CN212207219U

CN212207219U - Liquid chromatography-mass spectrometry detection equipment for biomacromolecule to-be-detected medicine

Info

Publication number: CN212207219U
Application number: CN202020830760.6U
Authority: CN
Inventors: 孙梦雅
Original assignee: Beijing Huashi Kangyuan Pharmaceutical Technology Co ltd
Current assignee: Beijing Huashi Kangyuan Pharmaceutical Technology Co ltd
Priority date: 2020-05-19
Filing date: 2020-05-19
Publication date: 2020-12-22
Anticipated expiration: 2030-05-19

Abstract

The utility model discloses a biological macromolecule detects liquid chromatography-mass spectrometry check out test set that medicine was used to detect, including liquid chromatography-mass spectrometry check out test set body, the equal fixed mounting in four ends of liquid chromatography-mass spectrometry check out test set body bottom has the mounting panel, the equal fixed mounting in bottom of four mounting panels has the stay tube, the slotted hole has all been seted up to the both sides of four stay tubes, the inside of four stay tubes all is provided with the connecting pipe, the bottom fixed mounting of connecting pipe has the wheel, the inside of connecting pipe is provided with two connecting blocks, the equal fixedly connected with connecting rod in one side that two connecting blocks were kept away from mutually, the connecting rod is kept away from the one end of connecting. The utility model discloses press during the removal and stimulate the connecting rod downwards, make the wheel expose in the supporting tube to the person of facilitating the use removes this check out test set, presses after removing the completion and upwards promotes the connecting rod, makes in the wheel withdrawal supporting tube, thereby avoids placing the position emergence skew of this check out test set of in-process.

Description

Liquid chromatography-mass spectrometry detection equipment for biomacromolecule to-be-detected medicine

Technical Field

The utility model relates to a check out test set specifically is a biological macromolecule detects liquid chromatography-mass spectrometry check out test set that medicine was used.

Background

The liquid chromatography-mass spectrometry reflects the complementation of the advantages of the chromatogram and the mass spectrum, combines the advantages of high separation capability of the chromatogram on a complex sample, high selectivity, high sensitivity and capability of providing relative molecular mass and structural information, and is widely applied to a plurality of fields such as pharmaceutical analysis, food analysis, environmental analysis and the like.

With the development of biotechnology, the research of biomacromolecule drugs becomes one of the fields with the greatest prospect at present, and biomacromolecule drugs need to be detected by using LC-MS detection equipment in the research process, and the existing LC-MS detection equipment is inconvenient to move, so that the practicability of LC-MS detection equipment is influenced. Therefore, we improve the above and propose a LC-MS detection device for detecting biological macromolecules.

Disclosure of Invention

In order to solve the technical problem, the utility model provides a following technical scheme:

the utility model relates to a liquid chromatography-mass spectrometry detection device for biological macromolecule to be detected, which comprises a liquid chromatography-mass spectrometry detection device body, four ends of the bottom of the liquid chromatography-mass spectrometry detection device body are fixedly provided with mounting plates, the bottoms of the four mounting plates are fixedly provided with supporting tubes, two sides of the four supporting tubes are provided with slotted holes, the insides of the four supporting tubes are provided with connecting tubes, the bottom of the connecting pipe is fixedly provided with a wheel, two connecting blocks are arranged inside the connecting pipe, the far sides of the two connecting blocks are fixedly connected with a connecting rod, one end of the connecting rod far away from the connecting pipe penetrates through the connecting pipe, penetrates through the slotted hole and extends to the outside of the supporting pipe, the outer surface of the connecting rod is fixedly sleeved with a limiting block located inside the slotted hole, and the outer surface of the connecting rod is provided with a return spring located inside the connecting rod.

As an optimal technical scheme of the utility model, the slotted hole comprises a square hole and two round holes, two communicate through the square hole between the round hole.

As a preferred technical scheme of the utility model, reset spring's one end and connecting block fixed connection, reset spring's the other end and connecting pipe fixed connection.

