CN212662906U - Resin adsorption system for heparin sodium extraction - Google Patents

Abstract

The utility model provides a resin adsorption system for heparin sodium draws, including the adsorption tank, the adsorption tank top is equipped with charge door and liquid feeding pipe, and the bottom is equipped with the bin outlet, and the liquid feeding pipe passes through the tee bend and is connected with liquid return pipe, and liquid return pipe lower extreme is connected with the fluid-discharge tube of adsorption tank lower extreme, and the fluid-discharge tube tip is equipped with the filter screen, is equipped with the delivery pump on the liquid return pipe, and the material in the adsorption tank passes through the rabbling mechanism stirring, and the rabbling mechanism is including setting up the agitator motor at the adsorption tank top, agitator motor's output and the (mixing) shaft connection of setting in the adsorption tank. The system makes the extracting solution fully contact with the resin, and ensures the full adsorption of the heparin sodium.

Description

Resin adsorption system for heparin sodium extraction

Technical Field

The utility model belongs to heparin sodium production facility field, in particular to a resin adsorption system for heparin sodium draws.

Background

The heparin sodium is a sodium salt of aminodextran sulfate, belongs to mucopolysaccharide substances, is mainly extracted from porcine or bovine intestinal mucosa, has an anticoagulant effect, and is an anticoagulant medicament with the most effective and largest clinical dosage. At present, heparin sodium cannot be artificially synthesized and can only be extracted from animal tissues.

In the production process of heparin sodium, firstly, the casing is salted, and then the preparation of the heparin sodium is completed through the procedures of resin adsorption, subsequent elution, precipitation, dehydration and the like after the salting.

In resin adsorption, sufficient stirring is required to make the resin and the extracting solution fully contact, otherwise the adsorption of the resin is influenced or the adsorption time is increased. After the resin adsorbs, mix with the residual liquid, still need carry out filter mechanism and filter, the resin is difficult to be collected, filters the back simultaneously, and protein or impurity can be adhered to on the resin surface, need wash once more, and a plurality of processes cause production efficiency to be lower.

Disclosure of Invention

The utility model aims to solve the technical problem that a resin adsorption system for heparin sodium draws is provided, makes extract and resin fully contact, guarantees the abundant absorption to heparin sodium.

In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: the utility model provides a resin adsorption system for heparin sodium draws, including the adsorption tank, the adsorption tank top is equipped with charge door and liquid feeding pipe, the bottom is equipped with the bin outlet, the liquid feeding pipe passes through the tee bend and is connected with liquid return pipe, liquid return pipe lower extreme is connected with the fluid-discharge tube of adsorption tank lower extreme, the fluid-discharge tube tip is equipped with the filter screen, be equipped with the delivery pump on the liquid return pipe, material in the adsorption tank passes through the rabbling mechanism stirring, the rabbling mechanism is including setting up the agitator motor at the adsorption tank top, agitator motor's output and the (mixing) shaft connection of setting in the adsorption tank, be equipped with.

In the preferred scheme, the end parts of the liquid discharge pipe and the liquid return pipe are respectively provided with a connecting flange, and the filter screen is arranged between the two connecting flanges.

In the preferred scheme, including filtering mechanism, filtering mechanism includes the rose box, is equipped with in the rose box and strains a section of thick bamboo, and the lateral wall of rose box one end is equipped with guide passageway intercommunication bin outlet and strains a section of thick bamboo, is equipped with the drive shaft in straining a section of thick bamboo, is equipped with second helical blade in the drive shaft, and the drive shaft is through setting up the driving motor drive in rose box one end, and the rose box bottom is equipped with the leakage fluid dram, and the one end that the guide passageway was kept away from to the rose box is equipped with and.

In a preferable scheme, a flushing pipe is arranged in the filter tank, and a spray head for discharging water to the filter cartridge is arranged on the flushing pipe.

In a preferred scheme, the number of the stirring mechanisms is two, and the rotation directions of the stirring shafts of the two groups of stirring mechanisms are opposite.

