CN212732113U - Pharmaceutic adjuvant is nitrogen gas replacement reation kettle for purification - Google Patents
Pharmaceutic adjuvant is nitrogen gas replacement reation kettle for purification Download PDFInfo
- Publication number
- CN212732113U CN212732113U CN202021278036.3U CN202021278036U CN212732113U CN 212732113 U CN212732113 U CN 212732113U CN 202021278036 U CN202021278036 U CN 202021278036U CN 212732113 U CN212732113 U CN 212732113U
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- CN
- China
- Prior art keywords
- reaction kettle
- bevel gear
- fixedly connected
- reation kettle
- purification
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 239000000546 pharmaceutical excipient Substances 0.000 title claims abstract description 19
- 238000000746 purification Methods 0.000 title claims abstract description 15
- 229910001873 dinitrogen Inorganic materials 0.000 title claims abstract description 7
- 238000006243 chemical reaction Methods 0.000 claims abstract description 60
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims description 28
- 238000005728 strengthening Methods 0.000 claims description 4
- 239000007769 metal material Substances 0.000 claims description 3
- 238000003466 welding Methods 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 24
- 238000007790 scraping Methods 0.000 abstract description 4
- 239000002699 waste material Substances 0.000 abstract description 4
- 238000004321 preservation Methods 0.000 abstract 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 8
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 8
- 229940093471 ethyl oleate Drugs 0.000 description 8
- 238000001914 filtration Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000003014 reinforcing effect Effects 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Mixers Of The Rotary Stirring Type (AREA)
Abstract
The utility model discloses a nitrogen gas replacement reation kettle is used in pharmaceutic adjuvant purification, including reation kettle casing, outer body and initiative bevel gear, reation kettle casing bottom and base fixed connection, and reation kettle casing upper end and headstock fixed connection, the outside parcel of reation kettle casing has the heat preservation to press from both sides the cover simultaneously to fixedly connected with coil pipe on the inside wallboard of reation kettle casing, inside lower extreme and fixed plate fixed connection of reation kettle casing, and the inside lower extreme fixed connection who passes through bearing and the interior body of rod of fixed plate, the last wallboard and last umbrella gear fixed connection that reation kettle casing was passed to interior body of rod upper end simultaneously, and interior body of rod downside and puddler fixed connection. The reaction kettle is replaced by nitrogen for purification of the pharmaceutic adjuvant, the lower bevel gear drives the scraper on the lower bevel gear to rotate through the outer pipe body, and the scraper carries out scraping operation on materials attached to the inner wall of the reaction kettle, so that the materials on the inner wall of the reaction kettle can be conveniently cleaned; and simultaneously reduces the waste of materials.
Description
Technical Field
The utility model relates to an ethyl oleate treatment facility science and technology technical field specifically is a nitrogen gas replacement reation kettle is used in pharmaceutic adjuvant purification.
Background
The ethyl oleate is a common pharmaceutical adjuvant, and the nitrogen replacement process of the ethyl oleate comprises the steps of taking an ethyl oleate raw material into a reaction kettle, adding 0.1% (g/g) of activated carbon, heating to 70-80 ℃, keeping the temperature and stirring for 30 minutes, circularly filtering with a hot plate frame, heating the liquid medicine to 140-150 ℃ after the liquid medicine is clarified, introducing nitrogen, performing oxide replacement, opening a vacuum valve, adjusting the vacuum degree to 0.03pa, performing reduced pressure replacement for 2 hours, cooling to below 45 ℃, performing bag-type filtration, pumping the filtrate into a stainless steel storage tank by a pump, mixing for 30 minutes, inspecting, performing precise filtration, and filling to obtain the ethyl oleate; when ethyl oleate is treated in the reaction kettle, part of ethyl oleate can be attached to the inner wall of the reaction kettle, the ethyl oleate attached to the inner wall of the reaction kettle is inconvenient to clean after the reaction is finished, and the reaction kettle structurally has an improved space.
In order to solve the defects existing in the current market, a nitrogen replacement reaction kettle for purifying pharmaceutic adjuvants is provided to solve the problems.
SUMMERY OF THE UTILITY MODEL
The utility model provides a technical problem lie in overcoming the defect that mentions in the background art, provide a pharmaceutic adjuvant is nitrogen gas replacement reation kettle for the purification. The lower bevel gear, the outer pipe body and the scraper are provided with a lower bevel gear which drives the scraper on the outer pipe body to rotate through the outer pipe body, and the scraper carries out scraping operation on materials attached to the inner wall of the reaction kettle, so that the materials on the inner wall of the reaction kettle can be conveniently cleaned; simultaneously reduces the waste of materials.
