CN212364325U - Sample analyzer and optical detection device - Google Patents

Abstract

The utility model provides a sample analyzer, optical detection device, this optical detection device include the optics base plate, and the light source base plate is adjusted in the slidability in the B direction and is set up on the optics base plate, and wherein, light source base plate or optics base plate are equipped with the sliding fit portion that the protrusion formula set up in order to reduce frictional force when carrying out the slidability and adjust.

Description

Sample analyzer and optical detection device

Technical Field

The utility model relates to a medical treatment detection and analysis technical field especially relates to a sample analyzer, optical detection device.

Background

The full-automatic analyzer is widely used in hospitals at all levels, medical inspection laboratories and regional detection centers due to high measurement speed, high accuracy and small reagent consumption.

Be equipped with detection device in the full autoanalyzer, detection device detects the sample in the optical detection pond through the optical detection mode.

However, the optical detection assembly in the existing detection device is usually large in structure, so that the miniaturization and integration of the whole machine are restricted, the adjustment is not convenient, and the clamping stagnation is easy to occur during the adjustment.

SUMMERY OF THE UTILITY MODEL

The application provides a sample analyzer, optical detection device to it is great to solve among the prior art optical detection subassembly common structure, has restricted the miniaturized integration of complete machine, and is not convenient for adjust, appears the technical problem of jamming easily during the regulation.

In order to solve the technical problem, the application adopts a technical scheme that: an optical detection device of a sample analyzer is provided, which includes an optical substrate on which a light source substrate is slidably adjustable in a B direction, wherein the light source substrate or the optical substrate is provided with a sliding fitting portion provided in a projecting manner to reduce a frictional force when the sliding adjustment is performed.

In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analyzer comprising the optical detection device and a laser module, the laser module comprising:

the light source base is provided with an assembly cavity and is arranged on the light source substrate in a slidable adjustment mode in the direction A;

the laser fixing plate is adjustably embedded in the assembly cavity in the directions of A, B and C;

the laser is embedded in the laser fixing plate and used for emitting laser to the direction A;

and the laser locking piece is used for adjusting and locking the laser fixing plate.

The beneficial effect of this application is: be different from prior art's condition, the utility model provides a sample analyzer, optical detection device compact structure, regulation convenience are difficult for appearing the jamming.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, it is obvious that the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without inventive efforts, wherein:

fig. 1 is a simplified optical path schematic diagram of an optical detection apparatus provided in an embodiment of the present invention;

fig. 2 is a schematic perspective view of an optical detection apparatus provided in an embodiment of the present invention;

FIG. 3 is a schematic diagram of a partial assembly of the optical detection device shown in FIG. 2;

FIG. 4 is a schematic diagram of a partial assembly of the optical detection device shown in FIG. 3;

FIG. 5 is a schematic diagram of a partial assembly of the optical detection device shown in FIG. 4;

FIG. 6 is a partial component schematic view of the laser module shown in FIG. 3;

FIG. 7 is a schematic perspective view of the laser module shown in FIG. 3;

FIG. 8 is a schematic perspective view of the laser module shown in FIG. 3;

FIG. 9 is a side schematic view of the laser module shown in FIG. 3;

FIG. 10 is a cross-sectional schematic view of the laser module shown in FIG. 7;

FIG. 11 is a partial component schematic view of the laser module shown in FIG. 7;

FIG. 12 is a partial component schematic view of the laser module shown in FIG. 7;

FIG. 13 is a partial component schematic view of the laser module shown in FIG. 7;

FIG. 14 is a partial component schematic view of the laser module shown in FIG. 7;

FIG. 15 is a schematic view of one manner of securing the laser module shown in FIG. 2;

FIG. 16 is a schematic diagram of a partial assembly of the optical detection device shown in FIG. 2;

FIG. 17 is an exploded view of the fluorescence receiving module shown in FIG. 16;

FIG. 18 is an exploded view of the fluorescence receiving module shown in FIG. 16;

FIG. 19 is a partial cross-sectional view of the optical detection device shown in FIG. 2;

FIG. 20 is a schematic diagram of the components of the optical detection apparatus shown in FIG. 2;

FIG. 21 is an exploded schematic view of the side-scatter focusing mirror adjustment module shown in FIG. 20;

FIG. 22 is a perspective view of the sheath flow cell assembly shown in FIG. 16;

FIG. 23 is a cross-sectional view of the sheath flow cell assembly and side-scatter focusing mirror conditioning module shown in FIG. 20.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that, if directional indications (such as upper, lower, left, right, front and rear … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are changed accordingly.

In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.

As shown in fig. 1 and fig. 2, the present invention provides an optical detection device, which includes an optical substrate 100, a first optical adjustment member 111, a second optical adjustment member 112, a sheath flow cell module 200, a side scattered light focusing mirror 250, a laser module (or called front optical module) 300, a light source substrate 310, a front scattered light receiving module 400, a side light splitting module 500, a side scattered light receiving module 600, and a fluorescence receiving module 700.

In the present invention, the extending direction of the optical axis (shown by the dotted line in fig. 10) of the laser module 300 is defined as the a direction, the B direction is defined as the a direction perpendicular to the a direction on the horizontal plane, the C direction is defined as the a direction perpendicular to the a direction on the vertical plane, which can be equivalent to the X/Y/Z direction of the rectangular spatial coordinate system, and of course, the three directions can be set non-perpendicularly.

