CN212346713U

CN212346713U - Magnetic tissue ablation electrode catheter and matched magnetic anchoring device

Info

Publication number: CN212346713U
Application number: CN202020793091.XU
Authority: CN
Inventors: 任冯刚; 高煦尧; 吕毅; 李青山; 韩鲁冰; 张雨驰
Original assignee: First Affiliated Hospital of Medical College of Xian Jiaotong University
Current assignee: First Affiliated Hospital of Medical College of Xian Jiaotong University
Priority date: 2020-05-14
Filing date: 2020-05-14
Publication date: 2021-01-15
Anticipated expiration: 2030-05-14

Abstract

The utility model relates to a magnetic tissue ablation electrode catheter and a matched magnetic anchoring device. The utility model discloses an electrode, connecting catheter, operating handle and magnetism anchoring device, electrode, connecting catheter and operating handle design as an organic whole constitute electrode catheter jointly, and electrode shell can adopt magnetic material to make, or extra installation magnet makes it have magnetism, can be controlled in order attached on alimentary canal inner wall focus surface by magnetism anchoring device. The utility model discloses can make and melt electrode catheter and get into the alimentary canal through the digestion scope, the electrode can be fixed in the focus surface under the supplementary of magnetic anchoring technique, and the treatment electric field scope that this electrode formed can cover pathological change alimentary canal mucosa, utilizes this electrode catheter can use irreversible electroporation or other electric pulse treatment techniques to melt the treatment to the tissue.

Description

Magnetic tissue ablation electrode catheter and matched magnetic anchoring device

Technical Field

The utility model relates to the field of medical equipment, a can put into the electric pulse discharge treatment equipment of alimentary canal through the scope is related to, especially relate to one kind can put into the alimentary canal through the scope in, can be by the tissue ablation electrode pipe and supporting magnetism anchoring device of magnetism anchoring technology control, can utilize irreversible electroporation or other electroporation treatment techniques to carry out the tissue ablation treatment to the alimentary canal.

Background

Digestive tract tumors including esophageal cancer, gastric cancer, colorectal cancer and the like are the most common malignant tumors, more than 350 million people are attacked and more than 200 million people are killed every year in the world, and the disease burden is serious. With the development of endoscope technology and the deepening of minimally invasive concept, endoscope treatment becomes a common method for treating digestive tract tumors, and the endoscope also establishes a convenient channel for the application of various new technologies in the digestive tract. Tumor ablation is a minimally invasive treatment technique. Usually, the activity of tumor tissue is destroyed by using an ablation electrode under the guidance of an image, so that the purpose of inactivating the tumor under the in-situ condition is achieved. Radiofrequency ablation (RFA), microwave ablation (MWA), high energy focused ultrasound (HIFU), laser ablation, and the like are more common thermal ablation techniques. Generally, the thermal ablation technology is mainly used for treating solid tumors such as liver, kidney, prostate, lung and bone. In recent years, radio frequency ablation technology for digestive tracts such as esophagus, biliary tract and the like under endoscopes is also available. However, due to energy control, complications such as perforation of digestive tract walls and bleeding are easy to occur when the thermal ablation technology is applied to the digestive tract, so that the safety and effectiveness problems are more caused, and the wide application is difficult. Irreversible electroporation (IRE) based on the microsecond pulsed electric field biological effect principle is a non-thermal ablation technology, and the main action principle is that microsecond Electroporation Pulse (EP) with certain intensity is applied to local tissues to destroy the transmembrane voltage (TMV) balance of cell membranes, so that a plurality of micropores are formed in a phospholipid bilayer structure on the surfaces of the cell membranes, and the permeability of the cell membranes is changed. When the electric field strength is higher than a certain threshold value, the perforation on the surface of the cell membrane cannot be repaired, the intracellular homeostasis is damaged, and finally the cell death is caused. Because microsecond EP has extremely short action time, the heat generated in the process can be quickly diffused and absorbed by the tissues, so that the IRE ablation process does not depend on the heat effect and cannot cause irreversible thermal injury to the tissues. In recent years, electroporation therapy techniques typified by IRE have been attracting much attention and studied intensively. IRE has been clinically applied in the treatment of solid tumors such as liver, pancreas, prostate, etc., and has a good therapeutic effect.

