CN212800374U - Automatic change reactor that acid-base adjusted - Google Patents
Automatic change reactor that acid-base adjusted Download PDFInfo
- Publication number
- CN212800374U CN212800374U CN202021062322.6U CN202021062322U CN212800374U CN 212800374 U CN212800374 U CN 212800374U CN 202021062322 U CN202021062322 U CN 202021062322U CN 212800374 U CN212800374 U CN 212800374U
- Authority
- CN
- China
- Prior art keywords
- acid
- reaction tank
- alkali
- reaction
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
- 230000008859 change Effects 0.000 title claims description 6
- 238000006243 chemical reaction Methods 0.000 claims abstract description 98
- 239000003513 alkali Substances 0.000 claims abstract description 65
- 238000003756 stirring Methods 0.000 claims abstract description 43
- 239000002585 base Substances 0.000 claims abstract description 36
- 239000012295 chemical reaction liquid Substances 0.000 claims abstract description 10
- 238000010438 heat treatment Methods 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 20
- 230000007246 mechanism Effects 0.000 claims description 13
- 230000002572 peristaltic effect Effects 0.000 claims description 12
- 230000009467 reduction Effects 0.000 claims description 7
- 238000003860 storage Methods 0.000 claims description 6
- 230000003750 conditioning effect Effects 0.000 claims 9
- 239000006260 foam Substances 0.000 abstract description 22
- 239000000843 powder Substances 0.000 abstract description 20
- 238000000034 method Methods 0.000 abstract description 17
- 230000008569 process Effects 0.000 abstract description 12
- 230000008844 regulatory mechanism Effects 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 230000004308 accommodation Effects 0.000 abstract description 2
- 230000009466 transformation Effects 0.000 abstract description 2
- 244000144977 poultry Species 0.000 description 19
- 210000000941 bile Anatomy 0.000 description 18
- 239000000463 material Substances 0.000 description 17
- 238000002156 mixing Methods 0.000 description 12
- 108090000790 Enzymes Proteins 0.000 description 10
- 102000004190 Enzymes Human genes 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000006872 improvement Effects 0.000 description 8
- 239000002994 raw material Substances 0.000 description 8
- 230000036983 biotransformation Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000001105 regulatory effect Effects 0.000 description 7
- BHTRKEVKTKCXOH-UHFFFAOYSA-N Taurochenodesoxycholsaeure Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(=O)NCCS(O)(=O)=O)C)C1(C)CC2 BHTRKEVKTKCXOH-UHFFFAOYSA-N 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- BHTRKEVKTKCXOH-LBSADWJPSA-N tauroursodeoxycholic acid Chemical group C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)CC1 BHTRKEVKTKCXOH-LBSADWJPSA-N 0.000 description 4
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 239000011344 liquid material Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 238000010008 shearing Methods 0.000 description 3
- 239000013543 active substance Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 241000282453 Ursus americanus Species 0.000 description 1
- 241000282454 Ursus arctos Species 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 235000021581 juice product Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model relates to the field of artificial bear gall powder industrialized production equipment, and discloses an automatic acid-base regulation reactor, which comprises a reaction tank, wherein an acid-base regulation mechanism is arranged in the reaction tank, the acid-base regulation mechanism comprises an alkali adding component and a defoaming component, the alkali adding component comprises an alkali adding pipe, and the bottom end of the alkali adding pipe is positioned below the reaction liquid level; the defoaming assembly comprises a stirring shaft which is rotatably connected inside the reaction tank, and the upper part of the stirring shaft is provided with a defoaming paddle. The utility model provides a biological conversion reactor among the prior art in acid-base accommodation process, alkali lye is blockked by the foam easily and is caused local alkali lye concentration in the reaction system too high, influences the problem of transformation reaction.
Description
Technical Field
The utility model relates to an artifical bear gall powder industrial production equipment field, concretely relates to automatic change reactor that acid-base adjusted.