The light source substrate 310 is slidably adjusted and arranged on the optical substrate 100 in the B direction, the sheath flow cell module 200 is arranged on the optical substrate 100, the laser module 300 is arranged on the light source substrate 310 and located at a first side of the sheath flow cell module 200, the laser module 300 includes a laser 340, a collimating lens 341, a front focusing mirror 342, a cylindrical mirror 343 and other components for providing laser light to the sheath flow cell module 200, the forward scattered light receiving module 400 is arranged at a side of the sheath flow cell module 200 away from the laser module 300, the forward scattered light receiving module 400, the sheath flow cell module 200 and the laser module 300 are arranged substantially in the first straight direction, the forward scattered light receiving module 400 includes a forward scattered light receiving plate 410, a forward scattered light receiving diaphragm 420 and at least one forward scattering adjusting piece 430 for adjusting in the a direction, the B direction or the C direction to improve the light receiving precision, the detection accuracy is improved, the front scattering adjusting element is preferably adjusted in the direction B, but may also be adjusted in two dimensions, for example, adjusted in the direction a or the direction C or both directions A, C simultaneously, the forward scattering light receiving module 400 is configured to receive forward laser light after passing through the sheath flow cell module 200, the side scattering light focusing mirror 250 is disposed at a second side of the sheath flow cell module 200, the second side and the first side may be perpendicular to each other, the side scattering light focusing mirror 250 is configured to receive side laser light after passing through the sheath flow cell module 200, the side beam splitting module 500 is disposed at a side of the side scattering light focusing mirror 250 away from the sheath flow cell module 200, the three elements of the side beam splitting module 500, the side scattering light focusing mirror 250, and the sheath flow cell module 200 are disposed substantially in a second linear direction, the second linear direction may be perpendicular to the first linear direction, the side beam splitting module 500 includes a dichroic mirror 510 and a filter 520, the side beam splitting module 500 has light splitting and filtering functions, the side beam splitting module 500 is configured to receive side laser light passing through the side scattered light focusing mirror 250, the side scattered light receiving module 600 is disposed at a first side of the side beam splitting module 500, the side scattered light receiving module 600 includes a side receiving plate 610, a side scattered light receiving diaphragm 620 and at least one side scattering adjusting element (not shown) to improve light receiving precision in the a direction, the B direction or the C direction and improve detection accuracy, the side scattering adjusting element is preferably adjusted in the B direction, although two-dimensional adjustment may also be performed, for example, adjustment in the a direction, the C direction or both directions of A, C, the side scattered light receiving module 600 is configured to receive laser light reflected by the side beam splitting module 500, the fluorescence receiving module 700 is disposed at a second side of the side beam splitting module 500, the fluorescence receiving module 700 includes a fluorescence receiving plate 740 and a fluorescence receiving diaphragm 741, the fluorescence receiving module 700 is configured to receive laser light transmitted by the side light splitting module 500, the fluorescence receiving module 700 includes an adjusting mechanism 752 and a fluorescence receiver 742 that are arranged side by side or in a stacked manner, as shown in fig. 2, when the adjusting mechanism 752 and the fluorescence receiver 742 are arranged side by side, the whole fluorescence receiving module 700 is in a vertically-placed long strip shape, the adjusting mechanism 752 extends to the side of the laser module 300, and limited space is fully utilized to make the whole product compact in overall structure, if the adjusting mechanism 752 and the fluorescence receiver 742 are arranged in a stacked manner, that is, the adjusting mechanism 752 is arranged on the side of the fluorescence receiver 742 away from the side light splitting module 500, the whole length of the fluorescence receiving module 700 will be shortened, but the thickness will be increased.

Wherein, after the point light source emitted by the laser 340 passes through the collimating lens 341, the front light focusing lens 342 and the cylindrical lens 343 in sequence, an elliptical (major axis about 100-200 um, minor axis about 10-30 um) light spot required for reaching the sheath flow cell module 200 can be formed, and a light source/light beam of the flow cytometry is formed; the light irradiates the particles (blood cells, etc.) to be measured in the sheath flow cell 201 of the sheath flow cell module 200, generates scattered light of various directions/angles, and generates excited fluorescence by irradiating the fluorescence-dyed particles; the forward scattering light receiving diaphragm 420 is used for selectively receiving scattering light signals within a certain angle range, generally a small angle range, such as 1-9 degrees, and the signals represent size information of particle volumes; since the side scattering needs to collect a large angle (a large angle is generally an angle within a range of ± 30 ° with the laser 340 as an axis, and the large angle is generally 90 ° with the laser 340), the side scattering first reaches the dichroic mirror 510, which has a function of selecting a certain range of wavelengths for reflection and projection, reflects the side scattering light (the complexity of contents such as reaction cell membranes, cytoplasm, nuclear membranes, etc. and the size of cell nuclei) to be collected to the side scattering light receiving module 600, and selectively transmits the excited fluorescence to reach the fluorescence receiving module 700.

As shown in fig. 1 to 16, the laser module 300 includes a light source substrate 310, a light source base 320, a laser fixing plate 330, a laser 340, a locking plate 350, a locking plate fixture 351, a first light source adjuster 331, a second light source adjuster 332, a laser pressing plate 344, a laser pressing plate locking member 345, a laser fixing plate locking member 333, an elastic pushing member 334, and a translational matching portion 336.

The light source substrate 310 is a machined part with good flatness, the light source base 320 is provided with a through assembly cavity 322, the assembly cavity 322 can be in a step cavity shape (including a circular cavity 340 for assembling a laser and a rectangular cavity for assembling the laser fixing plate 330) so as to facilitate limiting assembly of internal elements (such as the laser fixing plate 330 and the collimating lens 341), and the light source base 320 is further provided with an avoiding groove 353 at an end corner of the assembly cavity 322 matched with the laser pressing plate 344 so as to facilitate adjustment of the laser pressing plate 344.

Light source base 320 is adjusted in the slidable in A direction and is set up on light source base plate 310, and laser instrument fixed plate 330 is in A direction, B direction, C direction on the adjustability inlay locate assembly chamber 322 in, and laser instrument 340 inlays and locates in laser instrument fixed plate 330, and laser instrument 340 is used for sending laser to A direction, for the optical axis that makes laser instrument 340 is obtaining ideal state (for example coaxial with the axle center of assembly chamber 322), the utility model discloses set up to laser instrument fixed plate 330 and can adjust on A direction, B direction, the three direction of C direction.

