CN213031660U - Personalized intelligent drug delivery device based on micro-needle - Google Patents

Abstract

The utility model discloses a personalized intelligence device of dosing based on micropin, including arousing equipment and fracture auxiliary base plate, the back of fracture auxiliary base plate is equipped with sealed apron, is equipped with a plurality of holes in the fracture auxiliary base plate, and the position that the inner face of fracture auxiliary base plate corresponds every hole is equipped with the medicine carrying micropin respectively, is equipped with in the hole and can arouse the material. The intelligent personalized medicine feeding treatment can be intelligently realized according to the type and the area of the pathological changes, the personalized diagnosis-treatment can be intelligently completed under the condition that a doctor is absent, the maximum utilization of medical resources is facilitated, and meanwhile, the treatment efficiency of skin diseases can be greatly improved.

Description

Personalized intelligent drug delivery device based on micro-needle

Technical Field

The utility model relates to a about promoting the skin disease and dosing efficiency and intelligent technique of dosing especially relates to a personalized intelligence device of dosing based on micropin.

Background

At present, the total number of outpatients of skin diseases per year is increasing, and the intractable skin diseases such as psoriasis, vitiligo, alopecia, melanoma, wart and the like account for a considerable part of the outpatients of skin diseases.

Systemic administration, by oral, injection, transdermal, etc., is the most common method of treating skin disorders, particularly those associated with a variety of pathological conditions. Oral administration of drugs can damage the liver and destroy the activity of protein drugs; although the injection administration has high efficiency, adverse reactions are easy to generate, and the wound and the pain are accompanied.

Transdermal drug delivery has significant advantages, relatively: the medicine is directly and conveniently conveyed into blood or lymph circulation, so that individual difference of medication is reduced; the constant administration rate can avoid the peak-valley phenomenon of blood concentration; the administration can be interrupted at any time, and the convenience and the compliance are stronger. The stratum corneum in the skin prevents drugs, especially macromolecules and non-aqueous drugs, from entering the body by natural diffusion mechanisms.

In the prior art, a microneedle which is composed of a needle-shaped structure with the scale of hundreds of microns can pierce the stratum corneum of the skin in a painless mode, and a generated permeation channel can easily improve the diffusion efficiency of a medicament by several orders of magnitude and can not cause infection and anaphylactic reaction. There are individual differences between skin lesions, the type of drug must be determined according to the type of lesion, and the amount of drug administered in the same lesion should be adjusted during treatment.

At present, different types of microneedles made of various materials, including solid microneedles, hollow microneedles, drug-coated microneedles and soluble microneedles, have been developed, but none of them can realize personalized drug delivery treatment.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a personalized intelligence device of dosing based on micropin.

The utility model aims at realizing through the following technical scheme:

the utility model discloses a device of dosing of individualized intelligence based on micropin, including arousing equipment and fracture auxiliary base plate, the back of fracture auxiliary base plate is equipped with sealed apron, be equipped with a plurality of holes in the fracture auxiliary base plate, the position that the inner face of fracture auxiliary base plate corresponds every hole is equipped with the medicine carrying micropin respectively, it can arouse the material to be equipped with in the hole.

By the foregoing the technical scheme the utility model provides a can see out, the embodiment of the utility model provides a personalized intelligence device of dosing based on micropin, can be intelligent according to pathological change type and regional realization personalized treatment of dosing, can intelligent completion individualized diagnosis-treatment under the condition that the doctor lacked, help realizes medical resource maximize and utilizes, the treatment effeciency of the promotion skin disease that also can be very big simultaneously.

Drawings

Fig. 1 is a schematic structural diagram of a microneedle-based personalized intelligent drug delivery device according to an embodiment of the present invention.

Fig. 2 is an enlarged schematic view of a portion a of fig. 1.

Fig. 3 is a schematic flow chart of a microneedle-based personalized intelligent drug delivery method according to an embodiment of the present invention.

In the figure:

1. the device comprises a stimulated breakage microneedle, 2 a drug-loading microneedle, 3 an excitable material, 4 an excitation device, 5 a cavitation device, 6 a sealing cover plate, 7 a breakage auxiliary substrate.

Detailed Description

Embodiments of the present invention will be described in further detail below. Details not described in the embodiments of the present invention belong to the prior art known to those skilled in the art.

The utility model discloses a personalized intelligence device of dosing based on micropin, the concrete implementation mode of its preferred is:

including arousing equipment and fracture auxiliary substrate, fracture auxiliary substrate's the back is equipped with sealed apron, be equipped with a plurality of holes in the fracture auxiliary substrate, the position that fracture auxiliary substrate's inner face corresponds every hole is equipped with the medicine carrying micropin respectively, be equipped with in the hole and arouse the material.

The drug-carrying micro-needle and the hole on the fracture auxiliary substrate are coaxially arranged, and the root size of the drug-carrying micro-needle is 110-125% of the radial size of the hole.

The excitable material is a material which can be excited to expand by several times after cavitation under specific conditions. Such as liposome microcapsules encapsulating PFCs.

The height of the drug-loaded microneedle is 700 micrometers.

The excitation equipment is laser excitation equipment capable of emitting set wavelength.

