CN213091278U

CN213091278U - Sampling assembly for drug dissolution instrument

Info

Publication number: CN213091278U
Application number: CN202022213652.7U
Authority: CN
Inventors: 刘琨
Original assignee: Liaoning Huarui Pharmaceutical Co ltd
Current assignee: Liaoning Huarui Pharmaceutical Co ltd
Priority date: 2020-10-08
Filing date: 2020-10-08
Publication date: 2021-04-30
Anticipated expiration: 2030-10-08

Abstract

The utility model discloses a sampling subassembly for medicine is dissolved out appearance, including sampling case, lifting plate, sampler barrel, the sampler barrel is located inside the sampling case, the lifting plate is located the sampler case upper end, be equipped with the scale strip on the sampler barrel, the inside division board that is equipped with of sampler barrel, the division board becomes high liquid level sample chamber and low liquid level sample chamber with the internal partitioning of sampler barrel, high liquid level sample chamber and low liquid level sample chamber bottom are connected with short sampling tube and long sampling tube respectively, high liquid level sample chamber and low liquid level sample chamber bottom one side all are connected with the fluid-discharge tube. The utility model discloses a set up high liquid level sample chamber and low liquid level sample chamber to be connected with short sampling tube, long sampling tube respectively at high liquid level sample chamber and low liquid level sample chamber bottom, during the sample, can utilize short sampling tube, long sampling tube to take a sample simultaneously, highly take a sample to the different liquid levels of the solution liquid in the same dissolution cup, realize quick layering sample, can effectively improve the detection precision.

Description

Sampling assembly for drug dissolution instrument

Technical Field

The utility model relates to a relevant technical field of medicine sampling test specifically is a sampling subassembly that is used for medicine to dissolve out appearance.

Background

The drug dissolution rate refers to the dissolution rate and dissolution degree of a drug in a specified medium from a solid preparation such as a tablet or a capsule and the like under a certain condition, is an effective means for checking the quality and production process level of the preparation, is also a standard for evaluating the bioavailability and the uniformity of active ingredients of the preparation, and can effectively distinguish the difference of the bioavailability of the same drug, so that the drug dissolution rate is one of necessary items for controlling the quality of the drug, and rapid and accurate sampling is an important link in the drug dissolution rate detection process.

However, current sampling device is mostly manual operation, and the not convenient to control sample volume, during the sample simultaneously, can not carry out the layering sample in step, the sample effect is not good, influence the precision that detects easily, and during the sample, be not convenient for filter, lead to entering into the intraductal jam sampling tube of sample easily for the granule that dissolves, influence sample work, and some have filtering mechanism, the filter head is not convenient for dismantle change and cleanness, be not convenient for use, need improve.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a sampling subassembly for medicine is dissolved out appearance to solve the problem that proposes among the above-mentioned background art.

In order to solve the technical problem, the utility model provides a following technical scheme: a sampling component for a drug dissolution instrument comprises a sampling box, a lifting plate and a sampling cylinder, wherein the sampling cylinder is positioned in the sampling box, the lifting plate is positioned at the upper end of the sampling box, the sampling cylinder is provided with a scale strip, a partition plate is arranged inside the sampling cylinder, the separation plate separates the interior of the sampling cylinder into a high liquid level sampling cavity and a low liquid level sampling cavity, the bottom ends of the high liquid level sampling cavity and the low liquid level sampling cavity are respectively connected with a short sampling tube and a long sampling tube, one side of the bottom ends of the high liquid level sampling cavity and the low liquid level sampling cavity is connected with a liquid discharge pipe, a piston plate is arranged in the high liquid level sampling cavity, the upper end of the piston plate is connected with a piston rod, the top end of the piston rod is fixedly connected with the lower surface of the lifting plate, the top end of the inner part of the high liquid level sampling cavity is provided with a limiting electric push rod, and the inner structure of the low liquid level sampling cavity is the same as that of the high liquid level sampling cavity.

Furthermore, the joints of the short sampling tube, the long sampling tube and the liquid discharge tube and the sampling tube are all provided with check valves, and the check valves in the liquid discharge tube and the flow directions of the check valves in the short sampling tube and the long sampling tube are arranged in a reverse direction.

