CN212293606U - Bioreactor exhaust pipeline and bioreactor - Google Patents
Bioreactor exhaust pipeline and bioreactor Download PDFInfo
- Publication number
- CN212293606U CN212293606U CN202020968785.2U CN202020968785U CN212293606U CN 212293606 U CN212293606 U CN 212293606U CN 202020968785 U CN202020968785 U CN 202020968785U CN 212293606 U CN212293606 U CN 212293606U
- Authority
- CN
- China
- Prior art keywords
- pipeline
- valve
- filter
- bioreactor
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The embodiment of the utility model provides a bioreactor exhaust duct and a bioreactor, wherein the bioreactor exhaust duct comprises a controller, a first pipeline and a second pipeline; the first pipeline and the second pipeline respectively comprise a sterilization pipeline and a filtering pipeline; one end of the filter pipeline is used for being connected with the reactor tank body, and the other end of the filter pipeline is used for being connected with the exhaust port; one end of the sterilization pipeline is used for being connected with the steam outlet, and the other end of the sterilization pipeline is used for being connected with the sewage draining outlet; when the pressure in the reactor tank body is greater than or equal to a preset threshold value, the controller opens the filtering pipeline of the current standby pipeline, closes the filtering pipeline of the working pipeline, and opens the sterilizing pipeline of the working pipeline, wherein when the first pipeline is used as the working pipeline, the second pipeline is used as the standby pipeline, and when the second pipeline is used as the working pipeline, the first pipeline is used as the standby pipeline. The embodiment of the utility model provides a solve the problem that the bacterium passes through the reverse pollution cell culture liquid in the reactor of exhaust duct in the air.
Description
Technical Field
The embodiment of the utility model provides a bioreactor field especially relates to a bioreactor exhaust duct and bioreactor.
Background
The normal cell culture temperature is generally 27-37 ℃, and the culture period is generally 3-30 days. Therefore, some cell culture processes require a 30-day culture period at 37 ℃. When the deep layer in the tank is continuously ventilated, the waste gas often contains large water vapor. And because a hydrophobic filter element is required to be arranged in the filter, and the air passing is not water, the filter element in the filter is often blocked by water vapor in the waste gas, so that the normal exhaust is not realized, the problem of pressure rise in the tank is caused, and the cell culture failure is caused.
SUMMERY OF THE UTILITY MODEL
The embodiment of the utility model provides a bioreactor exhaust duct and bioreactor to filter core often is blockked up by the steam in the waste gas in the filter of solving current bioreactor, leads to unable normal exhaust, and the rise of jar internal pressure appears and leads to the problem of cell culture failure.
In order to solve the technical problem, the utility model discloses a realize like this:
in a first aspect, an embodiment of the present invention provides a bioreactor exhaust duct, including a controller, a first pipeline and a second pipeline;
the first pipeline and the second pipeline respectively comprise a sterilization pipeline and a filtering pipeline;
one end of the filter pipeline is used for being connected with the reactor tank body, and the other end of the filter pipeline is used for being connected with the exhaust port;
one end of the sterilization pipeline is used for being connected with the steam outlet, and the other end of the sterilization pipeline is used for being connected with the sewage draining outlet;
the controller is used for opening the filter pipeline of the current standby pipeline when the pressure in the reactor tank body is larger than or equal to a preset threshold value, closing the filter pipeline of the working pipeline and opening the sterilization pipeline of the working pipeline, wherein when the first pipeline is used as the working pipeline, the second pipeline is used as the standby pipeline, and when the second pipeline is used as the working pipeline, the first pipeline is used as the standby pipeline.
Optionally, the filtering pipeline includes a filter, a first pipeline, a second pipeline, a first valve and a second valve;
the first end of the filter is connected with the reactor tank body through the first pipeline, and the first valve is arranged on the first pipeline;
the second end of the filter is connected with the exhaust port through the second pipeline, and the second valve is arranged on the second pipeline;
the controller opens the filter line by controlling the opening of the first valve and the second valve.
Optionally, the sterilization pipeline includes a third pipeline, a fourth pipeline, a first temperature electrode, a first drain valve, a second temperature electrode, a second drain valve, a third valve, a fourth valve, and a fifth valve;
the third valve is arranged between the second valve and the first end of the filter and is used for being connected with the steam outlet and controlling the opening or closing of steam;
one end of the third pipeline is connected with the second end of the filter, and the other end of the third pipeline is connected with the sewage draining outlet;
the fourth valve is arranged on the third pipeline, one end of the fourth valve is connected with the second end of the filter, and the other end of the fourth valve is connected with one end of the first temperature electrode;
one end of the first drain valve is connected with the other end of the first temperature electrode, and the other end of the first drain valve is connected with the sewage draining outlet;
one end of the fourth pipeline is connected with the first end of the filter, and the other end of the fourth pipeline is connected with the sewage draining outlet;
the fifth valve is arranged on the fourth pipeline, one end of the fifth valve is connected with the first end of the filter, and the other end of the fifth valve is connected with one end of the second temperature electrode;
one end of the second drain valve is connected with the other end of the second temperature electrode, and the other end of the second drain valve is connected with the sewage draining outlet;
the controller opens the sterilization line by controlling the opening of the third valve, the fourth valve, and the fifth valve.
