CN213373758U - Cell transfer bag with flushing function - Google Patents
Cell transfer bag with flushing function Download PDFInfo
- Publication number
- CN213373758U CN213373758U CN202021424342.3U CN202021424342U CN213373758U CN 213373758 U CN213373758 U CN 213373758U CN 202021424342 U CN202021424342 U CN 202021424342U CN 213373758 U CN213373758 U CN 213373758U
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- bag
- pump chamber
- cell
- pump
- liquid
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- 238000012546 transfer Methods 0.000 title claims abstract description 31
- 238000011010 flushing procedure Methods 0.000 title abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 58
- 238000005406 washing Methods 0.000 claims abstract description 11
- 230000007246 mechanism Effects 0.000 claims abstract description 10
- 238000004891 communication Methods 0.000 claims abstract description 5
- 239000002504 physiological saline solution Substances 0.000 claims description 23
- 239000007924 injection Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 238000001802 infusion Methods 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 abstract description 63
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract description 30
- 239000011780 sodium chloride Substances 0.000 abstract description 21
- 210000000130 stem cell Anatomy 0.000 abstract description 13
- 238000000034 method Methods 0.000 description 16
- 230000008569 process Effects 0.000 description 10
- 239000000243 solution Substances 0.000 description 8
- 210000003958 hematopoietic stem cell Anatomy 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000002865 immune cell Anatomy 0.000 description 2
- 238000009630 liquid culture Methods 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 239000012266 salt solution Substances 0.000 description 2
- 210000001082 somatic cell Anatomy 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000002659 cell therapy Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model discloses a cell transfer bag with flushing function, which comprises a cell bag and a normal saline bag, wherein the normal saline bag is a single bag body or comprises at least two sub-bag bodies which are not communicated, and the single bag body or the sub-bag bodies of the normal saline bag are communicated with the cell bag through a liquid control mechanism; the liquid outlet pipe, the elastic pump chamber, the pump outlet pipe, the nozzle and the cell bag of the liquid control mechanism are sequentially in liquid communication; first check valve sets up on the drain pipe, and the liquid circulation direction of first check valve is from the one-way flow direction of drain pipe elasticity pump chamber, and the second check valve sets up on the pump exit tube, and the liquid circulation direction of second check valve is from the one-way flow direction pump exit tube of elasticity pump chamber, lies in the second check valve output on the pump exit tube and sets up the valve, and the end of pump exit tube sets up the nozzle. The utility model discloses can control the number of times of washing of normal saline, wash the opportunity, avoid stem cell solution to flow back in the saline bag simultaneously, conveniently adjust the power that normal saline washed the dynamics.
Description
Technical Field
The utility model relates to the technical field of medical equipment, in particular to cell transfer bag of function is washed in area.
Background
The cell therapy means that the normal or bioengineered human body cells are transplanted or input into the body of a patient, and the newly input cells can replace damaged cells and have stronger immune killing function, thereby achieving the purpose of treating diseases. The cells used include stem cells, immune cells, somatic cells, and the like. In the application process of the cells, the transfer and injection of the cells are involved, and at present, a disposable blood collecting and transfusing device is mostly used for the transfer of the cells.
In the process of cell injection, in order to avoid the residue and waste of cells on the disposable blood collecting and transfusing device bag body, the bag body needs to be flushed by physiological saline. However, since the physiological saline is introduced from the external environment, bacteria are easily introduced, which causes stem cell contamination and is inconvenient to operate. At present, the cell transfer bag is provided by the prior art, and certain technical problems are solved. The patent publication No. CN210096377U discloses a disposable stem cell and blood transfer bag, which comprises a transfer bag body, a breakable diaphragm and a physiological saline bag, wherein the transfer bag body and the physiological saline bag are both sealed structures, the transfer bag body and the physiological saline bag are fixedly connected through a connecting band, the breakable diaphragm is arranged in the connecting band, the transfer bag body is communicated with the physiological saline bag after the breakable diaphragm is broken, and the transfer bag body is provided with an output hose. The patent publication No. CN207137040U discloses a blood transfusion bag for hematopoietic stem cells, which includes: saline bag, hematopoietic cell bag; the saline bag is used for containing physiological saline for flushing the hematopoietic cell bag; the hematopoietic cell bag is used for containing hematopoietic stem cells to be infused; the lower end of the saline bag is connected with the upper end of the hematopoietic cell bag through a connecting pipe; and the middle part of the connecting pipe is provided with a switch valve.