Background
The fel Ursi powder is prepared from gallbladder of black bear or brown bear of Uridae, and has effects of clearing heat, suppressing hyperactive liver, improving eyesight, promoting bile flow, relieving spasm, and dissolving calculus. The bear gall powder mainly contains bile acid, and the main effective component of the bear gall powder is tauroursodeoxycholic acid (TUDCA), and the TUDCA content specified by Chinese pharmacopoeia is not less than 23%. At present, bear gall powder in the domestic medicine market is prepared by mainly relying on import and a method of taking gall from live bears, and the TUDCA prepared by a chemical synthesis method is not widely applied due to complicated steps, high cost and great environmental pollution. Adopts biotechnology to biologically convert the widely sourced poultry bile juice product into a substitute resource of natural bear gall powder, not only solves the problem of shortage of the bear gall powder resource, but also is beneficial to promoting the modernization process of the traditional Chinese medicine technology.
The industrial preparation of the artificial bear gall powder needs to introduce the poultry bile or the poultry gall cream or the poultry gall powder into a conversion reactor, after adding the invertase, the conversion temperature needs to be controlled within 20.0-30.0 +/-1.0 ℃, the pH value needs to be accurately controlled within 5.00-10.00 +/-0.05, and the mixture is fully stirred and reacted for 2-24 hours under the condition of low shearing force; the reaction was terminated after the completion of the conversion, and the conversion was completed. In the biotransformation reaction process, the accurate control of the pH of the reaction system is particularly important, and can directly influence the accumulation of effective active substances, but when the conversion reactor in the prior art adjusts the pH in the reaction system, alkali liquor is usually directly dripped into the reaction tank, but because of the characteristics of raw materials in the reaction system, foam is easily generated in the stirring reaction process, the foam can block the dispersion of the alkali liquor, so that the concentration of local alkali liquor in the reaction system is too high, and adverse effects can be generated on the conversion reaction.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing an automatic change reactor that acid-base was adjusted to solve the biotransformation reactor among the prior art in acid-base accommodation process, alkali lye is blockked by the foam easily and causes local alkali lye concentration too high in the reaction system, influences the problem of transformation reaction.
In order to achieve the above purpose, the utility model adopts the following technical scheme: an automatic acid-base regulation reactor comprises a reaction tank, wherein an acid-base regulation mechanism is arranged in the reaction tank, the acid-base regulation mechanism comprises an alkali adding component and a defoaming component, the alkali adding component comprises an alkali adding pipe, and the bottom end of the alkali adding pipe is positioned below the reaction liquid level; the defoaming assembly comprises a stirring shaft which is rotatably connected inside the reaction tank, and the upper part of the stirring shaft is provided with a defoaming paddle.
The principle and the advantages of the scheme are as follows: in the process of carrying out the bioconversion of the artificial bear gall powder, the reaction tank is a bioconversion place, a reaction system is formed after raw materials for the conversion reaction are added into the reaction tank, and the pH value of the reaction system has an important influence on the accumulation of effective active substances for the conversion reaction, so that the pH value of the reaction system needs to be accurately adjusted and controlled. In the technical scheme, the alkali adding pipe is used for dropwise adding alkali liquor into the reaction system during acid-base regulation. In the conversion reaction process, the poultry bile or the poultry bile paste or the poultry bile powder is usually required to be stirred in order to ensure the uniformity of a system, and due to the self characteristics of the poultry bile or the poultry bile paste or the poultry bile powder, the foam is extremely easy to generate in the stirring process, and due to the light foam quality, the foam can be accumulated on the upper part of the reaction liquid level, so that when the alkali liquor is dropwise added, the alkali liquor can be blocked by the foam and is difficult to mix uniformly or the mixing is not timely. This technical scheme is through setting up the defoaming oar on the (mixing) shaft for the defoaming oar when possessing basic stirring mixing function, can also carry out the defoaming to the foam that the reaction liquid level top produced and handle, avoids the foam to obstruct alkali lye, is favorable to the mixing of alkali lye. In addition, according to the technical scheme, the bottom of the alkali adding pipe extends to the position below the reaction liquid level, so that the accumulation position of foam is avoided, the problem that the foam hinders the uniform mixing of alkali liquor is fundamentally avoided, and the inactivation of cells or enzyme caused by overhigh local pH is avoided.