Optionally, the working temperature of the first temperature electrode or the second temperature electrode is greater than or equal to 121 ℃.
Optionally, the filter includes a filter shell and a filter element, the filter shell is fixed on the filter pipeline, and the filter element is fixed in the filter shell.
In a second aspect, the embodiments of the present invention further provide a bioreactor, which includes a reactor tank and a bioreactor exhaust duct connected to one end of the reactor tank as in any of the first aspect.
Optionally, the reactor tank is provided with a pressure sensor for detecting the pressure in the exhaust duct.
The embodiment of the utility model provides an in, bioreactor exhaust duct one is equipped with one, can utilize reserve exhaust duct to handle when the unusual condition appears damaging like the filter core, the too much filter core that leads to of foam damages, can also in time renew the filter core and sterilization process alone, sets up simply, safe and reliable to it is incessant to exhaust, can furthest guarantee the cell culture effect.
Drawings
Various other advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like reference numerals are used to refer to like parts throughout the drawings. In the drawings:
fig. 1 is a schematic structural diagram of an exhaust duct of a bioreactor according to an embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, not all, of the embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an exhaust duct of a bioreactor according to an embodiment of the present invention; the utility model provides a bioreactor exhaust duct, include: the device comprises a controller, a first pipeline and a second pipeline;
the first pipeline and the second pipeline respectively comprise a sterilization pipeline and a filtering pipeline;
one end of the filter pipeline is used for being connected with the reactor tank body, and the other end of the filter pipeline is used for being connected with the exhaust port;
one end of the sterilization pipeline is used for being connected with the steam outlet, and the other end of the sterilization pipeline is used for being connected with the sewage draining outlet;
the controller is used for opening the filter pipeline of the current standby pipeline when the pressure in the reactor tank body is larger than or equal to a preset threshold value, closing the filter pipeline of the working pipeline and opening the sterilization pipeline of the working pipeline, wherein when the first pipeline is used as the working pipeline, the second pipeline is used as the standby pipeline, and when the second pipeline is used as the working pipeline, the first pipeline is used as the standby pipeline.
The embodiment of the utility model provides an in, bioreactor exhaust duct one is equipped with one, can utilize reserve exhaust duct to handle when the unusual condition appears damaging like the filter core, the too much filter core that leads to of foam damages, can also in time renew the filter core and sterilization process alone, sets up simply, safe and reliable to it is incessant to exhaust, can furthest guarantee the cell culture effect.
In some embodiments of the present invention, optionally, the filtering line comprises a filter, a first pipe, a second pipe, a first valve V1, and a second valve V2;
the first end of the filter is connected with the reactor tank through the first pipeline, and the first valve V1 is arranged on the first pipeline;
the second end of the filter is connected with the exhaust port through the second pipeline, and the second valve V2 is arranged on the second pipeline;
the controller opens the filtering line by controlling the first valve V1 and the second valve V2 to open.
In the embodiment of the utility model, bioreactor exhaust duct's filtration pipeline simple structure, control mode easily realizes.
In some embodiments of the present invention, optionally, the sterilization line comprises a third pipeline, a fourth pipeline, a first temperature electrode TE1, a first trap S1, a second temperature electrode TE2, a second trap S2, a third valve V3, a fourth valve V4, and a fifth valve V5;
the third valve V3 is arranged between the second valve V2 and the first end of the filter and is used for being connected with the steam outlet and controlling the opening or closing of steam;
one end of the third pipeline is connected with the second end of the filter, and the other end of the third pipeline is connected with the sewage draining outlet;
the fourth valve V4 is arranged on the third pipeline, one end of the fourth valve V4 is connected with the second end of the filter, and the other end of the fourth valve V4 is connected with one end of the first temperature electrode TE 1;
one end of the first drain valve S1 is connected with the other end of the first temperature electrode TE1, and the other end is connected with the sewage outlet;
one end of the fourth pipeline is connected with the first end of the filter, and the other end of the fourth pipeline is connected with the sewage draining outlet;
the fifth valve V5 is arranged on the fourth pipeline, one end of the fifth valve V5 is connected with the first end of the filter, and the other end of the fifth valve V5 is connected with one end of the second temperature electrode TE 2;
one end of the second drain valve S2 is connected with the other end of the second temperature electrode TE2, and the other end is connected with the sewage outlet;
the controller opens the sterilization line by controlling the third valve V3, the fourth valve V4, and the fifth valve V5 to open.
