CN212688092U - Movable bionic micro-fluidic biochip device - Google Patents
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- CN212688092U CN212688092U CN202021422955.3U CN202021422955U CN212688092U CN 212688092 U CN212688092 U CN 212688092U CN 202021422955 U CN202021422955 U CN 202021422955U CN 212688092 U CN212688092 U CN 212688092U
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Abstract
The utility model relates to the technical field of microfluidic biochips, in particular to a movable bionic microfluidic biochip device, which comprises an installation bottom plate, a driving module, a clamp module and a microfluidic biochip; the clamp module comprises a first clamp unit and a second clamp unit, the first clamp unit and the second clamp unit are positioned on the mounting base plate, one end of the microfluidic biochip is connected with the first clamp unit, and the other end of the microfluidic biochip is connected with the second clamp unit; the first clamp unit and the second clamp unit are connected with the driving module; the utility model discloses a micro-fluidic biochip cooperation first anchor clamps module, second anchor clamps module and drive module, the contraction and the diastole of muscle can be simulated, can be used to organize the medicine screening and the construction of disease mechanism research model under the motion condition, have convenient operation and low cost's advantage.
Description
Technical Field
The utility model relates to a micro-fluidic biochip technical field especially relates to a movable bionical micro-fluidic biochip device.
Background
The microfluidic biochip has the characteristics of high efficiency, low consumption, small volume and the like, and is mainly applied to the fields of timely diagnosis, tissue simulation, cell analysis and the like.
The existing microfluidic biochip structure does not have a movement function, is difficult to simulate cell tissues under the movement condition, and is not beneficial to completing medicament screening and constructing a disease mechanism research model.
SUMMERY OF THE UTILITY MODEL
The technical problem to the cell tissue of micro-fluidic biochip that above-mentioned existence is difficult to under the simulated motion condition, the utility model provides a movable bionical micro-fluidic biochip device can simulate the shrink and the diastole of muscle, can be used to the medicine screening and the disease mechanism research model of organizing under the motion condition and establish, has convenient operation and low cost's advantage.
In order to solve the technical problem, the utility model provides a concrete scheme as follows:
a movable bionic micro-fluidic biochip device comprises an installation base plate, a driving module, a clamp module and a micro-fluidic biochip;
the clamp module comprises a first clamp unit and a second clamp unit, the first clamp unit and the second clamp unit are positioned on the mounting base plate, one end of the microfluidic biochip is connected with the first clamp unit, and the other end of the microfluidic biochip is connected with the second clamp unit;
the first clamp unit and the second clamp unit are connected with the driving module.
Optionally, a flow channel region is arranged on the microfluidic biochip, a plurality of flow channels are formed in the flow channel region, the microfluidic biochip is directly manufactured by a CAD model by adopting a 3D printing technology, and a complex flow channel structure can be manufactured, so that the microfluidic biochip has a complex three-dimensional flow channel structure, the environment of cells in a living body can be better simulated, and the original properties of the cells can be retained to the greatest extent.
Optionally, the first clamp unit includes a first mounting block and a first pressing block disposed at an upper end of the first mounting block; a first mounting groove is formed in the middle of the upper end of the first mounting block;
the second clamp unit comprises a second mounting block and a second pressing block arranged at the upper end of the second mounting block; a second mounting groove is formed in the middle of the upper end of the second mounting block;
two ends of the microfluidic biochip are respectively arranged in the first mounting groove and the second mounting groove;
the two ends of the microfluidic biochip are respectively provided with a first positioning hole and a second positioning hole;
the first pressing block is provided with a first connecting hole corresponding to the first positioning hole; a second connecting hole corresponding to the second positioning hole is formed in the second pressing block;
a first positioning screw penetrates between the first positioning hole and the first connecting hole, and a second positioning screw penetrates between the second positioning hole and the second connecting hole;
the two ends of the microfluidic biochip are respectively arranged in the first mounting groove and the second mounting groove, the microfluidic biochip is compressed by the first compression block and the second compression block, and then the microfluidic biochip is fixed through the matching of the first positioning hole, the first connecting hole and the first positioning screw and the matching of the second positioning hole, the second connecting hole and the second positioning screw, so that the phenomenon of displacement in the process of simulating muscle contraction and relaxation is prevented.
Optionally, a first silica gel gasket is arranged on the first mounting groove, a second silica gel gasket is arranged on the second mounting groove, and the first silica gel gasket and the second silica gel gasket are made of soft elastic silica gel, so that the anti-extrusion performance is good, the micro-fluidic biochip fixing process can be prevented from being damaged by extrusion, and the vibration of the driving module can be effectively reduced.
