CN213423209U - Kit for detecting pleural effusion PD-L1 expression level - Google Patents

Abstract

The utility model discloses a kit for hydrothorax PD-L expression level detects, comprises a box bod, the support groove has been cup jointed at the top of box body, a plurality of test tubes have been placed to the inside of bracket, the inside top of box body is equipped with the injection subassembly. This a kit for pleural effusion PD-L1 expression level detects, the accessible rubber head burette vertically corresponds with the test tube, and the clearance fit of clamp plate and standpipe, make to press the depression bar and can drive the clamp plate level and extrude a plurality of rubber head burettes, and then realize the effect of multitube with annotating, and it is equal to pour into the dose into, make the precision that detects better, the accessible gear is connected with the meshing of ring gear, and the light, the setting of observation window, can directly rotate the test tube and observe, and then judge the detection level through the colour depth, and link to each other through the joint of ejector pin with the recess, and the clearance fit of kelly and the lantern ring, make the test tube can fix a position fast to corresponding the position with the rubber head burette, and then be convenient for repetitious usage.

Description

Kit for detecting pleural effusion PD-L1 expression level

Technical Field

The utility model relates to a kit technical field that is used for hydrothorax PD-L1 expression level to detect specifically is a kit that is used for hydrothorax PD-L1 expression level to detect.

Background

Pleural effusion is a common clinical condition characterized by pathological fluid accumulation within the pleural cavity. The pleural cavity is a potential clearance between visceral layer and parietal pleura, has 5 ~ 15ml liquid in the normal people pleural cavity, plays lubricated effect when respiratory motion, has 500 ~ 1000 ml's liquid to form and absorb in the pleural cavity every day, and any reason leads to the production of pleural cavity intracavity liquid to increase or absorb and reduce, can produce pleural effusion. The apoptosis-ligand 1 is also called surface antigen cluster of differentiation 274 or B7 homolog, is a protein in human body, is coded by CD274 gene, and is often required to be detected after extraction, and the common method is immunohistochemistry.

A kit for pleural effusion PD-L1 expression level detects among the prior art is when using, can't realize the effect of multitube notes simultaneously, and the convenience of use is relatively poor, and injects the dosage inequality, leads to the precision of detection lower, and can not directly rotate the observation to the test tube during the detection, and the contrast of colour depth is not obvious, and is not convenient for repetitious usage, and then uses for people and causes inconvenience.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a kit that is used for pleural effusion PD-L1 to express the kit that the level detected to be used for pleural effusion PD-L1 among the prior art among the above-mentioned background art when using, can't realize the effect of multitube notes simultaneously, and the convenience of use is relatively poor, and injects the dose inequality, leads to the lower problem of precision of detection.

In order to achieve the above object, the utility model provides a following technical scheme: a kit for detecting the PD-L expression level of pleural effusion comprises a box body, wherein a bracket is sleeved at the top of the box body, the outer end of the bracket is fixedly connected with the upper part of the outer wall of the box body through a lock catch, the top of the bracket is rotatably connected with a cover plate, a reagent bottle is placed in the bracket, a bracket is rotatably connected below the inner wall of the box body, a plurality of test tubes are placed in the bracket, and an injection assembly is arranged above the inner part of the box body;

the injection assembly comprises a drawer, a rubber head dropper, a pressure plate, a first spring, a top block, a pressure lever, a second spring and a vertical rod;

the outer wall of drawer and the right-hand member clearance fit of box body, a plurality of rubber head drip tubes have been run through to the bottom of drawer, the inner wall top clearance fit of drawer has the clamp plate, the top of clamp plate is through the inner wall bottom fixed connection of first spring with the drawer, the equal clearance fit in the left and right sides of clamp plate has the montant, fixed connection at the bottom of montant and the inner wall of drawer, the top of clamp plate is equipped with the kicking block, the top rigid coupling of kicking block has the depression bar, the outer wall of depression bar and the bottom clearance fit in support groove, the outer wall of depression bar has cup jointed the second spring, the upper and lower both ends of second spring respectively with the top of depression bar and hold in the palm the inner wall bottom.

Preferably, the outer wall of the top block is a cambered surface.

Preferably, the rubber dropper and the test tube are distributed annularly, and every two rubber dropper and the test tube are longitudinally corresponding.

