CN212504662U

CN212504662U - High-efficient shikimic acid concentration system

Info

Publication number: CN212504662U
Application number: CN202021106355.6U
Authority: CN
Inventors: 吕浩; 唐正勇; 郭其杨
Original assignee: Nantong Kexing Graphite Equipment Co ltd
Current assignee: Nantong Kexing Graphite Equipment Co ltd
Priority date: 2020-06-16
Filing date: 2020-06-16
Publication date: 2021-02-09
Anticipated expiration: 2030-06-16

Abstract

The utility model relates to a concentrated system of high-efficient shikimic acid include the pans, the heater, the evaporimeter, the condenser, vacuum unit and circulating pump, the pans upper end is connected with the raw materials import, the design has the forced circulation pump on the export of pans lower extreme passes through the tube coupling heater and this pipeline, the pipeline coupling evaporimeter entry is passed through to the heater upper end, the pans upper end is connected to the discharge port of evaporimeter lower extreme, the exhaust outlet of evaporimeter upper end is connected the condenser upper end, the lixiviant holding vessel is connected to the condensate discharge port of condenser lower extreme, the vacuum unit is connected the bottom of condenser respectively and is on the upper side position and the pans upper end, the. The system has the advantages that the service life of the system equipment is long, and the production requirement is met; the whole system is in a totally closed state, and condensed water generated by evaporation can be used for extraction again, so that the effective utilization of resources is facilitated; under the condition of no steam, electric heating hot water can be used as a heat source, and normal pressure boiling water can be used for effective concentration.

Description

High-efficient shikimic acid concentration system

Technical Field

The utility model relates to a shikimic acid concentration technical field, concretely relates to high-efficient shikimic acid concentration system.

Background

Shikimic acid is present in the dry ripe fruit of Illicium verum of Magnoliaceae, and is mainly distributed in the south of mainland China. Shikimic acid is a monomeric compound extracted from Chinese medicine star anise. Shikimic acid has antiinflammatory and analgesic effects, and is intermediate of anticancer drugs. Shikimic acid has effects of resisting inflammation, relieving pain, and can be used as intermediate of antiviral and anticancer drugs by influencing arachidonic acid metabolism, inhibiting platelet aggregation, venous thrombosis and cerebral thrombosis. Shikimic acid is a raw material of a medicine for resisting avian influenza, namely Duffy and a medicine for treating SARS. 2017, 10 and 27, and the list of carcinogens published by the international cancer research institution of the world health organization is preliminarily collated for reference, and shikimic acid is in the list of 3 types of carcinogens. This requires that shikimic acid is not leaked during the manufacturing, especially concentration, and high vacuum concentration ensures that shikimic acid is not destroyed and raw materials are not leaked at the same time. Shikimic acid and lixiviant can corrode grade 304 and grade 316 stainless steel, the service life of equipment is not long in the concentration process, and the production requirement cannot be met.

SUMMERY OF THE UTILITY MODEL

In order to solve the technical problem, the utility model provides a high-efficient shikimic acid concentration system, the design is simple, convenient to use, and system's equipment long service life satisfies the production demand.

High-efficient shikimic acid concentration system include the pans, the heater, the evaporimeter, the condenser, vacuum unit and circulating pump, the pans upper end is connected with the raw materials import, the design has the forced circulation pump on the export of pans lower extreme passes through the tube coupling heater and this pipeline, the pipeline coupling evaporimeter entry is passed through to the heater upper end, the pans upper end is connected to the discharge port of evaporimeter lower extreme, the exhaust outlet of evaporimeter upper end connects the condenser upper end, the lixiviant holding vessel is connected to the condensate discharge port of condenser lower extreme, the vacuum unit is connected the bottom of condenser respectively and is on the upper side position and the pans upper end, the pans lower extreme still.

The heater, the evaporator and the condenser are manufactured and molded by impregnating impermeable graphite materials.

One side of the upper end of the heater is provided with a steam or hot water inlet, and one side of the lower end of the heater is provided with a condensed water outlet.

The evaporator comprises an upper end enclosure, a middle main body and a lower end enclosure, wherein the upper end enclosure and the lower end enclosure are respectively and correspondingly installed on the outer side of the middle main body, a medium inlet is designed on one side of the upper end of the middle main body, an exhaust outlet is designed in the middle of the upper end enclosure, a concentrated crystal discharge port is designed in the middle of the lower end enclosure, a steam heating interlayer is designed on the outer side of the middle main body, and a steam inlet and a steam outlet are designed on the outer.

The inside design of pans have a baffle, the baffle divide into left chamber and right chamber to the inside chamber of pans, the raw materials import is located the left chamber top of pans, the access connection of forced circulation pump is at the left chamber lower extreme of pans, the lower extreme discharge port of evaporimeter is connected in the right chamber top of pans and is stretched into right chamber through the pipeline and be close to the bottom position, the vacuum unit passes through the right chamber top of tube coupling at the pans, the right chamber lower extreme of pans is connected with the discharge port.

