CN213404956U - Respiratory detects gauze mask for virus - Google Patents
Respiratory detects gauze mask for virus Download PDFInfo
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- CN213404956U CN213404956U CN202021728974.9U CN202021728974U CN213404956U CN 213404956 U CN213404956 U CN 213404956U CN 202021728974 U CN202021728974 U CN 202021728974U CN 213404956 U CN213404956 U CN 213404956U
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Abstract
The application provides a respirator for detecting viruses in a respiratory system, which comprises a respirator body, wherein a sensor patch is arranged on the inner side of the respirator, and the sensor patch is provided with a circuit area and a sensing area; the sensing area is composed of a plurality of layers, and is sequentially provided with a filter layer, a sensing interface and an adhesive layer which is contacted with the inner side of the mask; the sensing interface has a protruding structure for capturing specific adsorption sites of a target biomarker in respiratory gas; and the circuit in the circuit area is used for detecting the influence of the sensing interface on the electric signal and outputting the electric signal. Therefore, the sensing interface has a protruding structure, so that the target biomarker is captured more conveniently, and the result can be detected more sensitively and more quickly.
Description
Technical Field
The application relates to the technical field of masks, in particular to a mask for detecting viruses in a respiratory system.
Background
In recent years, viral transmission and spreading associated with the respiratory system has been less optimistic and is increasing. Among these viruses, the common influenza virus, as well as SARS virus, and the novel coronavirus (COVID-19) can be transmitted by airborne droplets.
Currently, viruses of the respiratory system, such as novel coronaviruses, are collected by throat swab and then nucleic acid is detected. How to detect respiratory viruses under the more convenient and safer condition, even a suspected patient can conveniently and automatically detect the respiratory viruses is a technical problem to be solved at present, for example, the patent application with the Chinese patent application number of CN202010157459.8 discloses a mask capable of detecting novel coronavirus pneumonia pathogens and a using method thereof, and the mask is combined with a detection process to replace a pharyngeal swab to solve the problems.
However, according to the technical scheme of the mask, the collection mode is changed to be collection through respiration, but the result cannot be detected quickly due to the low virus content in the respiratory gas, and even a longer time is required, so that the mask is worn for about 30 minutes to obtain the result as mentioned in the above-mentioned chinese patent application No. CN 202010157459.8.
How to make the biosensor on the gauze mask have enough sensitivity to detect out the result more fast is the technical problem that this application will solve.
Disclosure of Invention
In view of the above, the present invention provides a respiratory mask for detecting viruses, which can detect respiratory viruses more rapidly.
The application provides a respirator for detecting viruses in a respiratory system, which comprises a respirator body, wherein a sensor patch is arranged on the inner side of the respirator, and the sensor patch is provided with a circuit area and a sensing area;
the sensing area is composed of a plurality of layers, and is sequentially provided with a filter layer, a sensing interface and an adhesive layer which is contacted with the inner side of the mask;
the sensing interface has a protruding structure for capturing specific adsorption sites for a target biomarker in respiratory gas;
and the circuit in the circuit area is used for detecting the influence of the sensing interface on the electric signal and outputting the electric signal.
Therefore, the sensing interface has a protruding structure, so that the arrangement is more favorable for capturing the target biomarker, and is more sensitive, and the result can be detected more quickly.
The sensing interface comprises a nano film, the surface of the nano film is provided with a plurality of nano thorns extending out of the surface, and the top ends of the nano thorns are specific adsorption sites of the target biomarker.
Therefore, the nano film with the nano thorn structure is more beneficial to capturing the target biomarker, so that the detection is more sensitive, and the result can be detected more quickly.
The sensing interface comprises a nanowire array, a plurality of nano-thorns extending out of the surface of the nanowire are arranged on the nanowire, and the top ends of the nano-thorns are specific adsorption sites of the target biomarkers.
Therefore, the nanowire array with the nano-thorn structure is more beneficial to capturing the target biomarker, so that the detection is more sensitive, and the result can be detected more quickly.
Wherein a spacing between adjacent nanowires in the nanowire array matches a target biomarker to be captured.
From the above, the requirement of the spacing between the nanowires also plays a role in screening viruses in size, so that the target biomarker can be captured more accurately, and therefore, the detection is more sensitive, and the result can be detected more quickly.
Wherein a pitch between the adjacent nanowires is 50 to 80 nanometers.
From the above, this spacing is suitable for screening for novel coronaviruses.
The nanowire array is a three-dimensional nanowire array.
Therefore, the three-dimensional array is more favorable for capturing the target biomarkers, so that the three-dimensional array is more sensitive, and the result can be detected more quickly.
