CN213148804U - Temperature adjusting structure, coupling device and biochemical analysis equipment - Google Patents

Abstract

The utility model discloses a structure, ally oneself with device and biochemical analytical equipment adjust temperature, the structure that adjusts temperature includes the casing and sets up in the casing: a mounting bin and a temperature adjusting component. Wherein the mounting bin is provided with a containing cavity; the temperature regulation subassembly sets up in one side of installation storehouse, and the temperature regulation subassembly includes interconnect's temperature control spare and the control unit, and the control unit control temperature control spare's braking is in order to adjust the temperature that holds in the cavity. The installation storehouse provides the installation of intercommunication pipeline and places the position, through set up temperature regulation subassembly in the casing, and then guarantees to hold the temperature in the cavity and be in the temperature range that actual test required to improve the efficiency of follow-up analysis experiment, and set up in the casing through each structural component, avoided installing the thermostatic equipment alone in the device outside, improve the convenience of detection and analysis on the use.

Description

Temperature adjusting structure, coupling device and biochemical analysis equipment

Technical Field

The utility model relates to a biochemical analysis device technical field, concretely relates to structure, ally oneself with and use device and biochemical analytical equipment adjust temperature.

Background

Qualitative and quantitative analysis of meaningful analytes in complex samples is of great significance to modern medicine, biology, food science and environmental science. Mass Spectrometry (MS) technology, which relies on measuring mass-to-charge ratio (m/z) of gaseous ions to detect and identify analytes, is one of the most powerful qualitative and quantitative detection techniques for organic analytes. The mass spectrum technology has extremely high selectivity, high sensitivity and rich information collection capability. In modern analytical chemistry, a complex sample is separated and then is in on-line combination with a mass spectrometry detection technology, so that a separation and detection two-dimensional biochemical analysis platform is formed, and the purpose of qualitative and quantitative analysis can be more efficiently completed. Currently, High Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), Supercritical Fluid Chromatography (SFC), Capillary Electrophoresis (CE), and the like are mainly used as separation techniques for the front end.

In the prior art, in the existing ion source structure, liquid chromatography (LC for short) is usually adopted as a separation front end, and an ion source is connected to an LC end to implement electrospray ionization ejection of an ejection liquid, thereby implementing biochemical analysis of a substance. In the practical use process, in order to improve the separation efficiency of the ion source, the LC column is often required to be heated, for example, in the analysis experiment process, the temperature is 40-80 ℃, and the ionization effect of the ejection liquid is the best, so that a specific constant temperature device is required to perform temperature control operation during ionization, and the use of the device is complicated, so that the experiment operation becomes complicated.

SUMMERY OF THE UTILITY MODEL

Therefore, the utility model discloses the technical problem that will solve lies in carrying out the electrospray ionization in-process among the prior art, owing to need specific constant temperature equipment to carry out the temperature control operation, it uses comparatively loaded down with trivial details for the experiment operation becomes complicated defect.

Therefore, the utility model provides a structure adjusts temperature, including the casing to and set up in the casing:

a mounting bin having a receiving cavity;

the temperature adjusting assembly is arranged on one side of the mounting bin and comprises a temperature control piece and a control unit which are connected with each other, and the control unit controls the braking of the temperature control piece to adjust the temperature in the accommodating cavity.

Optionally, in the temperature adjusting structure, the temperature control element includes a heater, the heater is connected to the control unit, and the control unit controls heating of the heater to adjust the temperature in the accommodating cavity;

and/or

The refrigerator is connected with the control unit, and the control unit controls the refrigeration of the refrigerator so as to adjust the temperature in the accommodating cavity.

Optionally, in the temperature adjustment structure, the temperature adjustment assembly further includes a sensor, the sensor is connected to the control unit, the sensor is configured to detect a temperature in the accommodating cavity, and the control unit controls the adjustment of the temperature control element through the temperature.

Optionally, in the temperature adjustment structure, the accommodating cavity is a rectangular cavity, and the mounting bin has at least two accommodating cavities;

or the accommodating cavity is a hollow cavity in a shape of a Chinese character 'hui'.

Optionally, the temperature adjusting structure comprises a casing

A bottom case;

the upper cover is arranged on the bottom shell in an openable and closable manner, and the temperature regulating assembly is arranged in the upper cover;

the upper cover with be equipped with between the drain pan and form the installation storehouse hold the cavity, the installation storehouse is installed hold in the cavity.

Optionally, in the temperature adjustment structure, an insulating member is further disposed on the upper cover, and the insulating member is installed between the installation bin and the temperature adjustment assembly and used for isolating and insulating the installation bin and the temperature adjustment assembly.

