CN213503882U

CN213503882U - Immune cell in-vitro amplification kit

Info

Publication number: CN213503882U
Application number: CN202022229342.4U
Authority: CN
Inventors: 孔鹏; 张雪梅
Original assignee: Shandong Qixin Biotechnology Co ltd
Current assignee: Shandong Qixin Biotechnology Co ltd
Priority date: 2020-10-09
Filing date: 2020-10-09
Publication date: 2021-06-22
Anticipated expiration: 2030-10-09

Abstract

The utility model discloses an external amplification kit of immunocyte, the power distribution box comprises a box body, bottom fixedly connected with base in the box, a plurality of standing groove has been seted up on the base, sliding connection has the sponge bottom plate on the standing groove inner wall, middle part sliding connection has the sliding plate in the box, the first jack of a plurality of has been seted up on the sliding plate, sliding connection has the slide bar in the spout, the first spring of fixedly connected with between slide bar and the spout inner wall, the slide bar is kept away from one and is served the fixedly connected with arc, top sliding connection has the loading board in the box, a plurality of second jack has been seted up on the loading board, the box top is equipped with the lid. The utility model discloses pass second jack downstream with the test tube during the use, make the inside extrusion of arc carry out the centre gripping to the test tube under the effect of first spring, test tube downstream adsorbs fixedly to the test tube in to the standing groove simultaneously under the effect of sucking disc.

Description

Immune cell in-vitro amplification kit

Technical Field

The utility model relates to the technical field of medical equipment, especially, relate to an in vitro amplification kit of immune cell.

Background

Natural killer cells are important immune cells in the body, are not only involved in anti-tumor, anti-viral infection and immune regulation, but also are involved in hypersensitivity reactions and the development of autoimmune diseases in some cases. NK cells play an important role in resisting viruses and tumors, and have great application prospects in adoptive immunotherapy because primary immune activation is not needed in the action of the NK cells. Immunotherapy using NK cells requires first expanding in vitro large numbers of NK cells with higher killing activity.

However, the existing NK cell in-vitro amplification kit has a fixed structure, can only be suitable for test tubes with fixed specifications, cannot be used after the size of the test tube is changed, and has low applicability, and reagent tubes inside the moving process are easy to collide, so that the reagent tubes are damaged.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving among the prior art "the kit structure is fixed, can only be applicable to the test tube of fixed specification, then can't use after the test tube size changes, the suitability is lower to the reagent pipe that removes in-process inside collides easily, thereby leads to the defect of reagent pipe damage", thereby provides an immune cell external amplification kit.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

an immunocyte in vitro amplification kit comprises a box body, wherein the bottom in the box body is fixedly connected with a base, the base is provided with a plurality of placing grooves, the inner walls of the placing grooves are slidably connected with a sponge bottom plate, the middle in the box body is slidably connected with a sliding plate, the sliding plate is provided with a plurality of first jacks, the inner walls of the first jacks are symmetrically provided with sliding grooves, the sliding grooves are slidably connected with sliding rods, a first spring is fixedly connected between the sliding rods and the inner walls of the sliding grooves, one end of each sliding rod, far away from the first spring, is fixedly connected with an arc-shaped plate, the top in the box body is slidably connected with a bearing plate, the bearing plate is provided with a plurality of second jacks, the inner walls of the second jacks are provided with elastic airbags, the box body is symmetrically and fixedly, the improved structure of the box is characterized in that a plurality of hollow rods are fixedly connected to the fixed plate, a first piston plate and a second piston plate are symmetrically and slidably connected to the inner wall of each hollow rod, a first connecting rod and a second connecting rod are fixedly connected to the first piston plate and the second piston plate respectively, the first connecting rod and the second connecting rod are fixedly connected to the bearing plate and the sliding plate respectively, and a cover body is arranged above the box body.

Preferably, a plurality of telescopic grooves are formed in the cover body, the test tube plugs are connected in the telescopic grooves in a sliding mode, second springs are fixedly connected between the test tube plugs and the inner walls of the telescopic grooves, and the diameters of the test tube plugs are gradually reduced from top to bottom.

