CN211697590U - Thermal physical parameter measuring system based on magnetic nanoparticles - Google Patents
Thermal physical parameter measuring system based on magnetic nanoparticles Download PDFInfo
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- CN211697590U CN211697590U CN202020440220.7U CN202020440220U CN211697590U CN 211697590 U CN211697590 U CN 211697590U CN 202020440220 U CN202020440220 U CN 202020440220U CN 211697590 U CN211697590 U CN 211697590U
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Abstract
The utility model provides a thermal physical parameter measurement system based on magnetic nano particle, including computer and data acquisition card, computer and data acquisition card are connected, data acquisition card is connected with constant temperature control module, magnetic field excitation module and weak magnetism measuring module respectively, and constant temperature control module is connected with the basin, is equipped with the sample test tube that holds magnetic nano particle sample in the basin, and magnetic field excitation module is connected with weak magnetism measuring module, and weak magnetism measuring module sets up the outside at the sample test tube. The utility model overcomes in the past the unicity of magnetism nanometer particle physical parameter system measurement condition, the physical parameter under the unable accurate measurement dynamic parameter intercoupling can realize multiple magnetic field excitation mode, and the physical parameter accurate measurement under the many physics intercoupling states under the alternating temperature environment can realize physical parameter dynamic deduction, has greatly expanded the measurement of magnetism nanometer particle thermal physical parameter dynamic characteristic.
Description
Technical Field
The utility model relates to a nanometer magnetism detects technical field and thermophysical parameter measurement's technical field, especially relates to a thermophysical parameter measurement system based on magnetic nanoparticle, realizes the measurement of different kind magnetic nanoparticle samples thermophysical parameter under different excitation modes, belongs to the experimental measurement field.
Background
Magnetic nanoparticles are an important nano material scientifically discovered in recent years, the particle size of the magnetic nanoparticles is about 1-100 nanometers, and due to the unique physical characteristics of the magnetic nanoparticles, the magnetic nanoparticles attract wide attention of the scientific community, so that a plurality of fields such as spintronic devices, drug transportation, magnetic particle imaging technology, magnetic nano temperature measurement technology and the like are generated, and the technical fields of industry and medical diagnosis are greatly expanded. Since the discovery of the giant magnetoresistance effect in magnetic nanomaterials, spin valves based on the giant magnetoresistance effect and spin electron devices of magnetic tunnel lamps have attracted much attention, because the spin electron devices have a wide application prospect in the directions of information storage, information reading and writing, magnetic dynamic memories and the like. The magnetic nanoparticles originate from magnetic nanoparticle targeted drug delivery proposed by Senyei and Widder in the aspect of drug delivery, are used as drug targeted carriers, move to a specified position through an external magnetic field control carrier, and release the drugs at a focus position fixed point by utilizing thermal fusion or a chemical principle, so that the drug curative effect is greatly provided, the influence of the side effect of the drugs is reduced, and the technical support is provided for refined drug treatment. The magnetic particle imaging technology is used for inverting the particle quantity or spatial distribution information of magnetic nanoparticles by utilizing the harmonic information of the magnetization response of the magnetic nanoparticles under the excitation of a gradient magnetic field and an alternating magnetic field. The magnetic particle imaging technology is a molecular-level medical diagnosis technology, and greatly improves the resolution in the field of medical images. The magnetic nano temperature measuring method is a real-time non-contact magnetic measuring method, and the principle is that the temperature is sensed by using magnetic nano particles, and the temperature information is inverted through the magnetization response information of the magnetic nano particles under the excitation of an external magnetic field. The appearance of the magnetic nano temperature measurement technology solves the technical bottleneck that the temperature information cannot be measured in real time in the tumor thermotherapy field, and is expected to greatly promote the rapid development of the tumor thermotherapy technology.
In conclusion, magnetic nanoparticles are rapidly developed in the fields, and provide a brand new technical means for the industrial and medical fields, but the application of the magnetic nanoparticles in the fields still has some technical problems. Through intensive research and analysis, it can be found that the physical characteristics of some applications of the magnetic nanoparticles are utilized, for example, the magnetic nanoparticles are used as a spintronic device to be applied to a magnetic memory device, the problem of heat generation is a technical bottleneck to be solved urgently, because the temperature is an important influence factor of the spin characteristics of the magnetic nanoparticles, the current research is still in vitro room temperature research, and the dynamic temperature-spin characteristics of the magnetic nanoparticles in a normal working state are unknown due to the lack of an effective technical means. In the aspect of drug transportation, individual differences enable the magnetic nanoparticles as targeting carriers to need precise temperature and magnetic field control in the aspects of external magnetic field targeting control and fixed-point drug release, and the requirement for precise measurement of physical parameters of the magnetic nanoparticles at different temperatures is high. The magnetic particle imaging technology and the magnetic nano temperature measurement technology are influenced by parameters such as saturation magnetization, concentration, particle size distribution and the like of magnetic nano particles, and how to realize accurate measurement under multi-parameter information fusion is a technical problem which troubles the fields.
