CN212051335U - Device for cell multidirectional migration experiment - Google Patents

Abstract

The utility model discloses a device for cell multidirectional migration experiments, first mounting bracket and second mounting bracket including the symmetry setting, rotate respectively on first mounting bracket and the second mounting bracket and install first pivot and second pivot, all the cover is equipped with the lifter plate in first pivot and the second pivot, and first pivot and second pivot all with the mutual screw-thread engagement of lifter plate, dismantle jointly on two lifters and install experimental apparatus, rotate on the lateral wall on first mounting bracket top and install the third pivot, the one end fixed mounting that first pivot was kept away from in the third pivot has the carousel, install transmission between third pivot and the first pivot. The utility model discloses in can be convenient install experimental apparatus to the lifter plate on or pull down from the lifter plate to the cell sap sample after can be convenient will testing takes out in the experimental apparatus, and what also can be convenient carries out rinse thoroughly to the experimental apparatus moreover, reasonable in design, excellent in use effect.

Description

Device for cell multidirectional migration experiment

Technical Field

The utility model relates to a cell migration technical field especially relates to a device is used in multidirectional migration of cell experiments.

Background

Cell migration, also known as cell crawling, cell movement, or cell movement, refers to the movement of a cell upon receiving a migration signal or sensing a gradient of some substance.

Through the retrieval, chinese patent No. CN207918816U discloses a device for cell multidirectional migration experiments, including the bottom plate, the equidistance is equipped with the cell division board on the bottom plate, the bottom plate is divided into four experimental regions through the cell division board, the center department of bottom plate is equipped with the cell and places the blind hole, the one end of cell division board is connected on the lateral wall that the blind hole was placed to the cell, the other end of cell division board is connected on the inside wall of bottom plate, the equidistance is equipped with four cell migration recesses on the bottom plate, the cell is placed and is equipped with the through-hole with cell migration recess assorted on the blind hole.

The existing device for the cell multidirectional migration experiment has the following defects: because experimental apparatus fixed mounting is on the movable block, be not convenient for pull down experimental apparatus from the movable block, so be not convenient for take out the cell sap sample after the experiment in the experimental apparatus during in-service use, also be not convenient for thoroughly wash experimental apparatus in addition, the result of use is poor.

SUMMERY OF THE UTILITY MODEL

The utility model aims at solving the unreasonable problem of device design for the multidirectional migration of cell experiment among the prior art, and the multidirectional migration of cell experiment device that provides.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a device for a cell multidirectional migration experiment comprises a first mounting frame and a second mounting frame which are symmetrically arranged, wherein a first rotating shaft and a second rotating shaft are respectively rotatably mounted on the first mounting frame and the second mounting frame, lifting plates are respectively sleeved on the first rotating shaft and the second rotating shaft, the first rotating shaft and the second rotating shaft are mutually in threaded engagement with the lifting plates, the two lifting plates are jointly detachably mounted with an experiment device, a third rotating shaft is rotatably mounted on the outer side wall of the top end of the first mounting frame, one end, far away from the first rotating shaft, of the third rotating shaft is fixedly mounted with a turntable, a transmission device is mounted between the third rotating shaft and the first rotating shaft, limiting bottom plates are jointly and fixedly mounted on the inner side walls of the bottoms of the first mounting frame and the second mounting frame, belt pulleys are fixedly mounted on the outer side walls of the bottoms of the first rotating shaft and the second rotating shaft, and the two belt pulleys are both positioned on the lower sides, and a belt is wound on the two belt pulleys together.

Preferably, equal fixed mounting has the deflector of mutually supporting with the lifter plate in first mounting bracket and the second mounting bracket, and the deflector all runs through the lifter plate setting.

Preferably, the outer side wall of the experimental device is symmetrically and fixedly provided with two connecting plates, the bottom walls of the two connecting plates are provided with a plurality of connecting screw rods in an inserted mode, the connecting screw rods penetrate through the lifting plate and extend to the lower side of the lifting plate, and each outer side wall at the bottom end of each connecting screw rod is connected with a fastening nut in a threaded mode.

Preferably, an annular limiting plate is fixedly mounted on the third rotating shaft, and an annular limiting groove matched with the annular limiting plate is formed in the first mounting frame.

Preferably, the transmission device comprises a first bevel gear and a second bevel gear which are fixedly arranged on the third rotating shaft and the first rotating shaft respectively, and the first bevel gear and the second bevel gear are in gear engagement with each other.