The beneficial effects of this technical scheme lie in:
1. among this technical scheme, set up the defoaming oar through the upper portion at the (mixing) shaft, can carry out the defoaming to the foam that produces above the reaction liquid level and handle, avoid the foam to obstruct alkali lye, be favorable to the mixing of alkali lye.
2. In the technical scheme, the bottom end of the alkali adding pipe is arranged at the position below the reaction liquid level, so that the accumulation position of foam is avoided, the problem that the foam blocks the uniform mixing of alkali liquor is fundamentally avoided, and the inactivation of cells or enzyme caused by overhigh local pH is avoided.
3. In the technical scheme, the defoaming technology is combined with a mode of avoiding foams when adding alkali, so that the timeliness of pH adjustment of a reaction system is ensured, and the biotransformation reaction is facilitated.
Preferably, as an improvement, the alkali adding pipe is detachably connected to the top of the reaction tank, the top end of the alkali adding pipe is communicated with an alkali liquor storage tank, and a peristaltic pump is arranged between the alkali adding pipe and the alkali liquor storage tank.
Among this technical scheme, just can realize adding the alkali and terminate the switching between adding the alkali through the switching of control peristaltic pump, and will add the alkali pipe and set to the mode of can dismantling the connection with the retort top, can conveniently add washing and maintenance after the alkali pipe uses.
Preferably, as an improvement, the alkali adding assembly further comprises a pH meter arranged inside the reaction tank, a touch screen and a controller electrically connected with the touch screen are arranged outside the reaction tank, and the peristaltic pump is controlled by the controller.
Among this technical scheme, when the biotransformation reaction goes on, operating personnel sets for the pH of reaction system through the touch-sensitive screen, touch-sensitive screen output instruction gives the controller, controller control peristaltic pump is opened, throw alkali lye into the reaction system along adding the alkali pipe, the pH meter can carry out real time monitoring to the pH of reaction system, when pH reaches predetermined value, the pH meter gives the controller with this signal transmission, controller control peristaltic pump is closed, stop adding alkali lye, thus, can realize that real time control reaction system is under the most suitable reaction pH, degree of automation is high through program control, and reaction system adjusts more in time.
Preferably, as an improvement, the defoaming paddle is provided with a plurality of saw teeth.
In this technical scheme, through set up the sawtooth on the defoaming oar, can strengthen the defoaming effect of defoaming oar.
Preferably, as an improvement, the middle part of the stirring shaft is fixedly connected with a push-up stirring paddle, and the lower part of the stirring shaft is fixedly connected with a parabolic turbine paddle.
In the technical scheme, the push-up stirring paddle at the middle part of the stirring shaft and the parabolic turbine paddle at the bottom of the stirring shaft are matched, so that solid or powdery materials at the bottom of the reaction tank can be pushed up and suspended for dissolution, the material stirring is facilitated to be sufficient, and the uniformity of raw material dispersion in a reaction system is ensured.
Preferably, as a modification, the top end of the reaction tank is provided with a speed reduction motor for driving the stirring shaft to rotate.
Among this technical scheme, at artifical bear bile powder bioconversion reaction in-process, gear motor can drive the (mixing) shaft low-speed rotation, and then guarantees to stir the in-process and be in under the effect of low shear force, can reduce the production of stirring process foam on the one hand, and on the other hand also avoids the too high activity that destroys cell or biological enzyme of shearing force.
Preferably, as an improvement, a reduction frame for supporting a reduction motor is fixedly connected to the top end of the reaction tank.
In this technical scheme, the gear reduction frame is used for supporting gear motor, guarantees gear motor steady operation.
