CN212699647U - Semi-automatic closed valsartan intermediate material post-treatment and packaging system - Google Patents
Semi-automatic closed valsartan intermediate material post-treatment and packaging system Download PDFInfo
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- CN212699647U CN212699647U CN202020390453.0U CN202020390453U CN212699647U CN 212699647 U CN212699647 U CN 212699647U CN 202020390453 U CN202020390453 U CN 202020390453U CN 212699647 U CN212699647 U CN 212699647U
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Abstract
The utility model belongs to the technical field of valsartan production facility, concretely relates to semi-automatic closed valsartan intermediate material aftertreatment and packaging system, including crystallization kettle, centrifuge, stock chest, first spiral material loading machine, desiccator, second spiral material loading machine, granulation machine and packagine machine. The utility model discloses can solve in the valsartan intermediate preparation process crystallization, separation, drying, pelletization, each process of vacuum package independent operation easily cause workman's operational load big, dust pollution environment when solid material changes the material, the solvent is volatile, the useless difficult scheduling problem of handling of tail, has simple structure, linkage convenient operation, and technological parameter sets for and regulates and control convenient characteristics.
Description
Technical Field
The utility model belongs to the technical field of valsartan production facility, concretely relates to semi-automatic closed valsartan intermediate material aftertreatment and packaging system.
Background
With the continuous application of pharmaceutical chemical production technology in the production and scientific research fields, the requirements on the environmental friendliness and automation of the existing separation device, drying device and packaging device are higher and higher, people are often required to leave materials in the production process so as to avoid adverse effects of pharmaceutical intermediates on people and environment, manual high-intensity labor is often required when traditional emptying and solid material bagging are carried out, the production efficiency is low, and mechanical impurities are easily brought into the packaged finished products in the later period. How to improve workman's labor efficiency, protection workman operational environment reduces waste gas emission simultaneously, reduces workman's operating load, is the problem that present pharmaceutical chemical industry field is badly to solve.
At present, a semi-automatic closed system assembling machine is applied to industrial production and scientific research processes, and can solve the problem of high management difficulty between devices.
SUMMERY OF THE UTILITY MODEL
The utility model aims at crystallizing, separating, drying, pelletization, packing each process exclusive operation in the valsartan intermediate preparation process easily cause workman's operational load big, dust pollution environment when solid material changes the material, the solvent is volatile, the useless difficult scheduling problem that handles of tail provides one kind and easily realizes automatic chain control, the higher semi-automatic closed material aftertreatment of environment friendly degree and packaging system.
In order to achieve the purpose, the utility model discloses a semi-automatic closed type valsartan intermediate material post-processing and packaging system, which comprises a crystallization kettle, a centrifuge, a storage tank, a first spiral feeding machine, a dryer, a second spiral feeding machine, a granulation machine and a packaging machine;
the discharge end of crystallization kettle bottom is linked together through the pan feeding end at pipeline and centrifuge's top, the discharge end of centrifuge bottom extends to the opening part on stock chest top through the pipeline, stock chest bottom discharge end extends to the pan feeding mouth department of first spiral material loading machine through the pipeline, first spiral material loading machine is equipped with the first discharging pipe that extends by supreme slope down, the discharge gate on first discharging pipe top extends to the opening part on desiccator top, desiccator bottom discharge end extends to the pan feeding mouth department of second spiral material loading machine through the management, second spiral material loading machine is equipped with the second discharging pipe that extends by supreme slope down, the discharge gate on second discharging pipe top extends to the opening part on granulation machine top, granulation machine bottom discharge end is connected with the packagine machine entrance point through the pipeline.
Preferably, the crystallization kettle is a refining crystallization kettle, and specifically is any one of an enamel reaction kettle, a stainless steel reaction kettle and a glass reaction kettle.
