CN2129581Y - Medical impedance and admittance picture respiration wave elimination instrument - Google Patents

Abstract

The utility model relates to a respiratory wave elimination instrument, which is used and combined with a blood wave physiological signal recorder. The instrument comprises one high-speed microprocessor system and one single-board computer terminal microprocessor system. The high-speed microprocessor system can carry out real-time digitization processing to multipath physiology signals and the single-board computer terminal microprocessor system can complete the waveform real-time display, the signal analysis, the characteristic value calculation and the result printing of each physiological signal. The high-speed microprocessor system of the instrument converts analog signals output by an impedance diagram or an admittance diagram to digital signals, then the cycle of electrocardiosignal is used to carry out synchronous identification to the cycle of the signals, and finally, according to a cardiac cycle, by using the method of adaptive digital filtering, interference to respiratory wave in the signals is eliminated.

Description

Medical impedance and admittance picture respiration wave elimination instrument

This utility model is that the respiratory wave of a kind of and medical blood ripple physiological signal monitor adapted is eliminated instrument.

Electrical impedance figure or electric dmittance chart medically are being called " rheography ", and it is to utilize bio-electrical impedance or electric conductance to receive inspection technique to trace in the tested zone fluctuation status of comprehensive volumetric blood.Because the rheography technology can be observed the sanguimotor fluctuation status of inside of human body non-invasi, have easy again, the advantage that can carry out repeatedly, therefore, in recent years, the rheography Clinical application obtains paying attention to and development, and some branches have been formed, such as: be called " the brain blood figure " that observes the cerebral blood circulation fluctuation status with this kind method, observe be called " lung hemogram " of partial circulating (also claiming pulmonary circulation) fluctuations in blood state, lung hemogram particularly, progressively obtain understanding and application in recent years, because it can reflect cardiovascular functional status from cardiac mechanical usefulness and partial circulating hemodynamic angle, at present, there is not other inspection method can accomplish this point as yet, therefore, the lung hemogram diagnostic techniques has special meaning and future aspect heart disease diagnosis, development along with the rheography technology, rheograph also just should improve thereupon and develop, existing rheograph, also claim blood ripple physiological signal monitor, their measurement is owing to be based on the bio-electrical impedance principle, thereby be subjected to very easily that Human Physiology is interferential to be influenced, the influence of respiratory wave is very serious when particularly measuring lung hemogram, make signal produce serious distortion, when clinical practice, for fear of this interference, have to allow the measured hold one's breath, this is for patient, particularly heart patient or child are difficult to cooperate, simultaneously, because the degree difference of holding one's breath, it also is not exclusively the same both having made the rheography of measuring at different time for same individual, therefore, the elimination respiratory wave disturbs, and accurately measures rheography and have clinical meaning widely under the state that human body is freely breathed.

The purpose of this utility model is to provide a kind of medical impedance, dmittance chart respiratory wave to eliminate instrument and various blood flowmeter adapted at above-mentioned situation, thereby the respiratory wave of eliminating in the blood ripple signal disturbs, and the measured is detected under the situation of eupnea.

Show according to Human Physiology analysis and experiment, the rheography signal is to go up total demonstration when the coordination mutually with the fluctuation situation of the arterial blood ripple of a cardiac cycle and venous blood ripple, the fluctuation of this blood shows the variation that causes blood volume in the tested zone, therefore, it and heart electricity excition are closely-related, that is: a heart electricity excition cycle, the period of waves that then must cause a blood ripple arranged; And respiratory wave is the demonstration of being breathed caused thoracic cavity volume-variation amount by lungs, and it is determined by the human body respiration rule and the heart electricity excition cycle has nothing to do.

Can judge according to above-mentioned analysis and experiment:

The first, rheography signal and respiratory wave are linear superposition, the cycle of rheography signal and the heart electricity excition cycle synchronisation of incoherent two periodic signals mutually.

The second, the equal right and wrong of rheography signal and respiratory wave are periodic signal stably, and it is non-stationary and periodically by individual variation and the decision of physiology pathological changes.