The utility model provides a pair of a resin adsorption system for heparin sodium draws carries the solution of adsorption tank bottom to the adsorption tank top through returning the liquid pipe, realizes the circulation flow of solution, combines first helical blade to the stirring of material, improves extract and adsorption resin's contact uniformity, improves the yield. Preferably, the mixture of the adsorbed resin and the solution is filtered by arranging the filter box and the filter cartridge, and the adsorption resin is discharged by conveying the mixture through the second spiral blade, so that the adsorption resin is favorably collected.

Drawings

The invention will be further explained with reference to the following figures and examples:

fig. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the preferred overall structure of the present invention;

in the figure: the device comprises an adsorption tank 1, a charging hole 2, a liquid adding pipe 3, a discharging hole 4, a liquid return pipe 5, a liquid discharge pipe 6, a filter screen 7, a conveying pump 8, a stirring motor 9, a stirring shaft 10, a first helical blade 11, a connecting flange 12, a filter box 13, a filter cartridge 14, a guide channel 15, a driving shaft 16, a second helical blade 17, a driving motor 18, a liquid discharge hole 19, a flushing pipe 20, a spray head 21 and a discharge hole 22.

Detailed Description

Example 1: as shown in figure 1, a resin adsorption system for heparin sodium extraction comprises an adsorption tank 1, wherein the top of the adsorption tank 1 is provided with a feed inlet 2 and a liquid feeding pipe 3, the feed inlet 2 is used for adding adsorption resin, the liquid feeding pipe 3 is communicated with the previous process through a conveying pipe and conveys the extract of the previous process into the adsorption tank 1, the bottom of the adsorption tank 1 is provided with a discharge outlet 4, the discharge outlet 4 is provided with a valve, the liquid feeding pipe 3 is connected with a liquid return pipe 5 through a tee joint, the lower end of the liquid return pipe 5 is connected with a liquid discharge pipe 6 at the lower end of the adsorption tank 1, the liquid discharge pipe 6 is provided with a valve, the end part of the liquid discharge pipe 6 is provided with a filter screen 7, the liquid return pipe 5 is provided with a conveying pump 8, the material in the adsorption tank 1 is stirred through a stirring mechanism, the stirring mechanism comprises a stirring motor 9 arranged at the top of the adsorption tank 1, the, the stirring shaft 10 is provided with a first helical blade 11.

During the specific use, add adsorption resin and extract and get into behind the adsorption tank 1, start agitator motor 9 and stir the misce bene, make the resin turn from top to bottom, open the valve on fluid-discharge tube 6, start delivery pump 8, carry the solution of adsorption tank 1 bottom to adsorption tank 1 top, filter screen 7 filters adsorption resin, realizes the circulation flow of solution, improves the contact homogeneity of extract and adsorption resin, improves adsorption efficiency.

Preferably, the end parts of the liquid discharge pipe 6 and the liquid return pipe 5 are provided with connecting flanges 12, and the filter screen 7 is arranged between the two connecting flanges 12.

The liquid discharge pipe 6 and the liquid return pipe 5 are connected through a connecting flange 12, and the filter screen 7 is convenient to replace.

Preferably, the filter device comprises a filter mechanism, the filter mechanism is connected with the adsorption tank 1 through a connecting frame, the filter mechanism comprises a filter box 13, a filter cartridge 14 is arranged in the filter box 13, a material guide channel 15 communicated with the material discharge port 4 and the filter cartridge 14 are arranged on the side wall of one end of the filter box 13, the aperture of the filter cartridge 14 is smaller than the particle size of the adsorption resin, a drive shaft 16 is arranged in the filter cartridge 14, the end part of the drive shaft 16 is rotatably arranged at the end part of the filter box 13 through a bearing, a second helical blade 17 is arranged on the drive shaft 16, the drive shaft 16 is driven by a drive motor 18 arranged at one end of the filter box 13, a liquid discharge port 19 is arranged at the bottom of the filter box 13, and a discharge.

