CN213467415U

CN213467415U - Polypeptide ultrafiltration device

Info

Publication number: CN213467415U
Application number: CN202021881714.5U
Authority: CN
Inventors: 凌建群; 于洋; 何龙
Original assignee: Jiangsu Jiatai Bio Technoloogy Co ltd
Current assignee: Jiangsu Jiatai Bio Technoloogy Co ltd
Priority date: 2020-09-01
Filing date: 2020-09-01
Publication date: 2021-06-18
Anticipated expiration: 2030-09-01

Abstract

The utility model discloses a polypeptide ultrafiltration device relates to ultrafiltration device technical field, including the base, the top fixed mounting of base has the box, and the inside upper end fixed mounting of box has first mounting panel, and the inside middle-end fixed mounting of box has the second mounting panel, and the inside lower extreme fixed mounting of box has the third mounting panel, and the last fixed surface of first mounting panel installs the stoste case. This polypeptide ultrafiltration device, through tubular ultrafiltration membrane subassembly, hollow fiber ultrafiltration membrane subassembly and tubular nanofiltration membrane subassembly establish ties and set up, according to the difference of membrane module trapped molecular weight, separate the polypeptide of different molecular weight step by step, obtain the polypeptide of different molecular weight, improve the filter effect, the aftertreatment of the polypeptide product of being convenient for, set up interior junction chamber, the connector, the inner seal circle, external seal gasket and chamber door, can conveniently maintain the change to tubular ultrafiltration membrane subassembly, hollow fiber ultrafiltration membrane subassembly and tubular nanofiltration membrane subassembly, moreover, the steam generator is simple in structure, high durability and convenient use.

Description

Polypeptide ultrafiltration device

Technical Field

The utility model relates to an ultrafiltration device technical field specifically is a polypeptide ultrafiltration device.

Background

Polypeptides are compounds in which alpha-amino acids are linked together by peptide bonds, and are also intermediates in the hydrolysis of proteins. The compounds obtained by dehydration condensation of two amino acid molecules are called dipeptides, and similarly, tripeptides, tetrapeptides, pentapeptides, and the like are also included. Generally, a compound formed by dehydrating and condensing three or more amino acid molecules can be called polypeptide; the ultrafiltration is one of membrane separation technologies taking pressure as a driving force, the aim of separating macromolecules from micromolecules is to use the ultrafiltration membrane with the aperture of 20-1000A degrees, and a hollow fiber ultrafilter (membrane) has the advantages of high filling density in a unit container, small occupied area and the like.

In chinese utility model patent application no: CN201721563527.0 discloses a polypeptide ultrafiltration device, this polypeptide ultrafiltration device, including the head tank, its characterized in that: the raw material tank is connected with a cartridge filter, the cartridge filter is connected with a first ultrafiltration pipe, and the first ultrafiltration pipe is connected with a second ultrafiltration pipe; the lower end of the first ultrafiltration pipe is connected with a three-way valve, one end of the three-way valve is connected with the lower end of the second ultrafiltration pipe, and the other end of the three-way valve is connected with the first filtration storage tank; the discharge hole of the first filtering storage tank is respectively connected with the feed inlet of the second ultrafiltration tube and the feed inlet of the third ultrafiltration tube; the discharge port of the third ultrafiltration pipe is connected with the second filtering storage tank; and the bottom ends of the first ultrafiltration tube, the second ultrafiltration tube and the third ultrafiltration tube are respectively connected with a waste liquid tank. This polypeptide ultrafiltration device, in the use, it still has the component that just can obtain required molecular weight scope through filtering many times, complex operation, inefficiency, can not play continuous fractionation's purpose to the polypeptide, and ultrafiltration device all adopts fixed connection's mode with main connecting line, and is inconvenient to maintain the change shortcoming to ultrafiltration subassembly.

Therefore, it is necessary to provide a polypeptide ultrafiltration device to solve the above problems.

SUMMERY OF THE UTILITY MODEL

Technical problem to be solved

An object of the utility model is to provide a polypeptide ultrafiltration device to solve the present needs that put forward in the above-mentioned background art and just can obtain the component of required molecular weight scope through filtering many times, complex operation, inefficiency, can not play continuous stage separation's purpose to the polypeptide, ultrafiltration device all adopts fixed connection's mode with main connecting line, and is inconvenient to the problem that ultrafiltration module maintained and changed.

