CN211704922U

CN211704922U - Animal brain stereotaxic operation auxiliary device

Info

Publication number: CN211704922U
Application number: CN201921918513.5U
Authority: CN
Inventors: 刘微微
Original assignee: Tianjin Kangting Biological Engineering Group Co Ltd
Current assignee: Tianjin Kangting Biological Engineering Group Co Ltd
Priority date: 2019-11-08
Filing date: 2019-11-08
Publication date: 2020-10-20
Anticipated expiration: 2029-11-08

Abstract

The utility model relates to an animal brain stereotaxic operation auxiliary device, including fixed establishment, experiment supporting mechanism and complementary unit, experiment supporting mechanism sets up on fixed establishment, and complementary unit sets up on experiment supporting mechanism, and experiment supporting mechanism includes support frame, spring chain and chevron shape skin support frame, and the support frame setting is on the bottom plate, and spring chain one end is passed through the screw activity and is fixed on the upper portion of backup pad, and the lower part hinge is equipped with chevron shape skin support frame, chevron shape skin support frame including two herringbone extension boards of symmetry, correspond on two herringbone extension boards and install the screw, the both ends of the end-to-end connection spring of two screws. The utility model has the advantages of being scientific and reasonable in design, the structure is practical, effectively solve among the animal brain stereotaxis artifical with apparatus such as tweezers prop open the fastness of experiment mouse head skin not good not hard up easily, experiment mouse capillary breaks out the incomplete blood of hemorrhage and can not real-time supervision animal heartbeat state a great deal of actual technical problem in difficult recovery and the experiment.

Description

Animal brain stereotaxic operation auxiliary device

Technical Field

The utility model belongs to animal experiment field relates to brain stereotaxic technique, especially an animal brain stereotaxic operation auxiliary device.

Background

The animal brain stereotaxic device is used for building various brain models in the field of zoology, the animal brain stereotaxic operation firstly needs to open the top of an animal head, the tissue between the skull and the skin is stripped to expose the skull, a coordinate point is located at the skull according to a reference coordinate, a drill bit is used for punching at the locating point, and finally a micro-injector is used for injecting reagents needed by model building into the hole. In the brain stereotaxic operation, when the skin at the top of the animal head is opened and the subsequent operation is carried out, the skin at the two sides of the opening needs to be spread towards the two sides so as to avoid covering the skull to influence the positioning, punching and injection.

The brain stereotaxic apparatus in the prior art has the following technical disadvantages:

1. the traditional brain three-dimensional positioning device is not provided with a device for stretching the skin at the opening, the skin at the opening needs to be stretched towards two sides by using tweezers manually to fix and expose the skull, the skin fixed by the tweezers is not firm enough, the skin at the two sides of the opening is easy to loosen, and the subsequent positioning and punching operation is influenced;

2. because the animal head is densely distributed with capillary vessels, the capillary vessels are frequently cut in the process of cutting the skin stripping tissue at the top of the animal head, so that the capillary vessels are broken and bleed, in addition, various blood vessels are also distributed in the brain area below the skull of the animal, when the drill bit drills holes at the coordinate point, the drill bit is also easy to touch the capillary vessels below the skull, so that the blood vessels in the positioning hole are broken and bleed, the blood covers the positioning hole after bleeding, the positioning hole is blurred, and the positioning and the punching are influenced;

3. the traditional brain stereotaxic device is not provided with a collection and treatment device for residual blood, after capillary blood vessels on the head of an animal bleed, a hemostatic sponge or a cotton ball needs to be manually clamped to stop bleeding, the hemostasis of the hemostatic sponge or the cotton ball is not thorough enough, repeated hemostasis is needed for many times, the labor cost and the operation time are consumed, and the smooth operation of brain stereotaxic operation is influenced;

4. in the animal brain stereotaxic process, due to different individual differences of animals, animals can die due to various objective reasons such as anesthetic dosage and manipulation of operators, and the traditional brain stereotaxic device is not designed with an animal heartbeat state real-time monitoring device, cannot monitor the heartbeat state of the animals at any time, cannot timely find signs of animal weakness and timely rescue, so that the animals die, and experimental operation is influenced.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to overcome prior art's weak point, provide one kind can effectively fix the experimental animal in the experimentation, can support behind the animal head skin opening and fix and can collect the animal brain stereotaxic operation auxiliary device who remains blood, real-time supervision animal heartbeat state in the experiment operation process.

The utility model provides a its technical problem take following technical scheme to realize:

the animal brain three-dimensional positioning operation auxiliary device comprises a fixing mechanism, an experiment supporting mechanism and an auxiliary mechanism, wherein the experiment supporting mechanism is arranged on the fixing mechanism, the auxiliary mechanism is arranged on the experiment supporting mechanism, the experiment supporting mechanism comprises a supporting frame, a spring chain and a herringbone skin supporting frame, the supporting frame is arranged on a bottom plate, one end of the spring chain is movably fixed on the upper portion of the supporting plate through a screw, the herringbone skin supporting frame is hinged to the lower portion of the spring chain, the herringbone skin supporting frame comprises two symmetrical herringbone supporting plates, screws are correspondingly arranged on the two herringbone supporting plates, and the tail ends of the two screws are connected with the two ends of a spring.