At least one pair of electrodes is needed to form a treatment electric field in the process of electric pulse treatment, one or more pairs of needle-type ablation electrodes are usually adopted to pierce the periphery of tumor tissue to realize the coverage of the treatment electric field on a target area, and the design form can be suitable for solid tumor ablation treatment but is not suitable for digestive tract tumor ablation treatment. Due to the lack of suitable ablation electrodes, electrical pulse therapy techniques have not been applicable in the digestive tract. Therefore, how to design an electrode suitable for digestive tract tissue ablation, how to place the ablation electrode in a target ablation area of the digestive tract under an endoscope or other minimally invasive conditions, and how to effectively fix the ablation electrode in the target ablation area in the treatment process are key technical problems to be solved.

SUMMERY OF THE UTILITY MODEL

For solving the above-mentioned technical problem who exists among the background art, the utility model provides a can put into the alimentary canal through the scope, firm anchoring in target ablation district, electrode conduit and magnetism anchoring device that can safely, effectively realize the alimentary canal tissue and melt.

The technical solution of the utility model is that: the utility model relates to a magnetic tissue melts electrode catheter and supporting magnetism anchoring device, its special character lies in: the device comprises an electrode, a connecting catheter, an operating handle and a magnetic anchoring device, wherein the electrode is connected with the operating handle through the connecting catheter, and the electrode has magnetism and can be adsorbed to the magnetic anchoring device.

Preferably, the electrode comprises a shell and two metal sheets representing different polarities, the metal sheets representing different polarities are arranged in the shell, and a first wiring hole communicated with the connecting conduit is formed in one end, connected with the connecting conduit, of the shell.

Preferably, the electrode further comprises two electrode sheet grooves, the two electrode sheet grooves are arranged in the shell, and the two metal sheets representing different polarities are respectively arranged in the two electrode sheet grooves.

Preferably, the two electrode sheet grooves are arranged in a concentric circle mode, the electrode sheet groove positioned at the center is circular, a circular metal sheet is installed in the electrode sheet groove, the electrode sheet groove positioned at the periphery is annular, and an annular metal sheet is installed in the electrode sheet groove.

Preferably, the electrode head is made of magnetic material, the surface of the electrode head is plated with an insulating layer to isolate current, and the two metal sheets representing different polarities are made of medical stainless steel or other conductive metals.

Preferably, the whole electrode is made of an insulating non-metallic material, and a magnet is fixed on one surface of the electrode.

Preferably, the connecting pipe comprises a spring pipe and two wires, the head and the tail of the spring pipe are respectively fixedly connected with the electrode and the operating handle, one end of the operating handle connected with the connecting pipe is provided with a second wire passing hole communicated with the connecting pipe, the other end of the operating handle is provided with the multi-core plug, one ends of the two wires are respectively connected with the two metal sheets representing different polarities through the first wire passing hole, and the other end of the two wires is connected with the multi-core plug through the second wire passing hole.

Preferably, the connecting conduit further comprises an outer sleeve, the spring tube is arranged in the outer sleeve, the length of the outer sleeve is slightly smaller than the total length of the spring tube, the length of the spring tube exposed in the alimentary canal can be adjusted by the operating handle through the design, the inner wall of the outer sleeve is coated with a coating promoting lubrication, the outer sleeve has certain toughness, the outer sleeve cannot bend in the process of adjusting the curvature and the shape along with the endoscope, and a buckle is arranged on the outer sleeve.

Preferably, the conducting wire is externally provided with an insulating layer and a shielding layer so as to ensure that short circuit does not occur in the power-on process, and meanwhile, the transmitted pulse signal is not interfered.