SUMMERY OF THE UTILITY MODEL
To the accurate measuring technical problem of physical characteristic parameter under the mutual fusion of current magnetism nanometer particle measurement system can not realize many physical parameters, the utility model provides a thermal physical parameter measurement system based on magnetism nanometer particle can realize different types of magnetic field excitation mode according to user demand, based on U type constant temperature basin and multilayer solenoid structure, satisfies the accurate measurement of the thermal physical parameter of magnetism nanometer particle of user under the mutual fusion environment of many physical parameters, overcomes the difficult problem that magnetism nanometer thermal physical characteristic parameter can't accurate measurement under dynamic environment in the past.
In order to achieve the above purpose, the technical solution of the present invention is realized as follows: the utility model provides a thermal physics parameter measurement system based on magnetic nano particle, includes computer and data acquisition card, and computer and data acquisition card are connected, data acquisition card is connected with constant temperature control module, magnetic field excitation module and weak magnetism measuring module respectively, and constant temperature control module is connected with the basin, is equipped with the sample test tube that holds the magnetic nano particle sample in the basin, and magnetic field excitation module is connected with weak magnetism measuring module, and weak magnetism measuring module sets up the outside at the sample test tube.
The weak magnetic measurement module comprises a measurement solenoid, a signal amplification circuit and a filter, the measurement solenoid is connected with the magnetic field excitation module, the measurement solenoid is arranged on the outer side of the sample test tube and is connected with the signal amplification circuit, the signal amplification circuit is connected with the filter, and the filter is connected with the data acquisition card; the measuring solenoid is a pair of coaxial reverse-phase wound solenoids I, and the solenoids I are connected with a signal amplifying circuit.
The magnetic field excitation module comprises a direct current excitation unit, a single-frequency alternating excitation unit and/or a double-frequency alternating excitation unit, and the direct current excitation unit, the single-frequency alternating excitation unit and/or the double-frequency alternating excitation unit are/is connected with the applying solenoid.
The apply solenoid comprises a high frequency solenoid, a low frequency solenoid, and a direct current solenoid, all of which are matched to solenoid I; the direct current excitation unit is connected with the direct current solenoid, the single-frequency alternating excitation unit is connected with the low-frequency solenoid and the high-frequency solenoid, and the double-frequency alternating excitation unit is connected with the low-frequency solenoid and the high-frequency solenoid; the high-frequency solenoid is sleeved on the outer side of the solenoid I, the low-frequency solenoid is sleeved on the outer side of the high-frequency solenoid, and the direct-current solenoid is sleeved on the outer side of the low-frequency solenoid.
The direct current excitation unit comprises a direct current power amplifier, and the direct current power amplifier is respectively connected with the data acquisition card and the direct current solenoid; the single-frequency alternating excitation unit and the double-frequency alternating excitation unit both comprise an alternating current power amplifier and a power filter, the alternating current power amplifier is connected with the data acquisition card, the alternating current power amplifier is connected with the power filter, and the power filter is connected with the low-frequency solenoid or the high-frequency solenoid.
The constant-temperature control module comprises a constant-temperature water tank, a temperature sensor and a communication module, a water pump is arranged in the constant-temperature water tank, the water pump is connected with the water tank through a water supply pipeline, and the water tank is connected with the constant-temperature water tank through a water return pipeline; a temperature sensor is arranged in the water tank and connected with a data acquisition card through a temperature transmitter, the data acquisition card is connected with a communication module, and the communication module is connected with a constant-temperature water tank.
The basin is the U-shaped basin, and the supply channel and the return water pipeline of thermostatic water tank are connected with the both ends of U-shaped basin respectively, and the sample test tube sets up on the upper portion of the one end of U-shaped basin, and solenoid structure fixes in the outside on the one end upper portion of U-shaped basin.