Preferably, an observation assembly is arranged below the box body;

the observation assembly comprises an observation window, an illuminating lamp, a gear ring, a gear, a rotating rod, a groove, a top rod, a lantern ring and a third spring;

the utility model discloses a box body, including box body, observation window, gear ring, gear, change lever, the bottom of observation window, the observation window is installed respectively in both ends about the box body, the inboard of observation window is equipped with the light, the bottom of light is installed in the bottom of box body, the top of observation window is equipped with the ring gear, the bottom of ring gear and the top fixed connection of bracket, the meshing of the top left side of ring gear is connected with the gear, the left end rigid coupling of gear has the bull stick, the outer wall of bull stick rotates with the left end of box body to be connected, the bottom of bull stick has the ejector pin through the recess joint, the lantern ring has been cup jointed to the outer wall of ejector pin, the right-hand member of the lantern ring and the left end fixed connection of box body.

Preferably, the contact surface of the ejector rod and the groove is a spherical surface.

Preferably, the lamp shade of light is circular, and sets up with the test tube of annular distribution with concentric.

Compared with the prior art, the beneficial effects of the utility model are that: this a kit for pleural effusion PD-L1 expression level detects, through the box body, the hasp, support the groove, the apron, the reagent bottle, the bracket, test tube and injection assembly's cooperation, make the device when using, the accessible rubber head burette corresponds with the vertical of test tube, and the clearance fit of clamp plate and standpipe, make to press the depression bar and can drive the clamp plate level and extrude a plurality of rubber head burettes, and then realize the effect that the multitube was annotated with, use the convenience and promote greatly, and pour into the dose and equate, make the precision that detects better.

Through the box body, the hasp, hold in the palm the groove, the apron, the reagent bottle, a bracket, the cooperation of test tube and observation subassembly, make the device when using, the accessible gear is connected with the meshing of ring gear, and the light, the setting of observation window, can directly rotate the test tube and observe, and then judge the detection level through the colour depth, and link to each other with the joint of recess through the ejector pin, and the clearance fit of kelly and the lantern ring, make the test tube can fix a position fast to correspond the position with gluey first burette, and then be convenient for repetitious use, and then use for people and facilitate.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic structural view of the bracket, cover plate and reagent bottle of FIG. 1;

FIG. 3 is a schematic view of the cartridge, holder and test tube of FIG. 1;

fig. 4 is a schematic structural view of the rotary rod, the gear and the ring gear in fig. 3.

In the figure: 1. the reagent bottle comprises a box body, 2, a lock catch, 3, a bracket, 4, a cover plate, 5, a reagent bottle, 6, a bracket, 7, an injection assembly, 701, a drawer, 702, a rubber head dropper, 703, a pressing plate, 704, a first spring, 705, a top block, 706, a pressing rod, 707, a second spring, 708, a vertical rod, 8, an observation assembly, 801, an observation window, 802, an illuminating lamp, 803, a gear ring, 804, a gear, 805, a rotating rod, 806, a groove, 807, a push rod, 808, a lantern ring, 809, a third spring, 9 and a test tube.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, the present invention provides a technical solution: the utility model provides a kit for pleural effusion PD-L1 expression level detects, comprises a box bod 1, the top of box body 1 has cup jointed and has held in the palm groove 3, hold in the palm groove 3 and be used for placing multiple reagent bottle, the outer end that holds in the palm groove 3 passes through hasp 2 and box body 1's outer wall top fixed connection, hasp 2 plays quick assembly disassembly's effect to holding in the palm groove 3 and box body 1, the top of holding in the palm groove 3 is rotated and is connected with apron 4, hold in the palm the inside of groove 1 and place reagent bottle 5, the inner wall below of box body 1 is rotated and is connected with bracket 6, a plurality of test tubes 9 have been placed to bracket 6's.