Optionally, a slide rail is arranged on the mounting bottom plate;
the bottom of the first mounting block is provided with a first sliding chute corresponding to the sliding rail;
the bottom of the second mounting block is provided with a second sliding groove corresponding to the sliding rail, and the microfluidic biochip can generate stable displacement through the matching of the sliding rail, the first sliding groove and the second sliding groove.
Optionally, the cross section of the sliding rail is inverted trapezoid, so that the connection and installation stability between the first sliding groove and the sliding rail and between the second sliding groove and the sliding rail are improved.
Optionally, the driving module includes a linear stepping motor and a lead screw connected to the linear stepping motor, so as to improve the movement control precision of the first clamp unit and the second clamp unit.
Optionally, the microfluidic biochip is made of PDMS material, so that the microfluidic biochip can be deformed by force within an elastic limit.
Compared with the prior art, the beneficial effects of the utility model reside in that: the utility model provides a pair of movable bionical micro-fluidic biochip device through the first anchor clamps module of micro-fluidic biochip cooperation, second anchor clamps module and drive module, can simulate the shrink and the diastole of muscle, can be used to organize the medicine screening and the establishment of disease mechanism research model under the motion condition, has convenient operation and low cost's advantage.
Drawings
Fig. 1 is a schematic diagram of an overall structure of a movable bionic microfluidic biochip device provided in an embodiment of the present invention.
Fig. 2 is a schematic structural diagram of a microfluidic biochip provided in an embodiment of the present invention.
Wherein, 1 is an installation bottom plate; 11 is a slide rail; 2 is a driving module; 21 is a linear stepping motor; 22 is a screw rod; 3 is a clamp module; 31 is a first gripper unit; 311 is a first mounting block; 312 is a first compact; 32 is a second gripper unit; 321 is a second mounting block; 322 is a second compact; 4 is a microfluidic biochip; 41 is a runner area; 42 is a first positioning hole; 43 is a second positioning hole; 5 is a first positioning screw; 6 is a second set screw; 7 is a first silica gel gasket; and 8 is a second silica gel gasket.
Detailed Description
In order to explain the technical solution of the present invention in detail, the following will combine the drawings of the embodiments of the present invention to perform clear and complete description on the technical solution of the embodiments of the present invention. It is to be understood that the embodiments described are only some of the embodiments of the present invention, and not all of them. All other embodiments, which can be obtained by a person skilled in the art without any inventive work based on the described embodiments of the present invention, belong to the protection scope of the present invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
For example, a movable biomimetic microfluidic biochip device comprising a mounting base plate, a drive module, a clamp module, and a microfluidic biochip; the clamp module comprises a first clamp unit and a second clamp unit, the first clamp unit and the second clamp unit are positioned on the mounting base plate, one end of the microfluidic biochip is connected with the first clamp unit, and the other end of the microfluidic biochip is connected with the second clamp unit; the first clamp unit and the second clamp unit are connected with the driving module.
The movable bionic micro-fluidic biochip device provided by the embodiment can simulate the contraction and relaxation of muscles by matching the micro-fluidic biochip with the first clamp module, the second clamp module and the driving module, can be used for drug screening and disease mechanism research model construction under the condition of tissue motion, and has the advantages of convenience in operation and low cost.
Referring to fig. 1 and 2, fig. 1 is a schematic diagram showing an overall structure of a movable bionic microfluidic biochip device; fig. 2 shows a schematic structure of a microfluidic biochip.
As shown in fig. 1 and fig. 2, the movable bionic microfluidic biochip device includes a mounting base plate, a driving module, a clamp module and a microfluidic biochip.
The mounting base plate is used for mounting the clamp module, the clamp module comprises a first clamp unit and a second clamp unit, the first clamp unit and the second clamp unit are located on the mounting base plate and connected with the driving module, and the first clamp unit and the second clamp unit move or are located under the control of the driving module. Myofibroblasts are encapsulated in capillaries of the microfluidic biochip, one end of the microfluidic biochip is connected with the first clamp unit, the other end of the microfluidic biochip is connected with the second clamp unit, namely, the microfluidic biochip is positioned by the first clamp unit and the second clamp unit, and the driving module controls the first clamp unit and the second clamp unit to move to drive the microfluidic biochip to contract and relax so as to simulate the contraction and relaxation of muscles.
It should be noted that, regarding the control of the first clamp unit and the second clamp unit by the driving module, the setting can be performed according to actual requirements, for example, the position of the first clamp unit is controlled to be fixed, and only the second clamp unit is displaced; or the position of the second clamp unit is controlled to be fixed, and only the first clamp unit displaces; or the first clamp unit and the second clamp unit are controlled to displace simultaneously.