The two patents realize the connection of the saline bag and the internal channel of the cell bag, but the direction of the saline flowing into the cell bag is fixed, the cell bag needs to be shaken in the washing process, and the stem cell solution is easy to pollute the channel in the process of shaking the cell bag. Therefore, it is urgently needed to design a cell transfer bag with a washing function, which can be operated conveniently, realize multiple washing and avoid the backflow of stem cells.
SUMMERY OF THE UTILITY MODEL
Technical problem to be solved
An object of the utility model is to provide a cell transfer bag of function is washed in area to it is fixed to solve the direction that current cell transfer bag salt solution flows in the cell bag, still need wave the cell bag in the washing process, waves the in-process of cell bag, leads to the problem that stem cell solution pollutes the passageway easily.
(II) technical scheme
For the cell that realizes above-mentioned area washing function shifts the bag and solves current cell and shifts the direction that bag salt solution flows in the cell bag and be fixed, the in-process that washes the in-process that still need wave the cell bag, wave the cell bag leads to stem cell solution to pollute the problem of passageway easily, the utility model provides a following technical scheme:
a cell transfer bag with a flushing function comprises a cell bag and a physiological saline bag, wherein the physiological saline bag is a single bag body or comprises at least two unconnected sub-bag bodies, and the single bag body or the sub-bag bodies of the physiological saline bag are communicated with the cell bag through a liquid control mechanism; the liquid control mechanism comprises a liquid outlet pipe, a first one-way valve, an elastic pump chamber, a second one-way valve, a pump-out pipe, a valve and a nozzle; the liquid outlet pipe, the elastic pump chamber, the pump outlet pipe, the nozzle and the cell bag are sequentially in liquid communication; the first one-way valve is arranged on the liquid outlet pipe, the liquid flowing direction of the first one-way valve flows from the liquid outlet pipe to the elastic pump chamber in a one-way mode, the second one-way valve is arranged on the pump outlet pipe, the liquid flowing direction of the second one-way valve flows from the elastic pump chamber to the pump outlet pipe in a one-way mode, a valve is arranged at the output end of the second one-way valve on the pump outlet pipe, and a nozzle is arranged at the tail end of the pump outlet pipe.
Preferably, the liquid outlet pipe, the first one-way valve, the elastic pump chamber, the second one-way valve and the pump-out pipe are tightly pressed and fixed between the cell bag and the physiological saline bag by two layers of films.
Preferably, the bottom of the physiological saline bag is provided with a groove, and the bottom of the groove is communicated with the liquid outlet pipe.
Preferably, the cell bag is externally provided with a liquid injection port and a liquid infusion port which are communicated with the cell bag.
Preferably, the elastic pump chamber comprises a frame, two layers of pump chamber walls which are oppositely arranged at intervals, a flexible pump chamber side wall and a spring; the outer edges of the two layers of pump chamber walls are clamped in the frame, springs are respectively arranged on the edges of the inner sides of the two layers of pump chamber walls, a circle of flexible pump chamber side wall is surrounded between the two layers of pump chamber walls, the flexible pump chamber side wall and the two layers of pump chamber walls are sealed to form an inner cavity of an elastic pump chamber, and the inner cavity of the elastic pump chamber is located on the inner side of the spring.
Preferably, the valve is a knob valve, and the valve is perpendicular to the side surface of the cell transfer bag.
