CN212491615U - Vacuum distillation device for cysteamine hydrochloride - Google Patents
Vacuum distillation device for cysteamine hydrochloride Download PDFInfo
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- CN212491615U CN212491615U CN201921249856.7U CN201921249856U CN212491615U CN 212491615 U CN212491615 U CN 212491615U CN 201921249856 U CN201921249856 U CN 201921249856U CN 212491615 U CN212491615 U CN 212491615U
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- cysteamine hydrochloride
- hydrochloric acid
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Abstract
The utility model relates to an organic synthesis engineering application technical field specifically is a vacuum distillation device of cysteamine hydrochloride, including stills, heater, condenser, dilute hydrochloric acid collecting tank and vacuum pump, stills are used for splendid attire and mixed hydrochloric acid, water and the semi-manufactured goods material of cysteamine hydrochloride, and the stills bottom communicates a circulating pump through the pipeline, and the circulating pump continues to pump the material pump to the heater in, and the heater is vertical to be placed, adopts steam heating, and its bottom is steam inlet, and its upper portion is equipped with the comdenstion water export; and the heated semi-finished product material containing saturated cysteamine hydrochloride is heated and then sent back to the upper part of the distillation still through a pipeline, the upper part of the distillation still is communicated with a condenser through a pipeline, an outlet of the condenser is communicated with a dilute hydrochloric acid collecting tank, and the upper part of the dilute hydrochloric acid collecting tank is communicated with a vacuum pump.
Description
Technical Field
The application relates to the technical field of organic synthesis equipment, in particular to a vacuum distillation device for cysteamine hydrochloride.
Background
Cysteamine is a pharmaceutical intermediate, and when added to feed, it can accelerate the growth of animals such as pigs and cattle and increase their lean meat percentage, because its pH value is alkaline, it can form salts with acids, and after forming salts with hydrochloric acid, it is called cysteamine hydrochloride.
Currently, cysteamine hydrochloride is produced by a production process of ethanolamine sulfate-mercaptothiazoline in industrial production, mercaptothiazoline is hydrolyzed in hydrochloric acid medium to generate cysteamine hydrochloride, in the synthesis process of the cysteamine hydrochloride, since high-concentration hydrochloric acid exists in reaction materials and the reaction temperature is about 110 ℃ in order to maintain the reaction, the hydrochloric acid at high temperature is easy to form acid mist above the reaction liquid level in a reaction kettle. Acid mist generated by hydrochloric acid easily corrodes a kettle cover of the reaction kettle, a kettle body of the reaction kettle and a connecting part between the kettle cover and the kettle body, so that the kettle cover cracks and perforates, reaction solution seeps out of holes, or acid mist and waste gas escape from the holes, and environmental pollution is caused. Meanwhile, the equipment loss rate is high, the production safety risk is high, and the maintenance cost is high; on the other hand, in order to obtain high-purity cysteamine hydrochloride, hydrochloric acid and water are evaporated, and qualified cysteamine hydrochloride products can be obtained.
The prior art generally adopts an enamel kettle to carry out vacuum distillation, but has obvious defects:
1. the heat exchange area of the enamel kettle is limited by only utilizing the enamel kettle, and the heat conduction performance is poor;
2. materials do not fully participate in the mass transfer process, the operation time of material purification is long (more than 20 days), the steam consumption is large, and the relative labor intensity of workers is high;
3. porcelain explosion and corrosion phenomena easily occur in the enamel kettle in a high-temperature hydrochloric acid medium, the content of iron in a product exceeds the standard, and the service life of equipment is short (half a year on average).
SUMMERY OF THE UTILITY MODEL
In order to overcome the defects of the prior art, the utility model relates to a vacuum distillation device of cysteamine hydrochloride.
A vacuum distillation device for cysteamine hydrochloric acid eave comprises a distillation still, a heater, a condenser, a dilute hydrochloric acid collecting tank and a vacuum pump, wherein the distillation still is used for containing a semi-finished product material mixed with hydrochloric acid, water and cysteamine hydrochloride, the bottom of the distillation still is communicated with a circulating pump through a pipeline, the circulating pump continuously pumps the material into the heater, the heater is vertically placed and heated by steam, the bottom of the heater is a steam inlet, and the upper part of the heater is provided with a condensed water outlet; and the heated semi-finished product material containing saturated cysteamine hydrochloride is heated and then sent back to the upper part of the distillation still through a pipeline, the upper part of the distillation still is communicated with a condenser through a pipeline, an outlet of the condenser is communicated with a dilute hydrochloric acid collecting tank, and the upper part of the dilute hydrochloric acid collecting tank is communicated with a vacuum pump.
The vacuum pump continuously pumps vacuum for the whole device, and as the pipe system and the tank body in the whole device have higher vacuum degrees, hydrochloric acid and moisture in the mixed material heated by the heater are evaporated in a gas phase mode, the evaporated gaseous hydrochloric acid is condensed into a liquid state by the condenser, and the condensed liquid is collected and then is collected in the dilute hydrochloric acid collecting tank; because the circulating pump and the vacuum pump continuously work, the whole vacuum distillation process is continuous, and dilute hydrochloric acid and water in the semi-finished product material are continuously distilled out, so that cysteamine hydrochloride in the material is continuously purified until the requirement of product purity is met.
