CN212199071U

CN212199071U - Mesalazine industrial preparation system

Info

Publication number: CN212199071U
Application number: CN202020109156.4U
Authority: CN
Inventors: 刘加林
Original assignee: Rizhao Balote Pharmaceutical Co ltd
Current assignee: Rizhao Balote Pharmaceutical Co ltd
Priority date: 2020-01-18
Filing date: 2020-01-18
Publication date: 2020-12-22
Anticipated expiration: 2030-01-18

Abstract

The utility model discloses a mesalazine industrial preparation system, including reation kettle, filter equipment I, filter cake washing device I, devitrification reaction unit, filter equipment II, filter cake washing device II, filtrating collecting box and mesalazine collecting box, reation kettle's export and filter equipment I's access connection, filter equipment I's filter cake export and filter cake washing device I's filter cake access connection, filter equipment I's filtrating export and devitrification reaction unit access connection, devitrification reaction unit export and filter equipment II access connection, filter equipment II filter cake export and filter cake washing device II access connection, filter equipment II filtrating export and filtrating collecting box access connection, filter cake washing device II's export and mesalazine collecting box access connection. The utility model can realize the industrialized production of mesalazine; moreover, the utility model also has the characteristics of simple structure, convenient use, low manufacturing cost and the like, and is suitable for popularization and application.

Description

Mesalazine industrial preparation system

Technical Field

The utility model relates to a preparation system, specific mesalazine industrial preparation system that says so.

Background

Mesalazine (Mesalazine), which is chemically named 5-aminosalicylic acid (5-ASA) and called masalazine, has obvious inhibition effect on inflammation of intestinal wall by using the ten treatments of mild and moderate ulcerative colitis and the maintenance treatment of ulcerative colitis. Mesalazine can inhibit synthesis of prostaglandin and formation of inflammatory medium leukotriene which can cause inflammation, thereby having remarkable inhibition effect on inflammation of intestinal mucosa and better effect on connective tissue of intestinal wall with inflammation. At present, 5-ASA is widely applied to clinical application and has become the first choice drug for treating inflammatory bowel disease ((IBD). Mesalazine has a large demand and the existing technology can not realize industrialized production of mesalamine, so a mesalamine preparation device is needed to be designed to realize industrialized production of mesalamine.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a mesalazine industrial preparation system to solve the problem that the prior art can't realize mesalazine industrial production.

The utility model discloses a following technical scheme realizes:

the utility model provides a mesalazine industrial preparation system, including reation kettle, filter equipment I, filter cake washing unit I, the crystallization reaction unit, filter equipment II, filter cake washing unit II, filtrating collecting box and mesalazine collecting box, reation kettle's export and the access connection of filter equipment I, filter equipment I's filter cake export and filter cake washing unit I's filter cake access connection, filter equipment I's filtrating export and the inlet connection of crystallization reaction unit, the crystallization reaction unit export and filter equipment II access connection, filter equipment II filter cake export and filter cake washing unit II access connection, filter equipment II filtrating export and filtrating collecting box access connection, filter cake washing unit II's export and mesalazine collecting box access connection.

According to the mesalazine industrial preparation system, the reaction kettle comprises a box body, a stirring mechanism is arranged in the box body, a first feeding hole is formed in the left side of the top surface of the box body, and a first outlet is formed in the lower portion of the right side of the box body.

According to the mesalazine industrial preparation system, the crystallization reaction device comprises a reaction box, a stirring mechanism is arranged in the reaction box, a second feeding hole is formed in the left side of the top surface of the reaction box, a first inlet is formed in the position, close to the lower part, of the left side of the reaction box, and a second outlet is formed in the position, close to the lower part, of the right side of the reaction box.

The mesalazine industrial preparation system comprises a filter box, a through hole is formed in the middle of the top surface of the filter box, which is close to the left side, a vertical shaft is arranged in the through hole, the periphery of the vertical shaft is in contact with the inner wall of the through hole, the vertical shaft can rotate in the through hole and can move up and down along the through hole, the bottom end of the vertical shaft is positioned in the filter box, a blade is arranged at the bottom end of the vertical shaft, two grooves which are symmetrically distributed around the through hole are formed in the top surface of the filter box, vertical multi-stage electric telescopic rods are fixedly arranged in the grooves, the movable ends of the two multi-stage electric telescopic rods are fixedly connected through a transverse plate, the top end of the vertical shaft is positioned outside the filter box, a second motor is fixedly arranged in the middle of the top surface of the transverse plate, the top end of the vertical shaft penetrates through the, the bottom surface of the filter box is provided with a filter cake outlet, a filtrate outlet is arranged below the right side of the filter box, and a second inlet is arranged below the left side of the filter box.

