CN211871830U

CN211871830U - Polypeptide synthesizer

Info

Publication number: CN211871830U
Application number: CN202020238118.9U
Authority: CN
Inventors: 徐红岩; 马敬祥
Original assignee: Shanghai Jifeng Biotechnology Co ltd
Current assignee: Shanghai Jifeng Biotechnology Co ltd
Priority date: 2020-03-02
Filing date: 2020-03-02
Publication date: 2020-11-06
Anticipated expiration: 2030-03-02

Abstract

The utility model relates to the technical field of chemical equipment, and particularly discloses a polypeptide synthesis device, which comprises a base, a solvent box, an air pump and a reaction tank, wherein two support frames are symmetrically and fixedly arranged on the base, a fixed hoop is fixedly arranged at the middle position of the reaction tank, two ends of the fixed hoop are fixedly connected with connecting rods, the connecting rods are rotatably connected on the inner side walls of the support frames, two ends of the reaction tank are provided with openings and are provided with valves, and the connecting rods at one end are coaxially and fixedly connected with gears; the inside fixed hydraulic stem that is provided with of support frame of one end, the one end fixedly connected with rack of hydraulic stem, the rack slides and sets up in the inside of support frame, rack and gear engagement, and sealing connection can be dismantled through the flange in the bottom of retort, junction fixedly connected with filter screen. The utility model discloses the advantage: simple structure, the upset is convenient, and the security is high, has avoided environmental pollution.

Description

Polypeptide synthesizer

Technical Field

The utility model relates to a chemical industry equipment technical field specifically is a polypeptide synthesizer.

Background

The peptide is a compound formed by connecting alpha-amino acids together by a peptide chain, is also an intermediate product of protein hydrolysis, is a compound formed by dehydrating and condensing two amino acid molecules and is called dipeptide, and similarly, tripeptide, tetrapeptide, pentapeptide and the like are also included, and a compound formed by dehydrating and condensing 10-100 amino acid molecules is called polypeptide, and the polypeptide has the characteristics of being directly absorbed by a human body and the like, so that the peptide is widely applied to the pharmaceutical industry. In the prior art, most polypeptide synthesis reaction devices can only carry out single reaction, the synthesis efficiency is low, a large amount of harmful gases and other gases can be generated in the synthesis reaction, the gases are directly discharged to the outside to pollute the environment, meanwhile, the bodies of experimenters can be damaged, and the safety is poor.

Chinese patent (publication No. CN 207671961U, bulletin date: 2018.07.31) discloses a polypeptide synthesis device, which solves the technical problems that the existing peptide resin cutting and filtering device has a complex and non-detachable structure, and reaction solvent and products are required to be repeatedly transferred during the polypeptide synthesis and cutting process and post-treatment, so that the volatilization and loss of the reaction solvent and the products are serious; the funnel is equipped with funnel body and funnel neck, funnel neck and funnel body structure as an organic whole, and the psammitolite is inlayed to funnel body inside, and funnel neck department is equipped with the nitrogen gas pipe, and nitrogen gas pipe and funnel neck pass through the three-way valve and connect, and breather pipe department is equipped with first valve. The device body upset is inconvenient, causes work efficiency low, is not convenient for popularize and implement.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a polypeptide synthesizer to solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme:

a polypeptide synthesizer is composed of base, solvent tank, air pump and reaction tank. Two support frames are symmetrically and fixedly arranged on the base, and the reaction process inside the reaction tank belongs to the prior art and is not described here. The fixed hoop that is provided with in intermediate position of retort, the both ends fixedly connected with connecting rod of fixed hoop, the connecting rod rotates to be connected on the inside wall of support frame. The two ends of the reaction tank are provided with openings and valves. Wherein the coaxial fixedly connected with gear of connecting rod of one end, the inside fixed hydraulic stem that is provided with of support frame of one end, the one end fixedly connected with rack of hydraulic stem, the rack slides and sets up in the inside of support frame, rack and gear engagement, under the effect of hydraulic stem, the rack slides in support frame inside to make gear revolve, gear revolve drives the retort and rotates, thereby can make the retort upset. Sealing connection can be dismantled through the flange in the bottom of retort, and junction fixedly connected with filter screen after the reaction, the filter screen can filter reaction liquid, has avoided reaction liquid to shift and has caused the loss of revealing. The reaction tank is disassembled, so that the cleaning of solid matters and the maintenance of the reaction tank are facilitated.

As a further aspect of the present invention: the bottom of base is provided with the universal wheel, is provided with the cardboard on the universal wheel, and the cardboard has the braking action to the universal wheel, and the setting up of universal wheel has made things convenient for the removal and the fixing of base.