Optionally, in the temperature adjustment structure, the upper cover is provided with a plurality of heat dissipation holes.

Optionally, in the temperature adjustment structure, the housing has a position-limiting and positioning end; the mounting bin is provided with a limiting mounting end, and the limiting positioning end and the limiting mounting end are arranged in an inserted mode.

A combination, comprising: the temperature adjusting structure is described above;

an ion source disposed within the housing;

the communicating pipeline is connected with the connecting end of the ion source and arranged in the accommodating cavity.

A biochemical analysis device comprises the combined device.

The technical scheme provided by the utility model, following advantage has:

1. the utility model provides a structure adjusts temperature, including the casing to and the setting is in the casing: the installation bin and the temperature adjusting assembly. Wherein, the installation storehouse has at least one and is used for holding the holding cavity of intercommunication pipeline. The temperature regulation subassembly sets up one side in the installation storehouse, the temperature regulation subassembly includes interconnect's temperature control spare and the control unit, the control unit control the braking of temperature control spare is in order to adjust hold the temperature in the cavity.

The temperature adjusting structure of this structure, installation storehouse provide the installation of intercommunication pipeline and place the position, through set up the temperature regulation subassembly in the casing, and then guarantee that the temperature that holds in the cavity is in the temperature range that actual test required to improve the efficiency of follow-up analysis experiment, and set up in the casing through each structural component, avoided installing the thermostatic equipment alone in the device outside, improve the convenience of detection and analysis on the use.

2. The temperature adjusting structure provided by the utility model, the temperature control part comprises a heater, the heater is connected with the control unit, and the control unit controls the heater to heat so as to adjust the temperature in the accommodating cavity; and/or the refrigerator is connected with the control unit, and the control unit controls the refrigeration of the refrigerator so as to adjust the temperature in the accommodating cavity.

The temperature adjusting structure of the structure can heat the air around the heater by the heater, and the hot air is guided into the accommodating cavity to improve the temperature in the accommodating cavity. The refrigerator cools the ambient air, and the temperature in the accommodating cavity can be reduced by introducing cold air cooled by the refrigerator into the accommodating cavity. Through the coordinated adjustment of the heater and the refrigerator, the required temperature in the accommodating cavity can be adjusted according to the actual temperature, the adjustable temperature range is further expanded, and the adaptability of the device is improved. Of course, only a refrigerator or a heater may be provided according to specific requirements, for example, the temperature of the use environment is usually higher or lower, and the temperature can be adjusted only by the refrigerator or the heater.

3. The utility model provides a structure adjusts the temperature, temperature regulation subassembly still includes the sensor, the sensor with the control unit is connected, the sensor is used for detecting the temperature that holds in the cavity, the control unit passes through temperature control the regulation of temperature control spare. The temperature adjusting structure with the structure and the arrangement of the sensor ensure the feedback of the actual temperature in the accommodating cavity, and the temperature adjusting structure is used as the standard of temperature adjustment to ensure the reliability of temperature adjustment.

4. The utility model provides a temperature adjusting structure, the containing cavity is a rectangular cavity, and the mounting bin is provided with at least two containing cavities; or the accommodating cavity is a hollow cavity in a shape of a Chinese character 'hui'. Different concrete shapes and the different structures that set up that hold the cavity can realize that the intercommunication pipeline is different in the cavity around establishing the mode to realize accomodating and synchronous temperature control to the intercommunication pipeline in limited space, and then, the installation storehouse design that holds the cavity more, under less overall volume, can realize holding of longer intercommunication pipeline through the winding, save heating time and the energy of economizing, further improve the integrated level of device.

5. The utility model provides a structure adjusts temperature, upper cover and drain pan are through the installation cavity that forms, realize the installation in installation storehouse, in addition, through setting up the insulating part, effective protection circuit and operating personnel's safety. The heat dissipation holes are arranged to discharge the redundant heat through the heat dissipation holes.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic structural view of a coupling device provided by the present invention;

FIG. 2 is a schematic structural view of the coupling device according to the present invention when the upper cover is opened;

FIG. 3 is an exploded view of the upper cover and mounting bin of FIG. 2;

fig. 4 is a schematic structural diagram of the installation bin provided by the present invention;

fig. 5 is a schematic view of a matching structure of the mounting bin and the bottom case provided by the present invention;

fig. 6 is a schematic structural diagram of a temperature control element provided by the present invention;

description of reference numerals:

1, installing a bin; 11-a containment cavity; 12-a limit mounting end;

2-temperature control; 21-a heater; 22-a refrigerator;

31-a bottom shell; 311-limit positioning end; 32-upper cover; 321-heat dissipation hole

4-an insulator;

5-ion source.

