CN212417558U - Continuous desalination device of soluble polypeptide - Google Patents

Abstract

A continuous soluble polypeptide desalting device mainly comprises a polypeptide mother liquor raw water tank for containing a salt-containing polypeptide mother liquor, a nanofiltration cartridge filter for removing particle impurities in the salt-containing polypeptide mother liquor, a nanofiltration membrane device for separating salt in the salt-containing polypeptide mother liquor, a temperature control device for cooling the polypeptide mother liquor raw water tank and a deionized water replenishing device for maintaining the content of deionized water in the polypeptide mother liquor raw water tank; the liquid inlet end of the nanofiltration cartridge filter is connected with the mother liquor raw water tank through a nanofiltration booster pump, the liquid outlet end of the nanofiltration cartridge filter is connected with the nanofiltration membrane device through a nanofiltration high-pressure pump, the nanofiltration membrane device separates the salt-containing polypeptide mother liquor after the particle impurities are removed by the nanofiltration cartridge filter, the separated salt-containing clear water is discharged through a nanofiltration water production pipe, and the separated mixed liquid is circulated into the polypeptide mother liquor raw water tank through a nanofiltration concentrated water pipe for secondary cycle desalination; the device has the characteristics of simple structure, low use cost, good separation effect and the like.

Description

Continuous desalination device of soluble polypeptide

Technical Field

The utility model belongs to the technical field of the material separation, concretely relates to continuous demineralizer of soluble polypeptide.

Background

In recent years, with the rapid development of the amino acid and polypeptide drug market, the prospect shows a favorable scene, the preparation and production technologies are more and more, the research and development of the soluble polypeptide separation and purification technology is increasingly concerned by experts, and a plurality of new processes and new technologies are applied, so that the research and development of the soluble polypeptide is promoted to become a hot spot in the scientific and technological field. However, the salt and impurities contained in the soluble polypeptide are not easy to separate, the existing separation process is complex, long in time, volatile, high in raw material consumption and low in recovery rate, and the using components of the soluble polypeptide are increased.

Disclosure of Invention

The to-be-solved technical problem of the utility model lies in, to the above-mentioned defect of prior art, provide a simple structure and low in production cost's soluble polypeptide continuous desalination device.

The utility model aims at completing the technical proposal that the device for continuously desalting soluble polypeptide mainly comprises a polypeptide mother liquor raw water tank for containing the salt polypeptide mother liquor, a nanofiltration security filter for removing particle impurities in the salt polypeptide mother liquor, a nanofiltration membrane device for separating salt in the salt polypeptide mother liquor, a temperature control device for cooling the polypeptide mother liquor raw water tank and a deionized water replenishing device for keeping the content of deionized water in the polypeptide mother liquor raw water tank; the liquid inlet end of the nanofiltration cartridge filter is connected with the polypeptide mother liquor raw water tank through a nanofiltration booster pump, the liquid outlet end of the nanofiltration cartridge filter is connected with the nanofiltration membrane device through a nanofiltration high-pressure pump, the nanofiltration membrane device separates the salt-containing polypeptide mother liquor with particle impurities removed by the nanofiltration cartridge filter, separated salt-containing clear water is discharged through a nanofiltration water production pipe, and separated mixed liquid is circulated into the polypeptide mother liquor raw water tank through the nanofiltration water concentration pipe for secondary circulation desalination.

Furthermore, the deionized water replenishing device comprises a reverse osmosis raw water tank and a reverse osmosis device for carrying out deionization separation on tap water in the reverse osmosis raw water tank; the reverse osmosis device mainly comprises a reverse osmosis booster pump, a reverse osmosis cartridge filter, a reverse osmosis high-pressure pump and a reverse osmosis membrane device which are sequentially connected through pipelines, wherein tap water in a reverse osmosis raw water tank is subjected to deionization separation in the reverse osmosis membrane device after suspended particles in the water are removed through the reverse osmosis cartridge filter, deionized water obtained after separation is used for replenishing water to a polypeptide mother liquor raw water tank through a reverse osmosis water production pipe, and concentrated water obtained after separation is discharged through a reverse osmosis concentrated water pipe.

Furthermore, the reverse osmosis device also comprises a reverse osmosis concentrated water return pipe for improving the water recovery rate of the device, one end of the reverse osmosis concentrated water return pipe is connected with the reverse osmosis concentrated water pipe, and the other end of the reverse osmosis concentrated water return pipe is connected with a water inlet of the reverse osmosis high-pressure pump.