Preferably, the discharge end of crystallization kettle bottom is equipped with the baiting valve, be equipped with material liquid level linkage controller on the baiting valve, the liquid level response end of material liquid level linkage controller sets up in the centrifuge, material liquid level linkage controller and baiting valve control connection, when drawing the material and reaching certain liquid level in the bag scraper lower part discharge centrifuge, liquid level response end sends the shut-off signal to material liquid level linkage controller, material liquid level linkage controller is again to the signals of baiting valve, closing of material liquid level linkage controller control baiting valve.
Preferably, the centrifuge is a bag-type scraper lower discharge centrifuge, the bag-type scraper lower discharge centrifuge is provided with a speed controller and a time setting instrument, and the speed controller and the time setting instrument are conventional equipment in the field.
Preferably, the dryer is any one of a double-cone rotary dryer, a fluidized bed and a fluidized bed furnace, and the dryer can set the working parameters and the working time of the dryer according to the material properties and the process.
Preferably, the granulator is a swing granulator, and the materials granulated by the granulator are packaged in a packaging machine in a closed manner to form a box.
Preferably, a weighbridge is arranged below the storage tank, and the weight of the materials in the storage tank after centrifugation can be obtained through weighing of the weighbridge.
Preferably, control switches of the crystallization kettle, the centrifuge, the first spiral feeding machine, the dryer, the second spiral feeding machine, the granulation machine and the packing machine are all arranged in a system control console in a centralized manner, and opening and closing of all parts in the system can be controlled in a unified manner through the system control console.
The utility model has the advantages that:
the utility model discloses in can solving separation, drying, pelletization, the packaging process after the purification of valsartan intermediate material, because artifical blowing, change the material and the intensity of labour who leads to is big, the material is uncovered and is caused environmental pollution scheduling problem, can reduce the human interference factor in the use to improve work efficiency, reduce workman's work intensity, realize the operational environment dustlessness, reach clean production requirement, the utility model discloses each part simple structure in the system, linkage convenient operation, technological parameter sets for and regulates and control the convenience, the system can improve the environmental friendliness degree, reduces dust and solvent exhaust emission, has effectively expanded valsartan intermediate production mode, has higher using value.
Drawings
Fig. 1 is a schematic structural diagram of a semi-automatic closed valsartan intermediate material post-treatment and packaging system according to the present invention; in the figure: 1. a refining crystallization kettle; 2. discharging centrifuge at the lower part of the bag-pulling type scraper; 3. a storage tank; 4. a wagon balance; 5. a first spiral feeder; 6. a rotary double cone dryer; 7. a second spiral feeder; 8. an oscillating granulator; 9. and (4) carrying out vacuum packaging.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings, but the scope of the invention is not limited thereto.
Semi-automatic closed type valsartan intermediate material aftertreatment and packaging system in each part model as follows:
the rotary dryer is a model SZG-2000, and structurally comprises: frame, inlet tube, ware body, vacuum tube and speed reducer.
The swing type granulator is model YK-160 and structurally comprises: the granulator main part, granule manufacturing mechanism, reducing gear box, screen cloth clamp pipe and motor frame.
Model of the refining crystallization kettle: K2000.
the spiral feeder is a YSDS-3 type automatic feeder: the YSDS-3 vibration spiral feeding machine can lift various powder materials, and the material box and the auger are made of stainless steel; the vibration amplitude of a feeding motor and a vibration motor of the spiral feeding machine is adjustable, the whole spiral can be conveniently disassembled, assembled and cleaned, and automatic feeding and automatic stopping can be realized in the feeding process; the screw, the charging bucket and the storage bin are in flexible connection, so that the disassembly is easy; the lower end of the charging barrel is provided with a valve and a forward and reverse rotation switch, so that the charging barrel is convenient to clean; the material loading height is decided according to the process, the machine can move freely, the material loading is fast, the machine is safe and reliable, and the vibrating motor in the storage bin can enable the material to automatically enter the spiral.
The vacuum packaging machine model: VSL-1200 type with the specification of 1200 kg/h.
The model of the liquid level linkage controller is as follows: DPBZ 301.