The circuit of the circuit area comprises a detection unit, an electric signal output unit, a wireless transmission unit and a power supply unit, wherein the detection unit, the electric signal output unit and the wireless transmission unit are sequentially coupled, and the power supply unit is used for supplying power to all units in the circuit area;
the detection unit is used for loading an electric signal to the sensing interface and detecting the change of the electric signal influenced by the sensing interface;
the electric signal output unit is used for outputting the detected electric signal;
the wireless transmission unit is used for sending out the signal output by the electric signal output unit.
Thus, a circuit can be arranged as necessary to output various types of electric signals such as an impedance signal, a voltage, a current, an inductance, a capacitance, a high frequency, and a low frequency.
The power supply unit is in a self-powered mode and comprises a patch battery.
By last, this mode is more applicable to users such as suspected patient and buys and detect by oneself, and the signal of the sensor paster on the gauze mask is received to terminals such as user's accessible cell-phone, panel computer to carry out the demonstration of result through corresponding APP, even through this APP and internet with the sending to corresponding hospital or appointed result collection side (like disease control center) of testing result.
The power supply unit is in a non-self-powered mode and is provided with an induction coil.
By last, this condition is more applicable to the hospital and gives the gauze mask of passive power supply to suspected patient, carries out the condition of signal acquisition by the handheld reading device of doctor, and the cost of gauze mask part can be lower owing to there being not paster battery under this kind of mode.
The sensing area part of the sensor patch is also provided with a supporting part, so that the sensor patch is in contact with the inner side of the mask in a mode of having a gap;
a filter layer is arranged between the sensing interface and the pasting layer;
the sensing interface has specific adsorption sites on both sides for capturing the target biomarkers in the breathing gas.
Therefore, the sensing interface has capture functions on two sides, so that the capture of the biomarkers is facilitated.
Drawings
Fig. 1 is a schematic diagram of a mask in communication with a smartphone in an embodiment;
FIG. 2 is a schematic diagram of an area arrangement of a sensor patch in one embodiment;
FIG. 3A is a schematic diagram of a nano-film sensor with a nano-grass structure according to an embodiment;
FIG. 3B is a schematic diagram of a nano-film sensor with a nano-grass structure according to another embodiment;
FIG. 4 is a schematic diagram of a nanowire sensor having a nano-stick in one embodiment;
FIG. 5 is a diagram of a sensor patch with a support portion in one embodiment.
Detailed Description
In the following description, reference is made to "some embodiments" which describe a subset of all possible embodiments, but it is understood that "some embodiments" may be the same subset or different subsets of all possible embodiments, and may be combined with each other without conflict.
In the following description, references to the terms "first \ second \ third, etc. or module a, module B, module C, etc. are used solely to distinguish between similar objects and do not denote a particular order or importance to the objects, but rather the specific order or sequence may be interchanged as appropriate to enable embodiments of the application described herein to be practiced in an order other than that shown or described herein.
In the following description, reference to reference numerals indicating steps, such as S100, S200 … …, etc., does not necessarily indicate that the steps are performed in this order, and the order of the preceding and following steps may be interchanged or performed simultaneously, where permissible.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used herein is for the purpose of describing embodiments of the present application only and is not intended to be limiting of the application.
In order to make the objects, technical solutions and advantages of the present application more clear, the present application will be further described in detail with reference to the accompanying drawings.
Generally, exhaled breath contains some markers for medical diagnosis, such as neocoronavirus, but the content is often very low, which causes certain difficulties in accurately and conveniently diagnosing exhaled breath-related diseases. This application is through the mode that sets up the sensor paster in the gauze mask, realizes the enrichment of marker by the gauze mask to through the structure of this application later-mentioned sensor paster, realize the detection of higher sensitivity. Fig. 1 shows an overall schematic view of a mask for detecting viruses for a respiratory system according to the present application, which includes a mask body 10 and a sensor patch 20 that can be attached to the inner side (the side facing the nose and mouth of a mask wearer) of the mask body. The sensor patch 20 collects biomarkers contained in the respiratory gas and uploads the results to the upper computer. Wherein the upper computer is a smart phone connected with the sensor patch bluetooth signal in the embodiment shown in fig. 1. The upper computer may also be other devices, which will be specifically described in the following embodiments.
Hereinafter, a key part of the present application, i.e., the sensor patch 20, will be described in detail.
The utility model provides an inboard of gauze mask is arranged in to the sensor paster, use the sensor paster to describe the sensor paster for outer with gauze mask looks subsides side below towards gauze mask person's mouth nose, the outside of this sensor paster can have pastes the layer, it is inboard to paste the gauze mask to convenient, wherein paste the position that the subsides district (like the strip district of pasting) of layer should not influence the gas circulation at the gauze mask position that the sensor paster corresponds, for example paste the district and be located around or both sides of pasting the layer.
