CN212091123U

CN212091123U - Suction filtration device for preparing palbocillin key intermediate

Info

Publication number: CN212091123U
Application number: CN201922328058.XU
Authority: CN
Inventors: 刘辉; 龚博文; 冯成亮
Original assignee: Shanghai Micro Mega Industry Co ltd
Current assignee: Shanghai Micro Mega Industry Co ltd
Priority date: 2019-12-23
Filing date: 2019-12-23
Publication date: 2020-12-08
Anticipated expiration: 2029-12-23

Abstract

The utility model discloses a suction filtration device of preparation pabocillin key midbody, including buchner flask and safety bottle, buchner flask opening part is connected with buchner funnel through first rubber buffer, the buchner funnel outer wall has cup jointed filter equipment, buchner funnel pegs graft in first rubber buffer, buchner flask body one side upper portion is equipped with the suction filtration pipe, safety bottle opening part is equipped with the second rubber buffer, the second rubber buffer pegs graft and has had connecting pipe and outlet duct, the suction filtration pipe passes through the hose and links to each other with the connecting pipe, the utility model discloses a setting up the filter equipment who cup joints at the buchner funnel outer wall, make liquid through two-layer filtration, reduced the loss of solid, the filter cake is collected more conveniently and effectively, has improved the yield.

Description

Suction filtration device for preparing palbocillin key intermediate

Technical Field

The utility model relates to a medicine synthesis instrument technical field specifically is a suction filtration device of preparation pabocillin key intermediate.

Background

Pabocillin is a cyclin-dependent kinase inhibitor and is used for treating ER positive/HER 2 negative postmenopausal metastatic breast cancer patients by combining with letrozole, the synthesis process of the Pabocillin relates to multiple suction filtration treatment, suction filtration is a solid-liquid separation technology commonly used in chemical processes, a vacuum pump is adopted to extract gas in a suction filtration bottle to form negative pressure, and the solid-liquid separation effect is accelerated and strengthened.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a suction filtration device of preparation pabocillin key midbody to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a suction filtration device of preparation pabocillin key midbody, includes buchner flask and safety bottle, buchner flask opening part is connected with buchner funnel through first rubber buffer, buchner funnel outer wall has cup jointed filter equipment, filter equipment includes fixed ring, handle and crosses the filter bag, buchner funnel pegs graft in first rubber buffer, buchner flask body one side upper portion is equipped with the suction filtration pipe, safety bottle opening part is equipped with the second rubber buffer, the second rubber buffer pegs graft and has connecting pipe and outlet duct, the suction filtration pipe passes through the hose and links to each other with the connecting pipe.

Preferably, fixed ring and handle formula structure as an organic whole, the internal diameter of ring equals buchner funnel's external diameter, fixed ring is worn to establish on the upper portion of crossing the filter bag, and the diameter less than or equal to buchner funnel's of crossing the filter bag internal diameter, crosses the filter bag and be waterproof material, and the bottom of crossing the filter bag is opened there are a plurality of holes of permeating water.

Preferably, the connecting pipe comprises a connecting branch pipe in the horizontal direction and a suck-back preventing branch pipe in the vertical direction, the suction filtering pipe is connected with the horizontal connecting branch pipe of the connecting pipe through a hose, and a safety valve is arranged above the suck-back preventing branch pipe.

Preferably, the length of the air outlet pipe is greater than that of the suck-back prevention branch pipe of the connecting pipe.

Preferably, a layer of filter paper is laid on the bottom of the filter bag and in the Buchner funnel.

Compared with the prior art, the beneficial effects of the utility model are that: this suction filtration device of preparation pabocillin key midbody, cup joint the filter equipment at buchner funnel outer wall through the setting, make liquid through two-layer filtration, the solid that the suction filtration was left mostly stays on the filter paper in the filter bag, only need when taking off the filter cake with upwards lift filter bag bottom can, only a small amount of solid on the filter paper in the buchner funnel, can not lead to the filter paper damage because of the solid is too much when taking off the filter paper again, the device filters through the two-stage, the loss of solid has been reduced, it is more convenient and effective that the filter cake is collected, the yield has been improved.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a front view of the filtering device of the present invention;

fig. 3 is a top view of the filtering apparatus of the present invention.