Preferably, the distillation still is made of carbon steel, and the PFA coating is sprayed on the inner surface of the distillation still.
Preferably, the circulating pump body is made of carbon steel, and a PFA coating is sprayed on the inner surface of the circulating pump body.
Preferably, the heater adopts a plate-hole graphite heat exchanger.
Preferably, the dilute hydrochloric acid collection tank is made of PP materials.
Preferably, a section of pipeline is further arranged at the bottom of the dilute hydrochloric acid collecting tank, the pipeline conveys the condensed and liquefied dilute hydrochloric acid into the hydrochloric acid storage tank through a dilute hydrochloric acid pump, and a pump body of the dilute hydrochloric acid conveying pump adopts a carbon steel lining F46.
Preferably, the vacuum pump is a water jet vacuum pump made of PP material.
Preferably, the stop valve is made of carbon steel lining tetrafluoroethylene.
Preferably, the expansion joint is made of stainless steel lining tetrafluoroethylene.
Preferably, the pipeline visual cup is made of PP materials.
Advantageous effects
By adopting the vacuum distillation device for cysteamine hydrochloride provided by the application, vacuum distillation is carried out by adopting a forced external circulation heating mode, the mass transfer efficiency of materials is greatly improved, and the purification efficiency of cysteamine hydrochloride is also greatly improved; a large amount of high-temperature-resistant PFA coatings and corrosion-resistant PP materials are used in the whole device, so that impurity iron ions introduced due to corrosion of the enamel kettle are avoided, and the purity stability of the product is more reliable.
Drawings
FIG. 1 is a general schematic diagram of an embodiment of the present invention;
wherein the content of the first and second substances,
the device comprises a distillation kettle 1, a circulating pump 2, a heater 3, a condenser 4, a dilute hydrochloric acid collecting tank 5, a dilute hydrochloric acid pump 6, a vacuum pump 7, a stop valve 8, a stop valve 9, a stop valve 13, an expansion joint 10, a thermometer 11, a pressure gauge 12, a pipeline visual cup 14, a condensed water outlet 15, a steam inlet 16, a hot water outlet 17, a cold water inlet 18 and a dilute hydrochloric acid storage tank 19.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be described in detail below. It is to be understood that the embodiments described are only some embodiments of the invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
Fig. 1 shows the whole vacuum distillation apparatus for purifying cysteamine hydrochloride, which comprises a distillation still 1, a heater 3, a condenser 4, a dilute hydrochloric acid collection tank 5 and a vacuum pump 7, wherein the distillation still 1 is used for containing a semi-finished product material mixed with hydrochloric acid, water and cysteamine hydrochloride, the bottom of the distillation still 1 is communicated with a circulating pump 2 through a pipeline, a stop valve 8 is arranged in the middle of the pipeline, the circulating pump 2 continuously pumps the material into the heater 3, the heater 3 is vertically placed and heated by steam, the bottom of the heater is a steam inlet 16, and the upper part of the heater is provided with a condensed water outlet 15; the heated semi-finished product material containing saturated cysteamine hydrochloride is heated and then sent back to the upper part of the distillation still 1 through a pipeline, the upper part of the distillation still 1 is also communicated with a condenser 4 through a pipeline, an outlet of the condenser 4 is communicated with a dilute hydrochloric acid collecting tank 5, and the upper part of the dilute hydrochloric acid collecting tank 5 is communicated with a vacuum pump 7.
A pipeline visual cup 14 made of PP materials is arranged between the outlet of the condenser 4 and the dilute hydrochloric acid collecting tank 5, so that whether the purification of the materials is completed or not can be conveniently observed.
The bottom of the dilute hydrochloric acid collecting tank 5 is also provided with a section of pipeline, and the pipeline conveys the condensed and liquefied dilute hydrochloric acid into the hydrochloric acid storage tank through a dilute hydrochloric acid pump 6.
An expansion joint 10 made of stainless steel is also arranged at the bottom of the heater 3 and is used for compensating the expansion and contraction of the pipeline caused by temperature difference and reducing the leakage of substances such as hydrochloric acid and the like caused by the loosening of the pipeline interface and the environmental pollution.
The principle of the whole device is as follows: the vacuum pump 7 continuously pumps vacuum for the whole device, and because the pipe system and the tank body in the whole device have higher vacuum degrees, hydrochloric acid and moisture in the mixed material heated by the heater 3 are evaporated in a gas phase mode, the evaporated gaseous hydrochloric acid is condensed into liquid state by the condenser 4, and the liquid hydrochloric acid is collected and then is collected in the dilute hydrochloric acid collecting tank; because the circulating pump 2 and the vacuum pump 7 continuously work, the whole vacuum distillation process is continuous, and dilute hydrochloric acid and water in the semi-finished product material are continuously distilled out, so that cysteamine hydrochloride in the material is continuously purified until the requirement of product purity is met.