Further, the inside driving motor that is equipped with of sample case, driving motor's output shaft fixedly connected with transmission lead screw, be equipped with screw-nut on the transmission lead screw, and the cover is equipped with a lift section of thick bamboo on the transmission lead screw, the inside of a lift section of thick bamboo and screw-nut's outer wall fixed connection, and the lift section of thick bamboo top extend to sample case outside and with lifting board lower fixed surface be connected.

Further, short sampling tube, long sampling tube bottom all are connected with the filter head, be equipped with the connecting pipe on the filter head, the filter head pass through the connecting pipe respectively with the adapter sleeve fixed connection that is equipped with on short sampling tube, the long sampling tube.

Further, adapter sleeve and short sampling tube, the inside intercommunication of long sampling tube, and all the protrusion is equipped with the stopper on the inside both sides wall of adapter sleeve, set up vertical spacing groove and the horizontal spacing groove that matches with the stopper on the connecting pipe lateral wall, vertical spacing groove and horizontal spacing groove intercommunication.

Furthermore, a sealing ring is arranged on the connecting pipe and located below the transverse limiting groove, and the connecting pipe is in sealed insertion connection with the connecting sleeve through the sealing ring.

Compared with the prior art, the utility model discloses the beneficial effect who reaches is:

(1) the utility model discloses a be equipped with the division board in the sampler barrel, and with sampler barrel internal partitioning become high liquid level sample chamber and low liquid level sample chamber, and be connected with short sampling tube, long sampling tube respectively at high liquid level sample chamber and low liquid level sample chamber bottom, during the sample, can utilize short sampling tube, long sampling tube takes a sample simultaneously, take a sample to the different liquid level height of the solution liquid in the same dissolution cup, realize quick layering sample, it is effectual to take a sample, can effectively improve the detection precision.

(2) The utility model discloses a set up the filter head to pass through connecting pipe and adapter sleeve and short sampling tube, long sampling tube with the filter head and be connected, during the installation, can insert the adapter sleeve with the filter head through the connecting pipe, make the stopper in the adapter sleeve at first block at vertical spacing inslot, then rotate the connecting pipe, make the stopper be located horizontal spacing inslot, the leakproofness and the leakproofness that the sealing washer can increase the connection simultaneously, connect stably, easy operation, it is clean to be convenient for change.

Drawings

The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention. In the drawings:

fig. 1 is a schematic view of the overall structure of the present invention;

fig. 2 is a schematic view of the internal structure of the present invention;

FIG. 3 is a schematic view of the connection structure of the section sampling tube and the filter head of the present invention;

FIG. 4 is a schematic structural view of a filter head of the present invention;

in the figure: 1. a sampling box; 2. lifting the plate; 3. a sampling tube; 4. a liquid discharge pipe; 5. a scale bar; 6. a partition plate; 7. a short sampling tube; 8. a long sampling tube; 9. a filter head; 10. a piston plate; 11. a piston rod; 12. a limiting electric push rod; 13. a lifting cylinder; 14. a drive motor; 15. a transmission screw rod; 16. a feed screw nut; 17. a connecting pipe; 18. connecting a sleeve; 19. a limiting block; 20. a longitudinal limit groove; 21. a seal ring; 22. and a transverse limiting groove.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, the present invention provides a technical solution: a sampling assembly for a drug dissolution instrument comprises a sampling box 1, a lifting plate 2 and a sampling barrel 3, wherein the sampling barrel 3 is positioned inside the sampling box 1, the lifting plate 2 is positioned at the upper end of the sampling box 1, a scale bar 5 is arranged on the sampling barrel 3, a partition plate 6 is arranged inside the sampling barrel 3, the partition plate 6 divides the inside of the sampling barrel 3 into a high liquid level sampling cavity and a low liquid level sampling cavity, the bottom ends of the high liquid level sampling cavity and the low liquid level sampling cavity are respectively connected with a short sampling tube 7 and a long sampling tube 8, one sides of the bottom ends of the high liquid level sampling cavity and the low liquid level sampling cavity are both connected with a liquid discharge tube 4, a piston plate 10 is arranged inside the high liquid level sampling cavity, the upper end of the piston plate 10 is connected with a piston rod 11, the top end of the piston rod 11 is fixedly connected with the lower surface of the lifting plate 2, and the top, the internal structure of the low liquid level sampling cavity is the same as that of the high liquid level sampling cavity.