In the figure: 1 buchner flask, 2 first rubber plugs, 3 buchner funnel, 4 filter equipment, 41 fixed ring, 42 handles, 43 filter bags, 5 buchner tubes, 6 hoses, 7 connecting pipes, 8 relief valves, 9 outlet ducts, 10 second rubber plugs, 11 safety bottles.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-3, the present invention provides a technical solution: a suction filtration device for preparing a key intermediate of palbocillin comprises a suction filtration bottle 1 and a safety bottle 11, wherein a buchner funnel 3 is connected to an opening of the suction filtration bottle 1 through a first rubber plug 2, the buchner funnel 3 is inserted into the first rubber plug 2, a filtering device 4 is sleeved on the outer wall of the buchner funnel 3, the filtering device 4 comprises a fixed ring 41, a handle 42 and a filter bag 43, the fixed ring 41 and the handle 42 are of an integral structure, the inner diameter of the fixed ring 41 is equal to the outer diameter of the buchner funnel 3, so that the fixed ring is firmly sleeved on the outer wall of the buchner funnel 3, the handle 42 is convenient for mounting and dismounting the filtering device 4, the fixed ring 41 is penetrated on the upper part of the filter bag 43, the diameter of the filter bag 43 is smaller than or equal to the inner diameter of the buchner funnel 3, one layer of filter paper is paved on the bottom of the filter bag, the filter bag 43 that is preferred can be water-proof PE plastic bag, during the suction filtration, liquid flows into the suction flask 1 from the hole of permeating water in the bottom, and through the filter bag 43 bottom filter paper and the filter paper both sides on buchner funnel 3 filter, the solid stays on the filter paper, suction flask 1 body one side upper portion is equipped with suction tube 5, safety flask 11 opening part is equipped with second rubber buffer 10, second rubber buffer 10 pegs graft and has connecting pipe 7 and outlet duct 9, connecting pipe 7 includes horizontal direction's connecting branch pipe and vertical direction's anti-suck-back branch pipe, is equipped with relief valve 8 above the anti-suck-back branch pipe, and outlet duct 9 length is greater than the anti-suck-back branch pipe length of connecting pipe 7, and suction flask 1 internal pressure is unbalanced with the external world during the sudden outage condition, and water suck-back into safety flask 11, because outlet duct 9 length is greater than the anti-suck-back branch pipe length of, the suction filtration pipe 5 is connected with a horizontal connection branch pipe of the connection pipe 7 through the hose 6, the air outlet pipe 9 is connected with the vacuum pump through the hose, negative pressure is generated in the suction filtration bottle 1 when the vacuum pump works, liquid is accelerated to seep out from the filter paper and flow into the suction filtration bottle, the safety valve 8 is closed to form a closed space to prevent suction filtration air leakage during suction filtration, after suction filtration is completed, the safety valve 8 is opened firstly to enable the air pressure in the suction filtration bottle 1 to be recovered to be consistent with the outside, then the vacuum pump is closed, and suck back is avoided.

The working principle is as follows: during suction filtration, the buchner funnel 1 is connected with the safety bottle 11 through a hose, the air outlet pipe 9 is connected with an external vacuum pump, a layer of filter paper is paved on the buchner funnel 3 and the bottom of the filter bag 43, the fixed ring 41 of the filter device 4 is sleeved on the outer wall of the buchner funnel 3, the filter bag 43 is positioned in the buchner funnel, the external vacuum pump is started, liquid to be separated is poured into the filter bag 43, negative pressure is formed in the buchner funnel 1, the liquid flows into the buchner funnel 1 through the water permeable holes at the bottom of the filter bag 43 and the water permeable holes of the buchner funnel, most of solid is remained on the filter paper at the bottom of the filter bag 43, a small amount of solid is remained on the filter paper in the buchner funnel 3, after suction filtration, the safety valve 8 is firstly opened and then the vacuum pump is closed, the handle 42 is held to take, the taking-out is convenient.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. The utility model provides a suction filter device of preparation pabocillin key midbody, includes suction filter bottle (1) and safety bottle (11), its characterized in that: buchner funnel (3) are connected with through first rubber buffer (2) to buchner funnel (1) opening part, buchner funnel (3) outer wall has cup jointed filter equipment (4), filter equipment (4) are including fixed ring (41), handle (42) and cross filter bag (43), buchner funnel (3) are pegged graft in first rubber buffer (2), buchner funnel (1) body one side upper portion is equipped with buchner tube (5), safety bottle (11) opening part is equipped with second rubber buffer (10), the second rubber buffer is pegged graft and is had connecting pipe (7) and outlet duct (9), buchner tube (5) link to each other with connecting pipe (7) through hose (6).

2. The suction filtration device for preparing the key intermediate of the palbocillin as claimed in claim 1, wherein: fixed ring (41) and handle (42) formula structure as an organic whole, the internal diameter of fixed ring (41) equals the external diameter of buchner funnel (3), wear to establish fixed ring (41) on the upper portion of crossing filter bag (43), cross the internal diameter of the diameter less than or equal to buchner funnel (3) of filter bag (43), cross filter bag (43) and be waterproof material, open the bottom of crossing filter bag (43) and have a plurality of holes of permeating water.

3. The suction filtration device for preparing the key intermediate of the palbocillin as claimed in claim 1, wherein: the connecting pipe (7) comprises a connecting branch pipe in the horizontal direction and a suck-back preventing branch pipe in the vertical direction, the suction filtration pipe (5) is connected with the horizontal connecting branch pipe of the connecting pipe (7) through a hose (6), and a safety valve (8) is arranged above the suck-back preventing branch pipe.

4. The suction filtration device for preparing the key intermediate of the palbocillin as claimed in claim 1, wherein: the length of the air outlet pipe (9) is greater than that of the suck-back prevention branch pipe of the connecting pipe (7).

5. The suction filtration device for preparing the key intermediate of the palbocillin as claimed in claim 1, wherein: and a layer of filter paper is paved at the bottom of the filter bag (43) and in the Buchner funnel (3).