According to above-mentioned 2 judgements, this utility model adopts following scheme to realize the purpose of this utility model: the analog signal conversion with impedance diagram instrument or the output of dmittance chart instrument becomes digital signal earlier, with the cycle of electrocardiosignal the cycle of blood ripple signal is discerned synchronously then, adopted the method for self-adaptive digital signal filtering to eliminate the interference of the respiratory wave in the blood ripple signal by cardiac cycle at last.This utility model concrete structure is: referring to Fig. 2, this instrument has a high speed microprocessor system that the multichannel physiological signal is carried out the real-time digitization processing, this system comprises: the analog switch 8 that receives the input of multichannel physiological signal, be connected on the sampling holder 9 of each analoging switch output end, the physiological signal of each sampling holder output is carried out the multi-channel gating switch 10 of order gating, the A/D converter 11 that each sampled signal that multi-channel gating switch is exported is successively carried out mould/number conversion, signal to A/D converter output carries out the temporary data register 12 of data, the control sampling, multi channel selecting, A/D conversion and data are deposited the sequence circuit 13 of sequential, being used to send action command works foregoing circuit in order, and have a high speed microprocessor 15 of data storage 14, one for eliminating the electrocardiosignal identification circuit 16 that the interferential subprogram of respiratory wave provides marking signal in the microcomputer 15, this instrument also has one can show and finish the single board computer terminal microprocessing systems 4 that signal analysis and eigenvalue calculation and result are printed in real time according to the waveform that the deal with data that the high speed microprocessor system is provided is finished each physiological signal, this system connects machine by a shared data reservoir 19 with described high speed microprocessor system.

The respiratory wave that this utility model can effectively be eliminated in the rheography signal disturbs or other randomness noise jamming, make patient under the eupnea situation, to detect, this be general rheograph can not accomplish, can also finish simultaneously the real-time demonstration of waveform and the functions such as signal analysis and eigenvalue calculation of multichannel physiological signal, this also is that existing rheograph is unexistent.

Describe in detail according to embodiment below.

Fig. 1, contour structures sketch map of the present utility model.

Fig. 2, block diagram of the present utility model.

Fig. 3, the circuit diagram of analog switch.

Fig. 4, sampling, multi channel selecting, A/D conversion, data are deposited the structure chart of sequence circuit.

Fig. 5, high speed microprocessor, data storage, the electrical schematic diagram of shared data storage.

Fig. 6, the schematic diagram of electrocardiosignal identification circuit.

Fig. 7, the electrocardiosignal sketch map.

Referring to Fig. 3, this routine analog switch is made of two CD4053 device 8-1, and it can admit the input of six tunnel analogue signals, and these signals are sent into the input of analog switch by porous socket 5, and by the P of microcomputer _1.4The open and close of mouth control analog switch, only requiring under the situation of observing the rheography waveform, should import electrocardio and blood ripple two-way analogue signal simultaneously,, can import corresponding analogue signal by other four tunnel standby input ports if also require to observe other physiological signal simultaneously.

Referring to Fig. 4, each road signals sampling keeper by a limit with device 9-1, sampling holder 9-2 and governing stage 9-3 constitute, multi-channel gating switch is made of device 10, the A/D conversion is made of device 11-1, data register is made of device 12-2, the clock circuit of A/D converter is made of crystal oscillator 11-2 and frequency divider 11-3, this circuit also provides the sequential lock-out pulse for sequence circuit simultaneously, sequence circuit reaches two monostable device 13-3 by coincidence counter 13-1 and programmable array 13-2 and constitutes, gating order by coincidence counter control multi-channel gating switch, and simultaneously by programmable array pre-register address, by the sequential that programmable array control A/D changes and data are deposited.

The work process of Fig. 3,4 circuit is as follows: during work, microcomputer 15 passes through P _1.4Mouth is opened the analog switch among Fig. 3, and each road signal enters sampling holder by follower, and microcomputer passes through P every a sampling period then _1.0Mouth is sent a pulse signal, start among Fig. 4 circuit working once, each work process is as follows: the P of microcomputer _1.0The sampled signal of mouth output, make the 2Q end of device 13-3 produce a trigger impulse, each sampling holder of this signal controlling is sampled simultaneously to each road signal and is kept, the LOAD end of coincidence counter 13-1 is sent in another pulse of 2 Q of device 13-3 end generation simultaneously, this device is changed to initial state, then the Q of this device _A, Q _B, Q _CThe initial value of end is added to A, B, the C control end of multi-channel gating switch 10, makes it select one road signal to pass through earlier, and the 2 Q end pulse of device 13-3 is also sent into programmable array together with the initial value of coincidence counter, makes its initialization, then its F ₆End produces the signal of a startup A/D device job, send into the SC end of device 11-1, then device 11-1 first via analogue signal that device 10 is sent into is carried out mould/number conversion, after mould/number conversion is finished, send by its SS end and to finish signal, the CK end that this signal is sent into device 13-1 makes it make counting, then its Q synchronously _A, Q _B, Q _CEnd produces a New count value, this count value control device 10 selects another road signals to send into device 11-1, this finish signal also 1 Q end output, one pulse signal of control device 13-3 with the I of the New count value entering apparatus 13-2 of device 13-1 ₁, I ₂, I ₃, I ₄End makes it at F ₅, F ₄, F ₃End produces write address and control signal, sends into the W of data register 12-2 _A, W _B, G _WEnd, then the first via signal of A/D device 11-1 output is imported in the data register by level converter 12-1 and is kept in, then the F of device 13-2 ₆End produces an enabling signal again, and starter 11-1 carries out mould/number conversion to another road signal, so repeat, and after all each road signals all convert and deposit data register in, the F of device 13-2 ₂End is to the INT of microcomputer ₁Mouth sends interrupt request singal, and microcomputer passes through P after in time detecting interrupt requests _1.1Mouth is sent the I that a recall signal is sent into device 13-2 ₅End is to remove F ₂The interrupt request singal of end, then microcomputer is taken each circuit-switched data away and is deposited in the data storage 14 from data register, and then passes through P _1.0Mouth is sent the triggering signal in next sampling period, and then the circuit among Fig. 4 is worked once again, so repeats down, makes each road signal deposit in the data storage 14 with the form of numeral.

