CN213430275U - Sampling needle for genetic detection before embryo planting - Google Patents

Abstract

The utility model discloses a genetics detects sampling needle before embryo is planted, including fixed needle and the biopsy needle that uses with the fixed needle cooperation, fixed needle and biopsy needle are integrated into one piece's hollow structure, fixed needle front end bending type has the fixed needle point, biopsy needle front end bending type has the biopsy needle point, is formed with the fixed needle tangent plane between the outer wall of fixed needle point and the fixed needle end port, and the axis of the fixed needle point of fixed needle point's fixed needle end port perpendicular to is formed with the biopsy needle tangent plane between the outer wall of biopsy needle point and the biopsy needle end port, and the axis of the biopsy needle end port perpendicular to biopsy needle point of biopsy needle point. The utility model discloses a genetics detects sampling needle before embryo planting, on the one hand because fixed needle is big with primary tissue area of contact, primary sample tissue is difficult to follow the most advanced slippage of fixed needle. On the other hand, when the fixed needle and the biopsy needle relatively cut and separate the original tissue and the sampling tissue, the fixed needle and the biopsy needle are not easy to slip, and are favorable for instantaneous accurate cutting.

Description

Sampling needle for genetic detection before embryo planting

Technical Field

The utility model relates to the technical field of medical equipment, concretely relates to supplementary reproduction embryo biopsy instrument of drawing materials, this instrument be one kind and carry out the sample needle that uses when the antenatal genetics of embryo planting detected the sample.

Background

The pre-embryo implantation genetic test (PGT) refers to that during the in vitro fertilization-embryo transplantation process, when the embryos of patients with genetic risks are cultured in vitro to Day3, Day5 or Day6, blastomere or trophectoderm biopsy is carried out, and genetic test is carried out on biopsy samples, so that embryos without genetic diseases are selected to be implanted into uterine cavities, thereby obtaining an assisted reproduction technology of normal fetuses, and the birth of children with genetic diseases can be effectively prevented. When biopsy sampling is carried out on blastomere and blastocyst trophoblast cells of polar body and embryo in the cleavage stage, materials are obtained by adopting a mechanical cutting method at present.

However, the sampling needle used in the mechanical cutting method for drawing materials at present consists of a fixed needle (i.e. holding) and a biopsy needle. Fixed needle and biopsy needle all are round neat mouthful, and when the biopsy needle had taken a sample, when need with the separation of primary tissue and sample tissue, at first place the primary tissue on fixed needle, on the one hand because fixed needle point end is slick and sly, fixed needle and primary tissue area of contact are little, and the primary sample tissue is easy from the most advanced slippage of fixed needle. On the other hand, when the fixed needle and the biopsy needle relatively cut and separate the original tissue and the sampling tissue, the tips of the two needles are round and flush, so the needle is easy to slip during cutting and is not beneficial to accurate cutting.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problem, the utility model provides a fixed needle and biopsy needle when carrying out the embryo before planting genetics and detect the sample can carry out accurate cutting in the twinkling of an eye to the target sample, and is very little to the damage of embryo simultaneously, the follow-up latent energy of developing of blastocyst has been preserved to the at utmost.

The utility model provides a technical scheme as follows that technical problem took:

the utility model provides a genetics detects sampling needle before embryo is planted, including fixed needle and the biopsy needle that uses with the fixed needle cooperation, fixed needle and biopsy needle are integrated into one piece's hollow structure, fixed needle front end is buckled and is formed with fixed needle point, biopsy needle front end is buckled and is formed with biopsy needle point, is formed with fixed needle tangent plane between the outer wall of fixed needle point and the fixed needle end port, and the axis of fixed needle end port perpendicular to fixed needle point is formed with biopsy needle tangent plane between the outer wall of biopsy needle point and the biopsy needle end port, and biopsy needle end port perpendicular to biopsy needle point's axis.

Further, the fixed needle section is 1 or 2 of the opposite surfaces, and the biopsy needle section is 1 or 2 of the opposite surfaces.

Furthermore, the fixed needle section is a plane or an inclined plane, and the biopsy needle section is a plane.

Furthermore, the inner diameter of the fixed needle tip is 15-20 μm, the outer diameter is 110-130 μm, the inner diameter of the biopsy needle tip is 25-35 μm, and the outer diameter is 95-120 μm.

Furthermore, the fixed needle and the needle tip of the fixed needle form an included angle of 100-.

In the use process, one end of the fixing needle is connected with the negative pressure suction apparatus, and the other end of the fixing needle fixes the sampled tissue under the action of negative pressure. One end of the biopsy needle is linked with the negative pressure suction apparatus, the other end of the biopsy needle sucks sampled tissue through the negative pressure effect, after the biopsy needle sucks a certain amount of sampled tissue, the sampled tissue needs to be separated from the sampled tissue, firstly, the sampled tissue is placed above the needle point of the fixed needle, the needle point of the biopsy needle cuts off the sampled tissue and the sampled tissue from top to bottom by utilizing the friction force between the needle point of the biopsy needle and the needle point of the fixed needle, and then, the sampled tissue is released for relevant detection.

Compared with the prior art, the utility model discloses following beneficial effect has:

(1) because there is 1 or 2 relative fixed needle tangent planes on fixed needle point, when needs will be taken a sample tissue and sample tissue separation, will be taken a sample the tissue and place fixed needle tangent plane top at first, because fixed needle tangent plane be plane or inclined plane, can provide bigger bearing area than the fixed needle point rounding off of current design, consequently, by the difficult slippage of sample tissue.