The sensor patch is a flexible sheet, and as shown in fig. 2, the sheet-shaped sensor patch has at least two regions, one region is a sensing region, and the other region is a flexible circuit region, wherein the flexible circuit region has a waterproof layer, and the two regions can be arranged side by side or in an enclosing manner, which is not limited in the present application and is preferable to how to miniaturize and compact the sensor patch.
Wherein the sensing area is arranged in a plurality of layers, and is sequentially provided with a filter layer, a sensing interface and the adhesive layer from inside to outside, and the following detailed description is given:
wherein the filter layer is adapted to lock in biological particles smaller than the size of the target to access and contact the adjacent sensing interface. The sieve pores of the filter layer are formed by round, rectangular, triangular and the combination shape thereof. The filtering layer is mainly used for filtering out oversize biological particles, and the size of a sieve pore of the filtering layer can be manufactured according to a target object to be detected.
Wherein, the sensing interface is attached with a site, such as an antibody, an aptamer and the like, which can be specifically adsorbed to biomarkers (such as bacteria, viruses, various proteins and the like) in the respiratory gas so as to capture the corresponding biomarkers. In order to improve the sensitivity of the sensing interface, the following structure is adopted in the present application to capture the biomarkers with higher efficiency, which is described in detail below:
sensing interface example 1: in the embodiment shown in fig. 3A, the body of the sensing interface is made of a nano-film, such as a resistive nano-film; the surface of the nano film is provided with a plurality of nano thorns extending out of the surface to form a nano grass structure, the top ends of the thorns are sensitive sites, namely the specific adsorption sites are attached, a three-dimensional sensing interface is formed through the structure of the nano grass, and compared with a smooth nano film attached with the specific adsorption sites, the efficiency of capturing viruses is improved. The nano-film with nano-spines can be formed by a nano-imprinting method, and the nano-spines can also be generated by forming polyelectrolyte PETX on the nano-film.
In fig. 3B, another embodiment is shown, and compared with fig. 3A, each nano-stick is further provided with a plurality of nano-sticks, so that a denser nano-grass structure is formed, and the efficiency of capturing viruses is further improved.
Sensing interface example 2: in the embodiment shown in fig. 4, the sensing interface body adopts nanowires, and the spacing between the nanowires matches the biomarker to be captured, for example, when the biomarker is a novel coronavirus, the spacing between the nanowires is 50-80 nm, so that the function of screening viruses is also achieved in the dimension. The nano wire is also provided with a plurality of nano thorns extending out of the surface of the wire to form a dendritic structure, the top ends of the thorns are sensitive sites, namely, the specific adsorption sites are attached, and through the branch-shaped structure, compared with the smooth nano wire attached with the specific adsorption sites, the efficiency of capturing the virus is improved. The figure shows a sensing interface composed of a 7-port nanowire array, and the nano-spines in the figure are only schematic diagrams. The planar nanowire array can be formed by a nanoimprint method or a screen printing method, and then the electrically connected first and second terminals are arranged on two sides. For the three-dimensional nanowire array, a plurality of planar nanowire arrays can be manufactured firstly, and then the planar nanowire arrays are overlapped to form a multilayer sheet, so that the three-dimensional nanowire array sensing interface is formed, and the virus capturing efficiency is further improved.
The circuit area is provided with a detection unit, an electric signal output unit and a wireless transmission unit which are coupled in sequence, and a power supply unit for supplying power to each unit of the circuit area. The detection unit is used for loading an electric signal to the sensing interface and detecting the change of the electric signal influenced by the sensing interface; the electric signal output unit is used for outputting the detected electric signals, and the wireless transmission unit is used for sending out the signals output by the electric signal output unit.
Due to the adsorption of the sensing interface to the target object, the electric signal loaded on the detection unit of the sensing interface changes, and the corresponding electric signal output unit outputs the changed electric signal. The type of the electrical signal may be an electrical signal applied to the detection unit of the sensing interface and a corresponding detected signal, such as an impedance signal, a voltage, a current, an inductance, a capacitance, a high frequency, a low frequency, and other various forms of certain electrical signals, and specifically, the type of the electrical signal is subject to the detection circuit adapted to the sensing interface. For example, when the sensing interface is an impedance detection circuit, the sensing interface may absorb the target biomarker and affect the mobility of electrons, so that the impedance value output by the impedance detection circuit may change, and the changed impedance value may be output by the electrical signal output unit. For another example, when the sensing interface is a high-frequency detection circuit, the sensing interface may absorb the target biomarker and affect the resonant frequency, and the frequency output by the high-frequency detection circuit may change, so that the changed frequency may be output by the electrical signal output unit.
The wireless transmission unit can set up as required, and the wireless transmission unit mainly comprises microcircuit, and the signal of telecommunication output unit output is direct or through wireless communication after the code, like wifi, bluetooth or RFID mode send away to by intelligent terminal, like the special reading equipment receipt of cell-phone, panel computer or doctor with the signal of telecommunication to show the biomarker content that contains in the breathing gas.