As a further aspect of the present invention: the reaction tank is of a cylindrical structure with thick middle and thin two ends, so that the raw materials can be conveniently added and the reaction liquid can be conveniently discharged.

As a further aspect of the present invention: the side of support frame is fixed on the base and is provided with the solvent case, and solvent incasement portion holds the organic solvent that can absorb harmful gas, and the air pump is given vent to anger the end and is stretched into the interior bottom of solvent case, and the inlet end intercommunication of air pump has the hose, the tip detachable of hose and the port intercommunication of retort. Under the drive of the air pump, harmful gas in the reaction tank enters the solvent box and is absorbed by the organic solvent in the solvent box, so that the phenomenon that reagents such as trifluoroacetic acid, phenol, ethanedithiol with odor and the like with corrosivity, irritation and volatility volatilize into the air to cause pollution and damage to the health of workers is avoided.

As a further aspect of the present invention: the solvent box lateral wall has seted up the observation window, and the setting of observation window is convenient for observe inside organic solvent's situation.

As a further aspect of the present invention: the observation window is marked with scale marks, and the arrangement of the scale marks is convenient for quantitatively observing the amount of the solvent in the solvent box.

Compared with the prior art, the beneficial effects of the utility model are that: under the effect of hydraulic stem, the rack slides in support frame inside to make gear revolve, gear revolve drives the retort and rotates, thereby can make the retort upset, the upset convenient and fast of retort has reduced work load. After the reaction, the filter screen can filter the reaction liquid, has avoided the reaction liquid to shift and has caused and reveal the loss. The reaction tank is disassembled, so that the cleaning of solid matters and the maintenance of the reaction tank are facilitated. Under the drive of the air pump, harmful gas in the reaction tank enters the solvent box and is absorbed by the organic solvent in the solvent box, so that the phenomenon that reagents such as trifluoroacetic acid, phenol, ethanedithiol with odor and the like with corrosivity, irritation and volatility volatilize into the air to cause pollution and damage to the health of workers is avoided. The utility model discloses the advantage: simple structure, the upset is convenient, and the security is high, has avoided environmental pollution.

Drawings

FIG. 1 is a schematic perspective view of a polypeptide synthesis apparatus.

FIG. 2 is a schematic diagram of the structure of the support frame in the right view of a polypeptide synthesis apparatus.

FIG. 3 is a schematic diagram of an interior elevation view of a scaffold in a polypeptide synthesis apparatus.

In the figure, a base 1, a solvent box 2, an air pump 3, a hose 4, a support frame 5, a reaction tank 6, a fixed hoop 7, scale marks 8, an observation window 9, a universal wheel 10, a filter screen 11, a hydraulic rod 12, a gear 13, a rack 14 and a connecting rod 15.

Detailed Description

In order to clearly understand the technical features, objects and effects of the present invention, the present invention will now be described with reference to the accompanying drawings.

Example 1

Referring to fig. 1-3, a polypeptide synthesis apparatus includes a base 1, a solvent tank 2, an air pump 3, and a reaction tank 6. The bottom of base 1 is provided with universal wheel 10, is provided with the cardboard on the universal wheel 10, and the cardboard has the braking action to universal wheel 10, and the setting up of universal wheel 10 has made things convenient for the removal and the fixing of base 1. Two support frames 5 are symmetrically and fixedly arranged on the base 1, and the reaction tank 6 is of a cylindrical structure with thick middle and thin two ends, so that the raw materials can be conveniently added and the reaction liquid can be conveniently discharged. The reaction process inside the reaction tank 6 is prior art and will not be described here. Fixed hoop 7 that is provided with of intermediate position of retort 6, the both ends fixedly connected with connecting rod 15 of fixed hoop 7, connecting rod 15 rotates to be connected on the inside wall of support frame 5. The two ends of the reaction tank 6 are provided with openings and valves. Wherein the coaxial fixedly connected with gear 13 of connecting rod 15 of one end, the inside fixed hydraulic stem 12 that is provided with of support frame 5 of one end, the one end fixedly connected with rack 14 of hydraulic stem 12, rack 14 slides and sets up in the inside of support frame 5, rack 14 and gear 13 meshing, under the effect of hydraulic stem 12, rack 14 slides in support frame 5 is inside, thereby make gear 13 rotate, gear 13 rotates and drives retort 6 and rotate, thereby can make retort 6 overturn. Sealing connection can be dismantled through the flange in retort 6's bottom, and junction fixedly connected with filter screen 11 after the reaction, filter screen 11 can filter reaction liquid, has avoided reaction liquid to shift and has caused the loss of revealing. The reaction tank 6 is disassembled, thereby facilitating the cleaning of the solids and the maintenance of the reaction tank 6.

