CN211845691U

CN211845691U - Hematopoietic stem cell transfer device

Info

Publication number: CN211845691U
Application number: CN202020251616.7U
Authority: CN
Inventors: 严家炜; 杨玉琼; 黄东平
Original assignee: Yijishan Hospital of Wannan Medical College
Current assignee: Yijishan Hospital of Wannan Medical College
Priority date: 2020-03-04
Filing date: 2020-03-04
Publication date: 2020-11-03
Anticipated expiration: 2030-03-04

Abstract

The utility model discloses a hematopoietic stem cell transfer device, which comprises an inner box body and an outer box body which are sleeved from inside to outside and form gaps, wherein the inner box body and the outer box body comprise shells with upper surfaces matched with and provided with end covers, and a plurality of groups of placing structures, and each group of placing structures comprises a placing frame and a partition component which are arranged from top to bottom in sequence; each partition component comprises a frame arranged along the circumferential direction of the inner wall of the shell, a cover plate is clamped on the frame, at least one through hole penetrates through the cover plate along the vertical direction, a blocking piece used for sealing the through hole is movably arranged on the through hole along the vertical direction, and the blocking piece can rotate around the central axis; the through holes in the two adjacent cover plates are arranged in a staggered mode in the vertical direction, and the blocking piece comprises a first blocking plate and a second blocking plate which are used for sealing the two adjacent cover plates respectively. The effect of storing and taking step by step according to the condition can be realized in one transfer box, and the transfer problem caused by insufficient hands in the transfer process is reduced.

Description

Hematopoietic stem cell transfer device

Technical Field

The utility model relates to a transportation field of stem cell, concretely relates to hemopoietic stem cell transfer device.

Background

Hematopoietic stem cells are adult stem cells in the blood system, are a heterogeneous population, have the ability to self-renew for a long period of time and the potential to differentiate into various types of mature blood cells. Therefore, in the medical field, hematopoietic stem cells are widely used for the treatment of hematological diseases, and at the same time, research on hematopoietic stem cells has never been stopped in clinical medicine.

Whether the method is applied to clinic or is researched, the method inevitably needs to be processed after collection and then transported, so that the quality of the hematopoietic stem cells is greatly influenced by the condition control of a transportation link in the transportation process.

Under many circumstances, receive the difference of region research condition and medical level etc, different medical institution or research institution often need to be transported to the hematopoietic stem cell after the collection, and because its whole journey needs cryogenic preservation, therefore, often adopt different transport case to different transportation places to place and transport respectively, this not only greatly increased the cost of transportation, and in the transportation, because the transportation of hematopoietic stem cell needs shockproof etc. consequently, often all adopt artifical transportation mode to miniature portable transport case, this will cause though whole volume is not big, but a plurality of transport cases all need artifical nurse and transportation, consequently, difficult carrying under certain circumstances of transportation, it shakes or other problems in the transportation to cause more easily. However, in the prior art, attention is often paid to the shock absorption of the box body, for example, a patent with application number 201821196172.0 discloses a multi-functional refrigerator for hematopoietic stem cells, which realizes shock absorption by arranging a plurality of shock absorption devices, thereby ensuring shock resistance in the transportation process. As mentioned above, such a method causes problems of difficulty in carrying and insufficient care during multi-directional transportation, which causes various problems during transportation. And if adopt a plurality of structures of placing the case and independently existing, then not only the volume is too big, is difficult to once only deposit a plurality ofly in small-size portable transfer box, and each independent relative movement appears easily between placing the case, further causes the scheduling problem that rocks in the transportation.

SUMMERY OF THE UTILITY MODEL

Therefore, the utility model provides a hemopoietic stem cell transfer device to can realize carrying out the substep according to the condition and deposit and take in a transfer box in realizing the transportation, reduce the transportation problem that causes inadequately because of the staff in the transportation.

In order to achieve the above object, the embodiments of the present invention provide the following technical solutions:

in one aspect of the utility model, the hematopoietic stem cell transfer device comprises an inner box body and an outer box body which are sleeved from inside to outside, a gap is formed between the inner box body and the outer box body, the inner box body comprises a shell body which is internally provided with a cavity and the upper surface of which is provided with an end cover in a matching way, and a plurality of groups of placing structures which are arranged in the cavity in sequence along the vertical direction, and each group of placing structures comprises a placing frame and a partition component which are arranged in sequence from top to bottom; and the number of the first and second electrodes,

each partition component at least comprises a frame arranged along the circumferential direction of the inner wall of the shell, a cover plate is clamped on the frame, at least one through hole penetrates through the cover plate along the vertical direction, a blocking piece used for sealing the through hole is movably arranged on the through hole along the vertical direction, and the blocking piece is arranged in a self-rotating manner by taking the central axis as an axis;

the through holes in the two adjacent cover plates are arranged in a staggered mode along the vertical direction, and the blocking piece comprises a first blocking plate and a second blocking plate which are used for sealing the two adjacent cover plates respectively.