(III) advantageous effects
Compared with the prior art, the utility model provides a cell transfer bag of function is washed in area possesses following beneficial effect:
1. by arranging the two one-way valves and the elastic pump chamber, the flushing frequency and the flushing time of the normal saline can be controlled, and meanwhile, the stem cell solution is prevented from flowing back into the saline bag;
2. the elastic pump chamber and the nozzle are arranged, and the strength of the flushing force of the physiological saline can be conveniently adjusted by controlling the sizes of the elastic pump chamber and the nozzle and the pressure of finger pressing;
3. the physiological saline bag comprises more than two sub-bag bodies which are not communicated, can be filled with cell reagents, liquid culture media and other solutions except physiological saline, meets various requirements in the cell transfusion process, and is suitable for transferring various cells such as stem cells, immune cells, somatic cells and the like.
Drawings
Fig. 1 is a schematic structural diagram of embodiment 1 of the present invention;
fig. 2 is a schematic structural diagram of embodiment 2 of the present invention;
fig. 3 is a schematic structural view of the spring pump chamber of the present invention.
In the figure: 1. a cell bag; 2. a saline bag; 3. a liquid outlet pipe; 4. a first check valve; 5. an elastic pump chamber; 6. a second one-way valve; 7. a pump-out tube; 8. a valve; 9. a nozzle; 11. a liquid injection port; 12. an infusion port; 21. a groove; 51. a frame; 52. a pump chamber wall; 53. a flexible pump chamber sidewall; 54. a spring.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
Example 1
As shown in fig. 1, a cell transfer bag with flushing function comprises a cell bag 1 and a saline bag 2, wherein the saline bag 2 is a single bag body, and the saline bag 2 is communicated with the cell bag 1 through a liquid control mechanism; the liquid control mechanism comprises a liquid outlet pipe 3, a first one-way valve 4, an elastic pump chamber 5, a second one-way valve 6, a pump-out pipe 7, a valve 8 and a nozzle 9; the liquid outlet pipe 3, the elastic pump chamber 5, the pump-out pipe 7, the nozzle 9 and the cell bag 1 are sequentially in liquid communication; first check valve 4 sets up on drain pipe 3, and the one-way flow direction of liquid of first check valve 4 flows to elastic pump room 5 from drain pipe 3, and second check valve 6 sets up on pump-out pipe 7, and the one-way flow direction of liquid of second check valve 6 flows to pump-out pipe 7 from elastic pump room 5, lies in the output of second check valve 6 on pump-out pipe 7 and sets up valve 8, and the end of pump-out pipe 7 sets up nozzle 9.
In this embodiment, the outlet tube 3, the first check valve 4, the elastic pump chamber 5, the second check valve 6, and the pump-out tube 7 are fixed between the cell bag 1 and the saline bag 2 by two layers of films.
In this embodiment, the bottom of the saline bag 2 has a groove 21, the bottom of the groove 21 is connected to the outlet pipe 3, and the groove 21 is preferably conical.
In this embodiment, the cell bag 1 is provided with a liquid inlet 11 and a liquid inlet 12 on the outside thereof, which communicate with the cell bag 1.
In this embodiment, the elastic pump chamber 5 includes a frame 51, two layers of pump chamber walls 52 arranged oppositely at intervals, a flexible pump chamber side wall 53 and a spring 54; the outer edges of the two layers of pump chamber walls 52 are clamped in the frame 51, springs 54 are respectively arranged on the inner edges of the two layers of pump chamber walls 52, a circle of flexible pump chamber side wall 53 is surrounded between the two layers of pump chamber walls 52, the flexible pump chamber side wall 53 and the two layers of pump chamber walls 52 are sealed to form an inner cavity of the elastic pump chamber 5, and the inner cavity of the elastic pump chamber 5 is located on the inner side of the spring 54. When the two layers of pump chamber walls 52 are pressed with a finger, the spring 54 is compressed and the volume of the inner cavity of the elastic pump chamber 5 becomes smaller; when the finger is released, the spring 54 pushes the two pump chamber walls 52 apart and the volume of the interior of the elastomeric pump chamber 5 increases.
In this embodiment, the valve 8 is a knob valve, the valve 8 is perpendicular to the side of the cell transfer bag, and the valve 8 is used to control the liquid flow of the pump-out tube 7.
