CN213018244U

CN213018244U - Sterile liquid introducing device in isolator

Info

Publication number: CN213018244U
Application number: CN202020986218.XU
Authority: CN
Inventors: 赵振波; 叶大林; 夏信群
Original assignee: Zhejiang Tailin Medical Engineering Co ltd
Current assignee: Zhejiang Tailin Medical Engineering Co ltd
Priority date: 2020-06-02
Filing date: 2020-06-02
Publication date: 2021-04-20
Anticipated expiration: 2030-06-02

Abstract

The utility model discloses an aseptic liquid introducing device in isolator aims at solving aseptic liquid and introduces isolator device structure complicacy, not enough with high costs. Aseptic liquid introducing device installs between isolator and aseptic liquid storage tank in the isolator, includes aseptic joint, filter, the peristaltic pump that connects gradually through external aseptic pipe, connects built-in aseptic pipe on the aseptic joint, and aseptic joint zonulae occludens is on the isolator, and inside isolator was arranged in to built-in aseptic pipe, connected external aseptic pipe between peristaltic pump and the aseptic liquid storage tank. The sterile liquid introducing device in the isolator has the advantages of simple structure, convenience in operation and greatly reduced cost.

Description

Sterile liquid introducing device in isolator

Technical Field

The utility model relates to an aseptic liquid transfer device, more specifically say, it relates to an aseptic liquid introducing device in isolator.

Background

With the implementation of new GMP in china, isolators are becoming an indispensable equipment in the production of sterile pharmaceutical products, and the isolators themselves provide the production environment for sterile pharmaceutical products, wherein it is most important to completely isolate the operators outside the production environment. The isolator adopts the hydrogen peroxide sterilization mode to realize the inside sterile environment of isolator now mostly, and the isolator sterilization needs certain time cycle, can put into the material before the isolator sterilization, treats to carry out aseptic technique after the sterilization finishes, but some materials can't accomplish to place for a long time in the isolator because of its characteristic itself, and this just needs transmit the material to the isolator inside under the condition that does not influence the inside sterile environment of isolator after the isolator sterilization.

At present, the Germany Sartorius SART device is mostly adopted in the aseptic liquid transmission isolator, aseptic liquid passes through the isolator and enters the isolator through cladding the aseptic hose in the device, but the device is expensive, the aperture of the matched hose is single, and the cost is overhigh.

SUMMERY OF THE UTILITY MODEL

The utility model overcomes aseptic liquid introduces isolator device structure complicacy, and is with high costs not enough, provides an aseptic liquid introducing device in isolator, its simple structure, convenient operation, greatly reduced the cost.

In order to solve the technical problem, the utility model discloses a following technical scheme: the utility model provides an aseptic liquid introducing device in isolator installs between isolator and aseptic liquid storage tank, includes aseptic joint, filter, the peristaltic pump that connects gradually through external aseptic pipe, connects built-in aseptic pipe on the aseptic joint, aseptic joint zonulae occludens on the isolator, and inside isolator was arranged in to built-in aseptic pipe, connected external aseptic pipe between peristaltic pump and the aseptic liquid storage tank.

The during operation, it is sealed with the ribbon to embed aseptic tube one end, the other end is connected to aseptic joint on, aseptic joint passes through external aseptic union coupling filter one end, external aseptic tube is connected to the filter other end, later put into the breathing bag with these parts that link together and seal, it sterilizes to put into damp and hot sterilizer with breathing the bag, take out breathing the bag after the damp and hot sterilization, put into the isolator before the sterilization with built-in aseptic tube, with aseptic joint zonulae occludens on the isolator, external aseptic tube on the filter is connected with the peristaltic pump. Then starting an isolator sterilization program, carrying out integral sterilization on the isolator, operating through a glove operation opening on the isolator after the isolator is sterilized, cutting off a sealing part of a ribbon at one end of a built-in sterile tube, and then carrying out sub-packaging operation on sterile liquid, wherein the whole operation process is completed in a sterile state. The sterile liquid introducing device in the isolator has the advantages of simple structure, convenience in operation and greatly reduced cost.

Preferably, the aseptic connector comprises a connecting disc and two connectors, the two connectors are respectively arranged on two end faces of the connecting disc, through holes are formed in the connectors, the through holes in the two connectors are mutually communicated, one connector is connected with the external aseptic tube, and the other connector is connected with the internal aseptic tube. The aseptic joint has simple structure, and the external aseptic tube, the internal aseptic tube and the connector are connected conveniently and reliably.

Preferably, a sleeve-shaped quick coupler is arranged at the connecting position of the isolator and the sterile coupler, and a connecting disc of the sterile coupler is tightly connected with the opening end of the quick coupler. The isolator is provided with a quick connector which is convenient for connecting with the aseptic connector.

Preferably, a sealing ring is arranged between the quick connector and the sterile connector. The sealing performance between the quick connector and the sterile connector is improved due to the arrangement of the sealing ring.