Detailed Description

The technical solution of the present invention will be described clearly and completely with reference to the accompanying drawings, and obviously, the described embodiments are some, but not all embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Furthermore, the technical features mentioned in the different embodiments of the invention described below can be combined with each other as long as they do not conflict with each other.

Example 1

The present embodiment provides a temperature adjustment structure, as shown in fig. 1 to 6, including: casing and setting in the casing: a mounting bin 1 and a temperature regulating assembly.

The installation bin 1 is provided with an accommodating cavity 11, and the accommodating cavity 11 is used for accommodating a communication pipeline; the temperature regulation subassembly includes interconnect's temperature control part 2 and the control unit, and the temperature regulation subassembly sets up in one side of installation storehouse 1, and the control unit control temperature control part 2's braking is in order to adjust the temperature in holding cavity 11.

In this embodiment, as shown in fig. 1 and 2, the housing includes a bottom case 31 and an upper cover 32. Wherein, the upper cover 32 can be arranged on the bottom shell 31 in an opening and closing way, and the temperature adjusting component is arranged in the upper cover 32; an installation cavity for installing the installation bin 1 is formed between the upper cover 32 and the bottom shell 31, and the installation bin 1 is installed in the installation cavity. Specifically, the upper cover 32 is pivotally connected to the lower case by a hinge, thereby realizing the mounting of the upper cover 32.

In the present embodiment, as shown in fig. 6, the temperature control member 2 includes a heater 21 and a refrigerator 22. The heater 21 is connected to a control unit, and the control unit controls the heater 21 to heat so as to regulate the temperature in the accommodating cavity 11. The refrigerators 22 are electrically connected to a control unit, respectively, and the control unit controls the refrigerators 22 to refrigerate to adjust the temperature inside the receiving cavity 11.

In the temperature adjustment structure provided in this embodiment, the heater 21 heats the air around the heater, and introduces the hot air into the accommodating cavity 11 to increase the temperature in the accommodating cavity 11. Refrigerator 22 cools the air around it, and by introducing the cool air cooled by refrigerator 22 into accommodation cavity 11, the temperature inside accommodation cavity 11 can be lowered. Through the cooperative adjustment of the heater 21 and the refrigerator 22, the required temperature in the accommodating cavity 11 can be adjusted according to the actual temperature, so that the adjustable temperature range is further expanded, and the adaptability of the device is improved. Of course, it is also possible to provide only the refrigerator 22 or only the heater 21 according to specific requirements, for example, the environment where the temperature is usually higher or lower, and the temperature adjustment can be realized only by the refrigerator 22 or the heater 21.

Specifically, in this embodiment, the heater 21 is a heating plate, the refrigerator 22 is a fan, the heating plate is connected to a power supply to supply heat, and the fan is used to dissipate heat. Both the heating plate and the fan are mounted in the upper cover 32 in this embodiment. As shown in fig. 1, the top cover 32 is provided with a plurality of heat dissipation holes 321. In the present embodiment, the heat dissipation hole 321 is a circular through hole.

As shown in fig. 2 and 3, an insulating member 4 is further provided on the upper cover 32, and the insulating member 4 is mounted on a wall surface facing one side of the lower case to isolate the insulating installation chamber 1 from the temperature adjusting assembly. The insulating member 4 is made of an insulating material, for example, ABS (Acrylonitrile Butadiene Styrene). Of course, other materials may be used to insulate the cartridge 1 from the temperature regulating assembly. In this embodiment, the insulating member 4 is provided with a communication hole to transfer hot air or cold air on one side of the temperature control member 2 into the installation cavity of the installation bin 1 through the communication hole.

In the embodiment, as shown in fig. 4, since the top surface of the installation bin 1 is an arc surface, as shown in fig. 3, the insulating member 4 has a strip-shaped structure with a semi-annular cross section, and the semi-annular arc surface can be buckled on the arc surface at the top of the installation bin 1. The bottom shell 31 further has an installation groove recessed from outside to inside, and two side wall surfaces of the installation bin 1 are in limit contact with two side wall surfaces of the installation groove.

In this embodiment, the temperature adjustment assembly further includes a sensor, the sensor is connected with the control unit, the sensor is used for detecting the temperature in the accommodating cavity 11, and the control unit controls the adjustment of the temperature control member through the temperature. The arrangement of the sensor ensures the feedback of the actual temperature in the accommodating cavity 11, and the feedback is used as the standard of temperature regulation to ensure the reliability of temperature regulation.