In some embodiments of the present invention, optionally, when the second valve is a three-way valve, the first end is connected to the reactor tank, the second end is connected to the first end of the filter, the third end is connected to the second temperature electrode through a fourth pipeline, and the fifth valve is disposed between the third end and the second temperature electrode.
In the embodiment of the utility model, one end of the sterilization pipeline of the exhaust pipeline of the bioreactor is connected with the steam outlet, and the other end is connected with the sewage discharge port, so that the sterilization pipeline works normally when the temperature electrode of the sterilization pipeline reaches a certain temperature; at the moment, steam flows to the first temperature electrode and the first drain valve through the fourth valve, and the first drain valve ensures that the pipeline does not overflow steam and water, so that water in the third pipeline is smoothly discharged to a sewage discharge outlet; the steam flows to the second temperature electrode and the second drain valve through the filter and the fifth valve, so that the sterilization control of the filter is finished, and the drainage and pollution discharge of the pipeline are realized.
In some embodiments of the present invention, optionally, the operating temperature of the first temperature electrode TE1 or the second temperature electrode TE2 is greater than or equal to 121 degrees celsius.
In the embodiment of the utility model, when the temperature electrode temperature reached 121 degrees centigrade, the sterilization pipeline began normal work.
In some embodiments of the present invention, optionally, the sterilization pipeline is closed after normal operation for 30-40 minutes.
In some embodiments of the present invention, optionally, the filter comprises a filter shell and a filter element, the filter shell is fixed on the filter pipeline, and the filter element is fixed in the filter shell.
The embodiment of the utility model provides an in, the filter comprises filter shell and filter core, simple structure, low cost.
The utility model also provides a bioreactor, including the reactor jar body and with what reactor jar body one end was connected as above-mentioned arbitrary embodiment bioreactor exhaust duct.
The embodiment of the utility model provides an in, one that bioreactor possesses is equipped with a bioreactor exhaust duct who uses, can utilize reserve exhaust duct to handle when the unusual condition appears damaging like the filter core, the too much filter core that leads to of foam damages, can also in time more renew the filter core and sterilization process alone to it is incessant to exhaust, can furthest guarantee the cell culture effect.
In some embodiments of the present invention, optionally, the reactor tank is provided with a pressure sensor for detecting the pressure in the exhaust duct.
In some embodiments of the utility model, optionally, when the pressure is greater than or equal to 0.58bar in the pipeline, open the filter line of current spare pipeline, close the filter line of working line to open the sterilization pipeline of working line.
The embodiment of the utility model provides an in, the reactor jar body sets up pressure sensor and realizes the pressure detection in the exhaust duct, and when the filter in the exhaust duct blockked up, the pressure in the exhaust duct triggered controller switched over the exhaust duct to reserve pipeline when rising to a certain threshold value in the certain time.
The embodiments of the present invention have been described with reference to the accompanying drawings, but the present invention is not limited to the above-mentioned embodiments, which are only illustrative and not restrictive, and those skilled in the art can make many forms without departing from the spirit and scope of the present invention.
Claims (7)
1. A bioreactor exhaust pipeline is characterized by comprising a controller, a first pipeline and a second pipeline;
the first pipeline and the second pipeline respectively comprise a sterilization pipeline and a filtering pipeline;
one end of the filter pipeline is used for being connected with the reactor tank body, and the other end of the filter pipeline is used for being connected with the exhaust port;
one end of the sterilization pipeline is used for being connected with the steam outlet, and the other end of the sterilization pipeline is used for being connected with the sewage draining outlet;
the controller is used for opening the filter pipeline of the current standby pipeline when the pressure in the reactor tank body is larger than or equal to a preset threshold value, closing the filter pipeline of the working pipeline and opening the sterilization pipeline of the working pipeline, wherein when the first pipeline is used as the working pipeline, the second pipeline is used as the standby pipeline, and when the second pipeline is used as the working pipeline, the first pipeline is used as the standby pipeline.
2. Bioreactor exhaust duct according to claim 1,
the filtering pipeline comprises a filter, a first pipeline, a second pipeline, a first valve and a second valve;
the first end of the filter is connected with the reactor tank body through the first pipeline, and the first valve is arranged on the first pipeline;
the second end of the filter is connected with the exhaust port through the second pipeline, and the second valve is arranged on the second pipeline;
the controller opens the filter line by controlling the opening of the first valve and the second valve.