And the temperature sensor is fixed at the upper part of the other end of the U-shaped water tank through an O-shaped ring.
The computer is connected with a display, and a human-computer interaction module is arranged on the display; the computer is internally provided with a signal conditioning unit and a thermal physical parameter inversion unit, the signal conditioning unit is connected with the thermal physical parameter inversion unit, and the signal conditioning unit is connected with a filter of the weak magnetic measurement module.
The utility model has the advantages that: magnetic nano solid powder particles, magnetic nano colloids or magnetic nano liquid samples are placed in sample test tubes, a water tank can provide any temperature and temperature change curve within the temperature range of 10-100 ℃ according to user requirements through adjustment of a constant-temperature control module, and then a magnetic field excitation module can provide various magnetic field excitation modes, such as a direct-current magnetic field, a single-frequency alternating magnetic field, a double-frequency alternating magnetic field or the combined magnetic field according to the user requirements; a pair of coaxial reversely wound solenoids is adopted to detect magnetization response signals of a magnetic nanoparticle sample under the excitation of a magnetic field, a strong interference noise source of an externally added excitation magnetic field is eliminated, a computer extracts the amplitude of each required harmonic through a high-precision harmonic detection algorithm, and multiple physical parameters of the magnetic nanoparticles can be accurately measured through a regularized nonlinear equation set solution algorithm according to a temperature-harmonic mathematical model or a concentration-harmonic mathematical model or a particle size distribution-harmonic mathematical model and the like. The utility model discloses greatly expand the measurement field of the hot physical parameter dynamic characteristic of magnetic nano particle, provide basis and support in fields such as spin electron device, drug transport, magnetic particle imaging and magnetic nano temperature measurement for magnetic nano particle.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic diagram of the data measurement shown in fig. 1.
FIG. 3 is an assembly view of the structure between the exciting coil, the detecting coil and the constant temperature water tank.
Fig. 4 is an exploded view of the structure of fig. 3.
In the figure, 1 is a solenoid I, 2 is a high-frequency solenoid, 3 is a low-frequency solenoid, 4 is a direct current solenoid, 5 is a sample test tube, 6 is a water tank, 7 is an O-ring, 8 is a temperature sensor, 9 is a weak magnetic measurement module, and 10 is a magnetic field excitation module.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without any creative effort belong to the protection scope of the present invention.
Example 1: as shown in fig. 1 and 2, a thermal physical parameter measurement system based on magnetic nanoparticles, including computer and data acquisition card, computer and data acquisition card are connected, data acquisition card is connected with constant temperature control module, magnetic field excitation module 10 and weak magnetic measurement module 9 respectively, data acquisition card output alternating current signal or direct current signal and convey to magnetic field excitation module 10, magnetic field excitation module 10 handles alternating current signal or alternating current signal, output amplified direct current signal or single frequency alternating signal or dual-frequency alternating signal or above-mentioned combination signal, constant temperature control module is connected with basin 6, be equipped with the sample test tube 5 that holds the magnetic nanoparticle sample in the basin, magnetic field excitation module 10 is connected with weak magnetic measurement module 9, weak magnetic measurement module 9 sets up the outside at sample test tube 5. The constant temperature control module adjusts the temperature in the water tank 6 to be constant, so that the magnetic nano sample in the sample test tube 5 keeps constant temperature. The direct current signal or alternating signal output by the magnetic field excitation module 10 acts on the weak magnetic measurement module 9, the weak magnetic measurement module 9 acts on the magnetic nano solid powder particles or the magnetic nano colloid or the magnetic nano liquid sample in the sample test tube 5 and detects the magnetic nano particle sample signal, the acquired measurement signal is discretized by a data acquisition card and then transmitted to a computer, and the computer performs signal processing and thermal physical parameter inversion to obtain the thermal physical parameter information of the magnetic nano particles.
The computer is connected with a display, and a human-computer interaction module is arranged on the display; the computer is internally provided with a signal conditioning unit and a thermal physical parameter inversion unit, the signal conditioning unit is connected with the thermal physical parameter inversion unit, and the signal conditioning unit is connected with a filter of the weak magnetic measurement module. The signal conditioning unit processes harmonic amplitude and phase information of magnetic nanoparticle magnetization response, the thermophysical parameter inversion unit inverts thermophysical parameters by using the existing inversion algorithm and displays the measured thermophysical parameter information of the magnetic nanoparticles through the display, and the man-machine interaction module can input data through a mouse and a keyboard so as to adjust input parameters, such as water temperature of a water tank or signal intensity output by the magnetic field excitation module 10.