The junction of the short sampling tube 7, the long sampling tube 8 and the liquid discharge tube 4 with the sampling tube 3 is provided with a one-way valve, the one-way valve in the liquid discharge tube 4 and the flow direction of the one-way valve in the short sampling tube 7 and the long sampling tube 8 are arranged in a reverse direction, liquid pumping and sampling can be carried out through the short sampling tube 7 and the long sampling tube 8, and liquid discharge after sampling is detected by the liquid discharge tube 4.

The sampling box is characterized in that a driving motor 14 is arranged inside the sampling box 1, an output shaft of the driving motor 14 is fixedly connected with a transmission screw rod 15, a screw rod nut 16 is arranged on the transmission screw rod 15, a lifting cylinder 13 is sleeved on the transmission screw rod 15, the inside of the lifting cylinder 13 is fixedly connected with the outer wall of the screw rod nut 16, the top end of the lifting cylinder 13 extends to the outside of the sampling box 1 and is fixedly connected with the lower surface of the lifting plate 2, the driving screw rod 15 can be driven to rotate by the driving motor 14, the screw rod nut 16 is driven to move upwards or downwards while the transmission screw rod 15 rotates, and therefore the lifting plate 2 is driven to move upwards or downwards to perform liquid pumping sampling or liquid discharging.

Short sampling tube 7, the 8 bottom of long sampling tube all are connected with filter head 9, be equipped with connecting pipe 17 on the filter head 9, filter head 9 through connecting pipe 17 respectively with the 18 fixed connection of adapter sleeve who is equipped with on short sampling tube 7, the long sampling tube 8, can utilize filter head 9 to filter the liquid medicine that enters into in short sampling tube 7, the long sampling tube 8, avoid the particulate matter to enter into short sampling tube 7, the interior jam sampling tube of long sampling tube 8.

Connecting sleeve 18 and short sampling tube 7, the inside intercommunication of long sampling tube 8, and all the protrusion is equipped with stopper 19 on the inside both sides wall of connecting sleeve 18, set up vertical spacing groove 20 and the horizontal spacing groove 22 that matches with stopper 19 on the connecting pipe 17 lateral wall, vertical spacing groove 20 and horizontal spacing groove 22 intercommunication can be so that filter head 9 and short sampling tube 7, long sampling tube 8 are connected convenient operation, and convenient to detach changes and cleans.

Be equipped with sealing washer 21 on the connecting pipe 17, sealing washer 21 is located horizontal spacing groove 22 below, connecting pipe 17 passes through sealing washer 21 and the sealed grafting of adapter sleeve 18, can utilize sealing washer 21 to increase the leakproofness that connecting pipe 17 and adapter sleeve 18 are connected to avoid entering into the liquid medicine in the adapter sleeve 18 and reveal, guarantee that the sample is effectual.