In some embodiments, the microfluidic biochip is provided with a flow channel region, the flow channel region is provided with a plurality of flow channels, the flow channel structure includes but is not limited to lattice structures such as regular dodecahedron and the like, the internal surface area of the flow channel can be greatly increased, the specific surface area can reach tens of times of that of a common pipeline-shaped flow channel, and more cells can be attached and grown.
The micro-fluidic biochip adopts a 3D printing technology, is directly manufactured by a CAD model, can manufacture a complex flow channel structure, has the complex three-dimensional flow channel structure, can better simulate the environment of cells in a living body, and furthest retains the original properties of the cells.
The traditional microfluidic biochip has various manufacturing procedures, a mold or a mask needs to be manufactured firstly, the microfluidic biochip is processed, the traditional manufacturing method is limited by the process principle, a complex internal flow channel cannot be processed, and the traditional microfluidic biochip does not have a movement function and is difficult to simulate cell tissues under the movement condition.
The microfluidic biochip in this example employs 3D printing technology to manufacture a microfluidic biochip with substance diffusion function and stable structure by printing polydimethylsiloxane.
By utilizing the 3D printing device, firstly, on a molding surface, the paving of a polydimethylsiloxane material is completed by ascending a layer of feeding assembly and descending a layer of molding assembly, after the material is stricken off by a scraper, the liquid level of the material is calm, the curing of a single material is completed by the exposure of a light machine, then the whole printing device is kept unchanged, an automatic liquid transfer device in the feeding assembly is moved to a set position, the polyethylene glycol diacrylate hydrogel containing biological cells is added quantitatively, the scraper continues to complete the strickling back and forth, the light machine is exposed again, and the curing is completed. So far, a plane containing various materials is solidified, and the cell tissue and the chip structure can be integrally formed by the circulation to obtain the microfluidic biochip.
The microfluidic biochip is made of PDMS (polydimethylsiloxane) material, namely polydimethylsiloxane material, so that the microfluidic biochip can be stressed and deformed within the elastic limit, and elastic photosensitive resin, rubber and the like can also be adopted.
In some embodiments, the first clamp unit includes a first mounting block and a first compression block disposed at an upper end of the first mounting block; a first mounting groove is formed in the middle of the upper end of the first mounting block;
the second clamp unit comprises a second mounting block and a second pressing block arranged at the upper end of the second mounting block; a second mounting groove is formed in the middle of the upper end of the second mounting block;
two ends of the microfluidic biochip are respectively arranged in the first mounting groove and the second mounting groove;
the two ends of the microfluidic biochip are respectively provided with a first positioning hole and a second positioning hole;
the first pressing block is provided with a first connecting hole corresponding to the first positioning hole; a second connecting hole corresponding to the second positioning hole is formed in the second pressing block;
a first positioning screw penetrates between the first positioning hole and the first connecting hole, and a second positioning screw penetrates between the second positioning hole and the second connecting hole;
the two ends of the microfluidic biochip are respectively arranged in the first mounting groove and the second mounting groove, the microfluidic biochip is compressed by the first compression block and the second compression block, and then the microfluidic biochip is fixed through the matching of the first positioning hole, the first connecting hole and the first positioning screw and the matching of the second positioning hole, the second connecting hole and the second positioning screw, so that the phenomenon of displacement in the process of simulating muscle contraction and relaxation is prevented.
In this example, the microfluidic biochip is rectangular, the first mounting groove and the second mounting groove are rectangular grooves, and the sizes of the two ends of the microfluidic biochip are respectively matched with the sizes of the first mounting groove and the second mounting groove, so that the microfluidic biochip can be stably mounted in the first mounting groove and the second mounting groove, and the first clamp unit and the second clamp unit are controlled by the driving module, and then the microfluidic biochip is driven to contract or relax.
In addition, because the microfluidic biochip is detachably mounted, the microfluidic biochip can be detached and replaced according to different biological detection requirements.
It should be noted that the shape of the microfluidic biochip is not limited in particular, and may be adjusted according to actual needs.
In some embodiments, the first mounting groove is provided with a first silica gel gasket, the second mounting groove is provided with a second silica gel gasket, and the first silica gel gasket and the second silica gel gasket are made of soft elastic silica gel, so that the micro-fluidic biochip fixing device has good anti-extrusion performance, can ensure that the micro-fluidic biochip is not damaged by extrusion in the fixing process, and can effectively reduce the vibration of the driving module.