The utility model discloses a method that foretell individualized intelligence device of dosing based on micropin realized dosing, the concrete implementation of its preferred is:

the method comprises the following steps:

placing the lesion area to a specified position of skin diagnosis equipment implanted with a neural network model;

the skin diagnosis is to take a picture of a target area to finish the judgment and the area segmentation of the lesion type, and the obtained data are respectively used for guiding the selection of the medicine and determining the excitation area in the administration process;

selecting a suitable base material and drug based on the discriminated lesion type;

preparing a drug-loaded microneedle capable of selectively exciting fracture;

applying the micro-needle to the lesion area, finishing scanning of the administration area according to the acquired area segmentation data, and finishing the excitation of the hollow material of the micro-needle to break the micro-needle with the help of the excitation equipment;

personalized intelligent dosing is completed and the evaluation is carried out through the curative effect.

The skin disease intelligent diagnosis system comprises a camera and a processing unit, a neural network trained through deep learning is implanted, and segmentation of lesion types and lesion areas can be intelligently achieved.

The utility model discloses a personalized intelligence device of dosing based on micropin, the treatment of can be intelligent according to pathological change type and regional realization personalized dosing, can intelligent accomplish individualized diagnosis-treatment under the condition that the doctor lacked, help realizes medical resource maximize and utilizes, also can be very big simultaneously promote the treatment effeciency of dermatosis.

The specific embodiment is as follows:

as shown in fig. 1 and fig. 2, the system comprises a set of intelligent diagnosis system for skin diseases, an excitation device and a selectively excitable broken microneedle.

The skin disease intelligent diagnosis system consists of a camera and a processing unit, is implanted with a neural network trained by deep learning, and can intelligently realize the segmentation of lesion types and lesion areas.

The excitation device finishes the excitation of the hollow material in the micro-needle to break the micro-needle by emitting laser with specific wavelength, and can be realized by using a region projection or a point scanning mode.

The selectively excitable and breakable microneedle consists of a microneedle, excitable material, a breaking auxiliary substrate and a sealing cover plate (figure 1).

Microneedles were prepared in a position coaxial to the holes in the fracture assisting substrate, with the base size of the microneedles being slightly larger than the size of the holes in the fracture assisting substrate (between 110-125%) (fig. 2). Too large a contact area may result in insufficient driving force for the excitable material, while too small a contact area may result in ineffective withdrawal of the microneedle after insertion.

The force provided by the contact area of the micro-needle and the fracture auxiliary substrate is the foundation for inserting the micro-needle into the tissue and the source of the force for completely pulling out the micro-needle outside the focal region after the treatment is finished.

The excitable material sealed in the hole of the fracture auxiliary substrate can cavitate under specific conditions, and the fracture of the microneedle can be controlled by the driving force caused by the instant expansion of the volume on the premise that the contact area of the microneedle and the fracture auxiliary substrate is lower than a certain range. The excitable material possesses biocompatibility, such as liposome microcapsules encapsulating PFC, etc.

The microneedle loaded with the drug has a height of about 700 micrometers, and can be prepared by a 3D printing or pouring method.

After the personalized administration is finished, the drawn micro-needle has no sharp object and toxicity, can be treated as common medical waste, and cannot cause pollution to the environment.

The microneedle-based personalized intelligent drug delivery workflow is shown in fig. 3, and is specifically expressed by the following characters:

placing the lesion region to the designated position of the skin diagnosis device implanted with the neural network model

The skin diagnosis is carried out by photographing the target region to judge the lesion type and segment the region, and the obtained data are respectively used for guiding the selection of the medicine and determining the excitation region in the administration process

Selecting suitable base material and drug based on the identified lesion type

Selectively stimulated rupture microneedles as shown in figure 1 were prepared according to a protocol

Applying the micro-needle to the lesion region, and completing the scanning of the drug administration region according to the acquired region segmentation data with the help of the vertex excitation equipment

Complete personalized intelligent drug delivery and evaluate the curative effect

The utility model discloses an advantage and positive effect:

can complete personalized painless transdermal drug delivery according to the types of skin diseases and the lesion areas, and has convenient operation.

The selectively fractured microneedles are all prepared from biodegradable or compatible materials, the drug loading can be quickly adjusted, the preparation process is simple, and the popularization is convenient.

The micro-needle has no sharp object and toxicity, can be treated as common medical waste, and does not pollute the environment.

The personalized administration mode of the technology can shorten the treatment time, reduce the treatment pain and also help to realize the maximum utilization of medical resources.

The above description is only for the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are all covered by the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims (5)

1. The utility model provides a device of dosing of individualized intelligence based on micropin, its characterized in that, is including arousing equipment and fracture auxiliary base plate, the back of fracture auxiliary base plate is equipped with sealed apron, be equipped with a plurality of holes in the fracture auxiliary base plate, the position that the inner face of fracture auxiliary base plate corresponds every hole is equipped with the medicine carrying micropin respectively, be equipped with in the hole and arouse the material.

2. A microneedle-based personalized intelligent drug delivery device according to claim 1, wherein the drug-loaded microneedles are coaxially arranged with the holes on the fracture assisting substrate, and the root size of the drug-loaded microneedles is 110-125% of the radial size of the holes.

3. A microneedle-based personalized smart drug delivery device according to claim 2, wherein the excitable material is a liposome microcapsule encapsulating PFC.

4. A microneedle-based personalized smart drug delivery device according to claim 3, wherein the drug-loaded microneedles are 700 microns in height.

5. A microneedle-based personalized intelligent drug delivery device according to claim 4, wherein the excitation device is a laser excitation device capable of emitting a set wavelength.

Images