As shown in fig. 4, the installation bin 1 is a block structure, the accommodating cavity 11 is a rectangular cavity recessed from outside to inside, and in this embodiment, the installation bin 1 has two accommodating cavities 11; the mounting bin 1 may be a brass material having a high thermal conductivity, further improving the constancy of temperature within the receiving cavity 11.

In this embodiment, as shown in fig. 4 and 5, the lower cover further has a position-limiting and positioning end 311; the mounting bin 1 is provided with a limiting mounting end 12, and a limiting positioning end 311 and the limiting mounting end 12 are arranged in an inserting mode. Particularly, the limiting positioning end 311 is a limiting groove, the limiting mounting end 12 is a mounting protrusion, and the limiting groove and the mounting protrusion are matched with each other, so that the limiting mounting of the mounting bin 1 can be realized, and the mounting reliability is further improved.

The temperature adjusting structure in this embodiment further includes a power connector (not shown) that is connected to an external power source via a power connection line, and the power connector is electrically connected to the temperature adjusting assembly in the housing, so as to supply power to the temperature adjusting assembly.

The structure that adjusts temperature that this embodiment provided, installation storehouse provide the installation of intercommunication pipeline and place the position, through set up the temperature regulation subassembly in the casing, and then guarantee to hold the temperature in the cavity and be in the temperature range that actual test required to improve the efficiency of follow-up analysis experiment, and set up in the casing through each structural component, avoided installing the thermostatic equipment alone in the device outside, improve the convenience of detection and analysis on the use.

Of course, in other alternative embodiments, the number of the installation chambers 1 may be more, such as three or four, as long as the accommodation cavity 11 is ensured to coil the communication pipe.

Of course, in other alternative embodiments, the receiving cavity 11 is also a hollow cavity of the clip type. The coiling of the communication pipe can also be realized. Different concrete shapes and different setting structures that hold cavity 11 can realize that the intercommunication pipeline is different in the cavity around establishing the mode to realize accomodating and synchronous temperature control to the intercommunication pipeline in limited space, and then, the design in installation storehouse 1 that holds cavity 11 more, under less overall volume, can realize holding of longer intercommunication pipeline through the winding, more can be energy-conserving when saving heat time, further improve the integrated level of device.

Example 2

This embodiment provides a coupling device, including: the temperature adjusting structure in embodiment 1, and the ion source 5 and the communication pipe, the ion source 5 is installed in the housing, the communication pipe is connected with the connection end of the ion source 5, and the communication pipe is installed in the accommodating cavity 11 of the installation bin 1.

Example 3

This example provides a biochemical analysis apparatus using the combination set provided in example 2.

Example 4

The embodiment provides an LC-MS (liquid chromatography-mass spectrometry) combined device, wherein the LC-MS is the combined device provided in the embodiment 2; the LC-MS coupling device is used for a liquid chromatograph as a coupling device at a separation front end, wherein a communication pipeline of the coupling device in embodiment 2 is an LC column, and the LC column can be heated by a temperature adjusting component in a use process, for example, the temperature is maintained between 40 ℃ and 80 ℃ to ensure that an ionization effect of an output end ejection liquid of the ion source 5 is better.

Example 5

The present embodiment provides an LC-MS biochemical analysis apparatus, including: the LC-MS combination provided in example 4, and a liquid chromatograph and a mass spectrometer disposed at both ends of the LC-MS combination. One end of the LC column is arranged in an installation bin 1 of the LC-MS coupling device, one end of the LC column is connected with the liquid chromatograph, and one side of the mass spectrometer is connected with the output end of the ion source 5.

Example 6

This example provides a CE-MS and LC-MS combination device, which uses the combination device (CE-MS; capillary electrophoresis mass spectrometry) provided in example 2; the CE-MS and LC-MS combination device is used for an electrophoresis apparatus and a liquid chromatograph as a combination device at a separation front end, wherein a communication pipeline of the combination device in embodiment 2 is an LC column, and when the LC-MS is required to be used in a use process, the LC column can be heated by a temperature adjusting assembly, for example, the temperature is maintained between 40 ℃ and 80 ℃ to ensure that an ionization effect of an output end ejection liquid of the ion source 5 is better.