As a preferred scheme of the present invention, the number of the through holes on each cover plate is two, and the through holes are arranged along the center line of the surface of the cover plate in an axisymmetric manner;

and connecting lines of the through holes on the two adjacent cover plates are vertically arranged.

As a preferable scheme of the present invention, the stopper further includes a rotating rod having one end located in the cavity and the other end extending to the outside of the inner box, and the first baffle and the second baffle are sequentially disposed on the rotating rod along the vertical direction;

the first baffle and the second baffle respectively comprise two stop blocks which are correspondingly arranged with the through holes, and connecting rods, one ends of the connecting rods are connected with the rotating rod, the other ends of the connecting rods are connected to the stop blocks, and a through groove which is the same as the cross section of the connecting rods and the rotating rod in shape is formed between the two through holes in each cover plate.

As a preferable aspect of the present invention, the frame includes a first frame body and a second frame body that are formed as an integral structure, the first frame body is connected to the casing, the second frame body is disposed above the first frame body and forms a gap with the casing, the cover plate includes a plate body and an extension portion that extends downward from a side surface of the plate body and is located in the gap;

and an elastic sealing ring with an arc surface is formed on the outer side surface of the second frame body close to the first frame body, and a clamping groove for clamping the elastic sealing ring is arranged on the extension part in a matching manner.

As an optimized scheme of the utility model, the inside wall of perforating hole is formed with wedge-shaped flexure strip along the circumferential direction, just the inclined plane orientation of flexure strip the top surface of apron, the bottom surface of flexure strip is located the top of the bottom surface of apron.

As a preferred scheme of the utility model, a through hole body is formed on the end cover, and the hole body is connected with a sleeve pipe positioned outside the inner box body through an elastic sealing ring, and the rotating rod part is arranged inside the sleeve pipe through a sealing rubber sheet;

the upper end of the sleeve is connected with a connecting piece, the rotating rod is rotatably arranged on the connecting piece, and a spring is connected between the connecting piece and the upper surface of the end cover.

As a preferred scheme of the utility model, the bull stick is including the many body of rod that cup joint in order, and many can remove along the axis direction between the body of rod.

As a preferred scheme of the utility model, the casing is the cylinder structure, just be close to in the casing the lateral wall of end cover one side is inwards sunken and is formed with the external screw thread, be provided with on the medial surface of end cover with external screw thread matched with internal thread.

As a preferred scheme of the utility model, a soft sealing sheet is further adhered on the outer side surface of the stop block;

the inner box body is made of glass fiber reinforced plastic.

As a preferable scheme of the present invention, the upper surface of the cover plate is partially recessed downward to form a hand-held groove.

As an optimized scheme of the utility model, still be provided with a plurality of slots that are used for depositing rack and/or apron in the clearance.

The utility model discloses an embodiment has following advantage:

1. through the arrangement of the plurality of groups of placing structures, a group of hematopoietic stem cell collecting bags or collecting tubes which need to be taken simultaneously are respectively placed in each group of placing structures according to actual conditions, and are sequentially placed according to the actual taking sequence, so that the taking sales volume and the convenience are improved;

2. the through holes in the cover plate and the stoppers are matched, so that when the liquid is required to be taken in sequence, the stoppers stop the corresponding through holes, the liquid nitrogen in the lower layer unused part is prevented from excessively leaking, and the effective control of the storage condition in the whole transfer process is ensured; in addition, in the previous boxing process, the communication of the whole inner box body can be realized by rotating the stopper, so that the filling of liquid nitrogen is facilitated;

3. through the setting of first baffle and second baffle, guaranteed that two cut off the subassembly and be a set of, set up dual airtight, and the control of the inside save condition of box has further been guaranteed to the crisscross mode that sets up.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It should be apparent that the drawings in the following description are merely exemplary, and that other embodiments can be derived from the drawings provided by those of ordinary skill in the art without inventive effort.

The structure, ratio, size and the like shown in the present specification are only used for matching with the content disclosed in the specification, so as to be known and read by people familiar with the technology, and are not used for limiting the limit conditions which can be implemented by the present invention, so that the present invention has no technical essential significance, and any structure modification, ratio relationship change or size adjustment should still fall within the scope which can be covered by the technical content disclosed by the present invention without affecting the efficacy and the achievable purpose of the present invention.