And the auxiliary mechanism comprises a support plate, a negative pressure suction device and an animal heartbeat frequency collector, the support plate is arranged on the support frame, the negative pressure suction device and the animal heartbeat frequency collector are arranged on the support frame, one end of the negative pressure suction device is provided with a connector connected with a backflow hose, and the other end of the negative pressure suction device is connected with a residual blood collecting bottle.

And, fixed establishment include bottom plate, stopper and gag lever post, two the stopper symmetry set up on the bottom plate the stopper on seted up the spacing groove, two the gag lever post can dismantle the symmetry and set up at the spacing inslot that corresponds, the gag lever post fix through the spiral shell knot that sets up on the stopper.

The utility model has the advantages that:

1. this device is provided with auxiliary device on traditional positioner, auxiliary mechanism includes negative pressure suction apparatus and animal heartbeat frequency collector, ware negative pressure suction apparatus one end is provided with the interface of connecting the refluence hose, blood collecting bottle is connected to the other end, after incomplete blood appears in the brain three-dimensional positioning process, open the negative pressure suction apparatus, pressure regulation, there is the negative pressure production in the incomplete blood collecting bottle, the negative pressure of production can be with incomplete blood suction draw in the collecting bottle, when the liquid in the incomplete blood collecting bottle reaches the take the altitude, the stop valve of collecting bottle top cap is automatic to be opened, stop incomplete blood and continue to flow in the collecting bottle, effectively prevent incomplete blood overflow collecting bottle and pollute the operation panel.

2. This device sets up animal heartbeat frequency collector, and the one end of collector meets through power cord and power, has designed collector starting switch, data acquisition line and data reading display screen, and the one end design of data line can laminate animal skin's module and the skin of animal heart department pastes the contact. In the brain stereotaxic process, press starting switch and start the heartbeat frequency collector, the real-time heartbeat frequency of animal can be passed through the data line and is transmitted to the collector in, shows on the display screen, makes things convenient for operating personnel to observe numerical value. The design enables the operator to monitor the state of the animal in real time in the whole process of animal brain stereotaxic positioning, and effectively avoids death caused by incapability of timely treating the animal.

3. This device experiment supporting mechanism includes support frame, spring chain and chevron shape skin support frame, and wherein spring chain one end is passed through screw movable fixation on the upper portion of backup pad, and the lower part hinge is equipped with chevron shape skin support frame, can be in the experimentation in nimble control experiment angle, avoid the experimental mouse excessively struggle and influence the experiment process.

4. The herringbone skin support frame of the device is used for propping open the skin of an animal after being cut, the herringbone skin support frame comprises two symmetrical herringbone support plates, the two herringbone support plates are in contact with the skin at the opening of the head of the animal to play a supporting role, the two herringbone support plates are correspondingly provided with screws, the tail ends of the two screws are connected with two ends of a spring, and the screws are used for adjusting the tightness of the spring, so that the opening and closing degree of the skin support frame is adjusted according to the size of the opening of the skin of the head of the animal.

5. The utility model has scientific and reasonable design and practical structure, and solves the problems that after the skin at the top of the head is cut by the animal brain stereotaxic positioning through the fixing mechanism, the skin at the two sides of the opening needs to be manually propped open to the two sides by using tools such as tweezers, and the firmness of the skin propped open by the tools such as the tweezers is poor and the loosening is easy to occur; the problems that in the animal brain stereotaxic operation, capillaries are densely distributed on the head and below the skull of an animal, the skin on the top of the animal head is cut off to peel off the tissue between the skin and the skull, a drill bit touches the capillaries in the brain area below the skull during punching, the capillaries are broken to bleed, and the traditional hemostatic sponge or cotton ball is not thorough in collecting and treating residual blood are solved; the problems that the heartbeat state of an animal cannot be monitored in real time in the stereotaxic process of the brain of the animal, the weak signs of the animal cannot be found in time in the stereotaxic process of the brain, and the animal is dead due to the fact that rescue cannot be carried out in time are solved.

Drawings

Fig. 1 is a front view of the present invention;

fig. 2 is an enlarged structure diagram of the herringbone skin support frame A in fig. 1.

Detailed Description

The present invention will be described in further detail with reference to the following embodiments, which are illustrative, not restrictive, and the scope of the invention should not be limited thereto.

The utility model provides an animal brain stereotaxis operation auxiliary device, as shown in figure 1, includes fixed establishment, experiment supporting mechanism and complementary unit, experiment supporting mechanism set up on fixed establishment, complementary unit set up on experiment supporting mechanism, fixed establishment include bottom plate 13, stopper 9 and gag lever post 11, two the stopper symmetry set up on the bottom plate the stopper on seted up the spacing groove, two the gag lever post can dismantle the symmetry and set up at the spacing inslot that corresponds, the gag lever post fix through the spiral shell knot 10 that sets up on the stopper.