As shown in fig. 2, the weak magnetic measurement module comprises a measurement solenoid, a signal amplification circuit and a filter, the measurement solenoid is connected with the magnetic field excitation module 10, the measurement solenoid is arranged outside the sample test tube 5, the measurement solenoid is connected with the signal amplification circuit, the signal amplification circuit is connected with the filter, and the filter is connected with the data acquisition card; the measuring solenoid is a pair of coaxial solenoids I1 wound in opposite phases, the solenoid I1 is connected with a signal amplifying circuit, and the two solenoids I1 are fixedly connected and wound in opposite phases, so that the interference of an excitation magnetic field is eliminated. Under the action of a magnetic field generated by the magnetic field excitation module 10, the measuring solenoid measures a measuring signal generated by the magnetic nano sample, the signal amplification circuit is used for amplifying the measuring signal, and the filter is used for filtering the harmonic wave of the measuring signal.
The magnetic field excitation module 10 comprises a direct current excitation unit, a single-frequency alternating excitation unit and/or a double-frequency alternating excitation unit, wherein the direct current excitation unit, the single-frequency alternating excitation unit and/or the double-frequency alternating excitation unit are/is connected with an applying solenoid, the direct current excitation unit, the single-frequency alternating excitation unit and/or the double-frequency alternating excitation unit respectively generate amplified direct current signals, single-frequency alternating signals, double-frequency alternating signals or combined signals, the amplified excitation signals act on the applying solenoid to generate corresponding magnetic fields, and the measuring solenoid measures response signals of the magnetic nano samples under the action of the direct current, alternating current or mixed magnetic fields to enable the measuring solenoid to generate corresponding measuring signals. The structure or assembly diagram of the measuring coil, the exciting coil and the constant-temperature water tank is shown in figure 3.
As shown in fig. 4, the applying solenoid includes a high frequency solenoid 2, a low frequency solenoid 3, and a direct current solenoid 4, the high frequency solenoid 2, the low frequency solenoid 3, and the direct current solenoid 4 all matching with a solenoid I1; the direct current excitation unit is connected with the direct current solenoid 4, and directly acts the direct current amplification signal on the direct current solenoid 4 to generate a direct current magnetic field. The single-frequency alternating excitation units are connected with the low-frequency solenoid 3 and the high-frequency solenoid 2, and the double-frequency alternating excitation units are connected with the low-frequency solenoid 3 and the high-frequency solenoid 2; the single-frequency alternating excitation unit directly acts the amplified single-frequency alternating current signal on the low-frequency solenoid 3 or the high-frequency solenoid 2, the double-frequency alternating excitation unit directly acts the amplified double-frequency alternating current signal on the low-frequency solenoid 3 or the high-frequency solenoid 2, the high-frequency solenoid 2 generates a high-frequency magnetic field, and the low-frequency solenoid 3 generates a low-frequency magnetic field. The high-frequency solenoid 2 is sleeved on the outer side of the solenoid I1, the low-frequency solenoid 3 is sleeved on the outer side of the high-frequency solenoid 2, the direct-current solenoid 4 is sleeved on the outer side of the low-frequency solenoid 3, the structure is compact, the higher the frequency is, the higher the required power amplifier output power is, if the high-frequency coil is sleeved on the outer side, the size is increased, the impedance is increased, the higher the required power is under the condition of generating the same magnetic field strength, the high-frequency coil is required to be placed on the innermost layer, the low frequency is placed on the middle layer. Secondly this structure is insensitive to sample position information, compares Helmholtz coil structure, can produce higher magnetic field under the same power output to solve Helmholtz coil structure simultaneously and receive the great shortcoming of sample position influence.
The direct current excitation unit comprises a direct current power amplifier which is respectively connected with the data acquisition card and the direct current solenoid 4; the DC power amplifier amplifies the DC signal output by the data acquisition card and acts on the DC solenoid 4 to make the DC solenoid generate a DC magnetic field. The single-frequency alternating excitation unit and the double-frequency alternating excitation unit both comprise an alternating current power amplifier and a power filter, the alternating current power amplifier is connected with the data acquisition card, the alternating current power amplifier is connected with the power filter, and the power filter is connected with the low-frequency solenoid 3 or the high-frequency solenoid 2. The dc power amplifier and the ac power amplifier amplify the dc signal and the ac signal, respectively, and the power amplifier amplifies system noise, such as noise of 50Hz and 150Hz in the power supply, while amplifying the useful signal, and the amplified signal needs to be filtered.