Fig. 1 is a schematic structural view of the hematopoietic stem cell transfer device provided by the present invention;

fig. 2 is a schematic view of the internal partial structure of the inner box body provided by the present invention;

fig. 3 is a schematic structural diagram of one of the cover plates provided by the present invention;

fig. 4 is a schematic structural view of another orientation of one of the cover plates provided by the present invention;

FIG. 5 is a schematic structural view of the cover plate adjacent to FIG. 3;

fig. 6 is a schematic view of a partial structure of the elastic sheet provided by the present invention;

fig. 7 is a schematic structural view of the joint between the rotating rod and the connecting sheet provided by the present invention.

In the figure:

1-an inner box body; 2-outer box body; 3-clearance;

11-end cap; 12-a housing; 13-placing the rack; 14-a partition assembly;

111-pore body; 112-elastic sealing ring; 113-a cannula;

121-external threads;

141-a frame; 142-a cover plate; 143-a stopper;

1411-a first frame; 1412-a second frame; 1413-elastic sealing ring;

1421-through hole; 1422-through slot; 1423-elastic sheet; 1424-hand-held slot; 1425-plate body; 1426-extensions; 1427-card slot;

1431 — a first baffle; 1432 — a second baffle; 1433-rotating rod; 1434-connecting piece; 1435-spring; 1436-fins;

31-slot.

Detailed Description

The present invention is described in terms of specific embodiments, and other advantages and benefits of the present invention will become apparent to those skilled in the art from the following disclosure. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

As shown in fig. 1-6, the utility model provides a hematopoietic stem cell transfer device, which comprises an inner box body 1 and an outer box body 2 which are sleeved from inside to outside, wherein a gap 3 is formed between the inner box body 1 and the outer box body 2, the inner box body 1 comprises a shell 12 which is internally provided with a cavity and is provided with an end cover 11 on the upper surface in a matching way, and a plurality of groups of placing structures which are arranged in the cavity in sequence along the vertical direction, and each group of placing structures comprises a placing frame 13 and a partition component 14 which are arranged in sequence from top to bottom; and the number of the first and second electrodes,

each partition assembly 14 at least includes a frame 141 circumferentially arranged along the inner wall of the housing 12, a cover plate 142 is fastened to the frame 141, at least one through hole 1421 is formed in the cover plate 142 in a penetrating manner along the vertical direction, a stopper 143 for sealing the through hole 1421 is movably arranged on the through hole 1421 along the vertical direction, and the stopper 143 is rotatably arranged with a central axis as an axis;

the through holes 1421 of two adjacent cover plates 142 are arranged in a staggered manner in the vertical direction, and the stoppers 143 include first stoppers 1431 and second stoppers 1432 for respectively sealing the two adjacent cover plates 142.

Of course, the rack 13 can be disposed in a manner that can be understood and used by those skilled in the art, for example, a structure having a plurality of placement holes for placing collection tubes, and further, the rack 13 can be disposed detachably, which can be performed in any manner that can be understood by those skilled in the art, for example, by means of the cooperation of structures such as snaps, or detachably connected by means of an auxiliary connection structure, and preferably, the sectional area of the detachable portion is not larger than the area of the frame 141, so that the detachment can be effectively realized.

In a preferred embodiment, the number of the through holes 1421 on each cover plate 142 is two, and the through holes are arranged along the center line of the surface of the cover plate 142 in an axisymmetric manner;

the connecting line of the through holes 1421 of two adjacent cover plates 142 is perpendicular to each other. Through the arrangement, the whole rotation process is generally rotated by 90 degrees, so that the marking is convenient to use, and the operation efficiency is improved.

In a more preferred embodiment, the stopper 143 further includes a rotating rod 1433 having one end located in the cavity and the other end extending to the outside of the inner case 1, and the first and

second stoppers

1431 and 1432 are sequentially disposed on the rotating rod 1433 in a vertical direction;

the first baffle 1431 and the second baffle 1432 each include two stoppers disposed corresponding to the through holes 1421, and a link having one end connected to the rotating rod 1433 and the other end connected to the stopper, and a through groove 1422 having the same cross-sectional shape as the link and the rotating rod 1433 is formed between the two through holes 1421 of each cover plate 142. Of course, the axis of the rotating rod 1433 is the central axis of the stopper 143, and the stoppers are disposed axisymmetrically with respect to the axis of the rotating rod 1433. It is further preferred that the entire stopper 143 is coaxially disposed with the housing 12 to further form the entire structure to be symmetrical.