The utility model discloses a theory of operation: the sampling amount in the sampling cylinder 3 can be limited according to the scale strips 5 on the sampling cylinder 3 by extending or contracting the limiting electric push rod 12 to realize quantitative sampling, the sampling box 1 is fixed above the dissolution cup, so that the short sampling tube 7 and the long sampling tube 8 are positioned in the same dissolution cup, then the driving motor 14 is started, the driving screw 15 is driven to synchronously rotate by the forward rotation of the driving motor 14, thereby the screw nut 16 is enabled to move upwards, the lifting cylinder 13 is driven to synchronously move upwards while the screw nut 16 moves upwards, the lifting cylinder 13 moves upwards to jack up the lifting plate 2, thereby a plurality of piston rods 11 connected with the lifting plate 2 are synchronously pulled upwards, the piston plate 10 moves upwards, negative pressure is generated in the high liquid level sampling cavity and the low liquid level sampling cavity, thereby liquid medicine is extracted from the short sampling tube 7 and the long sampling tube 8 to the high liquid level sampling cavity and the low liquid level sampling cavity, and layered sampling is realized, the sampling effect is ensured to be good, so that the detection precision can be increased, the filtering heads 9 are arranged at the bottom ends of the short sampling tube 7 and the long sampling tube 8, the filtering heads 9 can be utilized to filter liquid medicines entering the short sampling tube 7 and the long sampling tube 8, the sampling tubes are prevented from being blocked by dissolved particles entering the short sampling tube 7 and the long sampling tube 8, the filtering heads 9 are inserted into the connecting sleeve 18 through the connecting pipe 17, the limiting blocks 19 in the connecting sleeve 18 are firstly clamped in the longitudinal limiting grooves 20, then the connecting pipe 17 is rotated, the limiting blocks 19 are positioned in the transverse limiting grooves 22, meanwhile, the sealing rings 21 can increase the connection tightness and the connection tightness, the connection is stable, the operation is simple, and the filtering heads 9 can be conveniently replaced for cleaning; the utility model discloses simple structure, facilitate promotion and use.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A sampling assembly for a drug dissolution instrument is characterized by comprising a sampling box (1), a lifting plate (2) and a sampling cylinder (3), wherein the sampling cylinder (3) is positioned inside the sampling box (1), the lifting plate (2) is positioned at the upper end of the sampling box (1), a scale strip (5) is arranged on the sampling cylinder (3), a partition plate (6) is arranged inside the sampling cylinder (3), the partition plate (6) divides the inside of the sampling cylinder (3) into a high liquid level sampling cavity and a low liquid level sampling cavity, the bottom ends of the high liquid level sampling cavity and the low liquid level sampling cavity are respectively connected with a short sampling tube (7) and a long sampling tube (8), one side of the bottom ends of the high liquid level sampling cavity and the low liquid level sampling cavity are respectively connected with a liquid discharge tube (4), a piston plate (10) is arranged inside the high liquid level sampling cavity, and the upper end of the piston plate (10) is connected with a piston rod (, the top end of the piston rod (11) is fixedly connected with the lower surface of the lifting plate (2), the top end of the inner part of the high liquid level sampling cavity is provided with a limiting electric push rod (12), and the inner structure of the low liquid level sampling cavity is the same as that of the high liquid level sampling cavity.

2. A sampling assembly for a drug dissolution machine as claimed in claim 1, wherein: the sampling device is characterized in that the joints of the short sampling tube (7), the long sampling tube (8) and the liquid discharge tube (4) and the sampling tube (3) are all provided with check valves, and the check valves in the liquid discharge tube (4) and the flow directions of the check valves in the short sampling tube (7) and the long sampling tube (8) are arranged in a reverse direction.

3. A sampling assembly for a drug dissolution machine as claimed in claim 1, wherein: the sampling box is characterized in that a driving motor (14) is arranged inside the sampling box (1), an output shaft of the driving motor (14) is fixedly connected with a transmission lead screw (15), a lead screw nut (16) is arranged on the transmission lead screw (15), a lifting cylinder (13) is sleeved on the transmission lead screw (15), the inside of the lifting cylinder (13) is fixedly connected with the outer wall of the lead screw nut (16), and the top end of the lifting cylinder (13) extends to the outside of the sampling box (1) and is fixedly connected with the lower surface of a lifting plate (2).

4. A sampling assembly for a drug dissolution machine as claimed in claim 1, wherein: short sampling tube (7), long sampling tube (8) bottom all are connected with filter head (9), be equipped with connecting pipe (17) on filter head (9), filter head (9) through connecting pipe (17) respectively with short sampling tube (7), the last adapter sleeve (18) fixed connection that is equipped with of long sampling tube (8).

5. A sampling assembly for a drug dissolution machine as claimed in claim 4, wherein: connecting sleeve (18) and short sampling tube (7), long sampling tube (8) inside intercommunication, and all the protrusion is equipped with stopper (19) on the inside both sides wall of connecting sleeve (18), set up vertical spacing groove (20) and horizontal spacing groove (22) that match with stopper (19) on connecting pipe (17) lateral wall, vertical spacing groove (20) and horizontal spacing groove (22) intercommunication.

6. A sampling assembly for a drug dissolution machine as claimed in claim 5, wherein: be equipped with sealing washer (21) on connecting pipe (17), sealing washer (21) are located horizontal spacing groove (22) below, connecting pipe (17) are through sealing washer (21) and connecting sleeve (18) sealed grafting.