(II) technical scheme

In order to achieve the above purpose, the utility model discloses a following technical scheme realizes: a polypeptide ultrafiltration device comprises a base, wherein a box body is fixedly mounted at the top of the base, a first mounting plate is fixedly mounted at the upper end in the box body, a second mounting plate is fixedly mounted at the middle end in the box body, a third mounting plate is fixedly mounted at the lower end in the box body, a stock solution box is fixedly mounted on the upper surface of the first mounting plate, a liquid inlet pipe is movably mounted on one side of the top of the stock solution box, one end, away from the stock solution box, of the liquid inlet pipe penetrates through the box body, a tubular ultrafiltration membrane component is movably mounted at the top of the second mounting plate, a hollow fiber ultrafiltration membrane component is movably mounted at the top of the third mounting plate, a tubular nanofiltration membrane component is movably mounted on the lower surface in the box body, a first connection control valve is movably mounted on one side of the bottom of the box body, a first conveying pump is, one side fixed mounting of first pump that transports has the internal connection chamber, the inside movable mounting in internal connection chamber has the inner seal circle, the inside swing joint in internal connection chamber has the connector, the outer wall movable mounting of connector has the external seal gasket, one side connection of connector is in the one end of tubular ultrafiltration membrane subassembly, the one end movable mounting of tubular ultrafiltration membrane subassembly has first fluid-discharge tube, bottom one side movable mounting of tubular ultrafiltration membrane subassembly has the second connection control valve, the bottom fixed mounting of second connection control valve has the second to transport the pump, one side swing joint of second pump that transports has the hollow fiber milipore filter subassembly, the one end movable mounting of hollow fiber ultrafiltration membrane subassembly has the second fluid-discharge tube, bottom one side movable mounting of hollow fiber ultrafiltration membrane subassembly has the third connection control valve, the bottom fixed mounting of third connection control valve has the third to transport the pump, one side swing joint of third delivery pump has the tubular nanofiltration membrane subassembly, the one end movable mounting of tubular nanofiltration membrane subassembly has the third fluid-discharge tube, one side movable mounting of tubular nanofiltration membrane subassembly has the fourth fluid-discharge tube, the positive fixed mounting of box has the controller, the reverse side swing joint of box has the chamber door.

Preferably, the inside of box is equipped with the heat preservation.

Preferably, the tubular ultrafiltration membrane module, the hollow fiber ultrafiltration membrane module and the tubular nanofiltration membrane module have the same external structure.

Preferably, the inner connecting cavity is in threaded connection with the connecting head.

Preferably, the tubular ultrafiltration membrane assembly, the hollow fiber ultrafiltration membrane assembly and the tubular nanofiltration membrane assembly are all provided with heat-insulating layers outside.

Preferably, the box body is hinged with the box door.

Preferably, the tubular ultrafiltration membrane assembly, the hollow fiber ultrafiltration membrane assembly and the tubular nanofiltration membrane assembly are all horizontally placed.

(III) advantageous effects

Compared with the prior art, the utility model provides a polypeptide ultrafiltration device possesses following beneficial effect:

1. this polypeptide ultrafiltration device establishes ties through tubular ultrafiltration membrane subassembly, hollow fiber ultrafiltration membrane subassembly and tubular nanofiltration membrane subassembly and sets up, according to the difference of membrane module trapped molecular weight, separates step by step the polypeptide of different molecular weight to through first fluid-discharge tube, second fluid-discharge tube, third fluid-discharge tube and fourth fluid-discharge tube, can be in proper order with the discharge of the polypeptide of different molecular weight, obtain the polypeptide of different molecular weight, improve the filter effect, the aftertreatment of the polypeptide product of being convenient for has improved the efficiency of polypeptide production.

2. This polypeptide ultrafiltration device, through setting up interior joint chamber, connector, inner seal circle, external seal gasket and chamber door, tubular milipore filter subassembly, hollow fiber milipore filter subassembly and tubular milipore filter subassembly's exterior structure is the same, can conveniently maintain tubular milipore filter subassembly, hollow fiber milipore filter subassembly and tubular milipore filter subassembly and change simple structure, convenient to use.

Drawings

FIG. 1 is a front perspective view of the box structure of the present invention;

FIG. 2 is a schematic reverse side perspective view of the box structure of the present invention;

FIG. 3 is a schematic front sectional view of the structure of the box body of the present invention;

fig. 4 is an enlarged schematic view of the structure of the area a in fig. 3 according to the present invention.