The height of the partition is 1/5 of the internal height of the intermediate tank.

The utility model has the advantages of perfect process, convenient operation, long service life of system equipment and meeting the production requirement; the graphite has the characteristic of high-efficiency heat transfer, the heat transfer coefficient of the impregnated graphite can reach 120w/m.k, which is more than 4 times of that of stainless steel, the heat source used in concentration can be ensured to be as low as possible, and the energy conservation and environmental protection are facilitated; the whole system is in a totally closed state, and condensed water generated by evaporation can be used for extraction again, so that the effective utilization of resources is facilitated; under the condition of no steam, electric heating hot water can be used as a heat source, and normal pressure boiling water can be used for effective concentration.

Drawings

Fig. 1 is a schematic diagram of the present invention.

Fig. 2 is a schematic view of an evaporator according to the present invention.

Fig. 3 is a schematic top view of fig. 2.

Figure 4 is a schematic view of the tundish of the present invention.

Detailed Description

Referring to the attached drawings 1-4, the high-efficiency shikimic acid concentration system comprises an intermediate tank 1, a heater 2, an evaporator 3, a condenser 4, a vacuum unit 5 and a forced circulation pump 6, wherein the upper end of the intermediate tank 1 is connected with a raw material inlet 8, the outlet at the lower end of the intermediate tank 1 is connected with the heater 2 through a pipeline, the pipeline is provided with the forced circulation pump 6, the upper end of the heater 2 is connected with a medium inlet 34 of the evaporator 3 through a pipeline, a discharge outlet 36 at the lower end of the evaporator 3 is connected with the upper end of the intermediate tank, an exhaust outlet 35 at the upper end of the evaporator 3 is connected with the upper end of the condenser 4, a condensate 4 discharge outlet at the lower end of the condenser 4 is connected with a leaching agent storage tank 7, the vacuum unit. A cooling liquid inlet is designed on one side of the lower end of the condenser 4, and a cooling liquid outlet is designed on one side of the upper end of the condenser 4. The vacuum unit 5 is connected with the upper position of the bottom of the condenser 4 and provides power for the condenser 4 to extract media in the evaporator, the vacuum unit 5 is connected with the upper end of the intermediate tank 1 and provides power for the concentrated media at the bottom of the evaporator to be discharged into the intermediate tank, and the vacuum unit 5 also ensures that the vacuum degree in the evaporator is-60 kPa.

The heater 2, the evaporator 3 and the condenser 4 are manufactured and molded by impregnating impermeable graphite materials.

One side of the upper end of the heater 2 is provided with a steam or hot water inlet, and one side of the lower end of the heater 2 is provided with a condensed water outlet.

The evaporator 3 comprises an upper end enclosure 31, a middle main body 32 and a lower end enclosure 33, wherein the upper end enclosure 31 and the lower end enclosure 33 are respectively and correspondingly installed on the outer side of the middle main body 32, a medium inlet 34 is designed on one side of the upper end of the middle main body 32, an exhaust outlet 35 is designed in the middle of the upper end enclosure 31, a concentrated crystal discharge port 36 is designed in the middle of the lower end enclosure 33, a steam heating interlayer is designed on the outer side of the middle main body 32, and a steam inlet 37 and a steam outlet 38 are designed on the outer side. The medium inlet 34 is tangentially designed to the intermediate body 32, the boiling medium entering the apparatus swirls along the inner wall of the intermediate body of the evaporator, during which the liquid evaporates in the inner wall of the intermediate body, the evaporated secondary vapor exits through the exhaust outlet 35 and enters the condenser 4, and the concentrated medium exits through the concentrated crystal discharge outlet 36. The boiling medium moves tangentially along the inner wall of the equipment, and the annular line is longer, so that the evaporation is facilitated; the boiling medium forms a film-shaped medium layer on the inner wall of the equipment main body, and the film has high evaporation efficiency and good effect.

1 internally designed of pans has a baffle 11, baffle 11 divide into left chamber and right chamber to the inside chamber of pans 1, the raw materials import is located pans 1's left chamber top, force circulating pump 6's access connection is at pans 1's left chamber lower extreme, evaporator 3's lower extreme discharge port is connected in pans 1's right chamber top and is stretched into right chamber through pipeline 12 and be close to the bottom position, vacuum unit 5 passes through the pipe connection in pans 1's right chamber top, pans 1's right chamber lower extreme is connected with discharge port 9. The height of the partition is 1/5 of the internal height of the intermediate tank. The design of the partition plate is to prevent the crystals from being pumped away by the forced circulation pump again, the pipeline 12 extends to a position close to the bottom, the crystals are also prevented from splashing to the other left cavity, the solution in the right cavity can overflow from the upper part of the partition plate, when the system runs, the forced circulation pump cannot pump the solution, the pressure of the pump cannot reach, the whole system stops running, the solution in the intermediate tank is completely concentrated and crystallized, and the discharge port 9 is opened to discharge the solution.