Example 1
As shown in fig. 1, a semi-automatic closed type valsartan intermediate material post-processing and packaging system comprises a refining crystallization kettle 1, a bag-type scraper lower discharging centrifuge 2, a storage tank 3, a first spiral feeding machine 5, a rotary double-cone dryer 6, a second spiral feeding machine 8, a swing type granulation machine 7 and a vacuum packaging machine 9; in this embodiment, the refining crystallization kettle 1 is a stainless steel reaction kettle, the bag-pulling type scraper lower discharge centrifuge 2 is provided with a speed controller and a time setting instrument, and the bag-pulling type scraper lower discharge centrifuge 2 is a discharge instrument commonly used in the field and can be of a commonly used model and parameters, which is not described herein again;
the discharge end at the bottom of the refining crystallization kettle 1 is communicated with the feed end at the top of the discharge centrifuge 2 at the lower part of the bag-pulling type scraper through a pipeline, the discharge end at the bottom of the discharge centrifuge 2 at the lower part of the bag-pulling type scraper extends to the opening at the top end of the storage tank 3 through a pipeline, the discharge end at the bottom end of the storage tank 3 extends to the feed port of the first spiral feeding machine 5 through a pipeline, the first spiral feeding machine 5 is provided with a first discharge pipe which extends in an inclined manner from bottom to top, the discharge port at the top end of the first discharge pipe extends to the opening at the top end of the rotary double-cone drying machine 6, the discharge end at the bottom of the rotary double-cone drying machine 6 extends to the feed port of the second spiral feeding machine 8 through a pipeline, the second spiral feeding machine 8 is provided with a second discharge pipe which extends in an inclined manner from bottom to top, the discharge port at the top end of the second discharge pipe extends;
control switches of the refined crystallization kettle 1, the bag-pulling type scraper lower discharging centrifuge 2, the first spiral feeding machine 5, the rotary double-cone dryer 6, the second spiral feeding machine 8, the swing type granulation machine 7 and the vacuum packaging machine 9 are all arranged in a system control console in a centralized manner, and the opening and closing of all parts in the system can be controlled in a unified manner through the system control console. The control switch in the system console adopts a conventional arrangement mode in the field.
The discharge end of 1 bottom of refined crystallization cauldron is equipped with the baiting valve, be equipped with material liquid level linkage controller on the baiting valve, the liquid level response end of material liquid level linkage controller sets up in drawing bag formula scraper lower part discharge centrifuge 2, material liquid level linkage controller and baiting valve control connection, when drawing in bag formula scraper lower part discharge centrifuge 2 in the material reaches certain liquid level, liquid level response end sends closing signal to material liquid level linkage controller, material liquid level linkage controller is to the signals of baiting valve again, thereby control the closing of baiting valve, draw bag formula scraper lower part discharge centrifuge 2 to begin centrifugal work, when drawing bag formula scraper lower part discharge centrifuge 2 to reach operating time and stop centrifugation.
The lower part of the stock chest 3 is provided with a wagon balance 4, and the weight of the material in the stock chest 3 after centrifugation can be obtained by weighing the wagon balance 4.
The semi-automatic closed type valsartan intermediate material post-treatment and packaging system comprises the following specific steps:
1. placing the synthesized valsartan intermediate material into a refining crystallization kettle 1 for crystallization treatment, opening a discharge valve of the refining crystallization kettle 1 after the crystallization treatment, and placing a solid-liquid mixed material in the refining crystallization kettle 1 into a discharge centrifuge 2 at the lower part of a bag-pulling type scraper through a pipeline;
2. adjusting a speed controller and a time setting instrument through a control switch of the bag-pulling type scraper lower discharging centrifuge 2, setting the rotating speed and the time of the bag-pulling type scraper lower discharging centrifuge 2, starting the bag-pulling type scraper lower discharging centrifuge 2 until the set time is reached through setting a certain centrifugal rotating speed and working time, stopping the operation of the bag-pulling type scraper lower discharging centrifuge 2 at the moment, and transferring the materials in the bag-pulling type scraper lower discharging centrifuge 2 into a material storage tank 3 through a pipeline;
3. after being weighed, the materials in the storage tank 3 are transferred into a rotary double-cone dryer 6 through a first spiral feeding machine 5; the rotary double-cone dryer 6 sets the upper limit of the drying temperature and the drying time according to the process requirements; drying the materials in a rotary double-cone dryer 6 according to a set drying temperature to a set time to achieve the requirement of full drying; transferring the materials in the rotary double-cone dryer 6 into the swing type granulator 7 through a second spiral feeding machine 8 for granulation, transferring the granulated materials to the vacuum packaging machine 9 through a pipeline by the swing type granulator 7, and packaging the materials into boxes in a closed manner in the vacuum packaging machine 9.