In the figure: 1. a base; 2. a box body; 3. a first mounting plate; 4. a second mounting plate; 5. a third mounting plate; 6. a stock solution tank; 7. a liquid inlet pipe; 8. a tubular ultrafiltration membrane module; 9. a hollow fiber ultrafiltration membrane module; 10. a tubular nanofiltration membrane component; 11. a first connecting control valve; 12. a first delivery pump; 13. a first drain pipe; 14. a second connection control valve; 15. a second delivery pump; 16. a second drain pipe; 17. a third connection control valve; 18. a third delivery pump; 19. a third drain pipe; 20. an inner connecting cavity; 21. a connector; 22. a controller; 23. a fourth drain pipe; 24. a box door; 25. an inner seal ring; 26. and an outer sealing gasket.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, a polypeptide ultrafiltration device comprises a base 1, a box body 2 is fixedly installed on the top of the base 1, a heat insulation layer is arranged inside the box body 2, the internal temperature of the box body 2 is kept at a normal temperature state, the phenomenon that the temperature is too low and damages an ultrafiltration component is avoided, a first installation plate 3 is fixedly installed at the upper end inside the box body 2, a second installation plate 4 is fixedly installed at the middle end inside the box body 2, a third installation plate 5 is fixedly installed at the lower end inside the box body 2, a stock solution tank 6 is fixedly installed on the upper surface of the first installation plate 3, a liquid inlet pipe 7 is movably installed on one side of the top of the stock solution tank 6, one end, away from the stock solution tank 6, of the liquid inlet pipe 7 penetrates through the box body 2, a tubular ultrafiltration membrane component 8 is movably installed on the top of the second installation plate 4, a hollow fiber ultrafiltration membrane component 9, the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 are all provided with heat-insulating layers on the outer parts thereof, the temperature is prevented from being too low, the ultrafiltration component is damaged, the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 are all horizontally placed, so that the fixation is more stable, the components are prevented from moving in the filtering process, the components are damaged, one side of the bottom of the box body 2 is movably provided with a first connection control valve 11, the bottom of the first connection control valve 11 is fixedly provided with a first conveying pump 12, one side of the first conveying pump 12 is fixedly provided with an inner connecting cavity 20, the inner part of the inner connecting cavity 20 is movably provided with an inner sealing ring 25, the inner part of the inner connecting cavity 20 is movably connected with a connector 21, the inner connecting cavity 20 is in threaded connection with the connector 21, the maintenance and, one side of the connector 21 is connected with one end of the tubular ultrafiltration membrane component 8, the outer structures of the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 are the same, so that the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 can be maintained and replaced conveniently, one end of the tubular ultrafiltration membrane component 8 is movably provided with a first liquid discharge pipe 13, one side of the bottom of the tubular ultrafiltration membrane component 8 is movably provided with a second connection control valve 14, the bottom of the second connection control valve 14 is fixedly provided with a second delivery pump 15, one side of the second delivery pump 15 is movably connected with the hollow fiber ultrafiltration membrane component 9, one end of the hollow fiber ultrafiltration membrane component 9 is movably provided with a second liquid discharge pipe 16, one side of the bottom of the hollow fiber ultrafiltration membrane component 9 is movably provided with a third connection control valve 17, and the bottom of the third connection, one side of the third conveying pump 18 is movably connected with a tubular nanofiltration membrane component 10, one end of the tubular nanofiltration membrane component 10 is movably provided with a third liquid discharge pipe 19, one side of the tubular nanofiltration membrane component 10 is movably provided with a fourth liquid discharge pipe 23, the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 are arranged in series, polypeptides with different molecular weights are separated step by step according to different molecular weights of membrane components, and the polypeptides with different molecular weights can be sequentially discharged through the first liquid discharge pipe 13, the second liquid discharge pipe 16, the third liquid discharge pipe 19 and the fourth liquid discharge pipe 23, so that the polypeptides with different molecular weights are obtained, the filtering effect is improved, the post-treatment of polypeptide products is facilitated, the efficiency of polypeptide production is improved, the front side of the box body 2 is fixedly provided with a controller 22, the back side of the box body 2 is movably connected with a box door 24, and the box body 2 is hinged, through setting up interior joint chamber 20, connector 21, interior sealing washer 25, external seal gasket 26 and chamber door 24, tubular milipore filter subassembly 8, hollow fiber milipore filter subassembly 9 are the same with the outside structure of tubular nanofiltration membrane subassembly 10, can conveniently maintain tubular milipore filter subassembly 8, hollow fiber milipore filter subassembly 9 and tubular nanofiltration membrane subassembly 10 and change simple structure, convenient to use.

The electrical components presented in the document are all electrically connected with an external master controller and 220V mains, and the master controller can be a conventional known device controlled by a computer or the like.