Preferably, as an improvement, the bottom end of the reaction tank is communicated with a liquid outlet, and a liquid outlet valve is arranged at the liquid outlet.
Among this technical scheme, the setting of liquid outlet can carry out thorough recovery to the material after biotransformation is accomplished, avoids the residue of material.
Preferably, as a modification, a heating jacket is provided outside the reaction tank.
Among this technical scheme, heating jacket can heat the retort, and then realizes the regulation to conversion reaction temperature, guarantees that the reaction system is located the optimum temperature, does benefit to going on of conversion reaction, and heats through the mode of heating jacket, compares in prior art directly with the heating rod insert the heating mode in the reaction system, the heating is more even, can avoid local overheat and destroy cell or biological enzyme's activity.
Preferably, as an improvement, the detachable connection mode between the alkali adding pipe and the top of the reaction tank is a clamping connection.
In the technical scheme, the alkali adding pipe is connected with the top of the reaction tank by a clamp, the structure is simple, and the disassembly is convenient.
Drawings
FIG. 1 is a front view of a reaction tank in example 1 of the present invention;
FIG. 2 is a front view of the eccentric dwarf filter of FIG. 1;
FIG. 3 is a schematic view of the porous filter plate 1-1 of FIG. 2 in the direction of the axis;
fig. 4 is a schematic diagram of a control system in embodiment 1 of the present invention;
FIG. 5 is a front view of a reaction tank in example 2 of the present invention.
Detailed Description
The following is further detailed by way of specific embodiments:
reference numerals in the drawings of the specification include: the device comprises a touch screen 1, a controller 2, a vacuum port 3, a manual operation hole 4, a cylinder jacket steam inlet 5, a cylinder jacket steam condensate outlet 6, a bottom head jacket steam inlet 7, a bottom head jacket steam condensate outlet 8, an eccentric dwarf filter 9, a parabolic turbine paddle 10, an upward pushing type stirring paddle 11, a bottom head 12, a sanitary discharge ball valve 13, a temperature sensor 14, a pH meter 15, an alkali liquor port 16, an inner cylinder 17, a cylinder jacket 18, a heat preservation layer 19, an alkali adding pipe 20, a defoaming paddle 21, a non-condensable gas outlet 22, a peristaltic pump 23, a top head 24, a mechanical seal 25, a speed reduction rack 26, a speed reduction motor 27, a porous filter plate 28, a liquid outlet 29, a bottom head jacket 30, a purified water interface 31, a liquid material inlet 32, a heating jacket 33, an industrial steam inlet 34 and a condensate outlet 35.
Example 1
This embodiment is substantially as shown in figures 1-4 of the accompanying drawings: the utility model provides an automatic change reactor that acid-base was adjusted, includes retort, heating mechanism, feed mechanism, acid-base adjustment mechanism and rabbling mechanism.
As shown in fig. 1, the reaction tank is a place for bioconversion of the artificial bear gall powder, and comprises an inner cylinder body 17, a top end enclosure 24 and a bottom end enclosure 12 which are integrally formed, wherein a liquid outlet 29 is communicated with the bottom end of the bottom end enclosure 12, a liquid outlet valve is arranged at the position of the liquid outlet 29, and two vertically arranged support legs are welded at the bottom of the bottom end enclosure 12.
The heating mechanism is used for heating the inner cylinder 17 and comprises a heating jacket 33 fixedly connected to the outer portion of the inner cylinder 17, an industrial steam inlet 34, a condensed water outlet 35 and a non-condensable gas outlet 22 are communicated with the heating jacket, the industrial steam inlet 34 is communicated with a steam pipeline, a steam regulating valve (not shown in the figure) is fixedly connected to the steam pipeline, a temperature sensor 14 (model: PT100) is fixed in the inner cylinder 17, a touch screen 1 (model: Siemens KTP1200 Basic PN) and a controller 2 (model: Siemens S7-1500) electrically connected with the touch screen 1 are arranged outside the reaction tank, and the controller 2 can control the steam regulating valve to be opened and closed.