The injection component 7 comprises a drawer 701, a rubber head dropper 702, a pressure plate 703, a first spring 704, a top block 705, a pressure rod 706, a second spring 707 and a vertical rod 708, the outer wall of the drawer 701 is in clearance fit with the right end of the box body 1, a plurality of rubber head droppers 702 penetrate through the bottom of the drawer 701, the positions of the rubber head droppers 702 and the test tubes 9 are distributed annularly and longitudinally correspond to each other, the design enables the rubber heads at the tops of the rubber head droppers 702 to be compressed simultaneously when the pressure plate 703 is pressed down, further enables coloring agents to be dripped into the test tubes 9 simultaneously, the pressure plate 703 is in clearance fit above the inner wall of the drawer 701, the top of the pressure plate 703 is fixedly connected with the bottom of the inner wall of the drawer 701 through the first spring 704, the first spring 704 plays a role of upward supporting for the pressure plate 703, the vertical rods 708 are in clearance fit on the left side and the right side of the pressure plate 703, the, the vertical rod 708 plays a guiding role in guiding the pressure plate 703, a top block 705 is arranged above the pressure plate 703, the outer wall of the top block 705 is an arc surface, the design enables the top block 705 to automatically slide up and down when the drawer 701 is pulled, a pressure lever 706 is fixedly connected to the top of the top block 705, the outer wall of the pressure lever 706 is in clearance fit with the bottom of the bracket 3, a second spring 707 is sleeved on the outer wall of the pressure lever 706, the second spring 707 provides a limiting force for the pressure lever 706, and the upper end and the lower end of the second spring 707 are respectively abutted against the top of the pressure lever 706 and the bottom of the inner wall of the.

An observation assembly 8 is arranged below the box body 1, the observation assembly 8 comprises an observation window 801, an illuminating lamp 802, a gear ring 803, a gear 804, a rotating rod 805, a groove 806, a push rod 807, a lantern ring 808 and a third spring 809, the observation window 801 is respectively arranged at the left end and the right end of the box body 1, the illuminating lamp 802 is arranged at the inner side of the observation window 801, the lampshade of the illuminating lamp 802 is circular and is concentrically arranged with the test tubes 9 which are distributed in an annular shape, the illumination of the illuminating lamp 802 to different test tubes 9 is consistent due to the design, the bottom of the illuminating lamp 802 is arranged at the bottom of the box body 1, the gear ring 803 is arranged above the observation window 801, the bottom of the gear ring 803 is fixedly connected with the top of the bracket 6, the gear 804 is meshed with the left side of the top of the gear ring 803, the gear 804 rotates to drive the gear ring 803 to rotate, the rotating rod 805 is fixedly connected with the left end of the, the contact surface of ejector pin 807 and recess 806 is the sphere, the design can play the positioning action to bull stick 705 like this, ejector pin 707 and recess 706 gomphosis once when making every axial displacement of adjacent test tube 9 one, the outer wall of ejector pin 807 has cup jointed the lantern ring 808, lantern ring 808 plays the guide effect to ejector pin 807, the right-hand member of lantern ring 808 and the left end fixed connection of box body 1, the outer wall below of ejector pin 807 has cup jointed third spring 809, third spring 809 gives the ascending power of ejector pin 807, the upper and lower both ends of third spring 809 respectively with the bottom fixed connection of the lantern ring 808 and ejector pin 807.

In this embodiment, when the kit for detecting the expression level of pleural effusion PD-L1 is used, the kit is first placed in different test tubes of pleural effusion, at this time, the drawer 701 is pulled out, the colorant is sucked into the rubber-tipped dropper 702, the cover plate 4 is opened after the drawer 701 is reset, the pressing rod 706 is pressed, the pressing plate 703 is pressed downwards by the top block 705, the pressing plate 703 can slide downwards horizontally by the guide of the vertical rod 708, and the rubber-tipped dropper 2 is pressed simultaneously, so that the colorant can be injected into the test tube 9 simultaneously, the multi-tube co-injection effect is realized, the dropping dosage is the same, the detection precision is improved, at this time, the illuminating lamp 802 is powered on, the bracket 6 can be driven to rotate axially by the meshing connection of the gear 804 and the gear ring 803, the color of the test tube 9 can be directly observed by the observation window 801, the expression level of PD-1 can be detected by the depth of the color, and then promote the use convenience, can make ejector pin 807 and recess 806 joint when the secondary is used, can make test tube 9 vertically correspond with rubber head burette 702, make things convenient for people to use.