As an optimized technical scheme of the utility model, the through-hole has been seted up to the bottom of stay tube, the size of through-hole and the big or small looks adaptation of wheel.

As a preferred technical scheme of the utility model, the surface and the connecting pipe sliding connection of connecting block, and the surface of connecting block is smooth.

As a preferred technical scheme of the utility model, the inside of connecting pipe is provided with the expanding spring who is located between two connecting blocks, expanding spring's both ends respectively with two connecting block fixed connection.

The utility model has the advantages that: this kind of biological macromolecule waits to detect LC-MS detection equipment that medicine was used, presses down and stimulates the connecting rod downwards during the removal, makes the wheel expose in the supporting tube to the person of facilitating the use removes this detection equipment, presses down and upwards promotes the connecting rod after removing the completion, makes in the wheel withdrawal supporting tube, thereby avoids placing the position emergence skew of this detection equipment of in-process.

Drawings

The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention. In the drawings:

FIG. 1 is a schematic structural view of a LC-MS detection apparatus for biomacromolecule drugs to be detected according to the present invention;

FIG. 2 is a schematic view of the structure of the liquid chromatography mass spectrometry detection device for biological macromolecules to be detected;

FIG. 3 is a schematic diagram of the internal structure of a support tube of the LC-MS apparatus for detecting biological macromolecules to be detected;

FIG. 4 is a left side view structure diagram of the support tube of the LC-MS detection apparatus for biological macromolecule detection of drugs.

In the figure: 1. a LC-MS detection device body; 2. mounting a plate; 3. supporting a tube; 4. a square hole; 5. a circular hole; 6. a connecting pipe; 7. connecting blocks; 8. a connecting rod; 9. a limiting block; 10. a return spring; 11. a wheel; 12. a through hole; 13. a slot; 14. a telescoping spring.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are presented herein only to illustrate and explain the present invention, and not to limit the present invention.

Example (b): as shown in figure 1, figure 2, figure 3 and figure 4, the utility model relates to a liquid chromatography-mass spectrometry detection device for bio-macromolecule to be detected, which comprises a liquid chromatography-mass spectrometry detection device body 1, four ends of the bottom of the liquid chromatography-mass spectrometry detection device body 1 are all fixedly provided with mounting plates 2, the bottoms of four mounting plates 2 are all fixedly provided with supporting tubes 3, two sides of four supporting tubes 3 are all provided with slotted holes 13, the interiors of four supporting tubes 3 are all provided with connecting tubes 6, the bottom of the connecting tube 6 is fixedly provided with wheels 11, the interior of the connecting tube 6 is provided with two connecting blocks 7, one side of the two connecting blocks 7 away from each other is all fixedly connected with a connecting rod 8, one end of the connecting rod 8 away from the connecting tube 6 runs through the connecting tube 6 and passes through the slotted holes 13 and extends to the exterior of the supporting tubes 3, the outer surface of the connecting rod 8 is provided with a return spring 10 positioned inside the connecting pipe 6, and the model number applicable to the liquid chromatography-mass spectrometry detection device body 1 is 1260-60 type liquid chromatography-mass spectrometry detection device.

Wherein, slotted hole 13 comprises a square hole 4 and two round holes 5, through square hole 4 intercommunication between two round holes 5, the diameter of round hole 5 and stopper 9's diameter looks adaptation, the diameter of square hole 4 and the diameter looks adaptation of connecting rod 8.

Wherein, reset spring 10's one end and connecting block 7 fixed connection, reset spring 10's the other end and 6 fixed connection of connecting pipe, reset spring 10 can make the staff loosen connecting rod 8 after, stopper 9 can insert in round hole 5.

Wherein, the bottom of stay tube 3 has seted up through-hole 12, and the size of through-hole 12 and the big or small looks adaptation through-hole 12 of wheel 11 can make things convenient for wheel 11 to reciprocate.

Wherein, the surface and the 6 sliding connection of connecting pipe of connecting block 7, and the surface of connecting block 7 is smooth, and connecting block 7 can play the supporting role to connecting rod 8 to make connecting rod 8 and connecting pipe 6 be connected more stably.