According to the mesalazine industrial preparation system, the filter cake washing device I or the filter cake washing device II comprises a washing tank, a stirring mechanism is arranged in the washing tank, a filter screen is arranged in the washing tank and located below the stirring mechanism, a filter cake inlet is formed in the left side of the top surface of the washing tank, a water inlet is formed in the position, close to the upper side, of the left side of the washing tank, a third outlet is formed in the right side of the washing tank, the third outlet is located above the filter screen, and a fourth outlet is formed in the bottom surface of the washing tank.

According to the mesalazine industrial preparation system, the stirring mechanism comprises the first motor, the stirring shaft and the stirring blade, the first motor is installed in the middle of the top surface of the box body or the reaction box, the output end of the first motor is fixedly connected with the top end of the stirring shaft, the bottom end of the stirring shaft penetrates through the box body or the reaction box and is located inside the box body or the reaction box, and the stirring blade is arranged at the bottom end of the stirring shaft.

According to the mesalazine industrial preparation system, the left side and the right side of the through hole are respectively provided with the spherical grooves, the spherical grooves are internally provided with the balls in a matching manner, the balls can rotate in the corresponding spherical grooves, and the balls are in contact with the vertical shaft.

The utility model has the advantages that: the utility model can realize the industrialized production of mesalazine; moreover, the utility model also has the characteristics of simple structure, convenient use, low manufacturing cost and the like, and is suitable for popularization and application.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive labor.

Fig. 1 is a schematic structural diagram of the present invention; FIG. 2 is a schematic view of the structure of the filter unit I or the filter unit II; FIG. 3 is an enlarged view of section I of FIG. 2; FIG. 4 is a schematic diagram of the filter cake washing apparatus I or filter cake washing apparatus II of FIG. 1 and the structure thereof.

Reference numerals: the device comprises a reaction kettle 1, a filtering device I2, a filtering device I3, a filter cake washing device I, a crystallization reaction device 4, a filtering device II5, a filter cake washing device II6, a filtrate collecting box 7, a mesalazine collecting box 8, a box body 9, a first feeding hole 10, a reaction box 11, a second feeding hole 12, a first motor 13, a stirring shaft 14, a stirring blade 15, a filtering box 16, a through hole 17, a vertical shaft 18, a blade 19, a groove 20, a multi-stage electric telescopic rod 21, a transverse plate 22, a second motor 23, a diatomite filtering layer 24, a filter cake outlet 25, a filtrate outlet 26, a second inlet 27, a washing box 28, a filtering net 29, a filter cake inlet 30, a water inlet 31, a third outlet 32, a fourth outlet 33, a spherical groove 34 and a ball 35.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

As shown in fig. 1-4, an industrial mesalazine preparation system comprises a reaction kettle 1, a filtering device I2, a filter cake washing device I3, a crystallization reaction device 4, a filtering device II5, a filter cake washing device II6, a filtrate collecting box 7 and a mesalazine collecting box 8, wherein an outlet of the reaction kettle 1 is connected with an inlet of the filtering device I2, a filter cake outlet of the filtering device I2 is connected with a filter cake inlet of the filter cake washing device I3, a filtrate outlet of the filtering device I2 is connected with an inlet of the crystallization reaction device 4, an outlet of the crystallization reaction device 4 is connected with an inlet of the filtering device II5, a filter cake outlet of the filtering device II5 is connected with an inlet of the filter cake washing device II6, a filtrate outlet of the filtering device II5 is connected with an inlet of the filtrate collecting box 7, and an outlet of the filter cake washing device II6 is connected with an. When in use, firstly adding a proper amount of sodium carbonate solution into a reaction kettle 1, then slowly adding a proper amount of 2-hydroxy-5-nitrobenzoic acid into the reaction kettle 1, keeping the pH value of the solution in the reaction kettle 1 between 8 and 10, then adding a proper amount of Raney nickel into the reaction kettle 1, then hydrogenating for six hours at 60 ℃ and under the hydrogen pressure of 3 to 4MPa, cooling the materials to room temperature after the materials are completely reacted, adding a proper amount of sodium hydroxide solution, continuously stirring for a period of time, then enabling the reactant to flow into a filtering device I2, enabling a filter cake formed by filtering the reactant to enter a filter cake washing device I3 for washing, enabling the filtrate to flow into a crystallization reaction device 4, simultaneously adding a proper amount of hydrochloric acid into the crystallization reaction device 4 to adjust the pH value of the filtrate to between 2.5 and 3.0, and then continuously stirring for a period of time for crystallization reaction, then the filtrate flows into a filtering device II, a filter cake formed by filtering the filtrate enters a filter cake washing device II6 for washing, mesalazine is finally obtained, and meanwhile the filtrate after secondary filtering flows into a filtrate collecting box 7; the utility model can realize the industrialized production of mesalazine; moreover, the utility model also has the characteristics of simple structure, convenient use, low manufacturing cost and the like, and is suitable for popularization and application.