The laser 340 can be pressed in the laser fixing plate 330 by the laser pressing plate 344 and locked by the laser pressing plate locking member 345, the laser pressing plate locking member 345 can be a screw, a fastener or an adhesive member, the laser fixing plate 330 is provided with a step cavity, the laser pressing plate 344 comprises a sleeve part and a flange part, the sleeve part limits and abuts against the laser 340 in the step cavity of the laser fixing plate 330, and the laser pressing plate locking member 345 locks the flange part on the laser fixing plate 330 to fix the laser 340.

The locking plate 350 presses the laser fixing plate 330 into the light source base 320 by a locking plate fixture 351, the locking plate fixture 351 may be a screw, a fastener, an adhesive, or the like, and the laser fixing plate locking member 333 penetrates the locking plate 350 to adjust and lock the laser fixing plate 330. The laser fixing plate locking pieces 333 may be screws, etc., the number of the laser fixing plate locking pieces 333 may be 1, 2, or more, and when the number of the laser fixing plate locking pieces 333 is 2, they may be diagonally disposed, and by clockwise or counterclockwise rotation of any one of the 2 laser fixing plate locking pieces 333, the attitude of the laser fixing plate 330 may be adjusted, for example, the attitude of the laser fixing plate 330 may be adjusted to a vertical state.

The first light source adjusting part 331 extends into the light source base 320 through the adjusting hole 329 (see fig. 6) to adjust the laser fixing plate 330 in the direction B, the second light source adjusting part 332 extends into the light source base 320 through the adjusting hole 329 to adjust the laser fixing plate 330 in the direction C, the first light source adjusting part 331 and the second light source adjusting part 332 may be screws, screw pairs, etc., because the assembly precision of the laser fixing plate 330 is very high, in some embodiments, the first light source adjusting part 331 and the second light source adjusting part 332 may be taken away after the adjustment is completed to avoid the adjustment error by a non-professional, and of course, the first light source adjusting part 331 and the second light source adjusting part 332 may also be left on the light source base 320 to facilitate the adjustment by a professional.

As shown in fig. 10, the light source base 320 is further provided with a convex ring portion 323 corresponding to the assembly cavity, the convex ring portion 323 can be positioned and sleeved with a lens barrel portion 324 shown in fig. 8 and 9, and the lens barrel portion 324 can be used for arranging the optical lenses such as the front focusing lens 342 and the cylindrical lens 343. The lens barrel 324 and the light source base 320 can be integrally formed or assembled in a split manner, so that the precision is relatively high during integral forming, and the split manner is convenient to manufacture during assembly.

The first optical adjustment member 111 can be mounted on and connected to the light source base 320 through the light source substrate 310 or other additional board, the light source base 320 has a corresponding connection hole 113 for adjusting the sliding of the light source base 320 relative to the light source substrate 310 in the a direction, the second optical adjustment member 112 is mounted on and connected to the light source substrate 310 through the optical substrate 110 or other additional board for adjusting the sliding of the light source substrate 310 relative to the optical substrate 100 in the B direction, and the first optical adjustment member 111 and the second optical adjustment member 112 can be screw pairs, slider assemblies, motor assemblies, gear assemblies and other adjustment mechanisms, preferably screw pairs.

The adjustment requirements can be better met through the four adjusting pieces and the laser fixing plate locking piece 333, wherein the first light source adjusting piece 331 and the second light source adjusting piece 332 can be used for adjusting up, down, left and right, the first optical adjusting piece 111 and the second optical adjusting piece 112 can be relatively adjusted front, back, left and right, and the laser fixing plate locking piece 333 can adjust the overall inclination of the plate surface pose of the laser fixing plate 330.

The elastic pushing member 334 is embedded in the light source base 320 through an embedding hole 328 (see fig. 6) and elastically abuts against the surface of the laser fixing plate 330 away from the first light source adjusting member 331 and the second light source adjusting member 332, the elastic pushing member 334 may be an elastic ball plunger, a spring or elastic silica gel, the translational matching portion 336 is embedded in the light source base 320 and abuts against the surface of the laser fixing plate 330 away from the locking plate 350, and the first light source adjusting member 331 and the second light source adjusting member 332 form an adjusting mechanism with mutual pushing force with the elastic pushing member 334 when performing screw adjustment, so as to ensure good adjustment controllability. The laser fixing plate locking member 333 forms an adjusting mechanism with a mutual pushing force with the translational matching part 336 when performing the screw adjustment, so as to ensure good adjustment and control performance. Of course, the elastic pushing member 334 only acts as a passive cooperation, and does not push the position of the laser fixing plate locking member 333 to change due to the removal of the first light source adjusting member 331 and the second light source adjusting member 332.

The light source base 320 or the light source substrate 310 is provided with a sliding fit portion 321 (see fig. 6) arranged in a protruding manner to reduce friction force when the sliding adjustment is performed in the direction a, the light source substrate 310 or the optical substrate 100 is provided with a sliding fit portion 311 (see fig. 5) arranged in a protruding manner to reduce friction force when the sliding adjustment is performed in the direction B, the sliding fit portion (311, 321) may be a protruding portion of an integral structure on the optical substrate 100 or the light source substrate 310 and the light source base 320, or the sliding fit portion (311, 321) may be an elastic ball plunger or a ball (see fig. 8 and 9) embedded on the optical substrate 100, the light source substrate 310 or the light source base 320, and the friction force is reduced by reducing a contact area, so that the sliding adjustment is smoother.