Preferably, the magnetic anchoring means are constituted by a graspable housing and a cylindrical permanent magnet contained therein. The magnetic field formed by the magnetic anchoring device can attract and regulate the magnetic electrodes in the alimentary canal under the condition of spacing the chest wall or the abdominal wall of a human body, and the specification of the permanent magnet contained in the magnetic field can be adjusted according to different applicable people.

The utility model provides a pair of magnetic tissue melts electrode catheter and supporting magnetism anchoring device mainly divides into two parts, melts electrode catheter part and external magnetism anchoring device part. The ablation electrode catheter mainly comprises: the electrode at the front end is a core component responsible for transmitting an electroporation pulse signal to the alimentary canal tissue and playing a role in tissue ablation; the middle connecting catheter connects the electrode with the operating handle, and the whole length of the middle connecting catheter can be adjusted according to different endoscopes and different applicable scenes; the electrode catheter is connected with the electric pulse generating device through the cable by the operating handle at the rear end, and the operating handle can be controlled by an operator to adjust the exposed length of the front electrode in the digestive tract cavity. The electrode, the connecting catheter and the operating handle can be designed integrally to form an ablation electrode catheter, the shell of the electrode can be made of magnetic materials or additionally provided with a magnet to enable the electrode to have magnetism, and the electrode can be controlled by an external magnetic anchoring device and attached to the surface of a focus on the inner wall of the digestive tract. The extracorporeal magnetic anchoring device is partially composed of a graspable housing and a cylindrical permanent magnet contained therein. Therefore, the magnetic tissue ablation electrode catheter and the matched magnetic anchoring device provided by the utility model are optimally designed for the digestive endoscope, and can be well matched with the digestive endoscope; the adopted concentric circle type arrangement electrode structure can form a treatment electric field which can effectively cover a target ablation area; the electrode can be stably anchored in the target ablation area in the treatment process by utilizing the magnetic anchoring technology, and does not shift in the electroporation pulse treatment process, thereby reducing the operation difficulty of operating personnel.

Drawings

Fig. 1 is a schematic structural view of the present invention;

fig. 2 is a schematic structural view of an electrode according to the present invention;

FIG. 3 is a schematic cross-sectional view of a connecting conduit according to the present invention;

fig. 4 is a schematic structural view of the operating handle of the present invention;

FIG. 5 is a schematic view of the buckle structure of the present invention;

fig. 6 is a schematic view of the relative position of the magnetic anchoring device and the electrode catheter of the present invention;

fig. 7 is a diagram of the electric field distribution characteristic of the utility model for the wall of the ablation duct under different voltage intensities.

The reference numbers are as follows:

1. an electrode; 2. connecting a conduit; 3. an operating handle; 4. an electrode tab slot; 5. a first wiring hole; 6. a housing; 7. a wire; 8. a spring tube; 9. an outer sleeve; 10. an insulating layer; 11. a second wiring hole; 12. a multi-core plug; 13. a magnetic anchoring device; 14. buckling; 15. the abdominal wall; 16. an endoscope.

Detailed Description

Referring to fig. 1, the structure of the embodiment of the present invention includes an electrode 1, a connecting conduit 2, an operating handle 3 and a magnetic anchoring device 13, the electrode 1 is connected with the operating handle 3 through the connecting conduit 2, and can be designed as an integral structure, and jointly form an ablation electrode conduit, and the electrode 1 has magnetism and can be adsorbed to the magnetic anchoring device 13.