The side of support frame 5 is fixed on base 1 and is provided with solvent case 2, and solvent case 2 is inside to hold the organic solvent that can absorb harmful gas, and air pump 3 gives vent to anger the end and stretches into the interior bottom of solvent case 2, and the inlet end intercommunication of air pump 3 has hose 4, the tip detachable of hose 4 and the port intercommunication of retort 6. Under the drive of the air pump 3, harmful gas in the reaction tank 6 enters the solvent box 2 and is absorbed by the organic solvent in the solvent box 2, so that the phenomenon that reagents such as trifluoroacetic acid, phenol and ethanedithiol with bad odor, which are corrosive, irritant and volatile, volatilize into the air to cause pollution and damage to the health of workers is avoided.

The utility model discloses a theory of operation is: after the reaction is finished, the solvent and the washing liquid are filtered, the peptide resin is shrunk and dried, and under the action of the hydraulic rod 12, the rack 14 slides in the support frame 5, so that the gear 13 rotates, the gear 13 rotates to drive the reaction tank 6 to rotate, and the reaction tank 6 can be turned over. Vertically rotating the reaction tank 6 for 180 degrees, adding a cutting solvent to wash the peptide resin into the reaction tank 6, and cutting the peptide resin until the cutting reaction is finished; and rotating the reaction tank 6 by 180 degrees, communicating the hose 4 with the end part of the reaction tank 6, and carrying out suction filtration and washing to obtain the product. Under the drive of the air pump 3, harmful gas in the reaction tank 6 enters the solvent box 2 and is absorbed by the organic solvent in the solvent box 2, so that the phenomenon that reagents such as trifluoroacetic acid, phenol and ethanedithiol with bad odor, which are corrosive, irritant and volatile, volatilize into the air to cause pollution and damage to the health of workers is avoided.

Example 2

On the basis of embodiment 1, the side wall of the solvent tank 2 is provided with an observation window 9, and the arrangement of the observation window 9 is convenient for observing the condition of the internal organic solvent. The observation window 9 is marked with scale marks 8, and the arrangement of the scale marks 8 is convenient for quantitatively observing the amount of the solvent in the solvent tank 2.

The above-mentioned embodiments only represent the preferred embodiments of the present invention, and the description thereof is more specific and detailed, but not to be construed as limiting the scope of the present invention. It should be noted that, for those skilled in the art, without departing from the spirit of the present invention, several changes, modifications and substitutions can be made, which are all within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the appended claims.

Claims

1. A polypeptide synthesis device comprises a base (1), a solvent box (2), an air pump (3) and a reaction tank (6), wherein two support frames (5) are symmetrically and fixedly arranged on the base (1), and the polypeptide synthesis device is characterized in that a fixed hoop (7) is fixedly arranged in the middle of the reaction tank (6), two ends of the fixed hoop (7) are fixedly connected with connecting rods (15), the connecting rods (15) are rotatably connected to the inner side walls of the support frames (5), two ends of the reaction tank (6) are provided with openings and valves, and the connecting rods (15) at one end are coaxially and fixedly connected with gears (13);

the inside fixed hydraulic stem (12) that is provided with of support frame (5), the one end fixedly connected with rack (14) of hydraulic stem (12), rack (14) slide and set up in the inside of support frame (5), rack (14) and gear (13) meshing, and sealing connection can be dismantled through the flange in the bottom of retort (6), junction fixedly connected with filter screen (11).

2. The device for synthesizing polypeptide according to claim 1, wherein the bottom of the base (1) is provided with a universal wheel (10), and the universal wheel (10) is provided with a clamping plate.

3. The device for synthesizing polypeptide according to claim 1, wherein the reaction tank (6) is a cylindrical structure with a thick middle part and two thin ends.

4. The polypeptide synthesis device according to any one of claims 1 to 3, wherein a solvent tank (2) is fixedly arranged on the base (1) at the side of the support frame (5), an organic solvent for absorbing harmful gas is contained in the solvent tank (2), the air outlet end of the air pump (3) extends into the inner bottom of the solvent tank (2), the air inlet end of the air pump (3) is communicated with a hose (4), and the end part of the hose (4) is detachably communicated with the port of the reaction tank (6).

5. The device for synthesizing polypeptide of claim 4, wherein the side wall of the solvent tank (2) is provided with an observation window (9).

6. A polypeptide synthesis apparatus as claimed in claim 5, characterised in that the viewing window (9) is marked with graduations (8).