Preferably, the inner side walls of the top ends of the first mounting frame and the second mounting frame are fixedly provided with limit blocks matched with the lifting plate.

Compared with the prior art, the utility model discloses there is following beneficial effect:

1. the experimental device can be conveniently installed on or detached from the lifting plate, so that the cell sap sample after the experiment can be conveniently taken out of the experimental device, the experimental device can be conveniently and thoroughly cleaned, and the design is reasonable and the use effect is good;

2. rotate the carousel and reciprocate with experimental apparatus just can be convenient control lifter plate, not only convenient to use can prevent moreover that experimental apparatus from taking place acutely to rock when reciprocating to can avoid rocking because of experimental apparatus influences the cell migration, improve experimental data's accuracy.

Drawings

FIG. 1 is a schematic front view of an experimental apparatus for multi-directional cell migration according to the present invention;

fig. 2 is an enlarged view of a portion a of the structure of the device for cell multi-directional migration experiments according to the present invention.

In the figure: 1 first mounting bracket, 2 second mounting brackets, 3 first pivot, 4 second pivots, 5 lifter plates, 6 experimental apparatus, 7 connecting plates, 8 connecting screw rods, 9 fastening nuts, 10 third pivots, 11 turntables, 12 annular limiting plates, 13 first bevel gears, 14 second bevel gears, 15 limiting blocks, 16 limiting bottom plates, 17 belt pulleys and 18 belts.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments.

Referring to fig. 1-2, a device for cell multidirectional migration experiments, including first mounting bracket 1 and the second mounting bracket 2 that the symmetry set up, rotate respectively on first mounting bracket 1 and the second mounting bracket 2 and install first pivot 3 and second pivot 4, all overlap on first pivot 3 and the second pivot 4 and be equipped with lifter plate 5, and first pivot 3 and second pivot 4 all with 5 mutual threaded engagement of lifter plate, equal fixed mounting has the deflector of mutually supporting with lifter plate 5 in first mounting bracket 1 and the second mounting bracket 2, and the deflector all runs through 5 settings of lifter plate, can prevent that lifter plate 5 from taking place the offset when reciprocating.

Install experimental apparatus 6 on two lifter plates 5 jointly dismantles, symmetry fixed mounting has two connecting plates 7 on experimental apparatus 6's the lateral wall, it is equipped with a plurality of connecting screw 8 all to insert on two connecting plates 7's the diapire, and connecting screw 8 all runs through lifter plate 5 and extends to lifter plate 5's downside, equal threaded connection has fastening nut 9 on the lateral wall of every connecting screw 8 bottom, can be convenient install experimental apparatus 6 to lifter plate 5 on or pull down from lifter plate 5, thereby can be convenient take out the cell liquid sample after the experiment from experimental apparatus 6, and also can be convenient carry out rinse thoroughly experimental apparatus 6, reasonable in design, excellent in use effect.

Rotate on the lateral wall on first mounting bracket 1 top and install third pivot 10, the one end fixed mounting that first pivot 3 was kept away from in third pivot 10 has carousel 11, and fixed mounting has ring limiting plate 12 on the third pivot 10, sets up the annular spacing groove of mutually supporting with ring limiting plate 12 on the first mounting bracket 1 for rotation can only take place for third pivot 10.

Install transmission between third pivot 10 and the first pivot 3, transmission includes first bevel gear 13 and second bevel gear 14 of fixed mounting respectively on third pivot 10 and first pivot 3, and first bevel gear 13 and the mutual gear engagement of second bevel gear 14, it just can drive third pivot 10 and first bevel gear 13 rotation to rotate carousel 11, first bevel gear 13 and the mutual gear engagement of second bevel gear 14, consequently first bevel gear 13 rotates and can drive second bevel gear 14 and first pivot 3 and rotate, all fixed mounting has stopper 15 with lifter plate 5 mutually supporting on the inside wall on first mounting bracket 1 and the 2 tops of second mounting bracket, can prevent lifter plate 5 and transmission from contacting each other.