As shown in FIGS. 16-18, the fluorescence receiving module 700 comprises a fixed base 730, a first movable base 710, a second movable base 720, a fluorescence receiving plate 740, a fluorescence receiver 742, a first fluorescence adjustor 701, a second fluorescence adjustor 702, a first locking member 716, and a second locking member 726. The first and second retaining members 716, 726 may be screws. The fluorescence receiving module 700 includes an adjusting mechanism 752 and a fluorescence receiver 742 that are arranged side by side or stacked, as shown in fig. 2, when the adjusting mechanism 752 and the fluorescence receiver 742 are arranged side by side, the whole fluorescence receiving module 700 is vertically long, the adjusting mechanism 752 extends to the side of the laser module 300, and limited space is fully utilized to make the whole structure of the product compact, if the adjusting mechanism 752 and the fluorescence receiver 742 are arranged in a stacked manner, that is, the adjusting mechanism 752 is arranged on the side of the fluorescence receiver 742 away from the lateral splitting module 500, the whole length of the fluorescence receiving module 700 will be shortened, but the thickness will be increased.

The first movable base plate 710 is slidably adjusted in the direction C and is disposed on the fixed base 730,

the second movable substrate 720 is slidably adjusted in the a direction and disposed on the first movable substrate 710, and the fluorescence receiver 742 is fixed to the second movable substrate 720. Of course, in some embodiments, the second movable substrate 720 may not be provided, and the fluorescence receiving plate 740 may be slidably adjusted and disposed on the first movable substrate 710.

The fixing base 730 may include a main body plate 731 and a flap 732 disposed at a side of the main body plate 731, the flap 732 is used for disposing the first fluorescent adjusting member 701 to adjust the first moving base 710 in the C direction, and the first fluorescent adjusting member 701 may be an adjusting mechanism such as a screw pair, a slider assembly, a motor assembly, a gear assembly, etc.

The main body plate 731 is provided with a first guide post 734, the first moving substrate 710 is provided with a C-direction guide slot 714 matched with the first guide post 734, the main body plate 731 is provided with a first locking hole 735, the first moving substrate 710 is provided with a first locking slot 715 matched with the first locking hole 735, the first locking member 716 passes through the first locking slot 715 to be matched with the first locking hole 735, the first moving substrate 710 is provided with a second guide post 714, and the second moving substrate 720 is provided with an a-direction guide slot 724 matched with the second guide post 714.

The first moving substrate 710 is provided with a second locking hole 715, the second moving substrate 720 is provided with a second locking groove 725 matching with the second locking hole 715, the second locking member 726 passes through the second locking groove 725 to match with the second locking hole 715, the first moving substrate 710 includes a first plate 711, a second plate 712 and a third plate 713, the second plate 712 and the third plate 713 are bent oppositely from the edge of the first plate 711, the first plate 711 is attached to the main plate 731, the second plate 712 is parallel to the folded plate 732, and the third plate 713 is used for arranging the second fluorescent adjusting member 702 to adjust the second moving substrate 720 in the a direction.

The fluorescence receiving plate 740 is fixed to the second movable substrate 720, the fluorescence receiver 742 is fixed to the fluorescence receiving plate 740, the second movable substrate 720 has a through slot 721 aligned with the fluorescence receiver 742, the fluorescence receiver 742 can be embedded in the through slot 721, the fluorescence receiving module 700 further includes a fluorescence diaphragm 741, the fluorescence diaphragm 741 is fixed to the second movable substrate 720 and covers the through slot 721, and the fluorescence diaphragm 741 has an aperture 743 aligned with the fluorescence receiver 742.

As shown in fig. 19, the optical detection apparatus further includes an optical bottom case 91, an optical cover engaged with the optical bottom case 91, a lower shock absorbing member 93, an upper shock absorbing member 94 and a first connecting member 95, a second connecting member 96 is disposed on the optical bottom case 91, the second connecting member 96 may be a snap post or a threaded post integrally formed or assembled on the optical bottom case 91, the second connecting member 96 has a snap position or an internal thread, the lower shock absorbing member 93 is sleeved on the periphery of the second connecting member 96, the optical substrate 100 is disposed with a lower stepped hole 104 and an upper stepped hole 105, the optical substrate 100 is sleeved on the second connecting member 96 and pressed on the lower shock absorbing member 93 through the lower stepped hole 104, the outer peripheral wall of the upper shock absorbing member 94 is stepped, the upper shock absorbing member 94 is step-engaged with the upper stepped hole 105 and spaced between the second connecting member 96 and the optical substrate 100, the bottom surface of the upper shock absorbing member 94 and the top end of the lower shock absorbing member 93, the top end of the upper shock absorbing member 94 is higher than the top end of the second connecting member 96, and the first connecting member 95 is snap-fit or screw-fit with the second connecting member 96 and is pressed against the top end surface of the upper shock absorbing member 94 for a better anti-vibration support effect. The upper shock absorbing member 94 or the lower shock absorbing member 93 may be a silicone tube or a spring or other elements with good elastic properties.

The utility model provides an optical detection device compact structure, regulation convenience are difficult for appearing the jamming, and four regulating parts of its laser module 300 accessible and laser instrument fixed plate locking piece 333 carry out the multidimension degree and adjust, and the flexible operation is convenient, can reduce the frictional force when adjusting through setting up sliding fit portion 321 in addition, can smooth regulation, avoids the jamming. The utility model also provides a sample analyzer, this sample analyzer include aforementioned optical detection device, and this sample analyzer specifically can be hematology analyzer, flow cytometry, blood coagulation analyzer, immunoassay appearance etc..

As shown in fig. 1 to 14, the present invention further provides a laser module 300, where the laser module 300 includes an optical substrate 100, a first optical adjustment member 111, a second optical adjustment member 112, a light source substrate 310, a light source base 320, a laser fixing plate 330, a laser 340, a locking plate 350, a first light source adjustment member 331, a second light source adjustment member 332, a laser fixing plate locking member 333, an elastic pushing member 334, a translational matching portion 336, a collimating lens 341, a first inclined pressing member 360, and a second inclined pressing member 370.