Particularly, this embodiment reation kettle 1 include box 9, be equipped with rabbling mechanism in the box 9, the top surface left side of box 9 is equipped with first feed inlet 10, box 9 right side below is equipped with first export. The first feeding hole 10 is convenient for conveying materials into the box body 9, and the stirring mechanism is used for stirring to enable the reaction to be more sufficient.

Specifically, this embodiment crystallization reaction unit 4 include reaction box 11, be equipped with rabbling mechanism in the

reaction box

11, 11 top surfaces of reaction box left side is equipped with

second feed inlet

12, 11 left sides of reaction box are close to the below and are equipped with first import, 11 right sides of reaction box are close to the below and are equipped with the second export. The second feeding hole 12 is convenient for conveying materials into the reaction box 11, and meanwhile, the stirring mechanism can be used for enabling the crystallization reaction to be more sufficient.

Further, the filter device I2 or the filter device II5 described in this embodiment includes a filter box 16, a through hole 17 is formed in the middle of the top surface of the filter box 16 near the left side, a vertical shaft 18 is disposed in the through hole 17, the periphery of the vertical shaft 18 contacts with the inner wall of the through hole 17, the vertical shaft 18 can rotate in the through hole 17 and can move up and down along the through hole 17, the bottom end of the vertical shaft 18 is located in the filter box 16, a blade 19 is mounted at the bottom end of the vertical shaft 18, two grooves 20 are formed in the top surface of the filter box 16 and symmetrically distributed with respect to the through hole 17, vertical multi-stage electric telescopic rods 21 are fixedly mounted in the grooves 20, the movable ends of the two multi-stage electric telescopic rods 21 are fixedly connected through a horizontal plate 22, the top end of the vertical shaft 18 is located outside the filter box 16, a second motor 23 is fixedly mounted in the middle of the top surface of the, the diatomite filter layer 24 is positioned on the right side of the blade 19, the bottom surface of the filter box 16 is provided with a filter cake outlet 25, the right side lower part of the filter box 16 is provided with a filtrate outlet 26, and the left side lower part of the filter box 16 is provided with a second inlet 27. The reactant enters the filter box 16 through the second inlet 27, filter is formed by the diatomite filter layer 24, the filtrate flows out through the filtrate outlet 26 and enters the next-stage reaction device, meanwhile, the two multi-stage electric telescopic rods 21 shrink simultaneously, the two multi-stage electric telescopic rods 21 drive the transverse plate 22 to move downwards, the transverse plate 22 drives the second motor 23 and the vertical shaft 18 to move downwards, after the vertical shaft 18 descends to a proper height, the two multi-stage electric telescopic rods 21 stop extending, meanwhile, the second motor 23 starts working, the second motor 23 drives the vertical shaft 18 to rotate, the vertical shaft 18 drives the blade 19 to rotate, the filter cake can be stirred continuously, the filter cake is loosened and separated to form particles, and the scattered filter cake flows out through the filter cake outlet and enters the next-stage reaction device.

Further, the filter cake washing device I3 or the filter cake washing device II6 described in this embodiment includes a washing tank 28, a stirring mechanism is provided in the washing tank 28, a filter screen 29 is installed in the washing tank 28, the filter screen 29 is located below the stirring mechanism, a filter cake inlet 30 is provided on the left side of the top surface of the washing tank 28, a water inlet 31 is provided on the left side of the washing tank 28 near the upper side, a third outlet 32 is provided on the right side of the washing tank 28, the third outlet 32 is located above the filter screen 29, and a fourth outlet 33 is provided on the bottom surface of the washing tank 28. The filter cake passes through filter cake import 30 and gets into in the wash tank 28, and water injection in wash tank 28 through water inlet 31 simultaneously utilizes rabbling mechanism to stir, makes the filter cake fully contact with water, ensures to reach best washing effect, and the liquid after the washing flows out through fourth export 33, and the solid that stays on filter screen 29 flows out through third export 32.

Furthermore, the stirring mechanism described in this embodiment includes a first motor 13, a stirring shaft 14 and stirring blades 15, the first motor 13 is installed in the middle of the top surface of the box 9 or the reaction box 11, the output end of the first motor 13 is fixedly connected to the top end of the stirring shaft 14, the bottom end of the stirring shaft 14 penetrates through the box 9 or the reaction box 11 and is located inside, and the bottom end of the stirring shaft 14 is provided with the stirring blades 15. The purpose of stirring the materials can be achieved through the matching of the parts, the materials can be in full contact, and the reaction can be more thorough or the washing effect is better.

