CN211752663U

CN211752663U - A decoloration system for valaciclovir hydrochloride production

Info

Publication number: CN211752663U
Application number: CN202020119460.7U
Authority: CN
Inventors: 郑华章; 黄锋莉; 杨之生; 余超; 曾世伟; 孙瑜蔓
Original assignee: Yichang Tianren Pharmaceutical Co ltd
Current assignee: Yichang Tianren Pharmaceutical Co ltd
Priority date: 2020-01-19
Filing date: 2020-01-19
Publication date: 2020-10-27
Anticipated expiration: 2030-01-19

Abstract

The utility model provides a decoloration system for production of valaciclovir hydrochloride, including the decoloration jar, reation kettle's bin outlet passes through the pipeline and the delivery pump is connected with the charge door of decoloration jar, and the charge door is equipped with first valve, and decoloration tank deck portion is equipped with decolorant and adds the mouth, and the bottom is equipped with the leakage fluid dram, and the leakage fluid dram is equipped with the second valve, is equipped with the filter screen that the slope set up in the decoloration jar, and the decoloration jar corresponds the lower one side of filter screen and is equipped with the discharge port, and the discharge. The decolorizing agent of the system is convenient to replace, and the decolorizing agent and the solution do not need secondary filtration.

Description

A decoloration system for valaciclovir hydrochloride production

Technical Field

The utility model belongs to valaciclovir hydrochloride's production facility field, in particular to a decoloration system for valaciclovir hydrochloride production.

Background

The product often has color during the valacyclovir hydrochloride synthesis process, and needs to be decolored by an active agent. In the traditional production, activated carbon is usually added into a reaction kettle for adsorbing the pigment, and then a product containing the activated carbon is subjected to centrifugal filtration operation to achieve the aim of decoloring the product. However, the solution and the activated carbon are mixed together, and the activated carbon and the solution are separated by filtration of a filter device, so that the operation is complicated. CN204848709U discloses a device for valacyclovir hydrochloride decoloration, which consists of a reaction kettle and an active carbon decoloration column connected with the reaction kettle. The upper part of the reaction kettle is provided with a feed inlet, a circulating pipeline and a stirring device penetrating through the tank body, and a heating jacket is arranged outside the tank body; the bottom of the reaction kettle is provided with a discharge pipeline which is divided into two branches, wherein one pipeline is sequentially connected with a valve, a pump, a rotor flow meter, a valve, an active carbon decolorizing column and a valve, and forms a circulation loop with the reaction kettle, and the other pipeline is communicated with the atmosphere through the valve. The device can solve the separation problem of solution and active carbon, but the active carbon decoloration post is difficult to change after using a period of time, needs to shut down the change, influences production efficiency.

Disclosure of Invention

The utility model aims to solve the technical problem that a decoloration system for valaciclovir hydrochloride production is provided, and the decolorant is changed conveniently, and decolorant and solution do not need secondary filtration.

In order to solve the technical problem, the utility model discloses the technical scheme who adopts is: a decoloration system for production of valaciclovir hydrochloride, including the decoloration jar, reation kettle's bin outlet passes through the pipeline and the delivery pump is connected with the charge door of decoloration jar, and the charge door is equipped with first valve, and decoloration tank deck portion is equipped with decolorant and adds the mouth, and the bottom is equipped with the leakage fluid dram, and the leakage fluid dram is equipped with the second valve, is equipped with the filter screen that the slope set up in the decoloration jar, and the decoloration jar corresponds the lower one side of filter screen and is equipped with the discharge port, and.

In the preferred scheme, the lower end of the decoloring tank is provided with an air inlet pipe, the upper end of the decoloring tank is provided with an exhaust pipe, and the air inlet pipe and the exhaust pipe are both provided with third valves.

In a further scheme, an air homogenizing plate is arranged in the decolorizing tank, air homogenizing holes are formed in the air homogenizing plate, and the air homogenizing plate is arranged below the filter screen.

In a further scheme, the exhaust pipe is connected with a condenser.

In a preferable scheme, a liquid outlet of the decoloring tank is connected with a circulating pipe, the circulating pipe is connected with the reaction kettle, and a fourth valve is arranged on the circulating pipe.

The utility model provides a pair of a decoloration system for valaciclovir hydrochloride production, the solution after the decoloration need not filter the filtering decolorant again, reduces the processing step, when needs recycle the decolorant, only needs to open the closing cap simultaneously and can realize, easy operation is convenient. Preferably, multiple decolorizations are realized by arranging a circulating pipe, and the decolorization effect is improved.

Drawings

The invention will be further explained with reference to the following figures and examples:

fig. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the preferred overall structure of the present invention;

in the figure: the device comprises a decoloring tank 1, a reaction kettle 2, a pipeline 3, a delivery pump 4, a first valve 5, a second valve 6, a filter screen 7, an air inlet pipe 8, an exhaust pipe 9, a third valve 10, an air distribution plate 11, a condenser 12, a circulating pipe 13, a fourth valve 14, a feeding port 101, a decoloring agent feeding port 102, a liquid discharge port 103, a discharge port 104, a sealing cover 105 and an air distribution hole 1101.