The light source substrate 310 is a machined part with good flatness, the light source base 320 is arranged on the light source substrate 310 in a slidable manner in the direction a, the light source substrate 320 is arranged on the optical substrate 310 in a slidable manner in the direction B, the first optical adjusting piece 111 is mounted through the light source substrate 310 or other additional plates and connected with the light source base 320 and used for adjusting the sliding of the light source base 320 relative to the light source substrate 310 in the direction a, the light source base 320 is provided with a connecting hole 113 (see fig. 7) matched with the first optical adjusting piece 111, the second optical adjusting piece 112 is mounted through the optical substrate 110 or other additional plates and connected with the light source substrate 310, and the light source substrate 310 is provided with a connecting hole 114 (see fig. 5) corresponding to the second optical adjusting piece 112 and used for adjusting the sliding of the light source substrate 310 relative to the optical substrate 100 in the direction B. The first optical adjustment member 111 and the second optical adjustment member 112 may be adjustment mechanisms such as a screw pair, a slider assembly, a motor assembly, a gear assembly, etc.

The light source base 320 is provided with a through assembly cavity 322, which may be in a stepped cavity shape (including a circular cavity 340 for assembling the laser and a rectangular cavity for assembling the laser fixing plate 330) to facilitate the limit assembly of the internal components (such as the laser fixing plate 330 and the collimating lens 341).

The laser instrument fixed plate 330 is inlayed in the assembly chamber 322 in A direction, B direction, the adjustability of C direction, and laser instrument 340 is inlayed in locating laser instrument fixed plate 330 for to A direction lasing, for the optical axis of laser instrument 340 is obtaining ideal state (for example coaxial with the axle center of assembly chamber 322), the utility model discloses set up to laser instrument fixed plate 330 and can adjust on A direction, B direction, the three direction of C direction.

The laser collimating lens 341 is embedded in the assembly cavity 322 and located at the front side of the laser 340, the locking plate 350 cooperates with the light source base 320 to press the laser fixing plate 330 into the light source base 320, and the laser fixing plate locking member 333 penetrates through the locking plate 350 to adjust the laser fixing plate 330 and lock the attitude of the laser fixing plate 330 after adjustment. The laser fixing plate locking pieces 333 may be screws, etc., the number of the laser fixing plate locking pieces 333 may be 1, 2, or more, and when the number of the laser fixing plate locking pieces 333 is 2, they may be diagonally disposed, and by clockwise or counterclockwise rotation of any one of the 2 laser fixing plate locking pieces 333, the attitude of the laser fixing plate 330 may be adjusted, for example, the attitude of the laser fixing plate 330 may be adjusted to a vertical state.

The first light source adjusting part 331 protrudes into the light source base 320 through the adjusting hole 329 (see fig. 6) to adjust the laser fixing plate 330 in the B direction, and the second light source adjusting part 332 protrudes into the light source base 320 through the adjusting hole 329 (see fig. 6) to adjust the laser fixing plate 330 in the C direction. The first light source adjusting part 331 and the second light source adjusting part 332 may be screws, thread pairs, etc. since the assembly precision requirement of the laser fixing plate 330 is very high, in some embodiments, the first light source adjusting part 331 and the second light source adjusting part 332 may be taken away after the adjustment is completed to avoid the adjustment error by a non-professional person, and of course, the first light source adjusting part 331 and the second light source adjusting part 332 may also be left on the light source base 320 to facilitate the adjustment by a professional commissioning person.

As shown in fig. 10, the light source base 320 is further provided with a convex ring portion 323 corresponding to the assembly cavity, the convex ring portion 323 can be positioned and sleeved with a lens barrel portion 324 shown in fig. 8 and 9, and the lens barrel portion 324 can be used for arranging the optical lenses such as the front focusing lens 342 and the cylindrical lens 343.

The elastic pushing member 334 is embedded in the light source base 320 and elastically abuts against the surface of the laser fixing plate 330 away from the first light source adjusting member 331 and the second light source adjusting member 332, and the elastic pushing member 334 may be an elastic ball plunger, a spring, or elastic silica gel.

The translational mating portion 336 is embedded in the light source base 320, the translational mating portion 336 abuts against the surface of the laser fixing plate 330 away from the locking plate 350, and the translational mating portion 336 may be an elastic ball plunger, a ball, or a protrusion of an integrated structure to reduce friction when performing sliding adjustment. The first light source adjusting part 331 and the second light source adjusting part 332 form a mutual pushing force with the elastic pushing part 334 during the screw adjustment to ensure good adjustment controllability. The laser fixing plate locking member 333 forms a pushing force against the translational engaging portion 336 during the screw adjustment to ensure a good adjustment and control performance. Of course, the elastic pushing member 334 only acts as a passive cooperation, and does not push the position of the laser fixing plate locking member 333 to change due to the removal of the first light source adjusting member 331 and the second light source adjusting member 332.

The first tilting member 360 is fixed to the light source substrate 310, the light source base 320 is provided with a first press-connection portion 361 matched with the first tilting member 360, the first tilting member 360 is an elastic pressing sheet, a pressing block or an elastic ball plunger, and the first tilting member 360 can be fixed to the light source substrate 310, for example, as shown in fig. 3. When the first inclined pressing member 360 is an elastic ball plunger, referring to fig. 15, the first inclined pressing member 360 not only plays a role of elastically pressing the light source base 320 in an inclined manner, but also has a smaller frictional resistance due to the spherical contact at the pressed portion, and is relatively smoothly adjusted. The bottom and/or side surfaces of the light source substrate 310 are provided with a sliding-fit portion 321 of a resilient ball plunger, ball or protrusion to reduce friction when performing slidability adjustment.

The second slanted pressing member 370 is fixed to the optical substrate 100, the light source substrate 310 is provided with a second press-connection portion 371 matching with the second slanted pressing member 370, the second slanted pressing member 370 is an elastic pressing sheet or an elastic ball plunger, and the bottom surface and/or the side surface of the light source substrate 310 is provided with an elastic ball plunger, a ball or a protruding sliding fit portion to reduce friction force during sliding adjustment.