Example 2
As shown in fig. 2, a cell transfer bag with flushing function comprises a cell bag 1 and a saline bag 2, wherein the saline bag 2 in this embodiment comprises two disconnected sub-bags (in practical application, more than two sub-bags may be used), and the sub-bags of the saline bag 2 are communicated with the cell bag 1 through a liquid control mechanism; the liquid control mechanism comprises a liquid outlet pipe 3, a first one-way valve 4, an elastic pump chamber 5, a second one-way valve 6, a pump-out pipe 7, a valve 8 and a nozzle 9; the liquid outlet pipe 3, the elastic pump chamber 5, the pump-out pipe 7, the nozzle 9 and the cell bag 1 are sequentially in liquid communication; first check valve 4 sets up on drain pipe 3, and the one-way flow direction of liquid of first check valve 4 flows to elastic pump room 5 from drain pipe 3, and second check valve 6 sets up on pump-out pipe 7, and the one-way flow direction of liquid of second check valve 6 flows to pump-out pipe 7 from elastic pump room 5, lies in the output of second check valve 6 on pump-out pipe 7 and sets up valve 8, and the end of pump-out pipe 7 sets up nozzle 9.
In this embodiment, the outlet tube 3, the first check valve 4, the elastic pump chamber 5, the second check valve 6, and the pump-out tube 7 are fixed between the cell bag 1 and the saline bag 2 by two layers of films.
In this embodiment, the bottom of the saline bag 2 has a groove 21, the bottom of the groove 21 is connected to the outlet pipe 3, and the groove 21 is preferably conical.
In this embodiment, the cell bag 1 is provided with a liquid inlet 11 and a liquid inlet 12 on the outside thereof, which communicate with the cell bag 1.
In this embodiment, the elastic pump chamber 5 includes a frame 51, two layers of pump chamber walls 52 arranged oppositely at intervals, a flexible pump chamber side wall 53 and a spring 54; the outer edges of the two layers of pump chamber walls 52 are clamped in the frame 51, springs 54 are respectively arranged on the inner edges of the two layers of pump chamber walls 52, a circle of flexible pump chamber side wall 53 is surrounded between the two layers of pump chamber walls 52, the flexible pump chamber side wall 53 and the two layers of pump chamber walls 52 are sealed to form an inner cavity of the elastic pump chamber 5, and the inner cavity of the elastic pump chamber 5 is located on the inner side of the spring 54.
In this embodiment, the valve 8 is a knob valve, the valve 8 is perpendicular to the side of the cell transfer bag, and the valve 8 is used to control the liquid flow of the pump-out tube 7.
The working process of the cell transfer bag with the flushing function described in example 1 and example 2 is as follows:
opening the valve 8, pressing the elastic pump chamber 5 by fingers, reducing the internal volume of the elastic pump chamber 5, pumping out the physiological saline in the elastic pump chamber 5, stopping the liquid flow of the first one-way valve 4, circulating the liquid of the second one-way valve 6, pumping the physiological saline into the liquid outlet pipe 7, and then spraying out from the nozzle 9 to finish the spraying and flushing step of the physiological saline; the fingers stop pressing the elastic pump chamber 5, the elastic pump chamber 5 recovers under the elastic action, the internal volume is enlarged, at the moment, the liquid of the first one-way valve 4 circulates, the liquid of the second one-way valve 6 does not circulate, and therefore the normal saline is sucked into the liquid outlet pipe 3 from the normal saline bag 2 and then flows into the elastic pump chamber 5 through the first one-way valve 4, and the normal saline filling step is completed. Due to the existence of the first one-way valve 4 and the second one-way valve 6, the stem cell transfusion system can be washed at any time during the stem cell transfusion process, and meanwhile, the stem cell solution is prevented from flowing back into the saline bag.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The utility model provides a cell transfer bag of function is washed in area which characterized in that: the cell bag comprises a cell bag (1) and a physiological saline bag (2), wherein the physiological saline bag (2) is a single bag body or comprises at least two unconnected sub-bag bodies, and the single bag body or the sub-bag bodies of the physiological saline bag (2) are communicated with the cell bag (1) through a liquid control mechanism; the liquid control mechanism comprises a liquid outlet pipe (3), a first one-way valve (4), an elastic pump chamber (5), a second one-way valve (6), a pump outlet pipe (7), a valve (8) and a nozzle (9); the liquid outlet pipe (3), the elastic pump chamber (5), the pump outlet pipe (7), the nozzle (9) and the cell bag (1) are sequentially in liquid communication; first check valve (4) set up on drain pipe (3), just the liquid circulation direction of first check valve (4) is from drain pipe (3) one-way flow to elastic pump room (5), second check valve (6) set up on pump exit tube (7), just the liquid circulation direction of second check valve (6) is from elastic pump room (5) one-way flow to pump exit tube (7), it sets up valve (8) to lie in second check valve (6) output on pump exit tube (7), the end of pump exit tube (7) sets up nozzle (9).