In a further preferred embodiment, in order to better improve the fit tightness between the frame 141 and the cover plate 142 and improve the tightness of the environment during operation, the frame 141 includes a first frame 1411 and a second frame 1412 formed as an integral structure, the first frame 1411 is connected to the housing 12, the second frame 1412 is disposed above the first frame 1411 and forms a gap with the housing 12, the cover plate 142 includes a plate body 1425 and an extension 1426 extending downward from a side surface of the plate body 1425 and located in the gap;

an elastic sealing ring 1413 with an arc surface is formed on the outer side surface of the second frame body 1412 close to the first frame body 1411, and a clamping groove 1427 for clamping the elastic sealing ring 1413 is fittingly arranged on the extension portion 1426.

In order to further improve the sealing of the through hole 1421 by the stopper and avoid the problem of movement or falling out after sealing, a wedge-shaped elastic piece 1423 is formed on the inner side wall of the through hole 1421 along the circumferential direction, the inclined surface of the elastic piece 1423 faces the top surface of the cover plate 142, and the bottom surface of the elastic piece 1423 is located above the bottom surface of the cover plate 142. Through the arrangement, when the stopper is located below the elastic sheet 1423, the stopper can be prevented from falling out of the through hole 1421 only by being lifted upwards, meanwhile, due to the stretching of the elastic sheet 1423, the sealing of the stopper on the through hole 1421 is further improved, further, the bottom surface of the elastic sheet 1423 can be formed into a sawtooth shape, the upper surface of the stopper can be formed into a sawtooth structure matched with the stopper, so that the tight fit of the stopper and the through hole is ensured, the sealing performance of the stopper is improved, and meanwhile, the stopper located below cannot influence the taking out of the cover plate 142 after the next use.

In order to further ensure the sealing performance of the end cover 11 on the premise that the rotating rod 1433 penetrates through the end cover 11 and moves and rotates in the vertical direction, a penetrating hole body 111 is formed on the end cover 11, a sleeve 113 positioned outside the inner box body 1 is connected to the hole body 111 through an elastic sealing ring 112, and a part of the rotating rod 1433 penetrates through the sleeve 113 through a sealing rubber sheet;

a connection piece 1434 is connected to an upper end of the sleeve 113, the rotation lever 1433 is rotatably disposed on the connection piece 1434, and a spring 1435 is connected between the connection piece 1434 and an upper surface of the end cap 11. Through the further setting of spring 1435, through applying ascending pulling force to connection piece 1434 to further realize applying ascending pulling force to bull stick 1433, guarantee the stable airtight of dog. Of course, the rotating rod 1433 and the connecting piece 1434 may be relatively rotated, for example, as shown in fig. 7, an elastic fin 1436 may be provided on the outer circumferential surface of the rotating rod 1433, when the disassembly is required, the fin may be pressed, and further, there is a gap between the rotating rod 1433 and the connecting piece 1434.

In a more preferred embodiment, the rotating rod 1433 includes a plurality of rod bodies sleeved in sequence, and the plurality of rod bodies can extend and contract along the axial direction. Of course, the telescopic length of each telescopic rod body can be set according to the height of the actual partition assembly 14, and the telescopic length can be set by referring to the manner of folding the umbrella handle, which is not described herein. Of course, similar arrangements may be used herein.

In a further preferred embodiment, the housing 12 is a cylindrical structure, a side wall of the housing 12 close to one side of the end cover 11 is recessed inwards and is formed with an external thread 121, and an internal thread matching with the external thread 121 is arranged on an inner side surface of the end cover 11.

In order to further improve the sealing performance, a soft sealing sheet is further attached to the outer side face of the stop block. Meanwhile, in order to better improve the visibility in the operation process, the inner box body 1 is made of glass fiber reinforced plastic.

In a more preferred embodiment, the upper surface of the cover plate 142 is further partially recessed to form a holding groove 1424;

a plurality of slots 31 for storing the placing rack 13 and/or the cover plate 142 are also arranged in the gap 3. For placing the rack 13 and/or the cover 142 after disassembly.