The laser module 300 may further include a heating element (not shown), a temperature sensor 382 and a temperature switch (not shown), the light source base 320 is provided with an assembly groove 381 or an assembly hole (383, 384), the heating element, the temperature sensor 382 and the temperature switch are installed in the assembly groove 381 or the assembly hole (383, 384), the temperature sensor 382 may be covered by a cover plate 385 when installed in the assembly groove 381, the heating element may ensure that the collimating lens 341, the front light focusing mirror 342, the cylindrical mirror 343, and the like operate at a constant temperature, so as to ensure the consistency of light output, and the periphery of the light source base 320 may be further wrapped with heat insulation cotton to improve the heat insulation effect.

The utility model provides a laser module 300 compact structure, regulation convenience are difficult for appearing the jamming, and four regulating parts of laser module 300 accessible and laser instrument fixed plate locking piece 333 carry out the multidimension degree and adjust, and the flexible operation is convenient, can reduce the frictional force when adjusting through setting up sliding fit portion 321 in addition, can smooth regulation, avoids the jamming. The utility model also provides a sample analyzer, this sample analyzer include aforementioned laser module 300, and this sample analyzer specifically can be hematology analyzer, flow cytometry, blood coagulation analyzer, immunoassay appearance etc..

As shown in fig. 1 to 16, the present invention further provides an optical inspection apparatus, which includes an optical substrate 100, a light source substrate 310, a laser module 300, a first inclined pressing member 360, and a second inclined pressing member 370.

As shown in fig. 4 and 5, the light source substrate 310 is slidably adjustable in the B direction on the optical substrate 100, wherein the light source substrate 310 or the optical substrate 100 is provided with a sliding fitting portion 311 arranged in a protruding manner to reduce friction when the sliding adjustment is performed. The light source substrate 310 is provided with a guide adjusting groove 115, and the light source substrate 310 can be locked and adjusted in position by a screw 116 passing through the guide adjusting groove 115 after being slidably adjusted in the direction B.

As shown in fig. 3 and 6, the laser module 300 is slidably adjusted in the a direction and disposed on the light source substrate 310, the laser module 300 or the light source substrate 310 is provided with a sliding fitting portion 321, the laser module 300 is provided with a guide adjustment groove 354, and the adjustment position of the laser module 300 after being slidably adjusted in the a direction can be locked by a screw 355 (see fig. 3) passing through the guide adjustment groove 354.

The sliding fit portion 311 is a protrusion of an integrated structure on the optical substrate 100 or the light source substrate 310, or the sliding fit portion 311 is an elastic ball plunger or a ball embedded on the optical substrate 100 or the light source substrate 310.

The light source substrate 310 is provided with a first sliding adjustment area 372, the laser module 300 is slidably disposed in the first sliding adjustment area 372, the first sliding adjustment area 372 is composed of a first bottom wall 373 and a first guide side wall 374, the laser module 300 is abutted against the first guide side wall 374, the first optical adjustment member 111 is mounted through the light source substrate 310 and connected with the light source base 320, and is used for adjusting the sliding of the light source base 320 relative to the light source substrate 310 in the a direction, the first sliding adjustment area 372 can be an area recessed in the surface of the light source substrate 310, or a convex rib 374 is disposed on the light source substrate 310 to provide the first guide side wall.

As shown in fig. 3 or 15, the first pressing member 360 is fixed to the light source substrate 310, and is used for elastically pressing the laser module 300 so as to make one surface of the laser module 300 abut against the first guide sidewall 374, the first pressing member 360 is an elastic pressing piece or an elastic ball plunger, and the laser module 300 is provided with a first pressing part 361 (see fig. 7) abutting against the first pressing member 360.

As shown in fig. 16, the optical substrate 100 is provided with a second sliding adjustment region 101, the light source substrate 310 is slidably disposed in the second sliding adjustment region 101, the second sliding adjustment region 101 is composed of a second bottom wall 102 and a second guiding sidewall 103, the light source substrate 310 abuts against the second guiding sidewall 103, the optical inspection apparatus further includes a second optical adjustment member 112, the first optical adjustment member 112 is used for adjusting the sliding of the light source substrate 310 relative to the optical substrate 100 in the direction B, the second sliding adjustment region 101 may be a region recessed in the surface of the optical substrate 100, or a rib is provided on the optical substrate 100 to provide the second guiding sidewall 102.

The second pressing member 370 is fixed to the optical substrate 100 or other additional board, and is used to press and buckle the light source substrate 310 obliquely and elastically so as to make one surface of the light source substrate 310 abut against the second guiding sidewall 102, the second pressing member 370 is an elastic pressing sheet or an elastic ball plunger, the light source substrate 310 is provided with a second pressing part 371 abutting against the second pressing member 370,

the utility model provides an optical detection device compact structure, regulation convenience, frictional force is little, is difficult for appearing the jamming, and light source base plate 310 is adjusted in the slidability in the B direction and is set up on optical substrate 100 to light source base plate 310 or optical substrate 100 are equipped with the sliding fit portion 311 that the protrusion formula set up in order to reduce frictional force when carrying out the slidability and adjust. The utility model also provides a sample analyzer, this sample analyzer include aforementioned optical detection device, and this sample analyzer specifically can be hematology analyzer, flow cytometry, blood coagulation analyzer, immunoassay appearance etc..

As shown in fig. 16-18, the present invention further provides a fluorescence receiving module 700, wherein the fluorescence receiving module 700 comprises a fixing base 730, a first movable base 710, a second movable base 720, a fluorescence receiving plate 740, a fluorescence receiver 742, a first fluorescence adjuster 701, a second fluorescence adjuster 702, a first locking member 716, and a second locking member 726. The fluorescence receiving module 700 includes an adjusting mechanism 752 and a fluorescence receiver 742 that are arranged side by side or stacked, as shown in fig. 2, when the adjusting mechanism 752 and the fluorescence receiver 742 are arranged side by side, the whole fluorescence receiving module 700 is vertically long, the adjusting mechanism 752 extends to the side of the laser module 300, and limited space is fully utilized to make the whole structure of the product compact, if the adjusting mechanism 752 and the fluorescence receiver 742 are arranged in a stacked manner, that is, the adjusting mechanism 752 is arranged on the side of the fluorescence receiver 742 away from the lateral splitting module 500, the whole length of the fluorescence receiving module 700 will be shortened, but the thickness will be increased.