Detailed Description

As shown in fig. 1, a decoloration system for valaciclovir hydrochloride production, including two decoloration jar 1, reation kettle 2's bin outlet passes through pipeline 3 and delivery pump 4 and is connected with decoloration jar 1's charge door 101, charge door 101 is equipped with first valve 5, decoloration jar 1 top is equipped with decolorant inlet 102, in this embodiment, the decolorant is active carbon, decoloration jar 1 bottom is equipped with drain 103, drain 103 is equipped with second valve 6, be equipped with the filter screen 7 that the slope set up in the decoloration jar 1, decoloration jar 1 corresponds the lower one side of filter screen 7 and is equipped with discharge port 104, discharge port 104 is equipped with closing cap 105.

During the specific use, at first add the decolorant to filter screen 7 from decolorant inlet 102 on, after the reaction in reation kettle 2 is accomplished, open the valve of reation kettle 2's bin outlet, open delivery pump 4, carry the solution in reation kettle 2 to decoloration jar 1 in, the solution flows through the decolorant, realize the decoloration, open second valve 6 on the leakage fluid dram 103, arrange the solution after the decoloration to next process, when using for a period of time and need carrying out desorption to the decolorant, open closing cap 105, discharge the decolorant from discharge port 104, reuse after the desorption.

The solution after the system decoloration does not need to be filtered and filtered to remove the decolorant, the processing steps are reduced, and meanwhile, when the decolorant needs to be recycled, the solution can be obtained only by opening the sealing cover 105, and the operation is simple and convenient.

Preferably, the lower end of the decoloring tank 1 is provided with an air inlet pipe 8, the air inlet pipe 8 is connected with a steam generator, the upper end of the decoloring tank is provided with an exhaust pipe 9, and the air inlet pipe 8 and the exhaust pipe 9 are both provided with a third valve 10.

Steam is introduced into the decoloring tank 1 through the air inlet pipe 8, so that on one hand, when the solution is decolored, a decolorant can be preheated, and the decoloring effect is improved; on the other hand, the decolorizing agent can be desorbed through steam, and the service life of the decolorizing agent is prolonged.

Further, an air distribution plate 11 is arranged in the decoloring tank 1, an air distribution hole 1101 is formed in the air distribution plate 11, and the air distribution plate 11 is arranged below the filter screen 7.

Through setting up even gas board 11, can carry out even gas to the steam that passes through, improve the degree of consistency that steam passes through the decolorant.

Preferably, the exhaust pipe 9 is connected to a condenser 12. The steam discharged from the exhaust pipe 9 is condensed by the condenser 12 and discharged.

Preferably, the liquid outlet 103 of the decoloring tank 1 is connected with a circulating pipe 13, the circulating pipe 13 is connected with the reaction kettle 2, and the circulating pipe 2 is provided with a fourth valve 14.

By arranging the circulating pipe 13, the solution discharged from the liquid discharge port 103 can be conveyed to the reaction kettle 2, and enters the decoloring tank 1 again from the discharge port of the reaction kettle 2 for decoloring, so that the decoloring is realized for many times.

In the preferred scheme, as shown in fig. 2, the number of decoloration jar 1 is two, and pipeline 3 is connected with charge door 101 of two decoloration jars, and during the use, through opening the first valve 5 that the charge door 101 that every decoloration jar 1 corresponds, realizes two decoloration jar 1's used in turn, when carrying out the discharge to the decolorant in one of them decoloration jar 1 and retrieving the change, opens the first valve 5 of another decoloration jar 1 and uses, can not cause the discontinuity of production, makes things convenient for the change of decolorant.

Claims

1. A decoloration system for valaciclovir hydrochloride production which characterized in that: including decoloration jar (1), the bin outlet of reation kettle (2) passes through pipeline (3) and delivery pump (4) and is connected with charge door (101) of decoloration jar (1), charge door (101) are equipped with first valve (5), decoloration jar (1) top is equipped with decolorant inlet (102), the bottom is equipped with drain outlet (103), drain outlet (103) are equipped with second valve (6), be equipped with filter screen (7) that the slope set up in decoloration jar (1), decoloration jar (1) corresponds the lower one side of filter screen (7) and is equipped with discharge port (104), discharge port (104) are equipped with closing cap (105).

2. The decolorization system for valacyclovir hydrochloride production of claim 1, wherein: the lower end of the decoloring tank (1) is provided with an air inlet pipe (8), the upper end of the decoloring tank is provided with an exhaust pipe (9), and the air inlet pipe (8) and the exhaust pipe (9) are both provided with a third valve (10).

3. The decolorization system for valacyclovir hydrochloride production of claim 2, wherein: the decolorizing device is characterized in that an air homogenizing plate (11) is arranged in the decolorizing tank (1), air homogenizing holes (1101) are formed in the air homogenizing plate (11), and the air homogenizing plate (11) is arranged below the filter screen (7).

4. The decolorization system for valacyclovir hydrochloride production of claim 2, wherein: the exhaust pipe (9) is connected with the condenser (12).

5. The decolorization system for valacyclovir hydrochloride production of claim 1, wherein: a liquid outlet (103) of the decoloring tank (1) is connected with a circulating pipe (13), the circulating pipe (13) is connected with the reaction kettle (2), and a fourth valve (14) is arranged on the circulating pipe (13).