In order to achieve the above object, the utility model provides a following technical scheme: a nitrogen displacement reaction kettle for pharmaceutical excipient purification comprises a reaction kettle shell, an outer tube body and a driving bevel gear, wherein the bottom of the reaction kettle shell is fixedly connected with a base, the upper end of the reaction kettle shell is fixedly connected with a power box, the outer side of the reaction kettle shell is wrapped with a heat-insulating jacket, a coil pipe is fixedly connected to an inner wall plate of the reaction kettle shell, the lower end of the inner part of the reaction kettle shell is fixedly connected with a fixed plate, the inner part of the fixed plate is fixedly connected with the lower end of an inner rod body through a bearing, the upper end of the inner rod body penetrates through an upper wall plate of the reaction kettle shell to be fixedly connected with the upper bevel gear, and the lower side of the inner rod body is fixedly connected; a vacuum valve is arranged on the upper right side of the reaction kettle shell, and a charging pipe is arranged on the upper left side of the reaction kettle shell;
the upper end of the outer pipe body penetrates through the reaction kettle shell through the bearing to be fixedly connected with the lower bevel gear, the lower side of the outer pipe body is fixedly connected with the connecting rod, the upper end of the connecting rod is welded with the extension plate, and the right end of the connecting rod is fixedly connected with the scraper.
Preferably, the inner rod body and the outer tube body are of concentric circle structures, the inner portion of the outer tube body is fixedly connected with the inner rod body through two groups of fixed bearings, the inner rod body and the outer tube body are of a simultaneous rotating structure, and the rotating directions of the inner rod body and the outer tube body are opposite.
Preferably, the puddler evenly sets up to four groups along the lower extreme circumference position of the interior body of rod, and the tip of four groups puddlers all with stirring vane fixed connection.
Preferably, fixedly connected with strengthening rib between connecting rod and the scraper blade, and the strengthening rib is the right triangle structure of being made by the metal material, and the scraper blade is connected with the inside wallboard contact of reation kettle casing simultaneously to the scraper blade tip is the arc setting, and the surface of reation kettle casing is provided with circular shape observation window.
Preferably, the equal fixedly connected with in upper and lower both ends of connecting rod extends the board, and the extension board surface fixedly connected with of connecting rod upside stirs the board in three groups, stirs the board and sets up for the rectangle.
Preferably, the connecting rods are uniformly arranged in four groups along the circumferential position of the lower side of the outer pipe body, and the connecting rods and the scraping plates are combined together to form a T shape.
Preferably, the upper end of the driving bevel gear is meshed with the upper bevel gear, the lower end of the driving bevel gear is meshed with the lower bevel gear, the size of the upper bevel gear is consistent with that of the lower bevel gear, and a rod body of the driving bevel gear penetrates through a wall plate of the power box through a bearing to be fixedly connected with an output shaft of the speed reducing motor.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the lower bevel gear drives the scraper on the lower bevel gear to rotate through the outer pipe body, and the scraper carries out scraping operation on materials attached to the inner wall of the reaction kettle, so that the materials on the inner wall of the reaction kettle can be conveniently cleaned; meanwhile, the waste of materials is reduced;
2. the rotation opposite direction of puddler and connecting rod can realize carrying out abundant stirring work to the inside material of reation kettle, guarantees that the inside material of reation kettle is heated evenly.
Drawings
FIG. 1 is a front view of the structure of the present invention;
FIG. 2 is a schematic sectional view of the structure A-A of the present invention;
FIG. 3 is a top view of the stirring rod of the present invention;
fig. 4 is a schematic view of the structure and appearance of the present invention.