Preferably, an annular mounting groove is formed in the end face of the quick connector, a plurality of limiting grooves are uniformly distributed in the outer edge of the annular mounting groove, a connecting groove is formed in the end face of the connecting disc and corresponds to the sealing ring, the sealing ring is mounted between the annular mounting groove and the connecting groove, a plurality of limiting protrusions are arranged on the outer wall of the sealing ring and correspond to the limiting grooves one to one, and the limiting protrusions are tightly mounted in the limiting grooves. The sealing washer is installed between annular mounting groove and spread groove, and spacing arch is closely installed in the spacing groove, makes the sealing washer connect inseparabler reliable.

Preferably, the edge of the connecting disc is uniformly provided with a plurality of positioning plates, a plurality of locking columns are arranged on the quick connecting joint in a one-to-one correspondence mode with the positioning plates, L-shaped locking grooves are formed in the positioning plates and comprise axial sections and circumferential sections, sliding columns are arranged on the positioning plates, reset springs are arranged between the sliding columns and the positioning plates, one ends of the sliding columns are arranged between the axial sections and the circumferential sections in the locking grooves, the locking columns are inserted in the circumferential sections of the locking grooves, and shifting rods used for shifting the sliding columns are arranged on the sliding columns.

When the sterile connector is connected with the quick connector, the connecting disc cover is firstly closed onto the quick connector, the axial section of a locking groove in the positioning plate is inserted into the locking column, the locking column pushes the sliding column to move, after the locking column slides to the bottom of the axial section, the connecting disc rotates by an angle, the locking column slides into the circumferential section of the locking groove, the locking column is separated from the sliding column at the moment, the sliding column returns under the action of the reset spring, the locking column is limited, the locking column is prevented from sliding away from the circumferential section, and therefore the locking connection of the sterile connector and the quick connector is achieved. When the locking column needs to be disassembled, the shifting rod drives the sliding column to retract, then the aseptic joint rotates reversely, the locking column slides into the axial section from the circumferential section, and then the aseptic joint is pulled outwards, so that the disassembling can be realized. The aseptic joint and the quick coupler are convenient to disassemble and assemble, and the locking is reliable.

Preferably, a sliding groove is formed in the positioning plate and corresponds to the sliding column, the sliding column is slidably mounted in the sliding groove, the reset spring is mounted in the sliding groove, the positioning plate is connected with a limiting block, and the deflector rod abuts against the limiting block. The traveller is installed in the spout, and the slip is reliable, carries on spacingly through the stopper to the traveller, and is spacing reliable.

Preferably, the outer wall of the locking column is sleeved with a buffer sleeve, and the end face of the sliding column is provided with an inclined guide surface. The guide surface is convenient for the locking column to push the sliding column to move.

Preferably, the internal sterile tube and the external sterile tube are flexible tubes. The hose is convenient to install and lay.

Compared with the prior art, the beneficial effects of the utility model are that: the sterile liquid introducing device in the isolator has the advantages of simple structure, convenient operation and greatly reduced cost.

Drawings

Fig. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic view of the sterile fitting of the present invention;

FIG. 3 is a schematic view of the end face structure of the quick coupler of the present invention;

FIG. 4 is a schematic view of the connection structure of the aseptic joint and the quick coupler of the present invention;

in the figure: 1. isolator, 2, aseptic liquid storage tank, 3, aseptic joint, 4, the filter, 5, the peristaltic pump, 6, built-in aseptic pipe, 7, external aseptic pipe, 8, connection pad, 9, the connector, 10, anticreep mouth, 11, the ready-packaged joint, 12, the sealing washer, 13, the annular mounting groove, 14, the spacing groove, 15, the spread groove, 16, spacing arch, 17, the locating plate, 18, the locking post, 19, the axial segment, 20, the circumference section, 21, the traveller, 22, reset spring, 23, the driving lever, 24, the spout, 25, the stopper, 26, the cushion collar, 27, the spigot surface.

Detailed Description

The technical solution of the present invention is further described in detail by the following specific embodiments in combination with the accompanying drawings:

example (b): the utility model provides an aseptic liquid introducing device in isolator (see figure 1 to figure 4), installs between isolator 1 and aseptic liquid storage tank 2, includes aseptic joint 3, filter 4, peristaltic pump 5 that connect gradually through external aseptic pipe, connects built-in aseptic pipe 6 on the aseptic joint, and aseptic joint zonulae occludens is on the isolator, and inside isolator was arranged in to built-in aseptic pipe, connected external aseptic pipe 7 between peristaltic pump and the aseptic liquid storage tank. The internal sterile pipe and the external sterile pipe are flexible pipes.