The utility model discloses can realize that operational environment is dustless, carry out centralized control and artifical intermittent type nature operation to each part control switch through the system control platform, realize valsartan intermediate material aftertreatment and packaging system integration operation to reach clean production requirement, use the environmental protection as the purpose, effectively extended the application of valsartan intermediate production.
The above is only the preferred embodiment of the present invention, so all the equivalent changes or modifications made by the structure, features and principle in the claims of the present invention are included in the claims of the present invention.
Claims (7)
1. A semi-automatic closed type valsartan intermediate material post-processing and packaging system is characterized by comprising a crystallization kettle, a centrifugal machine, a storage tank, a first spiral feeding machine, a drying machine, a second spiral feeding machine, a granulation machine and a packaging machine;
the discharge end of crystallization kettle bottom is linked together through the pan feeding end at pipeline and centrifuge's top, the discharge end of centrifuge bottom extends to the opening part on stock chest top through the pipeline, stock chest bottom discharge end extends to the pan feeding mouth department of first spiral material loading machine through the pipeline, first spiral material loading machine is equipped with the first discharging pipe that extends by supreme slope down, the discharge gate on first discharging pipe top extends to the opening part on desiccator top, desiccator bottom discharge end extends to the pan feeding mouth department of second spiral material loading machine through the management, second spiral material loading machine is equipped with the second discharging pipe that extends by supreme slope down, the discharge gate on second discharging pipe top extends to the opening part on granulation machine top, granulation machine bottom discharge end is connected with the packagine machine entrance point through the pipeline.
2. The system of claim 1, wherein the crystallization kettle is any one of an enamel reaction kettle, a stainless steel reaction kettle, and a glass reaction kettle.
3. The system according to claim 1, wherein a discharge valve is arranged at the discharge end of the bottom of the crystallization kettle, a material liquid level linkage controller is arranged on the discharge valve, a liquid level sensing end of the material liquid level linkage controller is arranged in the centrifuge, and the material liquid level linkage controller is in control connection with the discharge valve.
4. The system of claim 1, wherein the centrifuge is a bag-type drag lower discharge centrifuge.
5. The system of claim 1, wherein the dryer is any one of a double cone rotary dryer, a fluidized bed, and a fluidized bed furnace.
6. The system of claim 1, wherein the granulator is a rocking granulator, and the material granulated by the granulator is packaged in a packaging machine in a closed manner.
7. The system of claim 1, wherein a weighbridge is disposed below the holding tank.
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| CN202020390453.0U CN212699647U (en) | 2020-03-25 | 2020-03-25 | Semi-automatic closed valsartan intermediate material post-treatment and packaging system |
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| CN202020390453.0U CN212699647U (en) | 2020-03-25 | 2020-03-25 | Semi-automatic closed valsartan intermediate material post-treatment and packaging system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315574A (en) * | 2021-12-31 | 2022-04-12 | 河南豫辰药业股份有限公司 | Preparation method of carbasalate calcium |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315574A (en) * | 2021-12-31 | 2022-04-12 | 河南豫辰药业股份有限公司 | Preparation method of carbasalate calcium |
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