The experimental support mechanism comprises a support frame 2, a spring chain 4 and a herringbone skin support frame 12, the support frame is arranged on a bottom plate, one end of the spring chain is movably fixed on the upper portion of a support plate through a screw 3, the herringbone skin support frame is hinged to the lower portion of the spring chain, as shown in figure 2, the herringbone skin support frame comprises two symmetrical herringbone support plates 15, screws 14 are correspondingly arranged on the two herringbone support plates, and the tail ends of the two screws are connected with two ends of a spring 16.

The auxiliary mechanism comprises a support plate 8, a negative pressure aspirator 6 and an animal heartbeat frequency collector 1, wherein the support plate is arranged on a support frame, the negative pressure aspirator and the animal heartbeat frequency collector are arranged on the support frame, one end of the negative pressure aspirator is provided with a connector 5 connected with a backflow hose, and the other end of the negative pressure aspirator is connected with a residual blood collecting bottle 7.

The utility model discloses a theory of operation:

this device is provided with auxiliary device on traditional positioner, complementary unit include negative pressure suction apparatus and animal heartbeat frequency collector, ware negative pressure suction apparatus one end is provided with the interface of connecting the refluence hose, blood collecting bottle is connected to the other end, after the incomplete blood appears in the brain stereotaxis in-process, open negative pressure suction apparatus, pressure regulation, there is the negative pressure production in the incomplete blood collecting bottle, the negative pressure of production can be with in the incomplete blood suction draws the collecting bottle, when the liquid in the incomplete blood collecting bottle reaches the take the altitude, the stop valve of collecting bottle top cap is automatic to be opened, stop incomplete blood to continue to flow in the collecting bottle, effectively prevent that incomplete blood from overflowing the collecting bottle and polluting the operation panel.

This device sets up animal heartbeat frequency collector, and the one end of collector meets through power cord and power, has designed collector starting switch, data acquisition line and data reading display screen, and the one end design of data line can laminate animal skin's module and the skin of animal heart department pastes the contact. In the brain stereotaxic process, press starting switch and start the heartbeat frequency collector, the real-time heartbeat frequency of animal can be passed through the data line and is transmitted to the collector in, shows on the display screen, makes things convenient for operating personnel to observe numerical value. The design enables the operator to monitor the state of the animal in real time in the whole process of animal brain stereotaxic positioning, and effectively avoids death caused by incapability of timely treating the animal.

This device experiment supporting mechanism includes support frame, spring chain and chevron shape skin support frame, and wherein spring chain one end is passed through screw movable fixation on the upper portion of backup pad, and the lower part hinge is equipped with chevron shape skin support frame, can be in the experimentation in nimble control experiment angle, avoid the experimental mouse excessively struggle and influence the experiment process.

The device is characterized in that a supporting frame is arranged on a bottom plate of a fixing mechanism, a herringbone supporting frame used for propping open the skin of the cut animal is designed, the herringbone supporting frame comprises two symmetrical herringbone supporting plates, the two herringbone supporting plates are in contact with the skin at the opening of the head of the animal to play a supporting role, screws are correspondingly arranged on the two herringbone supporting plates, the tail ends of the two screws are connected with two ends of a spring, and the screws are used for adjusting the tightness of the spring, so that the opening and closing degree of the skin supporting frame is adjusted according to the size of the opening of the skin of the head of the animal.

Although the embodiments of the present invention and the accompanying drawings are disclosed for illustrative purposes, those skilled in the art will appreciate that: various substitutions, changes and modifications are possible without departing from the spirit and scope of the present invention and the appended claims, and therefore, the scope of the present invention is not limited to the disclosure of the embodiments and the accompanying drawings.

Claims

1. An animal brain stereotaxic operation auxiliary device which is characterized in that: the experiment supporting mechanism is arranged on the fixing mechanism, the auxiliary mechanism is arranged on the experiment supporting mechanism, the experiment supporting mechanism comprises a supporting frame, a spring chain and a herringbone skin supporting frame, the supporting frame is arranged on a bottom plate, one end of the spring chain is movably fixed on the upper portion of a supporting plate through a screw, the herringbone skin supporting frame is hinged to the lower portion of the supporting plate and comprises two symmetrical herringbone supporting plates, screws are correspondingly arranged on the two herringbone supporting plates, and the tail ends of the two screws are connected with the two ends of a spring.

2. The animal brain stereotactic operation aid of claim 1, wherein: the auxiliary mechanism comprises a support plate, a negative pressure aspirator and an animal heartbeat frequency collector, wherein the support plate is arranged on the support frame, the negative pressure aspirator and the animal heartbeat frequency collector are arranged on the support frame, one end of the negative pressure aspirator is provided with a connector connected with a backflow hose, and the other end of the negative pressure aspirator is connected with a residual blood collecting bottle.

3. The animal brain stereotactic operation aid of claim 1, wherein: the fixing mechanism comprises a bottom plate, limiting blocks and limiting rods, the limiting blocks are symmetrically arranged on the bottom plate, limiting grooves are formed in the limiting blocks, the limiting rods can be detachably and symmetrically arranged in the corresponding limiting grooves, and the limiting rods are fixed through screw threads arranged on the limiting blocks.