Example 7

The present embodiment provides a CE-MS and LC-MS biochemical analysis apparatus, comprising: in the CE-MS and LC-MS combination apparatus provided in embodiment 6, since the ion source 5 in the CE-MS and LC-MS combination apparatus is a three-way structure, when the ion source 5 is used as a CE-MS, the output end of the ion source 5 is communicated with the mass spectrometer through a stainless steel spray needle, one input end of the ion source 5 is communicated with the electrophoresis apparatus through a separation capillary, and the other input end of the ion source 5 is communicated with the chemical auxiliary liquid. That is, at this time, both ends of the combined device are respectively communicated with the mass spectrometer and the electrophoresis apparatus.

When the ion source is used as an LC-MS, the ion source is used as a two-way pipeline, wherein the output end of the ion source 5 is communicated with a mass spectrometer through a stainless steel spray needle, and the input end of the ion source 5 is communicated with a liquid chromatograph through an LC column. That is, at this time, both ends of the combination device communicate with the mass spectrometer and the liquid chromatograph, respectively. Thereby allies oneself with uses the equipment and can be used for connecting the antitrochanter and the mass spectrograph and allies oneself with between liquid chromatograph and the mass spectrograph to can be in the seamless connection of the in-process that electrophoresis apparatus and liquid chromatograph switch, need not to carry out the antithetical couplet interface and change, constant temperature equipment is only called when LC-MS allies oneself with uses, is used for realizing heating the LC post.

In the CE-MS and LC-MS biochemical analysis devices in this embodiment, during use, in the CE-MS operating mode, the temperature adjustment assembly is not turned on, and the installation bin 1 is only used as a placement cavity for a capillary passage to guide a separation capillary into the ion source 5; when the liquid crystal display device is in an LC-MS working mode, the side edge of the tee joint is used as a chemical auxiliary liquid input end and is plugged by a plug, and the LC column is wound in the installation cavity, so that the temperature of the temperature adjusting component for the accommodating cavity 11 is adjusted, and the accommodating cavity 11 is ensured to be in a proper temperature range.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications can be made without departing from the scope of the invention.

Claims (10)

1. The utility model provides a structure adjusts temperature which characterized in that, includes the casing to and set up in the casing:

a mounting bin (1) having a receiving cavity (11);

the temperature regulation assembly is arranged on one side of the installation bin (1), the temperature regulation assembly comprises a temperature control piece (2) and a control unit which are connected with each other, and the control unit controls the braking of the temperature control piece (2) to regulate the temperature in the accommodating cavity (11).

2. Temperature-regulating structure according to claim 1, characterized in that the temperature control member (2) comprises:

a heater (21), wherein the heater (21) is connected with the control unit, and the control unit controls the heater (21) to heat so as to adjust the temperature in the accommodating cavity (11);

and/or

A refrigerator (22), the refrigerator (22) being connected with the control unit, the control unit controlling the refrigerator (22) to refrigerate to adjust the temperature in the receiving cavity (11).

3. Temperature conditioning structure according to claim 1 or 2,

the temperature regulation assembly further comprises a sensor, the sensor is connected with the control unit, the sensor is used for detecting the temperature in the accommodating cavity (11), and the control unit controls the regulation of the temperature control component (2) through the temperature.

4. Temperature conditioning structure according to claim 1 or 2,

the containing cavity (11) is a rectangular cavity, and the mounting bin (1) is provided with at least two containing cavities (11);

or the accommodating cavity (11) is a hollow cavity in a shape of a Chinese character 'hui'.

5. Temperature conditioning structure according to claim 1 or 2, wherein the housing comprises

A bottom case (31);

an upper cover (32) openably and closably provided on the bottom case (31), the temperature adjusting assembly being mounted in the upper cover (32);

an accommodating cavity for forming the installation of the installation bin (1) is arranged between the upper cover (32) and the bottom shell (31), and the installation bin (1) is installed in the accommodating cavity.

6. Temperature conditioning structure according to claim 5,

still be equipped with insulating part (4) on upper cover (32), insulating part (4) are installed installation storehouse (1) with between the temperature regulation subassembly for keep apart insulating installation storehouse (1) and temperature regulation subassembly.

7. A temperature conditioning structure according to claim 5, wherein said upper cover (32) is provided with a plurality of heat dissipating holes (321).

8. Temperature conditioning structure according to claim 1 or 2, characterized in that said housing has a limit positioning end (311); the mounting bin (1) is provided with a limiting mounting end (12), and the limiting positioning end (311) and the limiting mounting end (12) are arranged in an inserted mode.

9. A combination, comprising:

the temperature regulating structure of any one of claims 1-8;

an ion source (5) disposed within the housing;

the communicating pipeline is connected with the connecting end of the ion source (5) and is arranged in the accommodating cavity (11).

10. A biochemical analysis apparatus comprising a combination according to claim 9.

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