After adsorption is completed, a valve of the discharge port 4 is opened, the extracted residual liquid and the adsorption resin are conveyed into the filter cartridge 14 through the guide channel 15, the adsorbed solution flows into the filter box 13 through filtration of the filter cartridge 14 and is discharged from the liquid discharge port 19, and the adsorption resin is conveyed to the discharge port 22 to be discharged under the driving of the driving motor 18, so that the separation of the adsorption resin and the solution is realized, and the collection of the adsorption resin is facilitated.

Preferably, a flushing pipe 20 is arranged in the filter tank 13, the flushing pipe 20 is arranged above the filter cartridge 14, a spray head 21 for discharging water to the filter cartridge 14 is arranged on the flushing pipe 20, and the flushing pipe 20 is communicated with a water storage device through a pipeline and a water pump.

The filter cartridge 14 is flushed by the spray head 21, and the filtered adsorption resin is washed by the spray head 21 in the spiral conveying process of the adsorption resin, so that the filtration and the washing are simultaneously carried out, and the production efficiency is improved.

Example 2: unlike the embodiment 1, as shown in fig. 2, the number of the stirring mechanisms is two, and the rotation directions of the stirring shafts 10 of the two groups of stirring mechanisms are opposite.

Carry out not equidirectional rotation through (mixing) shaft 10, under first helical blade 11's drive, upwards turn with downwards the material in adsorbing tank 1 to be favorable to the intensive mixing of adsorption resin and extract, improve adsorption efficiency.

Claims (5)

1. A resin adsorption system for heparin sodium draws, a serial communication port, including adsorption tank (1), adsorption tank (1) top is equipped with charge door (2) and liquid feeding pipe (3), the bottom is equipped with bin outlet (4), liquid feeding pipe (3) are connected with liquid return pipe (5) through the tee bend, liquid return pipe (5) lower extreme is connected with fluid-discharge tube (6) of adsorption tank (1) lower extreme, fluid-discharge tube (6) tip is equipped with filter screen (7), be equipped with delivery pump (8) on liquid return pipe (5), the material in adsorption tank (1) passes through the rabbling mechanism stirring, the rabbling mechanism is including setting up agitator motor (9) at adsorption tank (1) top, the output of agitator motor (9) is connected with (10) of setting in adsorption tank (1), be equipped with first helical blade (11) on (mixing) shaft (10).

2. Resin adsorption system for heparin sodium extraction according to claim 1, characterized in that the ends of the liquid discharge pipe (6) and the liquid return pipe (5) are provided with connecting flanges (12), and the filter screen (7) is arranged between the two connecting flanges (12).

3. The resin adsorption system for heparin sodium extraction according to claim 1, which comprises a filtering mechanism, wherein the filtering mechanism comprises a filtering tank (13), a filtering cylinder (14) is arranged in the filtering tank (13), a material guide channel (15) communicated with the material discharge port (4) and the filtering cylinder (14) is arranged on the side wall of one end of the filtering tank (13), a driving shaft (16) is arranged in the filtering cylinder (14), a second helical blade (17) is arranged on the driving shaft (16), the driving shaft (16) is driven by a driving motor (18) arranged at one end of the filtering tank (13), a liquid discharge port (19) is arranged at the bottom of the filtering tank (13), and a discharge port (22) communicated with the filtering cylinder (14) is arranged at one end, far away from the material guide channel (15), of the filtering tank (13).

4. The resin adsorption system for heparin sodium extraction according to claim 3, wherein a flushing pipe (20) is arranged in the filter box (13), and a spray head (21) for discharging water to the filter cartridge (14) is arranged on the flushing pipe (20).

5. The resin adsorption system for heparin sodium extraction according to claim 1, wherein the number of the stirring mechanisms is two, and the rotation directions of the stirring shafts (10) of the two groups of stirring mechanisms are opposite.

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