Reference numbers in the figures: 1. a base; 2. a reaction kettle shell; 3. a coil pipe; 4. a fixing plate; 5. an inner rod body; 6. a stirring rod; 7. a heat-preserving jacket; 8. a connecting rod; 9. a squeegee; 10. an extension plate; 11. a stirring plate; 12. a vacuum valve; 13. an outer tubular body; 14. a power box; 15. a lower bevel gear; 16. a drive bevel gear; 17. an upper bevel gear; 18. a feed tube; 19. reinforcing ribs; 20. a stirring blade; 21. and (4) an observation window.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1-4, the present invention provides a technical solution: a nitrogen replacement reaction kettle for pharmaceutical excipient purification comprises a reaction kettle shell 2, an outer tube 13 and a driving bevel gear 16, wherein the bottom of the reaction kettle shell 2 is fixedly connected with a base 1, the upper end of the reaction kettle shell 2 is fixedly connected with a power box 14, a heat-insulating jacket 7 wraps the outer side of the reaction kettle shell 2, a coil 3 is fixedly connected to an inner wall plate of the reaction kettle shell 2, the lower end of the inner part of the reaction kettle shell 2 is fixedly connected with a fixed plate 4, the inner part of the fixed plate 4 is fixedly connected with the lower end of an inner rod body 5 through a bearing, the upper end of the inner rod body 5 penetrates through an upper wall plate of the reaction kettle shell 2 to be fixedly connected with an upper bevel gear 17, and the lower side of the inner rod body 5 is; the vacuum valve 12 is arranged on the upper right side of the reaction kettle shell 2, and the feeding pipe 18 is arranged on the upper left side of the reaction kettle shell 2; the inner rod body 5 and the outer tube body 13 are of concentric circle structures, the inner part of the outer tube body 13 is fixedly connected with the inner rod body 5 through two groups of fixed bearings, meanwhile, the inner rod body 5 and the outer tube body 13 are of simultaneous rotating structures, and the rotating directions of the inner rod body 5 and the outer tube body 13 are opposite; four groups of stirring rods 6 are uniformly arranged along the circumferential position of the lower end of the inner rod body 5, and the end parts of the four groups of stirring rods 6 are fixedly connected with the stirring blades 20; the upper end of the driving bevel gear 16 is meshed with the upper bevel gear 17, the lower end of the driving bevel gear 16 is meshed with the lower bevel gear 15, the size of the upper bevel gear 17 is consistent with that of the lower bevel gear 15, and the rod body of the driving bevel gear 16 penetrates through the wall plate of the power box 14 through a bearing to be fixedly connected with the output shaft of the speed reducing motor; the upper end of the outer pipe body 13 penetrates through the reaction kettle shell 2 through a bearing to be fixedly connected with the lower bevel gear 15, the lower side of the outer pipe body 13 is fixedly connected with the connecting rod 8, meanwhile, the upper end of the connecting rod 8 is welded with the extension plate 10, and the right end of the connecting rod 8 is fixedly connected with the scraper 9; a reinforcing rib 19 is fixedly connected between the connecting rod 8 and the scraper 9, the reinforcing rib 19 is of a right-angled triangular structure made of metal materials, the scraper 9 is in contact connection with an inner wall plate of the reaction kettle shell 2, the end part of the scraper 9 is arranged in an arc shape, and a circular observation window 21 is arranged on the outer surface of the reaction kettle shell 2; the upper end and the lower end of the connecting rod 8 are fixedly connected with extension plates 10, the surface of the extension plate 10 on the upper side of the connecting rod 8 is fixedly connected with three groups of stirring plates 11, and the stirring plates 11 are arranged in a rectangular shape; the connecting rods 8 are uniformly arranged in four groups along the circumferential position of the lower side of the outer tube body 13, and the connecting rods 8 and the scrapers 9 are combined together to form a T shape;
as shown in fig. 1: the left end of the feeding pipe 18 is communicated with a three-way device, one end of the three-way device is communicated with a material injection pipe, the other end of the three-way device is used for introducing nitrogen, and reacted materials can be discharged from a material discharge pipe at the bottom of the reaction kettle shell 2 to carry out the next treatment work; the coil 3 is internally used for adding heat conducting oil, and the heat conducting oil can carry out heating and cooling work on the reaction kettle through an electric heater;
as shown in fig. 1-3: initiative bevel gear 16 drives bevel gear 17 and bevel gear 15 rotation down respectively, realize the rotation work of outer body 13 and the interior body of rod 5 in proper order, connecting rod 8 drives scraper blade 9 and rotates, strike off the material that attaches to on the reation kettle inner wall, extension board 10 on the connecting rod 8 simultaneously, stirring board 11 can stir the inside material of reation kettle, puddler 6, stirring vane 20 stirs the inside material of reation kettle, puddler 6 is opposite with the direction of rotation of connecting rod 8, can realize carrying out sufficient stirring work to the inside material of reation kettle, guarantee that the inside material of reation kettle is heated evenly.