Although the invention has been described in detail with respect to the general description and the specific embodiments, it will be apparent to those skilled in the art that modifications and improvements can be made based on the invention. Therefore, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. A hematopoietic stem cell transfer device comprises an inner box body (1) and an outer box body (2) which are sleeved from inside to outside, and a gap (3) is formed between the inner box body (1) and the outer box body (2), and is characterized in that the inner box body (1) comprises a shell (12) which is internally provided with a cavity and the upper surface of which is provided with an end cover (11) in a matching way, and a plurality of groups of placing structures which are sequentially arranged in the cavity along the vertical direction, wherein each group of placing structures comprises a placing frame (13) and a partition component (14) which are sequentially arranged from top to bottom; and the number of the first and second electrodes,

each partition assembly (14) at least comprises a frame (141) arranged along the circumferential direction of the inner wall of the shell (12), a cover plate (142) is clamped on the frame (141), at least one through hole (1421) penetrates through the cover plate (142) along the vertical direction, a stopper (143) used for sealing the through hole (1421) is movably arranged on the through hole (1421) along the vertical direction, and the stopper (143) is arranged in a manner of rotating by taking a central axis as an axis;

the through holes (1421) on two adjacent cover plates (142) are arranged in a staggered manner along the vertical direction, and the stoppers (143) comprise a first stopper (1431) and a second stopper (1432) which are respectively used for sealing the two adjacent cover plates (142).

2. The hematopoietic stem cell transfer device of claim 1, wherein the number of the through holes (1421) of each cover plate (142) is two, and the through holes are axially symmetrical along a center line of the surface of the cover plate (142);

and the connecting lines of the through holes (1421) on the two adjacent cover plates (142) are arranged vertically.

3. The hematopoietic stem cell transfer device of claim 2, wherein the stopper (143) further comprises a rotating rod (1433) having one end located in the cavity and the other end extending to the outside of the inner case (1), and the first baffle (1431) and the second baffle (1432) are sequentially disposed on the rotating rod (1433) in a vertical direction;

the first baffle plate (1431) and the second baffle plate (1432) respectively comprise two stoppers arranged corresponding to the through holes (1421) and connecting rods, one ends of the connecting rods are connected with the rotating rod (1433), the other ends of the connecting rods are connected to the stoppers, and a through groove (1422) with the same cross section shape as that of the connecting rods and the rotating rod (1433) is formed between the two through holes (1421) on each cover plate (142).

4. The hematopoietic stem cell transfer device of claim 1, wherein the frame (141) comprises a first frame body (1411) and a second frame body (1412) formed as an integral structure, the first frame body (1411) is connected to the housing (12), the second frame body (1412) is disposed above the first frame body (1411) and forms a gap with the housing (12), the cover plate (142) comprises a plate body (1425) and an extension portion (1426) extending downward from a side surface of the plate body (1425) and located in the gap;

and an elastic sealing ring (1413) with an arc surface is formed on the outer side surface of the second frame body (1412) close to the first frame body (1411), and a clamping groove (1427) for clamping the elastic sealing ring (1413) is arranged on the extension portion (1426) in a matching manner.

5. The hematopoietic stem cell transfer device according to any one of claims 1 to 4, wherein the inner sidewall of the through hole (1421) is formed with a wedge-shaped elastic piece (1423) along the circumferential direction, and the slope of the elastic piece (1423) faces the top surface of the cover plate (142), and the bottom surface of the elastic piece (1423) is located above the bottom surface of the cover plate (142).

6. The hematopoietic stem cell transfer device according to claim 3, wherein the end cap (11) is formed with a hole (111) therethrough, the hole (111) is connected with a sleeve (113) located outside the inner case (1) through an elastic sealing ring (112), and the rotating rod (1433) is partially disposed inside the sleeve (113) through a sealing film;

a connecting piece (1434) is connected to the upper end of the sleeve (113), the rotating rod (1433) is rotatably arranged on the connecting piece (1434), and a spring (1435) is connected between the connecting piece (1434) and the upper surface of the end cover (11).

7. The hematopoietic stem cell transfer device of claim 6, wherein the rotating rod (1433) comprises a plurality of rods sequentially sleeved and can be extended and retracted along an axial direction.

8. The hematopoietic stem cell transfer device according to claim 7, wherein the housing (12) is a cylinder, and the side wall of the housing (12) near one side of the end cap (11) is recessed inward and formed with an external thread (121), and the inner side of the end cap (11) is provided with an internal thread matching with the external thread (121).

9. The hematopoietic stem cell transfer device of claim 3, wherein a soft sealing sheet is further attached to the outer side surface of the stopper;

the inner box body (1) is made of glass fiber reinforced plastic.

10. A hematopoietic stem cell transfer device according to any one of claims 1 to 3, wherein the cover plate (142) further has a hand-held recess (1424) formed partially recessed downward from the upper surface thereof;

the gap (3) is also provided with a plurality of slots (31) for storing the placing rack (13) and/or the cover plate (142).