Wherein, the inside of connecting pipe 6 is provided with the expanding spring 14 that is located between two connecting blocks 7, expanding spring 14's both ends respectively with two connecting blocks 7 fixed connection, expanding spring 14 can increase stopper 9 and insert the inside back stability of round hole 5 to prevent to remove or place the skew of the position emergence of in-process stopper 9.

When the detection device is required to be moved, firstly the detection device body 1 for liquid mass spectrometry is lifted upwards, then the connecting rod 8 is pressed, at the moment, the limit block 9 retracts into the supporting tube 3 under the action of the connecting rod 8 and is separated from the round hole 5, then the connecting rod 8 is pulled downwards, at the moment, the wheel 11 is exposed out of the supporting tube 3 under the action of the connecting rod 8, then the connecting rod 8 is loosened, at the moment, the action force of the reset spring 10 and the telescopic spring 14 pushes the connecting block 7 to enable the connecting rod 8 to drive the limit block 9 to be inserted into the round hole 5, so that a user can move the detection device conveniently, the connecting rod 8 is pressed after the movement is completed, at the moment, the limit block 9 retracts into the supporting tube 3 under the action of the connecting rod 8 and is separated from the round hole 5, then the connecting rod 8 is pulled upwards, at, then loosen connecting rod 8, reset spring 10 and expanding spring 14's effort promotes connecting block 7 this moment and makes connecting rod 8 drive stopper 9 and insert in the round hole 5, the bottom and the ground contact of stay tube 3 this moment to avoid placing the position of this check out test set and take place the skew.

In the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.

In the description of the present invention, it should also be noted that, unless otherwise explicitly specified or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The utility model provides a liquid chromatography-mass spectrometry detection equipment that biological macromolecule awaits measuring medicine and uses, includes liquid chromatography-mass spectrometry detection equipment body (1), its characterized in that, equal fixed mounting in four ends of liquid chromatography-mass spectrometry detection equipment body (1) bottom has mounting panel (2), and equal fixed mounting in bottom of four mounting panel (2) has stay tube (3), and slotted hole (13) have all been seted up to four both sides of stay tube (3), and the inside of four stay tube (3) all is provided with connecting pipe (6), the bottom fixed mounting of connecting pipe (6) has wheel (11), the inside of connecting pipe (6) is provided with two connecting blocks (7), and the one side that two connecting blocks (7) kept away from mutually all fixedly connected with connecting rod (8), the one end that connecting rod (8) kept away from connecting pipe (6) all runs through connecting pipe (6) and passes slotted hole (13) and extends to the outside of stay tube (, the outer fixed surface of connecting rod (8) has cup jointed stopper (9) that are located slotted hole (13) inside, the surface of connecting rod (8) is provided with reset spring (10) that are located connecting pipe (6) inside.

2. The LC-MS detection apparatus for biomacromolecule to be detected drug according to claim 1, wherein the slot (13) is composed of a square hole (4) and two round holes (5), and the two round holes (5) are communicated with each other through the square hole (4).

3. The liquid chromatography-mass spectrometry detection device for the biomacromolecule to be detected medicine, according to claim 1, wherein one end of the return spring (10) is fixedly connected with the connecting block (7), and the other end of the return spring (10) is fixedly connected with the connecting pipe (6).

4. The liquid chromatography-mass spectrometry detection device for the biomacromolecule to be detected drug is characterized in that a through hole (12) is formed in the bottom of the support tube (3), and the size of the through hole (12) is matched with that of the wheel (11).

5. The LC-MS detection device for biomacromolecules to be detected with drugs as claimed in claim 1, wherein the outer surface of the connection block (7) is slidably connected with the connection pipe (6), and the outer surface of the connection block (7) is smooth.

6. The liquid chromatography-mass spectrometry detection device for the biomacromolecule to be detected medicine is characterized in that an expansion spring (14) located between the two connecting blocks (7) is arranged inside the connecting pipe (6), and two ends of the expansion spring (14) are fixedly connected with the two connecting blocks (7) respectively.