Furthermore, in the present embodiment, a plurality of spherical grooves 34 are respectively formed in the left side and the right side of the through hole 17, the spherical grooves 34 are internally provided with balls 35 in a matching manner, the balls 35 can rotate in the corresponding spherical grooves 34, and the balls 35 are in contact with the vertical shaft 18. The friction between the vertical shaft 18 and the through hole 17 can be reduced by the cooperation of the spherical groove 34 and the ball 35, and the movement of the vertical shaft 18 can be made smoother.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention in its corresponding aspects.

Claims

1. A mesalazine industrial preparation system is characterized in that: comprises a reaction kettle (1), a filtering device I (2), a filter cake washing device I (3), a crystallization reaction device (4), a filtering device II (5), a filter cake washing device II (6), a filtrate collecting box (7) and a mesalazine collecting box (8), the outlet of the reaction kettle (1) is connected with the inlet of a filtering device I (2), the filter cake outlet of the filtering device I (2) is connected with the filter cake inlet of a filter cake washing device I (3), the filtrate outlet of the filtering device I (2) is connected with the inlet of a crystallization reaction device (4), the outlet of the crystallization reaction device (4) is connected with the inlet of a filtering device II (5), the filter cake outlet of the filtering device II (5) is connected with the inlet of a filter cake washing device II (6), the filtrate outlet of the filtering device II (5) is connected with the inlet of a filtrate collecting box (7), and the outlet of the filter cake washing device II (6) is connected with the inlet of a mesalazine collecting box (8).

2. The mesalazine industrial preparation system according to claim 1, wherein: reaction kettle (1) include box (9), be equipped with rabbling mechanism in box (9), box (9) top surface left side is equipped with first feed inlet (10), box (9) right side below is equipped with first export.

3. The mesalazine industrial preparation system according to claim 1, wherein: crystallization reaction unit (4) include reaction box (11), be equipped with rabbling mechanism in reaction box (11), reaction box (11) top surface left side is equipped with second feed inlet (12), reaction box (11) left side is close to below department and is equipped with first import, reaction box (11) right side is close to below department and is equipped with the second export.

4. The mesalazine industrial preparation system according to claim 1, wherein: the filter device I (2) or the filter device II (5) comprises a filter box (16), a through hole (17) is formed in the middle of the top surface of the filter box (16) and is close to the left side, a vertical shaft (18) is arranged in the through hole (17), the periphery of the vertical shaft (18) is in contact with the inner wall of the through hole (17), the vertical shaft (18) can rotate in the through hole (17) and can move up and down along the through hole (17), the bottom end of the vertical shaft (18) is positioned in the filter box (16), blades (19) are arranged at the bottom end of the vertical shaft (18), two grooves (20) which are symmetrically distributed relative to the through hole (17) are formed in the top surface of the filter box (16), vertical multi-stage electric telescopic rods (21) are fixedly arranged in the grooves (20), the movable ends of the two multi-stage electric telescopic rods (21) are fixedly connected through a transverse plate (22), the top end of the vertical shaft (18) is positioned outside, the top end of the vertical shaft (18) penetrates through the transverse plate (22) and is fixedly connected with the output end of the second motor (23), a diatomite filtering layer (24) is arranged in the filtering box (16), the diatomite filtering layer (24) is located on the right side of the blade (19), a filter cake outlet (25) is arranged on the bottom surface of the filtering box (16), a filtrate outlet (26) is arranged below the right side of the filtering box (16), and a second inlet (27) is arranged below the left side of the filtering box (16).

5. The mesalazine industrial preparation system according to claim 1, wherein: filter cake washing device I (3) or filter cake washing device II (6) including wash tank (28), be equipped with rabbling mechanism in wash tank (28), install filter screen (29) in wash tank (28), filter screen (29) are located the rabbling mechanism below, wash tank (28) top surface left side is equipped with filter cake import (30), wash tank (28) left side is close to top department and is equipped with water inlet (31), wash tank (28) right side is equipped with third export (32), third export (32) are located filter screen (29) top, wash tank (28) bottom surface is equipped with fourth export (33).

6. The system for industrially producing mesalazine according to claim 2, 3 or 5, wherein: the stirring mechanism comprises a first motor (13), a stirring shaft (14) and stirring blades (15), wherein the first motor (13) is installed in the middle of the top surface of the box body (9) or the reaction box (11), the output end of the first motor (13) is fixedly connected with the top end of the stirring shaft (14), the bottom end of the stirring shaft (14) penetrates through the box body (9) or the reaction box (11) and is located inside the stirring shaft (14), and the stirring blades (15) are arranged at the bottom end of the stirring shaft (14).

7. The mesalamine industrial preparation system according to claim 4, wherein: a plurality of spherical grooves (34) are respectively formed in the left side and the right side of the through hole (17), balls (35) are arranged in the spherical grooves (34) in a matched mode, the balls (35) can rotate in the corresponding spherical grooves (34), and the balls (35) are in contact with the vertical shaft (18).