Referring to fig. 2, the electrode includes a housing 6, two electrode sheet grooves 4 and metal sheets representing different polarities, the two electrode sheet grooves 4 are disposed on the front surface of the housing 6, and are used for installing the metal sheets representing the different polarities therein, the metal sheets are made of medical stainless steel or other conductive materials, wherein the electrode sheet groove located at the center is circular, the circular metal sheet is installed therein, the electrode sheet groove located at the periphery is annular, and the annular metal sheet is installed therein; the main body of the shell 6 is circular, the diameter of the main body is 15mm, the diameter of the circular metal sheet is 5-8mm, the width of the annular metal sheet is 2-4mm, and the distance between the two metal sheets is 2 mm; the two metal sheets represent high potential and ground respectively; the electrode tab slots 4 are shaped and arranged in a manner including, but not limited to, concentric circle form. The shell 6 can be made of magnetic metal material, the surface of which needs to be additionally plated with an insulating layer to block current, or made of non-magnetic material, and the back surface or the interior of which is additionally provided with a permanent magnet; one end of the shell 6 connected with the connecting conduit 2 is provided with a first wiring hole 5 communicated with the connecting conduit 2.

Referring to fig. 3, the function of the connecting conduit 2 includes, but is not limited to, connecting end to end, electrical, gas and liquid passages. The performance characteristics are that the device can be bent, and the internal part structure can be relatively moved to realize multiple degrees of freedom. The connecting conduit 2 comprises a spring tube 8 and an outer sleeve 9, the spring tube 8 and the head and tail electrodes 1 are fixedly connected with the operating handle 3, the outer diameter of the spring tube 8 is less than or equal to 2.8mm, the inner diameter of the spring tube 8 is greater than or equal to 2.0mm, two wires 7 capable of loading the highest 3kV electroporation pulse signals are arranged in the spring tube 8, one ends of the two wires 7 are respectively connected with two metal sheets of the electrodes 1 through a first wire routing hole 5, and an insulating layer 10 and a shielding layer are arranged outside the wires 7. The outer sleeve 9 is nested outside the spring tube 8 and used for being fixed with an endoscope body, but the spring tube 8 and the outer sleeve 9 are not fixed, the outer sleeve 9 is made of polytetrafluoroethylene materials, the inner diameter of the outer sleeve 9 is larger than or equal to 3.0mm, 3-4 semicircular buckles 14 are installed on the outer sleeve 9, when the endoscope is used, after a focus is found, the outer sleeve 9 and an endoscope catheter are connected through the buckles 14, the endoscope and the outer sleeve 9 are kept relatively fixed, and the spring tube 8 can be driven by the operation handle 3 to adjust the position of the electrode 1 so as to be positioned on the surface of the focus. Meanwhile, the exposed part of the spring tube 8 in the body can be bent, and the multi-degree-of-freedom movement of the electrode is realized.

Referring to fig. 4, a second wire hole 11 communicated with the connecting conduit 2 is arranged at one end of the operating handle 3 connected with the connecting conduit 2, a multi-core plug 12 is arranged at the other end of the operating handle, the second wire hole 11 is fixedly connected with the spring tube 8, and the wire 7 in the connecting conduit 2 is welded with the multi-core plug 12 through the second wire hole 11 and directly to the tail of the handle 3. The multi-conductor plug 12 may be connected to the pulse generator by a transmission cable.

Referring to fig. 5, the clip 14 of the connecting catheter 2 has one end sleeved on the outer sleeve 9 and the other end with an opening for clipping on the gastroscope catheter.

The magnetic anchoring device 13 is composed of a shell which can be held and a cylindrical permanent magnet contained in the shell, the diameter of the permanent magnet is more than or equal to 50mm, and the height of the permanent magnet is more than or equal to 10 mm; the device shell accords with human engineering design, can realize that the multi-angle freely grips. The key point of the magnetic anchoring device 13 is that the magnetic anchoring device has enough magnetic force to ensure that the electrode 1 which is placed in the body along with the endoscope 16 is stably anchored under the condition of human tissues such as the interval abdominal wall 15, the chest wall and the like, and the electrode 1 can not be displaced and fall off in the process of carrying out electric pulse treatment. The two-dimensional cross-section of the fixed relative position of the magnetic anchoring device 13, the electrode 1, the connecting catheter 2, and the endoscope 16 is shown in fig. 6.