Preferably, the box is internally and symmetrically provided with first magnetic stripes, the cover is internally and symmetrically provided with second magnetic stripes, and the first magnetic stripes are matched with the second magnetic stripes.

Preferably, the cover body is provided with a handle, and the handle is provided with an elastic pad.

Preferably, an arc-shaped groove is formed in the sponge bottom plate, a plurality of suckers are arranged in the arc-shaped groove, and the suckers are made of rubber materials.

Compared with the prior art, the beneficial effects of the utility model are that:

1. pass second jack downstream with the test tube during the use, pass first jack extrusion arc to both sides motion, make the slide bar inwards extrude under the effect of first spring, drive the arc and inwards extrude and carry out the centre gripping to the test tube, test tube downstream to the standing groove in simultaneously, with the sucking disc contact, adsorb fixedly to the test tube under the effect of sucking disc for the device is applicable in the test tube of different specifications, still can use after the test tube size changes, and the suitability is higher.

2. Cover the lid after the completion is placed to the test tube, make the test tube stopper fill in the test tube, when carrying this kit and take place vibrations, loading board up-and-down motion, drive head rod up-and-down motion, make first piston plate up-and-down motion, drive second piston plate up-and-down motion under the effect of cavity intracavity gas, make sliding plate up-and-down motion, cushion on vertical direction, carry out the ascending buffering of horizontal direction to the test tube under the effect of first spring and elastic air bag simultaneously, avoid removing the inside reagent pipe of in-process because of the collision, and lead to the damaged phenomenon of reagent pipe.

Drawings

FIG. 1 is a schematic front view of an in vitro immune cell amplification kit according to the present invention;

fig. 2 is an enlarged schematic view of a point a in fig. 1.

In the figure: the test tube comprises a box body 1, a base 2, a placing groove 3, a sponge bottom plate 4, a sucker 5, a sliding plate 6, a first jack 7, a sliding rod 8, a first spring 9, an arc plate 10, a bearing plate 11, a second jack 12, an elastic air bag 13, a fixing plate 14, a hollow rod 15, a first connecting rod 16, a first piston plate 17, a first magnetic strip 18, a cover body 19, a second magnetic strip 20, a test tube plug 21, a second spring 22 and a handle 23.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

Referring to fig. 1-2, an immunocyte in vitro amplification kit comprises a box body 1, wherein a base 2 is fixedly connected to the bottom in the box body 1, a plurality of placing grooves 3 are formed in the base 2, a sponge bottom plate 4 is slidably connected to the inner wall of the placing grooves 3, an arc-shaped groove is formed in the sponge bottom plate 4, a plurality of suckers 5 are arranged in the arc-shaped groove, the suckers 5 are made of rubber materials, the suckers 5 adsorb test tubes, so that the stability of the test tubes in the kit is improved, a sliding plate 6 is slidably connected to the middle in the box body 1, a plurality of first jacks 7 are formed in the sliding plate 6, sliding grooves are symmetrically formed in the inner wall of the first jacks 7, sliding rods 8 are slidably connected in the sliding grooves, first springs 9 are fixedly connected between the sliding rods 8 and the inner wall of the sliding grooves, an arc-shaped plate 10 is fixedly, a plurality of second jacks 12 are formed in the bearing plate 11, elastic air bags 13 are arranged on the inner walls of the second jacks 12, a fixing plate 14 is symmetrically and fixedly connected in the box body 1, the fixing plate 14 is located between the bearing plate 11 and the sliding plate 6, a plurality of hollow rods 15 are fixedly connected to the fixing plate 14, a first piston plate 17 and a second piston plate are symmetrically and slidably connected to the inner walls of the hollow rods 15, a first connecting rod 16 and a second connecting rod are fixedly connected to the first piston plate 17 and the second piston plate respectively, and the first connecting rod 16 and the second connecting rod are fixedly connected to the bearing plate 11 and the sliding plate 6 respectively.