The feeding mechanism is used for adding the biotransformation raw materials into the inner cylinder body 17, and comprises an adding type first feeding component arranged on the top end socket 24 and a negative pressure type second feeding component arranged at the lower part of the inner cylinder body 17. The first feeding assembly is used for feeding liquid poultry bile or poultry bile paste and comprises a vacuum port 3, a manual operation hole 4, a purified water interface 31 and a liquid material inlet 32 which are arranged on the top end socket 24; referring to fig. 2 and 3, the second feeding assembly is used for feeding powdered poultry gallbladder powder, and includes a material suction pipeline communicated with the lower portion of the inner cylinder 17, and a material discharge ball valve is installed on the material suction pipeline, in this embodiment, the material discharge ball valve is a sanitary material discharge ball valve 13 (a manual three-piece tank bottom ball valve, model: Φ 51), one end of the material suction pipeline far away from the inner cylinder 17 is communicated with an eccentric short filter 9, the feeding end and the discharging end of the eccentric short filter 9 are staggered (not coaxial), and a transversely arranged metal porous filter plate 28 is fixedly connected in the eccentric short filter 9.
The acid-base adjusting mechanism is used for adjusting the pH value of the reaction system in the inner cylinder body 17. The acid-base adjusting mechanism comprises a pH meter 15 (model: Inpro3100) fixed inside the inner cylinder 17, the pH meter 15 is electrically connected with the controller 2, the top end enclosure 24 is detachably connected with a base adding assembly, the base adding assembly in the embodiment comprises a base liquid port 16 arranged on the top end enclosure 24, the base liquid port 16 is connected with a vertically arranged base adding pipe 20 through a hoop, the bottom end of the base adding pipe 20 is positioned below the liquid level of the reaction liquid, the top end of the base adding pipe 20 is communicated with an alkali liquid storage tank (not shown in the figure), a peristaltic pump 23 is arranged between the base adding pipe 20 and the alkali liquid storage tank, and the peristaltic pump 23 is controlled by the controller 2.
The stirring mechanism is used for stirring the reaction system in the inner barrel 17, and comprises a speed reducing rack 26 fixedly connected to the top end enclosure 24, a speed reducing motor 27 is fixed on the speed reducing rack 26 through bolts, a vertically arranged stirring shaft is fixedly connected to the top end enclosure 24, the stirring shaft is driven to rotate by the speed reducing motor 27, and a mechanical seal 25 is arranged above the top end enclosure 24. The stirring shaft is provided with a stirring paddle component along the axial welding of the stirring shaft, the stirring paddle component comprises defoaming paddles 21 positioned on the upper part of the stirring shaft, two push-up stirring paddles 11 positioned in the middle of the stirring shaft and a parabolic turbine paddle 10 positioned on the lower part of the stirring shaft, the defoaming paddles 21 in the embodiment are four-blade sawtooth-shaped defoaming paddles 21, and the push-up stirring paddles 11 are four-oblique-blade push-up stirring paddles 11.
The specific implementation process is as follows: firstly, a certain amount of purified water is injected through a purified water interface 31, then a conversion raw material is added into the inner cylinder 17, when the conversion raw material is poultry bile or poultry bile paste, the poultry bile powder is directly injected into the inner cylinder 17 from a liquid material inlet 32 at the top end, when the conversion raw material is poultry bile powder, the poultry bile powder is injected into the inner cylinder 17 through the eccentric short filter 9 through vacuum suction, and in the process, because the feed end and the discharge end of the eccentric short filter 9 are not collinear, the poultry bile powder enters into a vortex shape, is fully dispersed by filtering of the metal porous filter plate 28 and then enters into the inner cylinder 17, and the generation of material embedding phenomenon can be reduced; then, cells or biological enzymes and other auxiliary materials are added through the manual operation hole 4, and the vacuum port 3 is utilized for vacuumizing, so that the inside of the inner cylinder body 17 is kept in a vacuum state.