The utility model discloses during implementation operation, at first fixed with outer tube 9 and scope body through buckle 14, it is fixed to ensure connecting tube 2 and scope, and multicore plug 12 and the pulse generator at operating handle 3 rear portion are connected, send into the alimentary canal with scope 16 together with connecting tube 2, utilize scope 16 to confirm the focus position. The spring tube 8 is operated by using the external operating handle 3, and the position of the electrode 1 is adjusted, so that the front surface of the electrode 1 is completely attached to the focus. At this time, the magnetic anchoring device 13 outside the body is close to the body surface of the abdomen, and the electrode 1 is magnetic, so that the electrode 1 inside the body and the magnetic anchoring device 13 are mutually attracted and fixed. And then starting a pulse generator, setting pulse parameters, releasing electroporation pulses, and treating the lesion tissues by the electroporation pulses for 1 or more cycles to ablate and damage the lesion tissues.

In order to further prove the utility model discloses structural design's advantage adopts the finite element analysis method to establish alimentary canal pipe wall two-dimensional model to and the prediction of effectively melting electric field distribution range, use circular electrode diameter to be 5mm in figure 7, the width of annular sheetmetal is 4mm, two electrode spacing is 2mm, calculate respectively that high potential voltage intensity is 500V, 750V, 1000V, 1250V, when 1500V and 1750V, the distribution when effectively treating electric field (E > 500V/cm).

The above is only the specific embodiments of the present disclosure, but the scope of the present disclosure is not limited thereto, and the scope of the present disclosure should be subject to the protection scope of the claims.

Claims

1. A magnetic tissue ablation electrode catheter and a matched magnetic anchoring device are characterized in that: the device comprises an electrode, a connecting catheter, an operating handle and a magnetic anchoring device, wherein the electrode is connected with the operating handle through the connecting catheter, and the electrode has magnetism and can be adsorbed to the magnetic anchoring device.

2. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 1, wherein: the electrode comprises a shell and two metal sheets representing different polarities, the metal sheets representing different polarities are arranged in the shell, and a first wiring hole communicated with the connecting conduit is formed in one end, connected with the connecting conduit, of the shell.

3. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 2, wherein: the electrode also comprises two electrode sheet grooves which are arranged in the shell, and the two metal sheets representing different polarities are respectively arranged in the two electrode sheet grooves.

4. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 3, wherein: the two electrode sheet grooves are arranged in a concentric circle mode, the electrode sheet groove located in the center is circular, a circular metal sheet is installed in the electrode sheet groove, the electrode sheet groove located on the periphery is annular, and an annular metal sheet is installed in the electrode sheet groove.

5. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 4, wherein: the electrode head is made of magnetic material, the surface of the electrode head is plated with an insulating layer to isolate current, and the two metal sheets representing different polarities are made of medical stainless steel or other conductive metals.

6. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 4, wherein: the whole electrode is made of an insulating non-metallic material, and a magnet is fixed on one surface of the electrode.

7. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of any one of claims 2 to 6, wherein: the connecting pipe comprises a spring pipe and two wires, the head and the tail of the spring pipe are fixedly connected with the electrode and the operating handle respectively, one end of the operating handle connected with the connecting pipe is provided with a second wire walking hole communicated with the connecting pipe, the other end of the operating handle is provided with a multi-core plug, one end of each wire is connected with two metal sheets representing different polarities through the first wire walking hole respectively, and the other end of each wire is connected with the multi-core plug through the second wire walking hole.

8. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 7, wherein: the connecting pipe further comprises an outer sleeve, the spring pipe is arranged in the outer sleeve, the length of the outer sleeve is slightly smaller than the total length of the spring pipe, and a buckle is arranged on the outer sleeve.

9. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 8, wherein: and an insulating layer and a shielding layer are arranged outside the lead.

10. The magnetic tissue ablation electrode catheter and mating magnetic anchoring device of claim 9, wherein: the magnetic anchoring device is composed of a grippable housing and a cylindrical permanent magnet contained therein.