3. Bioreactor exhaust duct according to claim 2,
the sterilization pipeline comprises a third pipeline, a fourth pipeline, a first temperature electrode, a first drain valve, a second temperature electrode, a second drain valve, a third valve, a fourth valve and a fifth valve;
the third valve is arranged between the second valve and the first end of the filter and is used for being connected with the steam outlet and controlling the opening or closing of steam;
one end of the third pipeline is connected with the second end of the filter, and the other end of the third pipeline is connected with the sewage draining outlet;
the fourth valve is arranged on the third pipeline, one end of the fourth valve is connected with the second end of the filter, and the other end of the fourth valve is connected with one end of the first temperature electrode;
one end of the first drain valve is connected with the other end of the first temperature electrode, and the other end of the first drain valve is connected with the sewage draining outlet;
one end of the fourth pipeline is connected with the first end of the filter, and the other end of the fourth pipeline is connected with the sewage draining outlet;
the fifth valve is arranged on the fourth pipeline, one end of the fifth valve is connected with the first end of the filter, and the other end of the fifth valve is connected with one end of the second temperature electrode;
one end of the second drain valve is connected with the other end of the second temperature electrode, and the other end of the second drain valve is connected with the sewage draining outlet;
the controller opens the sterilization line by controlling the opening of the third valve, the fourth valve, and the fifth valve.
4. The bioreactor exhaust duct of claim 3, wherein the operating temperature of the first temperature electrode or the second temperature electrode is greater than or equal to 121 degrees Celsius.
5. The bioreactor exhaust conduit according to claim 2, wherein the filter comprises a filter housing secured to the filter conduit and a filter cartridge secured within the filter housing.
6. A bioreactor comprising a reactor tank and a bioreactor vent line according to any one of claims 1 to 5 connected to one end of the reactor tank.
7. Bioreactor according to claim 6, wherein the reactor tank is provided with a pressure sensor for detecting the pressure in the exhaust conduit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020968785.2U CN212293606U (en) | 2020-06-01 | 2020-06-01 | Bioreactor exhaust pipeline and bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020968785.2U CN212293606U (en) | 2020-06-01 | 2020-06-01 | Bioreactor exhaust pipeline and bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212293606U true CN212293606U (en) | 2021-01-05 |
Family
ID=73940815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020968785.2U Active CN212293606U (en) | 2020-06-01 | 2020-06-01 | Bioreactor exhaust pipeline and bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212293606U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113755333A (en) * | 2020-06-01 | 2021-12-07 | 天信和(苏州)生物科技有限公司 | Bioreactor exhaust pipeline, bioreactor and exhaust pipeline control method |
-
2020
- 2020-06-01 CN CN202020968785.2U patent/CN212293606U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113755333A (en) * | 2020-06-01 | 2021-12-07 | 天信和(苏州)生物科技有限公司 | Bioreactor exhaust pipeline, bioreactor and exhaust pipeline control method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106082467B (en) | Water purifier capable of preventing water leakage and control method thereof | |
| CN212293606U (en) | Bioreactor exhaust pipeline and bioreactor | |
| CN204211515U (en) | High-voltage energy-storage back wash filter equipment | |
| CN203461899U (en) | Leakage-proof water-saving water purifier | |
| CN201534802U (en) | Household energy-saving pure-water machine | |
| CN213707901U (en) | Water purifier | |
| CN113755333A (en) | Bioreactor exhaust pipeline, bioreactor and exhaust pipeline control method | |
| KR20100033109A (en) | A purifier for water treatment | |
| CN205773582U (en) | A kind of sewage-treatment plant based on ozone catalytic technology | |
| CN203507823U (en) | Online restoring immersion ultrafiltration membrane pool for pumping water | |
| CN210286987U (en) | Ultra-filtration water purifying device capable of automatically backwashing | |
| JP5001511B2 (en) | Fuel cell system | |
| CN204607746U (en) | Without the need to the reverse osmosis water purifier of electricity consumption | |
| CN208732760U (en) | Purifier | |
| CN208802905U (en) | Back flushing purifier | |
| CN217542223U (en) | Pressure sensor with drainage valve | |
| CN212881889U (en) | But backwash milipore filter device | |
| CN206355845U (en) | A kind of immersion dehydration device after RO films water flowing test | |
| CN201232765Y (en) | Blowoff ball valve | |
| CN100540124C (en) | A kind of anti-penetration water purifier | |
| CN206486373U (en) | A kind of stationary frequency conversion starter cooling water system water replanishing device | |
| JP5395107B2 (en) | Fuel cell system | |
| CN204508966U (en) | A kind of ultra-filtration water purifier of manual valve exhaust | |
| CN211394051U (en) | Water purifier | |
| CN204381022U (en) | A kind of haemodialysis water making device cleaning sterilizing device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |