CN212882345U

CN212882345U - Dipalmitoyl phosphatidylcholine agitated vessel

Info

Publication number: CN212882345U
Application number: CN202020963391.8U
Authority: CN
Inventors: 杨锋; 李颖; 杨山水; 杨静; 程彦丰
Original assignee: Nanjing Jinkaimu Nano Materials Co ltd
Current assignee: Nanjing Jinkaimu Nano Materials Co ltd
Priority date: 2020-05-29
Filing date: 2020-05-29
Publication date: 2021-04-06
Anticipated expiration: 2030-05-29

Abstract

The utility model discloses a dipalmitoyl phosphatidylcholine agitated vessel relates to agitated vessel's technical field, aims at solving the agitated vessel bottom and can be owing to appear the solid too many to cause the bottom of the kettle or pipe blockage, lead to the problem that the material can't be carried. The technical scheme is characterized in that a liquid feed port, a powder feed port and a solid feed port are arranged at the top of a reaction kettle body, a material box is communicated above the powder feed port, a high-pressure air pump is arranged right above the material box, and a pressure pipe is communicated between the high-pressure air pump and the material box; the reaction kettle body is provided with a liquid discharge port and a solid discharge port, the liquid discharge port is higher than the solid discharge port, the liquid discharge port is provided with a filter plate, the solid discharge port is connected with a discharge pipe, and the discharge pipe is transversely connected with a screw conveyor. The utility model discloses the effect that prevents to appear the material and block up the reation kettle bottom has been reached.

Description

Dipalmitoyl phosphatidylcholine agitated vessel

Technical Field

The utility model belongs to the technical field of agitated vessel's technique and specifically relates to a dipalmitoyl phosphatidylcholine agitated vessel is related to.

Background

Dipalmitoyl phosphatidylcholine (DPPC) is an important artificially synthesized phospholipid, is mainly applied to the preparation of liposome, is an indispensable additive auxiliary material in liposome pharmaceutical preparations, has high purity and good stability, has stronger oxidation resistance than natural phospholipid, and has very ideal liposome preparation effect.

Chinese patent No. CN105753897B discloses a method for preparing DPPC, a synthetic phospholipid, using stirring equipment. In example 1, 50g of glycerophosphorylcholine, 200g of palmitic acid, 95g of DMAP, 1000mL of chloroform were added to a clean, dry 2000mL three-necked flask. Stirring by magnetic force uniformly, and replacing and protecting by argon. 165g of DCC was dissolved in 1000mL of chloroform, and the DCC-chloroform solution was added dropwise to the reaction system. The reaction is carried out for 5 hours under the condition of keeping away from light and at the temperature of below 20 ℃. A large amount of white insoluble solid appears in the reaction process, and the reaction is stopped by TLC detection. The reaction solution was filtered to remove DCU as a white insoluble solid, and a bright yellow transparent liquid was obtained.

The above prior art solutions have the following drawbacks: in industrial production, the bottom of the stirring equipment can cause the blockage of a kettle bottom or a pipeline due to the precipitation of too much solids, so that the materials cannot be conveyed. Production usually needs to be interrupted at this moment, and the plug of manual work to reation kettle bottom is clear away, and this just leads to production efficiency to reduce, and this brings certain potential safety hazard to field operation person's work simultaneously.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a dipalmitoyl phosphatidylcholine agitated vessel, it has the effect that prevents to appear the material and block up the reation kettle bottom.

The above utility model discloses an above-mentioned utility model purpose can realize through following technical scheme:

a dipalmitoyl phosphatidylcholine agitated vessel comprises a reaction kettle body, wherein a liquid feed inlet, a powder feed inlet and a solid feed inlet are formed in the top of the reaction kettle body, a material box is communicated above the powder feed inlet, a high-pressure air pump is arranged right above the material box, and a pressurizing pipe is communicated between the high-pressure air pump and the material box; the reaction kettle is characterized in that a liquid discharge port and a solid discharge port are formed in the reaction kettle body, the liquid discharge port is higher than the solid discharge port, a filter plate is arranged at the liquid discharge port, a discharge pipe is connected at the solid discharge port, and the discharge pipe is transversely connected with a screw conveyor.

The utility model discloses further set up to: the reation kettle is internal to be provided with the (mixing) shaft along vertical direction, the (mixing) shaft overcoat is equipped with the cartridge filter, the cartridge filter can be dismantled with the reation kettle body and be connected, the solid feed inlet is connected with the solid inlet pipe that stretches into in the cartridge filter.

The utility model discloses further set up to: the top symmetry of cartridge filter is provided with two installation pieces, be provided with the mounting groove that extends along vertical direction on the inside wall of the reation kettle body, the mounting groove top extends to reation kettle body roof, the installation piece with correspond mounting groove sliding connection, the mounting groove top is provided with the mounting panel, mounting panel and reation kettle body bolted connection, threaded connection has the screw rod on the mounting panel, the screw rod bottom is passed the mounting panel and is offseted with the installation piece.

The utility model discloses further set up to: the filter can be dismantled with the liquid discharge mouth and be connected, bolted connection between filter and the reation kettle body.

The utility model discloses further set up to: and the liquid discharge port and the solid discharge port are respectively provided with a first valve body and a second valve body.

The utility model discloses further set up to: the liquid discharge gate is provided with a plurality ofly and is located the circumference lateral wall of the reation kettle body respectively, each the highly all difference of liquid discharge gate, the solid discharge gate is located reation kettle body diapire, be provided with the observation window that is used for observing liquid level height on the reation kettle body, the observation window extends along vertical direction.

To sum up, the utility model discloses a beneficial technological effect does:

1. through the arrangement of the liquid feed inlet, the powder feed inlet, the solid feed inlet, the material box, the high-pressure air pump, the pressure pipe, the liquid discharge outlet, the solid discharge outlet, the filter plate, the discharge pipe and the screw conveyer, materials in different states enter the reaction kettle body through different inlets, the inlet blockage caused by different materials is avoided, the high-pressure air pump can increase the air pressure in the material box, so that the powdery materials can continuously enter the reaction kettle body, the liquid in the mixed liquid is filtered and discharged from the liquid discharge outlet, the blockage is avoided, precipitated precipitates are accumulated at the solid discharge outlet, and the precipitates enter the screw conveyer and are discharged under the action of gravity, and the accumulation is avoided;

2. through the arrangement of the filter cartridge and the solid feeding pipe, solid materials or impurities which are insoluble in water are limited in the filter cartridge to be cleaned uniformly, so that the solid materials or the impurities are prevented from being mixed with precipitates, the discharging pressure of the solid discharging port is increased, and the material purity of the solid discharging port is guaranteed;

3. through the setting of a plurality of different height liquid discharge gates and observation window, utilize the interface of observation window observation liquid level and solid sediment, find nearest liquid discharge gate above this interface, when avoiding blockking up, separate solid and liquid mixture most effectively.

Drawings

Fig. 1 is a schematic overall structure diagram of an embodiment of the present invention;

FIG. 2 is a sectional view of the inside of a reaction vessel body according to an embodiment of the present invention;

fig. 3 is a top view of the internal structure of the embodiment of the present invention.

In the figure, 1, a reaction kettle body; 11. a liquid feed port; 12. a powder feeding port; 13. a solids feed port; 14. a material box; 15. a high pressure air pump; 16. a pressurizing pipe; 3. a liquid discharge port; 31. a filter plate; 32. a first valve body; 4. a solid discharge port; 41. a discharge pipe; 42. a screw conveyor; 43. a second valve body; 5. a stirring shaft; 6. a filter cartridge; 61. a solids feed tube; 62. mounting blocks; 63. mounting grooves; 64. mounting a plate; 65. a screw; 7. and (4) an observation window.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

Referring to fig. 1, for the utility model discloses a dipalmitoyl phosphatidylcholine agitated vessel, including the reation kettle body 1, reation kettle body 1 top is provided with liquid feed inlet 11, powder feed inlet 12 and solid feed inlet 13, and powder feed inlet 12 top intercommunication has material box 14, is provided with high compression pump 15 directly over the material box 14, and the intercommunication has the forcing pipe 16 between high compression pump 15 and the material box 14. The high-pressure air pump 15 can increase the air pressure in the material box 14, so that the powdery materials can continuously enter the reaction kettle body 1, and the dust pollution caused by directly pouring the powdery materials into the powder feeding hole 12 is avoided. The materials in different states enter the reaction kettle body 1 from different inlets, so that the blockage caused by the fact that the liquid material, the solid and the powder share one inlet is avoided.

Referring to fig. 1, a liquid discharge port 3 and a solid discharge port 4 are arranged on a reaction kettle body 1, and the liquid discharge port 3 is higher than the solid discharge port 4. The liquid discharge port 3 and the solid discharge port 4 are respectively provided with a first valve body 32 and a second valve body 43. The liquid discharge ports 3 are arranged in a plurality and are respectively positioned on the circumferential side wall of the reaction kettle body 1, and the heights of the liquid discharge ports 3 are all different and are uniformly distributed from high to low. The solid discharge port 4 is located the 1 diapire of the reaction kettle body, and the solid discharge port 4 is connected with a discharge pipe 41, and the discharge pipe 41 is connected with a screw conveyer 42 arranged in the horizontal direction. The reaction kettle body 1 is provided with an observation window 7 for observing the height of the liquid level, and the observation window 7 extends along the vertical direction. The interface between the liquid level and the solid sediment is observed by using the observation window 7, the liquid discharge port 3 which is closest to the interface is found above the interface, the first valve body 32 is opened to discharge the liquid, and then the second valve body 43 and the screw conveyer 42 are opened to discharge the solid, so that the solid and the liquid mixture are separated most effectively while the blockage is avoided.

Referring to fig. 2, 3 departments of liquid discharge hole are provided with filter 31, and filter 31 can be dismantled with liquid discharge hole 3 and be connected, bolted connection between filter 31 and the reation kettle body 1, and convenient regular dismantlement filter 31 washs, avoids blockking up.

Referring to fig. 2, a stirring shaft 5 is arranged in the reaction kettle body 1 along the vertical direction, a filter cartridge 6 is sleeved outside the stirring shaft 5, the filter cartridge 6 is detachably connected with the reaction kettle body 1, and a solid feeding hole 13 is connected with a solid feeding pipe 61 extending into the filter cartridge 6.

For realizing the removable connection of cartridge filter 6 and the reation kettle body 1, refer to fig. 3, the top symmetry of cartridge filter 6 is provided with two installation pieces 62, be provided with the mounting groove 63 that extends along vertical direction on the inside wall of the reation kettle body 1, the mounting groove 63 top extends to the reation kettle body 1 roof, installation piece 62 with correspond mounting groove 63 sliding connection, mounting groove 63 top is provided with mounting panel 64, mounting panel 64 and the reation kettle body 1 bolted connection, threaded connection has screw rod 65 on the mounting panel 64, screw rod 65 bottom is passed mounting panel 64 and is offseted with installation piece 62.

The embodiment of this specific implementation mode is the preferred embodiment of the present invention, not limit according to this the utility model discloses a protection scope, so: all equivalent changes made according to the structure, shape and principle of the utility model are covered within the protection scope of the utility model.

Claims

1. The utility model provides a dipalmitoyl phosphatidylcholine agitated vessel, includes the reation kettle body (1), its characterized in that: a liquid feeding hole (11), a powder feeding hole (12) and a solid feeding hole (13) are formed in the top of the reaction kettle body (1), a material box (14) is communicated above the powder feeding hole (12), a high-pressure air pump (15) is arranged right above the material box (14), and a pressure pipe (16) is communicated between the high-pressure air pump (15) and the material box (14); the reactor is characterized in that a liquid discharge port (3) and a solid discharge port (4) are formed in the reactor body (1), the liquid discharge port (3) is higher than the solid discharge port (4), a filter plate (31) is arranged at the liquid discharge port (3), a discharge pipe (41) is connected at the solid discharge port (4), and the discharge pipe (41) is transversely connected with a screw conveyor (42).

2. The dipalmitoylphosphatidylcholine stirring apparatus according to claim 1, wherein: be provided with (mixing) shaft (5) along vertical direction in the reation kettle body (1), (mixing) shaft (5) overcoat is equipped with cartridge filter (6), cartridge filter (6) can be dismantled with reation kettle body (1) and be connected, solid feed inlet (13) are connected with solid inlet pipe (61) that stretch into in cartridge filter (6).

3. The dipalmitoylphosphatidylcholine stirring apparatus according to claim 2, wherein: the top symmetry of cartridge filter (6) is provided with two installation pieces (62), be provided with on the inside wall of the reation kettle body (1) along mounting groove (63) that vertical direction extends, mounting groove (63) top extends to the reation kettle body (1) roof, installation piece (62) and corresponding mounting groove (63) sliding connection, mounting groove (63) top is provided with mounting panel (64), mounting panel (64) and reation kettle body (1) bolted connection, threaded connection has screw rod (65) on mounting panel (64), screw rod (65) bottom is passed mounting panel (64) and is offseted with installation piece (62).

4. The dipalmitoylphosphatidylcholine stirring apparatus according to claim 1, wherein: the filter (31) is detachably connected with the liquid discharge hole (3), and the filter (31) is connected with the reaction kettle body (1) through bolts.

5. The dipalmitoylphosphatidylcholine stirring apparatus according to claim 1, wherein: the liquid discharge port (3) and the solid discharge port (4) are respectively provided with a first valve body (32) and a second valve body (43).

6. The dipalmitoylphosphatidylcholine stirring apparatus according to claim 1, wherein: liquid discharge gate (3) are provided with a plurality ofly and are located the circumference lateral wall of the reation kettle body (1) respectively, each the highly all difference of liquid discharge gate (3), solid discharge gate (4) are located reation kettle body (1) diapire, be provided with observation window (7) that are used for observing liquid level height on the reation kettle body (1), observation window (7) extend along vertical direction.