When the nitrogen gas is used for replacing the reaction kettle for purifying the pharmaceutic adjuvant, the reduction motor is driven by the reduction motor, the reduction motor is not shown in the drawing, an output shaft of the reduction motor drives an upper bevel gear 17 and a lower bevel gear 15 to rotate respectively through a driving bevel gear 16, the upper bevel gear 17 drives a stirring rod 6 below the upper bevel gear to rotate through an inner rod body 5, the stirring rod 6 drives stirring blades 20 to rotate, the materials in the reaction kettle are fully stirred, and therefore the heat conduction oil in a coil pipe 3 can uniformly heat the materials in the reaction kettle; the lower bevel gear 15 drives the scraper 9 on the lower bevel gear to rotate through the outer pipe body 13, and the scraper 9 scrapes off materials attached to the inner wall of the reaction kettle, so that the materials on the inner wall of the reaction kettle can be conveniently cleaned; meanwhile, the waste of materials is reduced, and the whole process of the work of the nitrogen replacement reaction kettle for the purification of the pharmaceutic adjuvant is realized.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The utility model provides a pharmaceutic adjuvant purifies uses nitrogen gas replacement reation kettle, includes reation kettle casing (2), outer body (13) and initiative bevel gear (16), its characterized in that: the bottom of the reaction kettle shell (2) is fixedly connected with the base (1), the upper end of the reaction kettle shell (2) is fixedly connected with the power box (14), meanwhile, the outer side of the reaction kettle shell (2) is wrapped with a heat-insulating jacket (7), a coil pipe (3) is fixedly connected onto a wall plate inside the reaction kettle shell (2), the lower end inside the reaction kettle shell (2) is fixedly connected with the fixing plate (4), the inside of the fixing plate (4) is fixedly connected with the lower end of the inner rod body (5) through a bearing, meanwhile, the upper end of the inner rod body (5) penetrates through an upper wall plate of the reaction kettle shell (2) and is fixedly connected with the upper umbrella-shaped gear (17), and the lower side of the inner rod body (5) is fixedly connected with the stirring rod; a vacuum valve (12) is arranged on the upper right side of the reaction kettle shell (2), and a feeding pipe (18) is arranged on the upper left side of the reaction kettle shell (2);
outer body (13) upper end passes reation kettle casing (2) through the bearing and links firmly with lower bevel gear (15), and the downside and connecting rod (8) fixed connection of outer body (13), and connecting rod (8) upper end and extension board (10) welding simultaneously to connecting rod (8) right-hand member and scraper blade (9) fixed connection.
2. The nitrogen replacement reaction kettle for purification of the pharmaceutic adjuvant according to claim 1, which is characterized in that: the inner rod body (5) and the outer tube body (13) are of concentric circle structures, the outer tube body (13) is fixedly connected with the inner rod body (5) through two groups of fixed bearings, the inner rod body (5) and the outer tube body (13) are of simultaneous rotating structures, and the rotating directions of the inner rod body (5) and the outer tube body (13) are opposite.
3. The nitrogen replacement reaction kettle for purification of the pharmaceutic adjuvant according to claim 1, which is characterized in that: the stirring rods (6) are uniformly arranged into four groups along the circumferential position of the lower end of the inner rod body (5), and the end parts of the four groups of stirring rods (6) are fixedly connected with the stirring blades (20).
4. The nitrogen replacement reaction kettle for purification of the pharmaceutic adjuvant according to claim 1, which is characterized in that: fixedly connected with strengthening rib (19) between connecting rod (8) and scraper blade (9), and strengthening rib (19) are the right angled triangle structure of making by the metal material, and scraper blade (9) are connected with the inside wallboard contact of reation kettle casing (2) simultaneously to scraper blade (9) tip is the arc setting, and the surface of reation kettle casing (2) is provided with circular shape observation window (21).
5. The nitrogen replacement reaction kettle for purification of the pharmaceutic adjuvant according to claim 1, which is characterized in that: the upper and lower both ends of connecting rod (8) are equal fixedly connected with and extend board (10), and extend board (10) fixed surface of connecting rod (8) upside is connected with three groups of stirring boards (11), and stirring board (11) are the rectangle setting.
6. The nitrogen replacement reaction kettle for purification of the pharmaceutic adjuvant according to claim 1, which is characterized in that: the connecting rods (8) are evenly arranged into four groups along the circumferential position of the lower side of the outer pipe body (13), and the connecting rods (8) and the scrapers (9) are combined together to form a T shape.
7. The nitrogen replacement reaction kettle for purification of the pharmaceutic adjuvant according to claim 1, which is characterized in that: the upper end of the driving bevel gear (16) is meshed with the upper bevel gear (17), the lower end of the driving bevel gear (16) is meshed with the lower bevel gear (15), the size of the upper bevel gear (17) is consistent with that of the lower bevel gear (15), and a rod body of the driving bevel gear (16) penetrates through a wall plate of the power box (14) through a bearing to be fixedly connected with an output shaft of the speed reducing motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021278036.3U CN212732113U (en) | 2020-07-03 | 2020-07-03 | Pharmaceutic adjuvant is nitrogen gas replacement reation kettle for purification |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021278036.3U CN212732113U (en) | 2020-07-03 | 2020-07-03 | Pharmaceutic adjuvant is nitrogen gas replacement reation kettle for purification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212732113U true CN212732113U (en) | 2021-03-19 |
Family
ID=75020615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021278036.3U Expired - Fee Related CN212732113U (en) | 2020-07-03 | 2020-07-03 | Pharmaceutic adjuvant is nitrogen gas replacement reation kettle for purification |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212732113U (en) |
-
2020
- 2020-07-03 CN CN202021278036.3U patent/CN212732113U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210319 |
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| CF01 | Termination of patent right due to non-payment of annual fee |