The first movable substrate 710 is slidably adjusted and arranged on the fixed seat 730 in the direction C, and the second movable substrate 720 is slidably adjusted and arranged on the first movable substrate 710 in the direction a; the fluorescence receiver 742 is fixed on the second movable substrate 720, the fixing base 730 includes a main body plate 731 and a flap 732 disposed on a side of the main body plate 731, the flap 732 is used for disposing the first fluorescence adjuster 701 to adjust the first movable substrate 710 in the direction C.

The main body plate 731 is provided with a first guiding post 734, the first moving substrate 710 is provided with a C-directional guiding slot 714 matching with the first guiding post 734, the main body plate 731 is provided with a first locking hole 735, the first moving substrate 710 is provided with a first locking slot 715 matching with the first locking hole 735, and the first locking member 716 passes through the first locking slot 715 and matches with the first locking hole 735.

The first moving substrate 710 is provided with a second guide post 714, the second moving substrate 720 is provided with an a-direction guide slot 724 matched with the second guide post 714, the first moving substrate 710 is provided with a second locking hole 715, the second moving substrate 720 is provided with a second locking slot 725 matched with the second locking hole 715, the second locking member 726 passes through the second locking slot 725 to be matched with the second locking hole 715, the first moving substrate 710 comprises a first plate 711, a second plate 712 and a third plate 713, the second plate 712 and the third plate 713 are bent reversely from the edge of the first plate 711, the first plate 711 is attached to the main plate 731, the second plate 712 is parallel to the folded plate 732, and the third plate 713 is used for arranging a second fluorescent adjusting member 702 to adjust the second moving substrate 720 in the a direction.

The fluorescence receiving plate 740 is fixed to the second movable substrate 720, the fluorescence receiver 742 is fixed to the fluorescence receiving plate 740, the second movable substrate 720 has a through slot 721 aligned with the fluorescence receiver 742, the fluorescence receiver 742 can be embedded in the through slot 721 1, the fluorescence diaphragm 741 is fixed to the second movable substrate 720 and covers the through slot 721, and the fluorescence diaphragm 741 has a light hole 743 aligned with the fluorescence receiver 742.

The utility model provides a fluorescence receiving module 700 compact structure, regulation convenience, the jamming is difficult for appearing, and adjustment mechanism 752 extends to laser module 300 place side, and the limited space of make full use of makes product overall structure compact. The utility model also provides a sample analyzer, this sample analyzer include aforementioned fluorescence receiving module 700, and this sample analyzer specifically can be hematology analyzer, flow cytometry, blood coagulation analyzer, immunoassay appearance etc..

As shown in fig. 20 to 23, the present invention further provides a module for adjusting a laterally scattered light focusing mirror, which comprises a mounting base 210, a supporting plate 220, an adjusting member 230, a linkage block 240, a guiding column 248, a locking member 252, a sheath flow cell module locking member 260 and an optical substrate 100.

The mounting base 210 is provided with a side wall 211 and a top wall 212, the side wall 211 and the top wall 212 enclose an inner cavity 213, the top wall 212 is provided with an opening 214 (see fig. 21) communicated with the inner cavity 213, and the inner cavity 213 is used for receiving the insertion assembly of the sheath flow cell module 200 and extends out of the opening 214 so that the sheath flow cell 201 of the sheath flow cell module 200 is arranged above the top wall 212. The sheath flow cell module 200 is rotatably adjustable and fixed relative to the mounting block 210.

The linkage block 240 is adjustably disposed on the top wall 212, and the linkage block 240 is used for disposing the side scattering light focusing mirror 250 corresponding to the sheath flow cell 201.

The adjusting member 230 is connected to the linkage block 240, and is used for adjusting the position of the linkage block 240 on the mounting seat 210, so as to adjust the distance between the side scattering light focusing mirror 250 and the sheath flow cell 201. The adjustment member 230 may be a screw, a threaded pair, a slider assembly, a motor assembly, a gear assembly, or other adjustment mechanism.

Specifically, the linkage block 240 includes a first linkage block 241, a second linkage block 242 connected to each other, and a third linkage block 243 may be connected to a side of the first linkage block 241 away from the second linkage block 242, the first linkage block 241 may be provided with a connection hole 247 to be connected to the adjusting member 230, or the third linkage block 243 may be provided with a connection hole 247, the first linkage block 241 is slidably disposed on the top wall 212, and the second linkage block 242 is used for disposing the side scattered light focusing mirror 250.

The second linkage block 242 has an extension 244 displaced from the first linkage block 241, and the side scattered light focusing mirror 250 is provided on the extension 244. In one embodiment, the second linkage block 242 may be L-shaped, and the side scatter focusing mirror 250 is disposed at an end of the L-shaped second linkage block 242.

The first linkage block 241 is provided with guide slots 246 corresponding to the guide posts 248, and the top wall 212 is provided with assembly holes 249 corresponding to the guide posts 248 to assemble the guide posts 248. The first linkage block 241 is provided with a locking groove 245 corresponding to the locking member, and the top wall 212 is provided with a locking hole 253 corresponding to the locking member 252. Roof 212 corresponds sheath and flows pond module retaining member 260 and is equipped with via hole 261, and sheath flows pond module retaining member 260 is used for passing via hole 261 and is connected in order to flow pond module 200 with the sheath, and is corresponding, and sheath flows pond module 200 and is equipped with flange 210, is equipped with on flange 210 and connects screw 211.

The supporting plate 220 is disposed at a side of the mounting base 210, and the supporting plate 220 is used for supporting the adjusting member 230. The mounting base 210 is fixed on the optical substrate 100, and the sheath flow cell module 200 penetrates through the optical substrate 100.