In order to avoid corrosion of the distillation still to the distillation still 3 due to high temperature and high concentration hydrochloric acid gas, the distillation still 3 is made of carbon steel, and a PFA coating is sprayed on the inner surface of the distillation still 3.
In order to reduce corrosion of hydrochloric acid components in the materials to the circulating pump, the pump body of the circulating pump is made of carbon steel, and a PFA coating is sprayed on the inner surface of the pump body.
In general, the heat exchanger for corrosive materials is preferably a plate-hole type graphite heat exchanger because the heat exchanger is made of a corrosion-resistant material such as a graphite heat exchanger.
Preferably, the dilute hydrochloric acid collection tank 5 is made of PP materials.
In order to reduce the corrosion of the dilute hydrochloric acid delivery pump and prolong the service life, the pump body of the dilute hydrochloric acid delivery pump adopts a carbon steel lining F46.
In this embodiment, the vacuum pump 7 is a PP water jet vacuum pump.
In this embodiment, the stop valve is made of carbon steel lined with tetrafluoroethylene.
In this embodiment, the expansion joint is made of stainless steel lined with tetrafluoroethylene.
In this embodiment, the pipeline visual cup is made of a PP material.
It should be noted that, since the innovation of the apparatus is not in the circuit portion, a circuit necessary for implementing the above technical solution is not described in the above embodiments, but as a person skilled in the art can fully draw a circuit connection diagram as required after understanding the technical solution of the present application and combining with the drawings, and thus, redundant description is omitted here.
In addition, the embodiment is only used as a case for realizing the technical scheme of the application, and some technical details cannot be set forth one by one, but the understanding of the application by a person skilled in the art is not affected, and the person skilled in the art can fully make corresponding details perfect on the basis of understanding the application.
The above description is only for the specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art can easily think of the changes or substitutions within the technical scope of the present invention, and all should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A vacuum distillation device of cysteamine hydrochloride is characterized in that: the device comprises a distillation kettle (1), a heater (3), a condenser (4), a dilute hydrochloric acid collecting tank (5) and a vacuum pump (7), wherein the distillation kettle (1) is used for containing materials mixed with hydrochloric acid, water and cysteamine hydrochloride, the bottom of the distillation kettle (1) is communicated with a circulating pump (2) through a pipeline, the circulating pump (2) continuously pumps the materials into the heater (3), the heater (3) is heated by steam, the bottom of the heater (3) is a steam inlet (16), and a condensed water outlet (15) is arranged at the upper part of the heater (3); the heated semi-finished product material containing saturated cysteamine hydrochloride is heated and then sent back to the upper part of the distillation still (1) through a pipeline, the upper part of the distillation still (1) is communicated with a condenser (4) through another pipeline, an outlet of the condenser (4) is communicated with a dilute hydrochloric acid collecting tank (5), and the upper part of the dilute hydrochloric acid collecting tank (5) is communicated with a vacuum pump (7).
2. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 1, wherein: the distillation still (1) is made of carbon steel, and a PFA coating is sprayed on the inner surface of the distillation still.
3. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 2, wherein: the pump body of the circulating pump (2) is made of carbon steel, and a PFA coating is sprayed on the inner surface of the pump body.
4. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 3, wherein: and the heater (3) adopts a plate hole type graphite heat exchanger.
5. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 4, wherein: the dilute hydrochloric acid collection tank (5) is made of PP materials.
6. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 5, wherein: the vacuum distillation device for the cysteamine hydrochloride further comprises a dilute hydrochloric acid delivery pump (6), and a pump body of the dilute hydrochloric acid delivery pump (6) adopts a carbon steel lining F46.
7. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 6, wherein: the vacuum pump (7) is a water jet vacuum pump made of PP materials.
8. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 7, wherein: the vacuum distillation device for the cysteamine hydrochloride further comprises stop valves (8, 9, 13), and the stop valves (8, 9, 13) are made of carbon steel lining tetrafluoroethylene.
9. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 8, wherein: the vacuum distillation device for the cysteamine hydrochloride further comprises an expansion joint (10), and the expansion joint (10) adopts stainless steel lining tetrafluoroethylene.
10. The vacuum distillation apparatus for cysteamine hydrochloride according to claim 9, wherein: the vacuum distillation device for the cysteamine hydrochloride further comprises a pipeline visual cup (14), and the pipeline visual cup (14) is made of PP materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921249856.7U CN212491615U (en) | 2019-08-05 | 2019-08-05 | Vacuum distillation device for cysteamine hydrochloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921249856.7U CN212491615U (en) | 2019-08-05 | 2019-08-05 | Vacuum distillation device for cysteamine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212491615U true CN212491615U (en) | 2021-02-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921249856.7U Active CN212491615U (en) | 2019-08-05 | 2019-08-05 | Vacuum distillation device for cysteamine hydrochloride |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212491615U (en) |
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2019
- 2019-08-05 CN CN201921249856.7U patent/CN212491615U/en active Active
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