(2) By utilizing the friction force between the biopsy needle section and the fixed needle section, when the biopsy needle section cuts off the sampled tissue and the sampled tissue from top to bottom, the two needles are easy to slip when cutting, unlike the smooth design of the two needle tips in the existing design, and the end ports of the two needles are designed to be flat and flush, thereby realizing instant cutting.

(3) Before cutting off, the section of the fixed needle and the section of the biopsy needle can be extruded to be thinnest and not easy to slip at a certain point compared with the smooth design of the prior design, the wound surface is very small, even under many conditions, the blastocyst can not shrink after biopsy, the damage to the blastocyst is very small, and the subsequent development potential of the blastocyst is preserved to the maximum extent.

Drawings

FIG. 1 is a schematic view of a fixed needle and biopsy needle configuration;

FIG. 2 is an enlarged view of a portion of the fixed needle tip and biopsy needle tip of FIG. 1;

FIG. 3 is a schematic view showing a structure in which a section of the fixing pin of embodiment 1 is a plane;

FIG. 4 is an enlarged view of a portion of the fixing pin of FIG. 3 with a cut plane being a plane;

FIG. 5 is a schematic view showing a sectional plane of the biopsy needle according to example 1;

FIG. 6 is an enlarged view of a portion of the biopsy needle of FIG. 5 with a planar cut surface

FIG. 7 is an enlarged view of a portion of the structure of example 2 in which the section of the fixing pin is a slant;

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

Example 1: genetic detection sampling needle before embryo planting as shown in fig. 1, 2, 3, 4, 5, 6, including fixed needle and the biopsy needle that uses with fixed needle cooperation, fixed needle and biopsy needle are integrated into one piece's hollow structure, fixed needle front end bending type is formed with fixed needle point, biopsy needle front end bending type is formed with biopsy needle point, is formed with fixed needle tangent plane between the outer wall of fixed needle point and the fixed needle end port, and fixed needle end port perpendicular to fixed needle point's axis is formed with biopsy needle tangent plane between the outer wall of biopsy needle point and the biopsy needle end port, and biopsy needle end port perpendicular to biopsy needle point's axis. In this embodiment, the number of the fixed needle sections is 1, the number of the biopsy needle sections is 1, the fixed needle sections are planes, the biopsy needle sections are planes, the inner diameter of the needle point of the fixed needle is 20 μm, the outer diameter of the needle point of the fixed needle is 120 μm, the inner diameter of the needle point of the biopsy needle is 30 μm, the outer diameter of the needle point of the biopsy needle is 110 μm, the fixed needle and the needle point of the fixed needle form an included angle of 120 degrees, and the biopsy needle and the needle point of the biopsy needle form.

Example 2: the pre-embryo genetic testing sampling needle shown in FIG. 7 is different from that of example 1 in that the number of the fixed needle sections is 1, and the fixed needle section is a bevel.

Because fixed needle tangent plane can provide bigger bearing area for plane or inclined plane, the biopsy needle tangent plane is the plane, when needs will be taken a sample tissue and sample tissue separation, will be taken a sample tissue at first and place fixed needle tangent plane top, when biopsy needle tangent plane top-down cut off by sample tissue and sample tissue, two needles are difficult to skid relatively, can realize cutting in the twinkling of an eye.

The foregoing is a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of improvements and decorations can be made without departing from the principle of the present invention, and these improvements and decorations are also considered as the protection scope of the present invention.

Claims (5)

1. The utility model provides a genetics detects sampling needle before embryo is planted, including fixed needle (1) and biopsy needle (2) with fixed needle (1) cooperation use, fixed needle (1) and biopsy needle (2) are integrated into one piece's hollow structure, fixed needle (1) front end is buckled and is formed with fixed needle point (11), biopsy needle (2) front end is buckled and is formed with biopsy needle point (21), its characterized in that: a fixed needle tangent plane (12) is formed between the outer wall of the fixed needle point (11) and the fixed needle tail end port (14), the fixed needle tail end port (14) is perpendicular to the central axis of the fixed needle point (11), a biopsy needle tangent plane (22) is formed between the outer wall of the biopsy needle point (21) and the biopsy needle tail end port (24), and the biopsy needle tail end port (24) is perpendicular to the central axis of the biopsy needle point (21).

2. The pre-embryo-planting genetic testing sampling needle of claim 1, wherein: the fixed needle section (12) is 1 or 2 of the opposite surfaces, and the biopsy needle section (22) is 1 or 2 of the opposite surfaces.

3. The pre-embryo-planting genetic testing sampling needle of claim 2, wherein: the fixed needle tangent plane (12) is a plane or an inclined plane, and the biopsy needle tangent plane (22) is a plane.

4. The pre-embryo-planting genetic testing sampling needle of claim 1, wherein: the inner diameter of the fixed needle point (11) is 15-20 μm, the outer diameter is 110-130 μm, the inner diameter of the biopsy needle point (21) is 25-35 μm, and the outer diameter is 95-120 μm.

5. The pre-embryo-planting genetic testing sampling needle of claim 1, wherein: the fixed needle (1) and the fixed needle point (11) form an included angle of 100 DEG and 135 DEG, and the biopsy needle (2) and the biopsy needle point (21) form an included angle of 100 DEG and 135 deg.

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