Furthermore, the temperature control device is a water circulation cooling device, and a temperature sensor and an automatic control valve for controlling a water cooling pipeline in the water circulation cooling device are arranged in the water circulation cooling device.

The utility model has the advantages of: the utility model discloses utilized the permselectivity of nanofiltration membrane to carry out the salinity desorption to containing salt polypeptide mother liquor, simply understood soluble polypeptide mother liquor as the mixed liquid of polypeptide, salinity, water, got rid of the salinity that contains in the mother liquor to improve the quality of polypeptide mother liquor, when the mother liquor passes through the nanofiltration membrane, the polypeptide can be held back in the concentrate by the nanofiltration membrane, and the salinity then permeable this semipermeable membrane, thereby reached the effect of polypeptide and salinity separation; the method has the characteristics of simple process, low production cost, effective production cost saving and the like.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention.

Detailed Description

To make the objects, technical solutions and advantages of the present invention more clearly understood by those skilled in the art, the present invention will be further described with reference to the accompanying drawings and examples.

As shown in fig. 1, the continuous soluble polypeptide desalting apparatus of the present invention mainly comprises a polypeptide mother liquor raw water tank 9 for containing a salt-containing polypeptide mother liquor, a nanofiltration cartridge filter 12 for removing particle impurities in the salt-containing polypeptide mother liquor, a nanofiltration membrane device 14 for separating salt in the salt-containing polypeptide mother liquor, a temperature control device 10 for cooling the polypeptide mother liquor raw water tank 9, and a deionized water replenishing device 7 for maintaining the content of deionized water in the polypeptide mother liquor raw water tank 9; the liquid inlet end of the nanofiltration cartridge filter 12 is connected with the polypeptide mother liquor raw water tank 9 through a nanofiltration booster pump 11, the liquid outlet end of the nanofiltration cartridge filter 12 is connected with the nanofiltration membrane device 14 through a nanofiltration high-pressure pump 13, the nanofiltration membrane device 14 separates the salt-containing polypeptide mother liquor from which the particle impurities are removed by the nanofiltration cartridge filter 12, the separated salt-containing clear water is discharged through a nanofiltration water production pipe 15, and the separated mixed liquid is circulated into the polypeptide mother liquor raw water tank 9 through a nanofiltration concentrated water pipe 16 for secondary cycle desalination; the temperature control device 10 is a water circulation cooling device, and a temperature sensor and an automatic control valve for controlling a water cooling pipeline in the water circulation cooling device are arranged in the water circulation cooling device.

Referring to fig. 1, the deionized water replenishing device 7 includes a reverse osmosis raw water tank 1 and a reverse osmosis device for performing deionization and separation on tap water in the reverse osmosis raw water tank 1; the reverse osmosis device mainly comprises a reverse osmosis booster pump 2, a reverse osmosis cartridge filter 3, a reverse osmosis high-pressure pump 4 and a reverse osmosis membrane device 5 which are sequentially connected through pipelines, running water in a reverse osmosis raw water tank 1 is subjected to deionization separation in the reverse osmosis membrane device 5 after suspended particles in the water are removed through the reverse osmosis cartridge filter 3, deionized water obtained after separation is subjected to water replenishing on a polypeptide mother liquor raw water tank 9 through a reverse osmosis water production pipe 17, and concentrated water obtained after separation is discharged through a reverse osmosis concentrated water pipe 6; the reverse osmosis device also comprises a reverse osmosis concentrated water return pipe 8 for improving the water recovery rate of the device, one end of the reverse osmosis concentrated water return pipe 8 is connected with the reverse osmosis concentrated water pipe 6, and the other end of the reverse osmosis concentrated water return pipe is connected with a water inlet of the reverse osmosis high-pressure pump 4.

When the device is used, firstly, the salt-containing polypeptide mother liquor to be desalted is placed in a polypeptide mother liquor raw water tank 9 (because the set of nanofiltration device needs continuous cycle concentration operation, the water temperature can rise, and therefore the raw water tank needs to be matched with a temperature control device 10), after primary pressurization is carried out through a nanofiltration booster pump 11, particle impurities contained in the mother liquor are removed through a nanofiltration safety filter 12 to ensure the use safety of a nanofiltration membrane device 14, the water pressure is improved through a nanofiltration high-pressure pump 13 and is brought into the nanofiltration membrane device 14, after the separation effect of the nanofiltration membrane device 14, the nanofiltration water production pipe 15 discharges salt-containing clear water, and a nanofiltration concentrated water pipe 16 recycles mixed liquid with polypeptide, clear water and salt content (part of salt content is reduced) into the polypeptide mother liquor raw water tank 9 again to prepare for secondary cycle desalting.