The aseptic joint comprises a connecting disc 8 and two connectors 9, the two connectors are respectively arranged on two end faces of the connecting disc, through holes are arranged on the connectors, the through holes on the two connectors are mutually communicated, one connector is connected with the external aseptic tube, and the other connector is connected with the internal aseptic tube. The connector tip is equipped with anticreep mouth 10, and anticreep mouth outer wall slope sets up and is step-like structure. The isolator is provided with a sleeve-shaped quick coupler 11 at the connecting position with the sterile coupler, and a connecting disc of the sterile coupler is tightly connected with the opening end of the quick coupler. A sealing ring 12 is arranged between the quick connector and the sterile connector. The quick connector is characterized in that an annular mounting groove 13 is formed in the end face of the quick connector, a plurality of limiting grooves 14 are uniformly distributed in the outer edge of the annular mounting groove, a connecting groove 15 is formed in the end face of the connecting disc and corresponds to the sealing ring, the sealing ring is mounted between the annular mounting groove and the connecting groove, a plurality of limiting protrusions 16 are arranged on the outer wall of the sealing ring and correspond to the limiting grooves one to one, and the limiting protrusions are tightly.

The edge of the connecting disc is uniformly provided with a plurality of positioning plates 17, a plurality of locking columns 18 are arranged on the quick connecting joint in a one-to-one correspondence manner with the positioning plates, L-shaped locking grooves are formed in the positioning plates and comprise axial sections 19 and circumferential sections 20, sliding columns 21 are arranged on the positioning plates, reset springs 22 are arranged between the sliding columns and the positioning plates, one ends of the sliding columns are arranged between the axial sections and the circumferential sections in the locking grooves, the locking columns are inserted in the circumferential sections of the locking grooves, and shift levers 23 used for shifting the sliding columns are arranged on the sliding columns. The locating plate is provided with a sliding groove 24 corresponding to the sliding column, the sliding column is slidably mounted in the sliding groove, the reset spring is mounted in the sliding groove, the locating plate is connected with a limiting block 25, and the deflector rod abuts against the limiting block. The outer wall of the locking column is sleeved with a buffer sleeve 26, and the end face of the sliding column is provided with an inclined guide face 27. The locking post closely blocks in the circumference section, prevents aseptic joint axial float.

The above-described embodiments are merely preferred and are not intended to limit the present invention in any way, and other variations and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims.

Claims

1. The utility model provides an aseptic liquid introducing device in isolator installs between isolator and aseptic liquid storage tank, characterized by includes aseptic joint, filter, the peristaltic pump that connects gradually through external aseptic pipe, connects built-in aseptic pipe on the aseptic joint, and aseptic joint zonulae occludens is on the isolator, and inside the isolator was arranged in to built-in aseptic pipe, connected external aseptic pipe between peristaltic pump and the aseptic liquid storage tank.

2. The apparatus as claimed in claim 1, wherein the aseptic liquid introducing means comprises a connecting plate, two connectors respectively disposed on two end surfaces of the connecting plate, the connectors having through holes, the through holes of the two connectors being communicated with each other, one connector being connected to the external aseptic tube, and the other connector being connected to the internal aseptic tube.

3. The apparatus as claimed in claim 2, wherein a sleeve-shaped quick coupler is provided at a position of the isolator where the aseptic coupling is connected, and a connecting plate of the aseptic coupling is tightly connected to an open end of the quick coupler.

4. The apparatus as claimed in claim 3, wherein a packing is installed between the quick coupler and the aseptic coupler.

5. The device as claimed in claim 4, wherein the quick coupler has an annular mounting groove formed on its end surface, a plurality of limit grooves are formed on the outer edge of the annular mounting groove, a connecting groove is formed on the end surface of the connecting plate corresponding to the sealing ring, the sealing ring is mounted between the annular mounting groove and the connecting groove, a plurality of limit protrusions are formed on the outer wall of the sealing ring corresponding to the limit grooves, and the limit protrusions are tightly fitted in the limit grooves.

6. The sterile liquid introducing apparatus for isolator as claimed in claim 3, 4 or 5, wherein a plurality of positioning plates are uniformly arranged on the edge of the connecting plate, a plurality of locking posts are arranged on the quick-connect connector in one-to-one correspondence with the positioning plates, an L-shaped locking groove is formed in the positioning plate, the locking groove comprises an axial section and a circumferential section, a sliding post is arranged on the positioning plate, a return spring is arranged between the sliding post and the positioning plate, one end of the sliding post is arranged in the locking groove at a position between the axial section and the circumferential section, the locking post is inserted in the circumferential section of the locking groove, and a driving lever for driving the sliding post is arranged on the sliding post.

7. The device as claimed in claim 6, wherein the positioning plate has a sliding groove corresponding to the sliding post, the sliding post is slidably mounted in the sliding groove, the return spring is mounted in the sliding groove, the positioning plate is connected to the stopper, and the shift lever abuts against the stopper.

8. The device as claimed in claim 6, wherein the locking post has a buffer sleeve on its outer wall and an inclined guide surface on its end surface.

9. The apparatus for introducing a sterile liquid into an isolator as claimed in any one of claims 1 to 5, wherein the inner sterile tube and the outer sterile tube are flexible tubes.