The working principle is as follows: when in use, the polypeptide stock solution is put into the stock solution box 6 through the liquid inlet pipe 7, the controller 22 controls to open the first connection control valve 11 to enable the polypeptide stock solution to enter the tubular ultrafiltration membrane component 8 for first filtration under the action of the first conveying pump 12, open the second connection control valve 14 to enable the polypeptide stock solution after the first filtration to be subjected to second filtration under the action of the second conveying pump 15, open the third connection control valve 17 to enable the polypeptide stock solution after the second filtration to be subjected to third filtration under the action of the third conveying pump 18, open the fourth liquid discharge pipe 23 to enable the polypeptide clear liquid after the third filtration to be discharged and collected from the fourth liquid discharge pipe 23, close the first connection control valve 11, the second connection control valve 14, the third connection control valve 17 and the fourth liquid discharge pipe 23, open the first liquid discharge pipe 13, the second liquid discharge pipe 16 and the third liquid discharge pipe 19, the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 are made to intercept polypeptide stock solutions with different molecular sizes and respectively discharge the polypeptide stock solutions to obtain polypeptides with different molecular weights, the filtration effect is improved, the post-treatment of a polypeptide product is facilitated, the efficiency of polypeptide production is improved, whether the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 can be normally used or not can be judged according to the discharged polypeptide stock solutions with different molecular sizes, when the damage or poor filtration effect of the interior of the component is judged, the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 can be maintained and replaced according to the arranged inner connecting cavity 20, the connector 21, the inner sealing ring 25, the outer sealing gasket 26 and the box door 24, the external structures of the tubular ultrafiltration membrane component 8, the hollow fiber ultrafiltration membrane component 9 and the tubular nanofiltration membrane component 10 are the same, simple structure, convenient to use has improved the efficiency of polypeptide production.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A polypeptide ultrafiltration device, comprising a base (1), characterized in that: the top fixed mounting of base (1) has box (2), the inside upper end fixed mounting of box (2) has first mounting panel (3), the inside middle-end fixed mounting of box (2) has second mounting panel (4), the inside lower extreme fixed mounting of box (2) has third mounting panel (5), the last fixed surface of first mounting panel (3) installs stoste case (6), top one side movable mounting of stoste case (6) has inlet tube (7), the one end that stoste case (6) were kept away from in inlet tube (7) runs through box (2), the top movable mounting of second mounting panel (4) has tubular ultrafiltration membrane subassembly (8), the top movable mounting of third mounting panel (5) has hollow fiber ultrafiltration membrane subassembly (9), the inside lower surface movable mounting of box (2) has tubular ultrafiltration membrane subassembly (10), the utility model discloses a tank body, including box (2), bottom one side movable mounting of box (2) has first connection control valve (11), the bottom fixed mounting of first connection control valve (11) has first pump (12) of transporting, one side fixed mounting of first pump (12) of transporting has interior junction chamber (20), the inside movable mounting of interior junction chamber (20) has interior sealing washer (25), the inside movable connection of interior junction chamber (20) has connector (21), the outer wall movable mounting of connector (21) has external seal gasket (26), the one end at tubular ultrafiltration membrane subassembly (8) is connected to one side of connector (21), the one end movable mounting of tubular ultrafiltration membrane subassembly (8) has first drain pipe (13), bottom one side movable mounting of tubular ultrafiltration membrane subassembly (8) has second connection control valve (14), the bottom fixed mounting of second connection control valve (14) has the second to transport pump (15), one side of the second conveying pump (15) is movably connected with a hollow fiber ultrafiltration membrane component (9), one end of the hollow fiber ultrafiltration membrane component (9) is movably provided with a second liquid discharge pipe (16), a third connecting control valve (17) is movably arranged at one side of the bottom of the hollow fiber ultrafiltration membrane component (9), the bottom of the third connecting control valve (17) is fixedly provided with a third delivery pump (18), one side of the third conveying pump (18) is movably connected with a tubular nanofiltration membrane component (10), one end of the tubular nanofiltration membrane component (10) is movably provided with a third liquid discharge pipe (19), a fourth liquid discharge pipe (23) is movably arranged at one side of the tubular nanofiltration membrane component (10), the front surface of the box body (2) is fixedly provided with a controller (22), and the back surface of the box body (2) is movably connected with a box door (24).

2. The polypeptide ultrafiltration device of claim 1, wherein: and a heat insulation layer is arranged in the box body (2).

3. The polypeptide ultrafiltration device of claim 1, wherein: the tubular ultrafiltration membrane component (8), the hollow fiber ultrafiltration membrane component (9) and the tubular nanofiltration membrane component (10) have the same external structure.

4. The polypeptide ultrafiltration device of claim 1, wherein: the inner connecting cavity (20) is in threaded connection with the connector (21).

5. The polypeptide ultrafiltration device of claim 1, wherein: and heat preservation layers are arranged outside the tubular ultrafiltration membrane component (8), the hollow fiber ultrafiltration membrane component (9) and the tubular nanofiltration membrane component (10).

6. The polypeptide ultrafiltration device of claim 1, wherein: the box body (2) is hinged with the box door (24).

7. The polypeptide ultrafiltration device of claim 1, wherein: the tubular ultrafiltration membrane component (8), the hollow fiber ultrafiltration membrane component (9) and the tubular nanofiltration membrane component (10) are all horizontally arranged.