The operator sets the reaction temperature on the touch screen 1: 20.0-30.0 ℃, touch-sensitive screen 1 output instruction gives controller 2, and controller 2 opens the steam control valve for industrial steam enters into heating jacket 33 by industrial steam inlet 34 in, heats the reaction system through the mode of heat-conduction heat transfer, and the partial condensation phenomenon can appear after the steam heat transfer, and the comdenstion water that the condensation becomes at this moment can be followed comdenstion water outlet 35 and discharged, and the noncondensation part is then can be followed noncondensation gas outlet 22 and discharged. The temperature sensor 14 can carry out real-time monitoring to the reaction system temperature in the inner cylinder 17, when the temperature reaches the set temperature, the temperature sensor 14 transmits a signal to the controller 2, the controller 2 controls the steam regulating valve to be closed, and the steam heating is stopped, so that the reaction system can be controlled to be at the optimal reaction temperature in real time.
The pH value (specific value in 5.00-10.00) is set on the touch screen 1, the touch screen 1 outputs an instruction to the controller 2, the controller 2 controls the peristaltic pump 23 to be started, the alkali liquor is added into the reaction system along the alkali adding pipe 20, and due to the characteristics of raw materials, foam is easily generated in the stirring process and influences the dispersion of the alkali liquor. In this embodiment, the bottom of the alkali adding tube 20 is located below the reaction liquid level, which is beneficial to alkali liquid mixing and avoids local over-high pH to cause cell or enzyme inactivation. The pH meter 15 can monitor the pH value of the reaction system in real time, when the pH value reaches a preset value, the pH meter 15 transmits the signal to the controller 2, the controller 2 controls the peristaltic pump 23 to be closed, and the alkali liquor is stopped being added, so that the reaction system can be controlled to be under the optimal reaction pH value in real time.
After the conversion reaction is finished, the touch screen 1 sets the reaction temperature to be 60.0-85.0 ℃, the touch screen 1 outputs an instruction to the controller 2, the controller 2 opens the steam regulating valve, so that the industrial steam enters the heating jacket from the industrial steam inlet, the reaction system is heated in a heat conduction and heat exchange mode, the temperature of the reaction system is raised to be 60.0-85.0 ℃, cells or biological enzymes are inactivated to stop the reaction, and the biological conversion process is finished. The liquid outlet 29 of bottom head 12 bottom is used for the ejection of compact of reaction back material, through setting up liquid outlet 29 in the bottom of bottom head 12, can guarantee that the ejection of compact is thorough, avoids producing the material and remains the problem.
The embodiment utilizes the mode of avoiding the foam when the rotatory defoaming technique combines with the alkali, has guaranteed the promptness that reaction system pH adjusted, is favorable to going on of biotransformation reaction.
Example 2
As shown in fig. 5, the present embodiment is different from embodiment 1 only in that: the heating mechanism in this embodiment adopts a two-stage steam heating medium heat exchange heating mode, the heating mechanism includes a cylinder jacket 18 welded to the outside of the inner cylinder 17 and a bottom head jacket 30 welded to the outside of the bottom head 12, and the cylinder jacket 18 and the bottom head jacket 30 are both wrapped with an insulating layer 19. A cylinder jacket steam inlet 5 communicated with an industrial steam pipe is formed in the cylinder jacket 18, and a cylinder jacket steam condensate outlet 6 and a noncondensable gas outlet 22 are formed in the cylinder jacket 18; the bottom head jacket 30 is provided with a bottom head jacket steam inlet 7 communicated with an industrial steam pipe, and the bottom head jacket 30 is also provided with a bottom head jacket steam condensate outlet 8 and a non-condensable gas outlet 22.