1 top of box is equipped with lid 19, the flexible groove of a plurality of has been seted up on the lid 19, sliding connection has test tube stopper 21 in the flexible inslot, fixedly connected with second spring 22 between test tube stopper 21 and the flexible inslot wall, test tube stopper 21 from top to bottom diameter diminishes gradually, make test tube stopper 21 and test tube combine to avoid the solution in the handling to splash, second spring 22 also can cushion the test tube simultaneously, the symmetry is equipped with first magnetic stripe 18 in the box 1, the symmetry is equipped with second magnetic stripe 20 in the lid 19, first magnetic stripe 18 cooperatees with second magnetic stripe 20, cooperation through first magnetic stripe 18 and second magnetic stripe 20, make lid 19 closely laminate with box 1, be equipped with handle 23 on the lid 19, be equipped with the cushion on handle 23, make things convenient for the staff to operate lid 19 through handle 23.

In the utility model, when the user uses the device, the test tube passes through the second jack 12 to move downwards, passes through the first jack 7 to extrude the arc-shaped plate 10 to move towards two sides, the sliding rod 8 is pressed inwards under the action of the first spring 9, the arc-shaped plate 10 is driven to be pressed inwards to clamp the test tube, meanwhile, the test tube moves downwards to the placing groove 3 to be contacted with the sucker 5, the test tube is adsorbed and fixed under the action of the sucker 5, the cover body 19 is covered after the test tube is placed, the test tube plug 21 is plugged into the test tube, when the reagent box is carried and vibrated, the bearing plate 11 moves up and down to drive the first connecting rod 16 to move up and down, so that the first piston plate 17 moves up and down, the second piston plate is driven to move up and down by the action of the gas in the hollow rod 15, so that the sliding plate 6 moves up and down, the buffer is carried out in the vertical direction, and simultaneously the buffer is carried out in the horizontal direction on the test tube under the action of the first spring 9 and the elastic air bag 13.

The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.

Claims

1. An immune cell in-vitro amplification kit comprises a box body (1) and is characterized in that a base (2) is fixedly connected to the bottom in the box body (1), a plurality of placing grooves (3) are formed in the base (2), sponge bottom plates (4) are slidably connected to the inner walls of the placing grooves (3), a sliding plate (6) is slidably connected to the middle in the box body (1), a plurality of first inserting holes (7) are formed in the sliding plate (6), sliding grooves are symmetrically formed in the inner walls of the first inserting holes (7), sliding rods (8) are slidably connected in the sliding grooves, first springs (9) are fixedly connected between the sliding rods (8) and the inner walls of the sliding grooves, an arc-shaped plate (10) is fixedly connected to one end, away from the first springs (9), of the sliding rods (8), a bearing plate (11) is slidably connected to the top in the box body (1), the bearing plate (11) is provided with a plurality of second jacks (12), the inner wall of each second jack (12) is provided with an elastic air bag (13), the box body (1) is internally and symmetrically and fixedly connected with a fixing plate (14), the fixing plate (14) is located between the bearing plate (11) and the sliding plate (6), the fixing plate (14) is fixedly connected with a plurality of hollow rods (15), the inner wall of each hollow rod (15) is symmetrically and slidably connected with a first piston plate (17) and a second piston plate, the first piston plate (17) and the second piston plate are respectively and fixedly connected with a first connecting rod (16) and a second connecting rod, the first connecting rod (16) and the second connecting rod are respectively and fixedly connected onto the bearing plate (11) and the sliding plate (6), and a cover body (19) is arranged above the box body (1).

2. The kit for in vitro amplification of immune cells according to claim 1, wherein the cover (19) has a plurality of slots, the slots are slidably connected with the test tube plugs (21), the second spring (22) is fixedly connected between the test tube plugs (21) and the inner walls of the slots, and the diameter of the test tube plugs (21) decreases gradually from top to bottom.

3. The kit for in vitro amplification of immune cells according to claim 1, wherein a first magnetic stripe (18) is symmetrically arranged in the box body (1), a second magnetic stripe (20) is symmetrically arranged in the cover body (19), and the first magnetic stripe (18) is matched with the second magnetic stripe (20).

4. The kit for in vitro amplification of immune cells according to claim 1, wherein the cover (19) is provided with a handle (23), and the handle (23) is provided with an elastic pad.

5. The kit for in vitro amplification of immune cells according to claim 1, wherein the sponge bottom plate (4) is provided with an arc-shaped groove, a plurality of suckers (5) are arranged in the arc-shaped groove, and the suckers (5) are made of rubber materials.