The high-efficiency shikimic acid concentration process comprises the following steps,

1) the method comprises the steps of putting raw materials into a middle tank, leaching a shikimic acid solution with 4% formic acid in the middle tank, heating the solution by a heater at the temperature of 70 ℃, extracting the leached solution from the bottom of the middle tank by a forced circulation pump, enabling the leached solution to enter the bottom of the heater, enabling the solution to travel upwards from the bottom of the heater, and enabling the solution to form a gas-liquid mixture when the solution reaches an outlet at the top of the heater in the whole process.

2) The gas-liquid mixture in the heater is conveyed to an evaporator, the vacuum degree in the evaporator is-60 kPa, the temperature is 70 ℃, and flash evaporation is carried out.

3) The secondary steam generated in the evaporator was fed to a condenser and cooled to 30 ℃ to form a 4% formic acid solution.

4) And discharging the concentrated solution in the evaporator into an intermediate tank from the lower part, circulating the solution in the intermediate tank for multiple times through a forced circulation pump to accelerate the crystallization of the solution until the solution can not be pumped by the forced circulation pump, opening a discharge port at the lower part of the intermediate tank to discharge the concentrated crystals, naturally cooling, and air-drying to obtain shikimic acid crystals.

The shikimic acid solution in the step 1) is a shikimic acid solution with the concentration of 20 percent.

And (3) conveying the 4% formic acid solution generated in the step 3) to a heater for recycling.

Use examples:

taking 4% formic acid extracted shikimic acid as an example, the evaporation amount is 1000kg per hour, the evaporation temperature is 70 ℃, and 0.2MPa steam is used as a heat source.

1. The evaporation pressure was 40 kPa.

2. The heater, the evaporator and the condenser are manufactured by impregnating impermeable graphite with phenolic resin, the impermeable graphite is impregnated with the phenolic resin in a connecting pipeline between the heater and the evaporator, and reinforced polypropylene linings are adopted in the other forced circulation pumps, the intermediate tank and pipeline pipe fittings; the structure and the material design improve the corrosion resistance of the whole system and prolong the service life of the whole system.

3. And (2) carrying out 15 square meters on the specification of the heater, DN450x500 on the specification of the evaporator, namely 30 square meters on the condenser, carrying out 1m cultivation on the intermediate tank, carrying out 20 m forced circulation pump lift and 1.5m cultivation on the intermediate tank, and carrying out 3.5kwx2 on the vacuum pump unit.

4. 150kg of concentrated solution is generated every hour after concentration, the concentrated solution is finally discharged into a crystallization storage tank through a middle tank and crystallized after natural cooling, and finally, air drying is carried out by adopting a fan.

5. 1000kg/h of condensed water was produced and reused as an extractant.

Claims

1. High-efficient shikimic acid concentration system, a serial communication port, it includes the pans, the heater, the evaporimeter, the condenser, vacuum unit and circulating pump, the pans upper end is connected with the raw materials import, the design has forced circulation pump on the export of pans lower extreme passes through the tube coupling heater and this pipeline, the medium import of tube coupling evaporimeter is passed through to the heater upper end, the pans upper end is connected to the discharge port of evaporimeter lower extreme, the exhaust outlet connection condenser upper end of evaporimeter upper end, the lixiviant holding vessel is connected to the condensate discharge port of condenser lower extreme, the bottom upper position and the pans upper end of condenser are connected respectively to the vacuum unit, the pans lower extreme still is connected with.

2. The system as claimed in claim 1, wherein the heater, evaporator and condenser are made of impermeable graphite material.

3. The system for concentrating shikimic acid with high efficiency as claimed in claim 1, wherein the heater is provided with an inlet for steam or hot water on one side of the upper end and a condensed water outlet on one side of the lower end.

4. The efficient shikimic acid concentration system of claim 1, wherein the evaporator comprises an upper head, a middle body and a lower head, the upper head and the lower head are respectively and correspondingly installed on the outer side of the middle body, a medium inlet is designed on one side of the upper end of the middle body, an exhaust outlet is designed in the middle of the upper head, a concentrated crystal discharge port is designed in the middle of the lower head, a steam heating interlayer is designed on the outer side of the middle body, and a steam inlet and a steam outlet are designed on the outer side of the steam heating interlayer.

5. The system for concentrating shikimic acid with high efficiency as claimed in claim 1, wherein the middle tank is designed with a partition plate, the partition plate divides the inner cavity of the middle tank into a left cavity and a right cavity, the raw material inlet is located above the left cavity of the middle tank, the inlet of the forced circulation pump is connected to the lower end of the left cavity of the middle tank, the lower end discharge port of the evaporator is connected to the upper part of the right cavity of the middle tank and extends into the right cavity through a pipeline to be close to the bottom position, the vacuum unit is connected to the upper part of the right cavity of the middle tank through a pipeline, and the lower end of the right cavity of the middle tank is.

6. The system as claimed in claim 5, wherein the height of the partition is 1/5.