Before the conversion reaction proceeds, the operator sets the reaction temperature on the touch screen 1: 20.0-30.0 ℃, the touch screen 1 outputs an instruction to the controller 2, the controller 2 opens the steam regulating valve, so that the steam inlet 7 of the bottom head jacket is opened, industrial steam enters the bottom head jacket 30 from the steam inlet 7 of the bottom head jacket, the bottom of the inner cylinder 17 is heated, the heat exchange area is small at the moment, the heating is mild, the problem that cells or biological enzymes are inactivated due to local overheating of a reaction system can be avoided, partial condensation phenomenon can occur after steam heat exchange, condensed water can be discharged from the steam condensed water outlet 8 of the bottom head jacket, and the uncondensed part can be discharged from the non-condensed gas outlet 22. The temperature sensor 14 can carry out real-time monitoring to the reaction system temperature in the inner cylinder 17, when the temperature reaches the set temperature, the temperature sensor 14 transmits a signal to the controller 2, the controller 2 controls the steam regulating valve to be closed, and the steam heating is stopped, so that the reaction system can be controlled to be at the optimal reaction temperature in real time.
After the conversion reaction is finished, the touch screen 1 sets the reaction temperature to be 60.0-85.0 ℃, the touch screen 1 outputs an instruction to the controller 2, the controller 2 opens the steam regulating valve, so that industrial steam enters along the steam inlet 5 of the cylinder jacket and the steam inlet 7 of the bottom head jacket at the same time, at the moment, the cylinder jacket 18 and the bottom head jacket 30 heat the inner cylinder 17 at the same time, the heat exchange area is large, the temperature is quickly increased to be 60.0-85.0 ℃, cells or biological enzymes are quickly inactivated to stop the reaction, and the biological conversion process is finished.
In the embodiment, a two-section type temperature control mode is adopted, and when the conversion reaction is carried out, steam is introduced for heating only through the bottom head jacket 30, so that the heat exchange area is small, and accurate temperature control can be realized; after the conversion reaction is finished, the bottom head jacket 30 and the barrel jacket 18 are simultaneously used for introducing steam for heating, the heat exchange area is large, the purpose of rapidly heating up and terminating the reaction can be realized, the structure is reasonable, and the operation flexibility is higher.
The above description is only an example of the present invention, and the detailed technical solutions and/or characteristics known in the solutions are not described too much here. It should be noted that, for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (10)
1. The utility model provides an automatic change reactor that acid-base adjusted, includes the retort, be provided with acid-base adjustment mechanism in the retort, its characterized in that: the acid-base adjusting mechanism comprises an alkali adding component and a defoaming component, the alkali adding component comprises an alkali adding pipe, and the bottom end of the alkali adding pipe is positioned below the reaction liquid level; the defoaming assembly comprises a stirring shaft which is rotatably connected inside the reaction tank, and defoaming paddles are arranged on the upper part of the stirring shaft.
2. An automated acid-base conditioning reactor as claimed in claim 1, wherein: the alkali adding pipe is detachably connected to the top of the reaction tank, the top end of the alkali adding pipe is communicated with an alkali liquor storage tank, and a peristaltic pump is arranged between the alkali adding pipe and the alkali liquor storage tank.
3. An automated acid-base conditioning reactor as claimed in claim 2, wherein: the alkali adding assembly further comprises a pH meter arranged inside the reaction tank, a touch screen and a controller electrically connected with the touch screen are arranged outside the reaction tank, and the peristaltic pump is controlled by the controller.
4. An automated acid-base conditioning reactor as claimed in claim 3, wherein: the defoaming paddle is provided with a plurality of saw teeth.
5. An automated acid-base conditioning reactor as claimed in claim 4, wherein: the middle part of the stirring shaft is fixedly connected with an upward pushing type stirring paddle, and the lower part of the stirring shaft is fixedly connected with a parabola turbine paddle.
6. An automated acid-base conditioning reactor as claimed in claim 5, wherein: and a speed reduction motor for driving the stirring shaft to rotate is arranged at the top end of the reaction tank.