In the description of the present invention, it is to be understood that the terms "coaxial", "bottom", "one end", "top", "middle", "other end", "upper", "one side", "top", "inner", "front", "center", "both ends", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "disposed," "connected," "fixed," "screwed" and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through an intermediate medium, and may be connected through the inside of two elements or in an interaction relationship between two elements, unless otherwise specifically defined, and the specific meaning of the above terms in the present invention will be understood by those skilled in the art according to specific situations.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (6)

1. A kit for detecting the expression level of pleural effusion PD-L1, comprising a kit body (1), characterized in that: a supporting groove (3) is sleeved at the top of the box body (1), the outer end of the supporting groove (3) is fixedly connected with the upper part of the outer wall of the box body (1) through a lock catch (2), the top of the supporting groove (3) is rotatably connected with a cover plate (4), a reagent bottle (5) is placed in the supporting groove (3), a bracket (6) is rotatably connected to the lower part of the inner wall of the box body (1), a plurality of test tubes (9) are placed in the bracket (6), and an injection assembly (7) is arranged above the inner part of the box body (1);

the injection assembly (7) comprises a drawer (701), a rubber head dropper (702), a pressing plate (703), a first spring (704), a top block (705), a pressing rod (706), a second spring (707) and a vertical rod (708);

the outer wall of the drawer (701) is in clearance fit with the right end of the box body (1), a plurality of rubber-head droppers (702) penetrate through the bottom of the drawer (701), a pressure plate (703) is in clearance fit above the inner wall of the drawer (701), the top of the pressure plate (703) is fixedly connected with the bottom of the inner wall of the drawer (701) through a first spring (704), the left side and the right side of the pressure plate (703) are both in clearance fit with a vertical rod (708), the bottom of the vertical rod (708) is fixedly connected with the bottom of the inner wall of the drawer (701), a top block (705) is arranged above the pressure plate (703), the top of the top block (705) is fixedly connected with a pressure rod (706), the outer wall of the pressure lever (706) is in clearance fit with the bottom of the bracket (3), a second spring (707) is sleeved on the outer wall of the pressure lever (706), the upper end and the lower end of the second spring (707) are respectively propped against the top of the pressure lever (706) and the bottom of the inner wall of the bracket (3).

2. The kit for detecting the expression level of PD-L1 in pleural effusion according to claim 1, wherein: the outer wall of the top block (705) is an arc surface.

3. The kit for detecting the expression level of PD-L1 in pleural effusion according to claim 1, wherein: the positions of the rubber head dropper (702) and the test tube (9) are distributed in an annular shape, and every two rubber head droppers are longitudinally corresponding to each other.

4. The kit for detecting the expression level of PD-L1 in pleural effusion according to claim 1, wherein: an observation assembly (8) is arranged below the box body (1);

the observation assembly (8) comprises an observation window (801), an illuminating lamp (802), a gear ring (803), a gear (804), a rotating rod (805), a groove (806), a top rod (807), a lantern ring (808) and a third spring (809);

the observation window (801) is respectively installed at the left end and the right end of the box body (1), an illuminating lamp (802) is arranged on the inner side of the observation window (801), the bottom of the illuminating lamp (802) is installed at the bottom of the box body (1), a gear ring (803) is arranged above the observation window (801), the bottom of the gear ring (803) is fixedly connected with the top of the bracket (6), a gear (804) is meshed and connected with the left side of the top of the gear ring (803), a rotating rod (805) is fixedly connected with the left end of the gear (804), the outer wall of the rotating rod (805) is rotatably connected with the left end of the box body (1), a top rod (807) is clamped at the bottom of the rotating rod (805) through a groove (806), a lantern ring (808) is sleeved on the outer wall of the top rod (807), the right end of the lantern ring (808) is fixedly connected with the left end of the box body (1), a third spring (809), the upper end and the lower end of the third spring (809) are respectively fixedly connected with the lantern ring (808) and the bottom of the top rod (807).

5. The kit for detecting the expression level of PD-L1 in pleural effusion according to claim 4, wherein: the contact surface of the ejector rod (807) and the groove (806) is a spherical surface.

6. The kit for detecting the expression level of PD-L1 in pleural effusion according to claim 4, wherein: the lamp shade of light (802) is circular, and sets up with test tube (9) that the annular distributes are concentric.

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