the action of the focusing orifice 20, the charged ions 100 can be focused and enter the mass spectrometer 60. Therefore, the ionization efficiency can be improved, and the detection effect is ensured. Secondly, the contact ionization of the electrospray and the sample to be detected is carried out in the ionization chamber 11 with better sealing performance, and the air outside the shell 10 can enter the ionization chamber and the mass spectrometer 60, so that the reduction of the sensitivity of the method caused by the generation of background interference can be avoided.
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above examples only represent some embodiments of the present invention, and the description thereof is more specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several variations and modifications can be made, which are within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", and the like, indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.
In the present application, unless expressly stated or limited otherwise, the first feature may be directly on or directly under the second feature or indirectly via intermediate members. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.
Claims (16)
1. An ion source apparatus, comprising:
the device comprises a shell and a focusing orifice plate, wherein the shell is provided with an ionization chamber, and is also provided with a sample inlet, a sample outlet and a gas inlet which are communicated with the ionization chamber, the sample outlet and the gas inlet are respectively positioned at two opposite ends of the shell, the focusing orifice plate is connected with the shell, the focusing orifice plate is provided with a through hole, the through hole is communicated with the sample outlet, and the through hole is also used for being communicated with a mass spectrum inlet of a mass spectrometer;
the spray capillary penetrates through the shell and extends into the ionization chamber, the spray end of the spray capillary faces the through hole, and a spray area is formed to cover the through hole;
the air path assembly is provided with a first air blowing end, the first air blowing end is communicated with the air inlet, and auxiliary air at the first air blowing end enters the ionization chamber through the air inlet; and
the sample injection assembly, the output of the sample injection assembly with the sample injection port is communicated, and the input of the sample injection assembly is used for introducing a sample to be detected.
2. The ion source apparatus of claim 1, further comprising an ultraviolet lamp and/or a corona discharge needle; when the ion source device comprises the ultraviolet lamp, a light-transmitting part opposite to the spraying area is arranged on the shell, and the ultraviolet lamp transmits ultraviolet light to the spraying area through the light-transmitting part; when the ion source device includes when the corona discharge needle, the corona discharge needle runs through the casing stretches into in the ionization chamber, just the discharge end of corona discharge needle is located spray region.
3. The ion source device of claim 1, further comprising a first heating element for heating the housing.
4. An ion source apparatus according to claim 3, wherein said first heating member is plural, and plural first heating members are provided on said housing at regular intervals.
5. The ion source apparatus of claim 1, wherein the spray capillary is a fused silica capillary.
6. The ion source apparatus of claim 1, wherein the housing further comprises a flow equalizing chamber and a flow equalizing plate for separating the ionization chamber from the flow equalizing chamber, the flow equalizing plate is provided with a plurality of flow equalizing holes, the flow equalizing chamber is communicated with the ionization chamber through the flow equalizing holes, and the gas inlet is disposed on a wall of the flow equalizing chamber and is communicated with the flow equalizing chamber.
7. The ion source apparatus of claim 6, wherein the housing further comprises a filler block, one side of the filler block is connected to a central portion of the flow equalizing plate, the other opposite side of the filler block is connected to the housing, the flow equalizing chamber is an annular chamber circumferentially disposed around the filler block, and the flow equalizing holes are spaced around the flow equalizing plate.
8. The ion source device of claim 1, wherein the gas path assembly further comprises a second blowing end, an airflow space is arranged between a side surface of the focusing orifice plate facing away from the ionization chamber and a sample introduction end surface of the mass spectrometer, the airflow space is communicated with the through hole, and the second blowing end is communicated with the airflow space.
9. The ion source apparatus of claim 1, wherein the through hole comprises a tapered section and a through section, wherein the aperture of the tapered section gradually increases from the side of the focusing aperture plate facing the ionization chamber to the side facing away from the ionization chamber, and the through section is communicated with the tapered section; the through hole can be arranged at the sample introduction end of the mass spectrometer, the hole wall of the conical section is used for forming an airflow interval with the end face of the sample introduction end of the mass spectrometer, and the inner wall of the straight-through section is used for being in sealing fit with the side wall of the sample introduction end of the mass spectrometer; the air path assembly is also provided with a second air blowing end, and the second air blowing end is communicated with the air flow at intervals.