Common fixed mounting has limit bottom plate 16 on the inside wall of first mounting bracket 1 and 2 bottoms of second mounting bracket, equal fixed mounting has belt pulley 17 on the lateral wall of first pivot 3 and 4 bottoms of second pivot, and two belt pulleys 17 all are located limit bottom plate 16's downside, jointly around being equipped with belt 18 on two belt pulleys 17, first pivot 3 rotates and just can drive belt 18, belt pulley 17 and 4 rotations of second pivot, because first pivot 3 and second pivot 4 respectively with two lifter plates 5 intermeshing, consequently first pivot 3 and 4 rotations of second pivot can drive lifter plate 5 and experimental apparatus 6 and reciprocate, high durability and convenient use, and take place acutely when can preventing experimental apparatus 6 from reciprocating to rock, thereby can avoid rocking because of experimental apparatus 6 and influence the cell migration, the accuracy of experimental data has been improved.

The utility model discloses in, it just can drive third pivot 10 and first bevel gear 13 to rotate carousel 11, first bevel gear 13 and 14 intermeshing gears of second bevel gear, consequently first bevel gear 13 rotates and to drive second bevel gear 14 and first pivot 3 and rotate, first pivot 3 rotates and just can drive belt 18, belt pulley 17 and second pivot 4 rotate, because first pivot 3 and second pivot 4 respectively with two lifter plates 5 intermeshing, consequently first pivot 3 and second pivot 4 rotate and to drive lifter plate 5 and experimental apparatus 6 and reciprocate.

Further, unless otherwise specifically stated or limited, the above-described fixed connection is to be understood in a broad sense, and may be, for example, welded, glued, or integrally formed as is conventional in the art.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

The above, only be the concrete implementation of the preferred embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and any person skilled in the art is in the technical scope of the present invention, according to the technical solution of the present invention and the utility model, the concept of which is equivalent to replace or change, should be covered within the protection scope of the present invention.

Claims (6)

1. The utility model provides a device for cell multidirectional migration experiments, includes first mounting bracket (1) and second mounting bracket (2) that the symmetry set up, its characterized in that: the device is characterized in that a first rotating shaft (3) and a second rotating shaft (4) are respectively rotatably mounted on the first mounting frame (1) and the second mounting frame (2), lifting plates (5) are respectively sleeved on the first rotating shaft (3) and the second rotating shaft (4), the first rotating shaft (3) and the second rotating shaft (4) are respectively in threaded engagement with the lifting plates (5), two experimental devices (6) are jointly demounted and mounted on the lifting plates (5), a third rotating shaft (10) is rotatably mounted on the outer side wall of the top end of the first mounting frame (1), a turntable (11) is fixedly mounted at one end, far away from the first rotating shaft (3), of the third rotating shaft (10), a transmission device is mounted between the third rotating shaft (10) and the first rotating shaft (3), and a limiting bottom plate (16) is jointly fixedly mounted on the inner side walls of the bottoms of the first mounting frame (1) and the second mounting frame (2), equal fixed mounting has belt pulley (17) on the lateral wall of first pivot (3) and second pivot (4) bottom, and two belt pulleys (17) all are located the downside of spacing bottom plate (16), two on belt pulley (17) jointly around being equipped with belt (18).

2. The device for the multidirectional migration experiment of the cells according to claim 1, wherein: equal fixed mounting has the deflector of mutually supporting with lifter plate (5) in first mounting bracket (1) and second mounting bracket (2), and the deflector all runs through lifter plate (5) setting.

3. The device for the multidirectional migration experiment of the cells according to claim 1, wherein: symmetry fixed mounting has two connecting plates (7), two on the lateral wall of experimental apparatus (6) all insert on the diapire of connecting plate (7) and be equipped with a plurality of connecting screw (8), and connecting screw (8) all run through lifter plate (5) and extend to the downside of lifter plate (5), every equal threaded connection has fastening nut (9) on the lateral wall of connecting screw (8) bottom.

4. The device for the multidirectional migration experiment of the cells according to claim 1, wherein: an annular limiting plate (12) is fixedly mounted on the third rotating shaft (10), and an annular limiting groove matched with the annular limiting plate (12) is formed in the first mounting frame (1).

5. The device for the multidirectional migration experiment of the cells according to claim 1, wherein: the transmission device comprises a first bevel gear (13) and a second bevel gear (14) which are fixedly arranged on a third rotating shaft (10) and a first rotating shaft (3) respectively, and the first bevel gear (13) and the second bevel gear (14) are in gear engagement with each other.

6. The device for the multidirectional migration experiment of the cells according to claim 1, wherein: and limiting blocks (15) matched with the lifting plate (5) are fixedly mounted on the inner side walls at the top ends of the first mounting frame (1) and the second mounting frame (2).

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