2. The cell transfer bag with washing function according to claim 1, wherein: the liquid outlet pipe (3), the first one-way valve (4), the elastic pump chamber (5), the second one-way valve (6) and the pump outlet pipe (7) are tightly pressed and fixed between the cell bag (1) and the physiological saline bag (2) by two layers of films.
3. The cell transfer bag with washing function according to claim 1, wherein: the bottom of the physiological saline bag (2) is provided with a groove (21), and the bottom of the groove (21) is communicated with the liquid outlet pipe (3).
4. The cell transfer bag with washing function according to claim 1, wherein: and a liquid injection port (11) and a liquid infusion port (12) which are communicated with the cell bag (1) are arranged outside the cell bag (1).
5. The cell transfer bag with washing function according to claim 1, wherein: the elastic pump chamber (5) comprises a frame (51), two layers of pump chamber walls (52) which are oppositely arranged at intervals, a flexible pump chamber side wall (53) and a spring (54); the outer edges of the two layers of pump chamber walls (52) are clamped in the frame (51), springs (54) are respectively arranged on the edges of the inner sides of the two layers of pump chamber walls (52), a circle of flexible pump chamber side wall (53) surrounds between the two layers of pump chamber walls (52), the flexible pump chamber side wall (53) and the two layers of pump chamber walls (52) are sealed to form an inner cavity of the elastic pump chamber (5), and the inner cavity of the elastic pump chamber (5) is located on the inner side of the springs (54).
6. The cell transfer bag with washing function according to claim 1, wherein: the valve (8) is a knob valve, and the valve (8) is vertical to the side surface of the cell transfer bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021424342.3U CN213373758U (en) | 2020-07-20 | 2020-07-20 | Cell transfer bag with flushing function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021424342.3U CN213373758U (en) | 2020-07-20 | 2020-07-20 | Cell transfer bag with flushing function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213373758U true CN213373758U (en) | 2021-06-08 |
Family
ID=76200638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021424342.3U Active CN213373758U (en) | 2020-07-20 | 2020-07-20 | Cell transfer bag with flushing function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN213373758U (en) |
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2020
- 2020-07-20 CN CN202021424342.3U patent/CN213373758U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Hu Yu Inventor after: Mei Heng Inventor after: Yao Weiqi Inventor after: Tang Yuxiang Inventor after: Shi Lei Inventor after: Zhang Yu Inventor before: Yao Weiqi Inventor before: Mei Heng Inventor before: Tang Yuxiang Inventor before: Shi Lei Inventor before: Zhang Yu |
|
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231227 Address after: 430000, Room 10, 17th Floor, Building 1, Huigu Space, No. 4 Luoyu East Road, Donghu New Technology Development Zone, Wuhan City, Hubei Province Patentee after: Wuhan Jimeini Technology Co.,Ltd. Address before: 430022 No. 1277 Jiefang Avenue, Jianghan District, Hubei, Wuhan Patentee before: UNION HOSPITAL TONGJI MEDICAL College HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY |
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| TR01 | Transfer of patent right |