Referring to Fig. 5, high speed microprocessor 15 adopts single-chip microcomputer 8051, data, address and the control bus of the depositor in its data address and the control bus A map interlinking 4, device 62256 is data storages 14, device V61C32P shares data storage 19, it is also referred to as the twoport data storage, data, the address of its communication port and microcomputer 15, control bus joins, the data of single board computer system 4 among another one communication port and Fig. 2, address, control bus join, thereby realize company's machine of two systems.

Referring to Fig. 7, the P ripple and the QRS that have indicated electrocardiosignal among the figure involve the T ripple, and the name of this each ripple of signal is medically general name.Electrocardiosignal identification circuit described in Fig. 3 mainly is that P ripple in the electrocardiosignal and QRS ripple are discerned, that is to say that the processing by this circuit produces an index pulse at the rising edge place of P ripple and QRS ripple, send into microcomputer 15, microcomputer is discerned the cycle of blood ripple signal synchronously according to this index pulse, and according to cardiac cycle blood ripple signal is done elimination and inhale the processing of exhaling wave interference.

Referring to Fig. 6, electrocardiosignal is amplified by the differential of differential amplifier 16-1, by diode 16-2 the rising edge of each ripple among Fig. 7 is done detection, control each ripple by comparison amplifier 16-3 then and on certain level, produce a saltus step pulse, the two monostable device 16-4 of this pulse-triggered produce corresponding pulses, adopting two-way is the needs of controlling owing to level, and the two row pulses that two monostable device 16-4 produce equal state are sent to the P of microcomputer through programmable array 16-5 composition sequence state _1.2And P _1.3Mouthful, after it finishes a cardiac cycle pulse train state memorization, just to the INT of microcomputer ₀Mouth is sent out interrupt requests, and microcomputer is in time answered, and passes through P _1.5Mouth is sent recall signal to eliminate F ₆The request signal of end, microcomputer is discerned and above-mentioned period treatment blood ripple signal synchronously according to this pulse train then, disturbs thereby eliminate respiratory wave.

Again referring to Fig. 2, system 4 is single board computer microterminal processing systems of a standard, this system is furnished with keyboard 3, display panel 1, the D/A conversion delivery outlet of printer 2 and Ge Lu signal can be furnished with monitor at this equipped at outlet port, and display panel, printer and monitor all belong to outut device, monitor is finished tracing of each road waveform, can carry out the real-time demonstration of each road waveform and the signal analysis and the eigenvalue calculation of certain road waveform according to the requirement of keyboard operation on display.If desired, this system can also be provided with a shared storage 6, so that connect machine with more large-scale pico computer.

Referring to Fig. 1, display panel 1 and keyboard 3 among Fig. 2 are installed on the shell, and the 2nd, printer, the 5th, signal input socket, the 7th, D/A changes delivery outlet.

Claims (1)

1, medical impedance, dmittance chart respiratory wave are eliminated instrument, it is characterized in that:

1.1, have one the multichannel physiological signal carried out the high speed microprocessor system that real-time digitization is handled, this system comprises:

1.1.1, receive the input of multichannel physiological signal analog switch 8,

1.1.2, be connected on the sampling holder 9 of each analoging switch output end,

1.1.3, the physiological signal of each sampling holder output is carried out the multi-channel gating switch 10 of order gating,

1.1.4, each sampled signal that multi-channel gating switch is exported successively A/D converter 11 of carrying out mould/number conversion,

1.1.5, the signal of A/D converter output is carried out the temporary data register 12 of data,

1.1.6, control sampling, multi channel selecting, A/D conversion and data deposit the sequence circuit 13 of sequential,

1.1.7, be used to send action command and foregoing circuit is worked in order and have a high speed microprocessor 15 of data storage 14,

1.1.8, one for eliminating the interferential subprogram of respiratory wave and provide the electrocardiosignal identification circuit 16 of marking signal in the microcomputer 15,

1.2, have one and can show in real time according to the waveform that the deal with data that the high speed microprocessor system is provided be finished each physiological signal and can finish the single board computer terminal microprocessing systems 4 that signal analysis and eigenvalue calculation and result are printed, this system connects machine by a shared data reservoir 19 with described high speed microprocessor system.

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