As the nanofiltration water production pipe 15 is continuously discharged outwards, the water level of the polypeptide mother liquor raw water tank 9 is continuously reduced, and a piece of deionized water is required to be introduced for ensuring the continuous desalination operation, the invention takes tap water produced by reverse osmosis as the deionized water supplement, the tap water enters the reverse osmosis raw water tank 1, enters the reverse osmosis safety filter 3 under the action of the reverse osmosis booster pump 2 to remove suspended particles possibly in the water so as to ensure the safety of the reverse osmosis membrane device 5, and enters the reverse osmosis membrane device 5 under the action of the reverse osmosis high-pressure pump 4 to carry out deionization separation. The concentrated water of the separated water production enters a reverse osmosis concentrated water pipe 6 for discharging, and the deionized water of the water production enters a reverse osmosis water production pipe 17 to be used as the water supplement of a polypeptide mother liquor raw water tank 9; in order to save water resources, the reverse osmosis device is additionally provided with a reverse osmosis concentrated water return pipe 8 so as to improve the water recovery rate of the reverse osmosis device. With the continuous salt discharge of the water produced by the nanofiltration equipment and the continuous supplement of the deionized water of the reverse osmosis equipment, the salt content in the polypeptide mother liquor containing salt is gradually reduced, and finally the high-quality polypeptide liquid meeting the requirements is achieved.

The invention defaults that the salt contained in the mother liquor is monovalent salt mainly comprising sodium chloride, and if other multivalent salt is contained in the mother liquor in actual use, the salt can be converted into monovalent salt through ion exchange resin treatment in advance.

The specific embodiments described herein are merely illustrative of the principles of the present invention and its efficacy, and are not intended to limit the invention. Modifications and variations can be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the present invention. Therefore, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical idea of the present invention shall be covered by the claims of the present invention.

Claims (4)

1. A continuous soluble polypeptide desalting device, which is characterized in that: the device mainly comprises a polypeptide mother liquor raw water tank for containing the salt-containing polypeptide mother liquor, a nanofiltration cartridge filter for removing particle impurities in the salt-containing polypeptide mother liquor, a nanofiltration membrane device for separating salt in the salt-containing polypeptide mother liquor, a temperature control device for cooling the polypeptide mother liquor raw water tank, and a deionized water replenishing device for maintaining the content of deionized water in the polypeptide mother liquor raw water tank; the liquid inlet end of the nanofiltration cartridge filter is connected with the polypeptide mother liquor raw water tank through a nanofiltration booster pump, the liquid outlet end of the nanofiltration cartridge filter is connected with the nanofiltration membrane device through a nanofiltration high-pressure pump, the nanofiltration membrane device separates the salt-containing polypeptide mother liquor with particle impurities removed by the nanofiltration cartridge filter, separated salt-containing clear water is discharged through a nanofiltration water production pipe, and separated mixed liquid is circulated into the polypeptide mother liquor raw water tank through the nanofiltration water concentration pipe for secondary circulation desalination.

2. The continuous soluble polypeptide desalination apparatus of claim 1, wherein: the deionized water replenishing device comprises a reverse osmosis raw water tank and a reverse osmosis device for carrying out deionization separation on tap water in the reverse osmosis raw water tank; the reverse osmosis device mainly comprises a reverse osmosis booster pump, a reverse osmosis cartridge filter, a reverse osmosis high-pressure pump and a reverse osmosis membrane device which are sequentially connected through pipelines, wherein tap water in a reverse osmosis raw water tank is subjected to deionization separation in the reverse osmosis membrane device after suspended particles in the water are removed through the reverse osmosis cartridge filter, deionized water obtained after separation is used for replenishing water to a polypeptide mother liquor raw water tank through a reverse osmosis water production pipe, and concentrated water obtained after separation is discharged through a reverse osmosis concentrated water pipe.

3. The continuous soluble polypeptide desalination apparatus as claimed in claim 2, wherein: the reverse osmosis device also comprises a reverse osmosis concentrated water return pipe for improving the water recovery rate of the device, one end of the reverse osmosis concentrated water return pipe is connected with the reverse osmosis concentrated water pipe, and the other end of the reverse osmosis concentrated water return pipe is connected with a water inlet of the reverse osmosis high-pressure pump.

4. The continuous soluble polypeptide desalting device according to any one of claims 1 to 3, wherein: the temperature control device is a water circulation cooling device, and a temperature sensor and an automatic control valve for controlling a water cooling pipeline in the water circulation cooling device are arranged in the water circulation cooling device.

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