The power supply unit may be a self-powered mode or a passive power supply mode, as exemplified below:
when the system is in a self-powered mode, for example, when a patch battery (or button battery) is provided, the system is more suitable for users such as suspected patients to purchase and detect themselves, the users can receive signals of the sensor patch on the mask through terminals such as mobile phones and tablet computers of the users, display results through corresponding APPs, and even send detection results to corresponding hospitals or appointed result collectors (such as disease control centers) through the APPs and the Internet.
When the power supply unit is in a non-self-powered mode, i.e., a passive power supply mode, the power supply unit needs to be powered by the special reading device based on electromagnetic induction, and the electric signal output by the wireless transmission unit is sent to the special reading device. In this case, passive power supply by an RFID system is mainly used, that is, the power supply unit is mainly constituted by an induction coil, and the induction coil is supplied with power by electromagnetic induction of a dedicated reader to other units in the circuit area. This condition is applicable to the hospital and gives the gauze mask of passive power supply to suspected patient, carries out the condition that signal acquisition by the handheld reading device of doctor, and the cost of gauze mask part can be lower owing to there being not paster battery under this kind of mode.
In addition, as shown in fig. 5, the sensing region of the sensor patch of the present application may further include a supporting member, such as one or more bendable plastic wires embedded therein, so that the sensor patch is attached to the inside of the mask with a gap. The sensing area in fig. 5 has two bendable plastic wires, and other materials that do not affect signal transmission may be used instead of plastic wires. Because the sensor patch and the mask are provided with a gap, the gas flow in the sensing area of the sensor patch is facilitated, and the capture of the biomarker is facilitated. On the basis, the multiple layers of the sensing area can be changed into a filtering layer, a sensing interface, a filtering layer and an adhesive layer from inside to outside in sequence, and the position of the adhesive layer which does not influence the gas flow is arranged.
As can be seen from the above, the respiratory mask of the embodiments of the present application can detect respiratory viruses more conveniently and safely, and can capture biomarkers more efficiently, so as to detect respiratory viruses more rapidly than the background art.
The above description is only exemplary of the present application and should not be taken as limiting the present application, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (10)
1. A respiratory system detects the gauze mask for virus, including the gauze mask body, characterized by that, the inboard of this gauze mask has sensor paster, this sensor paster has circuit area and sensing area;
the sensing area is composed of a plurality of layers, and is sequentially provided with a filter layer, a sensing interface and an adhesive layer which is contacted with the inner side of the mask;
the sensing interface has a protruding structure for capturing specific adsorption sites for a target biomarker in respiratory gas;
and the circuit in the circuit area is used for detecting the influence of the sensing interface on the electric signal and outputting the electric signal.
2. The mask of claim 1 wherein said sensing interface comprises a nano-film having a plurality of nano-spikes extending from the surface, the tips of the nano-spikes being specific adsorption sites for target biomarkers.
3. The mask of claim 1 wherein said sensing interface comprises an array of nanowires with a plurality of nano-spikes extending from the surface of the nanowires, the tips of the nano-spikes being specific adsorption sites for the target biomarkers.
4. The mask of claim 3 wherein the spacing between adjacent nanowires in said array of nanowires matches a target biomarker to be captured.
5. The mask of claim 4 wherein said spacing between adjacent nanowires is 50 to 80 nanometers.
6. The mask of claim 3, 4 or 5 wherein said nanowire arrays are three-dimensional nanowire arrays.
7. The mask according to claim 1, wherein the circuit of the circuit area comprises a detection unit, an electric signal output unit and a wireless transmission unit which are coupled in sequence, and a power supply unit for supplying power to each unit of the circuit area;
the detection unit is used for loading an electric signal to the sensing interface and detecting the change of the electric signal influenced by the sensing interface;
the electric signal output unit is used for outputting the detected electric signal;
the wireless transmission unit is used for sending out the signal output by the electric signal output unit.
8. The mask of claim 7 wherein said power unit is self powered and includes a patch battery.
9. The mask of claim 7 wherein said power unit is non-self powered and has an induction coil.
10. The mask of claim 1 wherein said sensor patch sensing area further comprises a support member to allow the sensor patch to be placed in contact with the inside of the mask with a gap;
a filter layer is arranged between the sensing interface and the pasting layer;
the sensing interface has specific adsorption sites on both sides for capturing the target biomarkers in the breathing gas.
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| CN112869259A (en) * | 2020-08-18 | 2021-06-01 | 天津大学 | Respiratory detects gauze mask for virus |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112869259A (en) * | 2020-08-18 | 2021-06-01 | 天津大学 | Respiratory detects gauze mask for virus |
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