In some embodiments, the mounting base plate is provided with a slide rail; the bottom of the first mounting block is provided with a first sliding chute corresponding to the sliding rail; the bottom of the second mounting block is provided with a second sliding groove corresponding to the sliding rail, and the microfluidic biochip can generate stable displacement through the matching of the sliding rail, the first sliding groove and the second sliding groove.
Specifically, the cross-section of slide rail is for falling trapezoidal, and the cross-section of first spout and second spout is for falling trapezoidal together, falls the trapezium structure and can improve being connected and installation stability between first spout, second spout and the slide rail.
In some embodiments, the driving module includes a linear stepping motor and a lead screw connected to the linear stepping motor, and the lead screw is driven by the linear stepping motor to precisely control the movement of the first and second clamp units.
It is understood that different embodiments among the components in the above embodiments can be combined and implemented, and the embodiments are only for illustrating the implementation of specific structures and are not limited to the implementation of the embodiments.
The embodiments of the present invention have been described in detail with reference to the drawings, but the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Claims (8)
1. A movable bionic micro-fluidic biochip device is characterized by comprising an installation base plate (1), a driving module (2), a clamp module (3) and a micro-fluidic biochip (4);
the clamp module (3) comprises a first clamp unit (31) and a second clamp unit (32), the first clamp unit (31) and the second clamp unit (32) are positioned on the installation base plate (1), one end of the microfluidic biochip (4) is connected with the first clamp unit (31), and the other end of the microfluidic biochip (4) is connected with the second clamp unit (32);
the first clamp unit (31) and the second clamp unit (32) are connected with the driving module (2).
2. The movable bionic microfluidic biochip device according to claim 1, wherein a flow channel region (41) is arranged on the microfluidic biochip (4), and a plurality of flow channels are formed on the flow channel region (41).
3. The movable biomimetic microfluidic biochip device according to claim 1, wherein the first clamp unit (31) comprises a first mounting block (311) and a first pressing block (312) disposed at an upper end of the first mounting block (311); the middle part of the upper end of the first mounting block (311) is provided with a first mounting groove;
the second clamp unit (32) comprises a second mounting block (321) and a second pressing block (322) arranged at the upper end of the second mounting block (321); a second mounting groove is formed in the middle of the upper end of the second mounting block (321);
two ends of the microfluidic biochip (4) are respectively arranged in the first mounting groove and the second mounting groove;
a first positioning hole (42) and a second positioning hole (43) are respectively arranged at two ends of the microfluidic biochip (4);
the first pressing block (312) is provided with a first connecting hole corresponding to the first positioning hole (42); a second connecting hole corresponding to the second positioning hole (43) is formed in the second pressing block (322);
a first positioning screw (5) penetrates between the first positioning hole (42) and the first connecting hole, and a second positioning screw (6) penetrates between the second positioning hole (43) and the second connecting hole.
4. The movable bionic microfluidic biochip device according to claim 3, wherein the first mounting groove is provided with a first silica gel gasket (7), and the second mounting groove is provided with a second silica gel gasket (8).
5. The movable bionic microfluidic biochip device according to claim 3, wherein the mounting base plate (1) is provided with a slide rail (11);
the bottom of the first mounting block (311) is provided with a first sliding groove corresponding to the sliding rail (11);
the bottom of the second mounting block (321) is provided with a second sliding groove corresponding to the sliding rail (11).
6. The movable biomimetic microfluidic biochip device according to claim 5, wherein the cross section of the slide rail (11) is an inverted trapezoid.
7. The movable bionic microfluidic biochip device according to claim 1, wherein the driving module (2) comprises a linear stepping motor (21) and a lead screw (22) connected with the linear stepping motor (21).
8. The mobile biomimetic microfluidic biochip device according to claim 1, wherein the microfluidic biochip (4) is made of PDMS material.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202021422955.3U CN212688092U (en) | 2020-07-17 | 2020-07-17 | Movable bionic micro-fluidic biochip device |
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| CN202021422955.3U CN212688092U (en) | 2020-07-17 | 2020-07-17 | Movable bionic micro-fluidic biochip device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113368918A (en) * | 2021-06-21 | 2021-09-10 | 合肥瀚海星点生物科技有限公司 | Multi-channel liquid separation device and method based on microfluidic printing |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113368918A (en) * | 2021-06-21 | 2021-09-10 | 合肥瀚海星点生物科技有限公司 | Multi-channel liquid separation device and method based on microfluidic printing |
| CN113368918B (en) * | 2021-06-21 | 2022-04-26 | 合肥瀚海星点生物科技有限公司 | Multi-channel liquid separation device and method based on microfluidic printing |
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