7. An automated acid-base conditioning reactor as claimed in claim 6, wherein: and the top end of the reaction tank is fixedly connected with a speed reducing rack for supporting a speed reducing motor.
8. An automated acid-base conditioning reactor as claimed in any one of claims 1 to 7, wherein: the bottom end of the reaction tank is communicated with a liquid outlet, and a liquid outlet valve is arranged at the position of the liquid outlet.
9. An automated acid-base conditioning reactor as claimed in any one of claims 1 to 7, wherein: and a heating jacket is arranged outside the reaction tank.
10. An automated acid-base conditioning reactor as claimed in claim 2, wherein: the detachable connection mode between the alkali adding pipe and the top of the reaction tank is clamp connection.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202021062322.6U CN212800374U (en) | 2020-06-10 | 2020-06-10 | Automatic change reactor that acid-base adjusted |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202021062322.6U CN212800374U (en) | 2020-06-10 | 2020-06-10 | Automatic change reactor that acid-base adjusted |
Publications (1)
Publication Number | Publication Date |
---|---|
CN212800374U true CN212800374U (en) | 2021-03-26 |
Family
ID=75095670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202021062322.6U Withdrawn - After Issue CN212800374U (en) | 2020-06-10 | 2020-06-10 | Automatic change reactor that acid-base adjusted |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN212800374U (en) |
-
2020
- 2020-06-10 CN CN202021062322.6U patent/CN212800374U/en not_active Withdrawn - After Issue
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN201612148U (en) | Fermentation machine used for livestock and poultry excrement regeneration feed | |
CN108753609A (en) | The adaptive equipment of integrated 3-phase dry type anaerobic fermentation and its production biogas method | |
CN212800374U (en) | Automatic change reactor that acid-base adjusted | |
CN208472052U (en) | Starch milk and liquefier comprehensive utilization system for heat energy in fructose production process | |
CN110813127A (en) | A agitating unit for producing compound microbial organic fertilizer | |
CN216093150U (en) | Plant essential oil emulsification reation kettle | |
CN212800375U (en) | Biological conversion reactor | |
CN212800376U (en) | Reactor of vacuum material loading | |
CN215939950U (en) | Three-monomer concentration esterification neutralization kettle | |
CN210700109U (en) | Reation kettle of rapid cooling | |
CN2472811Y (en) | Propylene polymerizing still | |
CN219117392U (en) | Assembled combined saccharification equipment for beer production | |
CN206837920U (en) | A kind of damping type medicinal liquid agitating mixing arrangement with dregs of a decoction separation | |
CN209968221U (en) | Buffer solution preparation tank | |
CN219764499U (en) | Purification equipment with accelerate evaporation structure | |
CN110586006A (en) | Reaction kettle with novel stirring device | |
CN217016603U (en) | Water treatment workshop basicity demineralized water comprehensive utilization device | |
CN219950940U (en) | High-efficient honey wine fermenting installation | |
CN217473535U (en) | Chloroethylene intermittent suspension polymerization kettle combined stirring device | |
CN216172236U (en) | Open type stainless steel reaction kettle | |
CN215549995U (en) | Outdoor environmental protection garbage bin production is with modified mechanism of novel macromolecular material | |
CN212451402U (en) | Horizontal rotary food fermentation equipment for food processing | |
CN221016015U (en) | Chemical industry solid-liquid reation kettle | |
CN217715754U (en) | Novel filtering, washing and drying process equipment for lithium battery grade cellulose product | |
CN216303798U (en) | Enzyme reaction device that rose natural pigment drawed |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
AV01 | Patent right actively abandoned | ||
AV01 | Patent right actively abandoned | ||
AV01 | Patent right actively abandoned |
Granted publication date: 20210326 Effective date of abandoning: 20231023 |
|
AV01 | Patent right actively abandoned |
Granted publication date: 20210326 Effective date of abandoning: 20231023 |