The utility model provides a side direction scattered light focusing mirror adjusting module can avoid conventional sheath to flow pond module 200 from last down when installing, and the sheath flows pond 201 surface can be touched to the hand, arouses the pollution of optical surface.

The utility model also provides a sample analyzer, this sample analyzer includes aforementioned side direction scattered light focusing mirror adjusting module.

In the above embodiment, during adjustment, the light beam and/or the focus of the light source or the receiving module are adjusted based on the sheath flow seat, so as to ensure that the light beam is aligned with the center of the sample particle flow of the sheath flow cell 201, and obtain a suitable light spot size. Therefore, the utility model discloses a multi-module multidimension is adjusted, not only fully guarantees the compactness and the utilization ratio in space, improves the precision that optical detection especially, and is significant to sample analyzer's detection, and the regulation effect detailed description of each module is as follows:

the laser module has four-dimensional adjustment, namely the optical substrate 100, the light source substrate 310, the first optical adjustment part 111 and the second optical adjustment part 112 cooperate to adjust the size of a light spot in the direction a and adjust the position of a light beam in the directions B and C, so as to ensure that the light beam is aligned with the center of the sample particle flow of the sheath flow cell 201.

The sheath flow cell module 200 has two-dimensional adjustment, namely rotation adjustment, and adjustment of the distance between the sheath flow cell module 200 and the side scattered light focusing mirror 250, which is also used for calibrating the position and the focus of a light beam; in addition, since the fluorescence receiving module 700 is used, the sheath flow cell module 200 only adjusts the B direction, and the a direction is fixed, so as to avoid the influence of the movement of the a direction on the optical detection of the forward scattered light receiving module 400, and to save the structure of the detection module, so that the space is more compact.

The forward scattered light receiving module 400 adopts one-dimensional adjustment, i.e., adjustment in the B direction, mainly to align the light beam with the optical aperture and improve the accuracy of optical path detection; it is of course also possible to adjust in two dimensions and to make the space more compact by arranging the adjusting mechanism and the receiving section side by side.

The fluorescence receiving module 700 employs two-dimensional adjustment, both the a-direction and B-direction adjustments aligning the beam with the aperture.

The side scatter light receiving module 600 is adjusted in one dimension, or two dimensions, but preferably one dimension, or one dimension is also used to align the receiving aperture with the light beam.

The above is only the embodiment of the present invention, not the limitation of the patent scope of the present invention, all the equivalent structures or equivalent processes of the present invention are utilized, or directly or indirectly applied to other related technical fields, and the same principle is included in the patent protection scope of the present invention.

Claims (10)

1. An optical inspection apparatus, comprising:

an optical substrate;

a light source substrate slidably adjusted in the B direction and provided on the optical substrate;

wherein the light source substrate or the optical substrate is provided with a sliding fitting portion which is provided in a protruding manner to reduce friction when sliding adjustment is performed.

2. The optical inspection device according to claim 1, further comprising a laser module slidably adjustable in the a direction provided on the light source substrate, the laser module or the light source substrate being provided with the slide-fitting portion.

3. The optical inspection device of claim 1, wherein:

the sliding fit part is a protruding part of an integrated structure on the optical substrate or the light source substrate; or

The sliding fit part is an elastic ball plunger or a ball which is embedded on the optical substrate or the light source substrate.

4. The optical detection device according to claim 2, characterized in that: the laser module is arranged in the first sliding adjusting area in a sliding manner; and/or the first sliding adjustment area is formed by a first bottom wall and a first guide side wall, and the laser module is abutted against the first guide side wall; and/or the optical detection device further comprises a first optical adjusting screw, wherein the first optical adjusting screw is installed through the light source substrate and connected with the laser module and used for adjusting the sliding of the laser module relative to the light source substrate in the A direction.

5. The optical inspection device of claim 4,

the first sliding adjusting area is an area sunken on the surface of the light source substrate; or

And the light source substrate is provided with a convex rib to provide the first guide side wall.

6. The optical inspection device of claim 4, further comprising a first biasing member secured to the light source substrate for resiliently biasing the laser module such that a surface of the laser module abuts the first guide sidewall; and/or the first inclined pressing piece is an elastic pressing piece or an elastic ball plunger, and a first pressing part which is abutted against the first inclined pressing piece is arranged on the laser module.

7. The optical inspection device of claim 1, wherein: the optical substrate is provided with a second sliding adjusting area, and the light source substrate is arranged in the second sliding adjusting area in a sliding manner; and/or the second sliding adjustment area is composed of a second bottom wall and a second guide side wall, and the light source substrate is abutted against the second guide side wall; and/or the optical detection device further comprises a second optical adjusting screw, wherein the second optical adjusting screw is installed through the optical substrate and connected with the light source substrate and used for adjusting the sliding of the light source substrate relative to the optical substrate in the B direction.

8. The optical inspection device of claim 7, wherein:

the second sliding adjustment area is an area sunken in the surface of the optical substrate; or

And the light source substrate is provided with a convex rib to provide the second guide side wall.

9. The optical inspection device of claim 7, further comprising a second biasing member fixed to the optical substrate for resiliently biasing the light source substrate to abut a surface of the light source substrate against the second guide sidewall; and/or the second inclined pressing piece is an elastic pressing piece or an elastic ball plunger, and a second pressing part abutted against the second inclined pressing piece is arranged on the light source substrate.

10. A sample analyzer, comprising the optical detection device of any one of claims 1-9 and a laser module, the laser module comprising:

the light source base is provided with an assembly cavity and is arranged on the light source substrate in a slidable adjustment mode in the direction A;

the laser fixing plate is adjustably embedded in the assembly cavity in the directions of A, B and C;

the laser is embedded in the laser fixing plate and used for emitting laser to the direction A;

and the laser locking piece is used for adjusting and locking the laser fixing plate.

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