10. The ion source apparatus according to claim 8 or 9, wherein the gas path assembly includes a first gas inlet pipe, a second gas inlet pipe, and a third gas inlet pipe, one end of the first gas inlet pipe is used for introducing the auxiliary gas, the other end of the first gas inlet pipe is respectively communicated with one end of the second gas inlet pipe and one end of the third gas inlet pipe, the other end of the second gas inlet pipe is the first gas blowing end, and the other end of the third gas inlet pipe is the second gas blowing end.
11. The ion source apparatus of claim 10, wherein the first gas inlet tube is provided with a first flow regulating valve and a first filter.
12. The ion source apparatus of claim 10, wherein the gas circuit assembly further comprises an exhaust pipe, the other end of the first gas inlet pipe is further connected to the exhaust pipe, and the exhaust pipe is provided with a second flow regulating valve.
13. The ion source apparatus of claim 1, wherein the sample assembly comprises a first sample inlet tube and a second sample inlet tube; one end of the first sample inlet pipe is communicated with the sample inlet, and the other end of the first sample inlet pipe is used for introducing the sample to be detected; one end of the second sample inlet pipe is used for being communicated with the sample inlet, and the other end of the second sample inlet pipe is used for introducing the sample to be detected.
14. The ion source apparatus of claim 13, wherein the sample introduction assembly further comprises a second filter for filtering out particles in the sample to be measured entering the first sample introduction tube, and a second heating element for heating the sample to be measured.
15. The ion source apparatus of claim 13, wherein the sample introduction assembly further comprises a third filter for filtering out volatile organic compounds from the sample to be measured entering the second sample introduction tube.
16. A mass spectrometry detection system comprising an ion source apparatus according to any one of claims 1 to 15 and a mass spectrometer having a mass spectrometer inlet in communication with the through bore.
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| CN202022624447.XU CN213519856U (en) | 2020-11-13 | 2020-11-13 | Mass spectrum detection system and ion source device |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112309823A (en) * | 2020-11-13 | 2021-02-02 | 广州禾信仪器股份有限公司 | Mass spectrum detection system and ion source device |
| CN116525404A (en) * | 2023-04-13 | 2023-08-01 | 广东智普生命科技有限公司 | Ion source for nasal exhalation on-line analysis, exhalation detection system and detection method |
| CN118311128A (en) * | 2024-04-15 | 2024-07-09 | 合肥谱佳医学检验实验室有限公司 | Ultraviolet light assisted electrospray device and method |
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2020
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112309823A (en) * | 2020-11-13 | 2021-02-02 | 广州禾信仪器股份有限公司 | Mass spectrum detection system and ion source device |
| WO2022099907A1 (en) * | 2020-11-13 | 2022-05-19 | 广州禾信仪器股份有限公司 | Mass spectrometry detection system and ion source device |
| CN116525404A (en) * | 2023-04-13 | 2023-08-01 | 广东智普生命科技有限公司 | Ion source for nasal exhalation on-line analysis, exhalation detection system and detection method |
| CN116525404B (en) * | 2023-04-13 | 2024-02-20 | 广东智普生命科技有限公司 | Ion source for nasal exhalation on-line analysis, exhalation detection system and detection method |
| CN118311128A (en) * | 2024-04-15 | 2024-07-09 | 合肥谱佳医学检验实验室有限公司 | Ultraviolet light assisted electrospray device and method |
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Address after: 510535 No. 16, Xinrui Road, Huangpu District, Guangzhou, Guangdong Patentee after: GUANGZHOU HEXIN INSTRUMENT Co.,Ltd. Patentee after: Kunshan Hexin Mass Spectrometry Technology Co., Ltd Address before: 510700 Room 102, building A3, 11 Kaiyuan Avenue, Huangpu District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU HEXIN INSTRUMENT Co.,Ltd. Patentee before: Kunshan Hexin Mass Spectrometry Technology Co., Ltd |