The constant-temperature control module comprises a constant-temperature water tank, a temperature sensor 8 and a communication module, a water pump is arranged in the constant-temperature water tank, the water pump is connected with the water tank 6 through a water supply pipeline, and the water tank is connected with the constant-temperature water tank through a water return pipeline; a temperature sensor 8 is arranged in the water tank 6, the temperature sensor 8 is connected with a data acquisition card through a temperature transmitter, the data acquisition card is connected with a communication module, and the communication module is connected with a constant-temperature water tank. The communication module is VISA or GPIB, is a standard communication interface or a communication protocol and is used for carrying out signal communication according to a specific communication protocol. For example, common RS232 and RS485 may be referred to as a communication interface, or a communication protocol, but the communication distances between the two are relatively weak, and the reliability is relatively low. The constant temperature water tank is the water tank of automatically regulated temperature, and can self-make, also can purchase, for example the constant temperature water tank of Tianjin Bilang laboratory glassware manufacturing company production, the model is BILON. The temperature sensor 8 is a PT100 platinum resistance temperature sensor, detects the temperature of circulating water in the water tank 6 in real time, transmits the temperature to the data acquisition card through the temperature transmitter, provides a temperature feedback signal for the data acquisition card, transmits the feedback signal to the constant temperature water tank through the communication module, adjusts the temperature of water pumped out from a water supply pipeline of the constant temperature water tank in real time, and controls the temperature of a test sample in the water tank 6 to be constant in a closed loop mode.
As shown in fig. 3, the water tank 6 is a U-shaped water tank, the water supply pipeline and the water return pipeline of the thermostatic water tank are respectively connected with two ends of the U-shaped water tank, the sample test tube 5 is arranged on the upper portion of one end of the U-shaped water tank, the measuring solenoid and the applying solenoid are both fixed on the outer side of the upper portion of one end of the U-shaped water tank, that is, the measuring solenoid and the applying solenoid are both arranged on the outer side of the sample test tube 5, so that the measuring solenoid measures a measuring signal, that is, an excitation response signal, of the magnetic nano sample in the sample test tube. The water supply pipeline sets up the upper portion at the one end of U-shaped basin, and the water supply pipe sets up near sample test tube 5 promptly, guarantees that the water around the sample test tube 5 is invariable temperature. The temperature sensor 8 and the water supply line are provided at the other end of the U-shaped water tank. The temperature sensor 8 is fixed on the upper part of the other end of the U-shaped water tank through an O-shaped ring 7, and the sealing performance of the U-shaped water tank is guaranteed.
The operation steps are as follows: (1) the method comprises the steps of placing a magnetic nano solid powder particle or magnetic nano colloid or magnetic nano liquid sample in a sample test tube 5, sending constant temperature information to a data acquisition card by a computer, transmitting the constant temperature information to a constant temperature water tank through a communication module, starting a water pump to inject constant temperature water into a U-shaped water tank, detecting the temperature of circulating water in the U-shaped water tank in real time by a temperature sensor 8, providing a temperature feedback signal for the data acquisition card, and controlling the temperature of the test sample in the U-shaped water tank to be constant in a closed loop mode. (2) The signal (direct current signal or single frequency alternating signal or double frequency alternating signal or the combination signal) output by the data acquisition card is amplified in power by a power amplifier (direct current amplification or alternating current amplification), and then is sent to a power filter for signal conditioning, and an exciting and applying solenoid is excited to generate an exciting magnetic field (direct current magnetic field or single frequency alternating magnetic field or double frequency alternating magnetic field or mixed magnetic field). (3) A pair of coaxial reversely wound solenoids I detect magnetization response signals of the magnetic nanoparticle samples under an excitation magnetic field, the magnetization response signals are sent to a data acquisition card through a signal amplification circuit and a filter to be subjected to signal acquisition, and the data acquisition card is subjected to discretization processing of the signals. (4) The signal conditioning unit processes signals obtained by discrete acquisition of the data acquisition card, extracts harmonic amplitude and phase information of magnetic nanoparticle magnetization response by using the existing computer program, and the thermophysical parameter inversion unit reversely finds magnetic nanoparticle concentration, temperature and particle size distribution information according to the harmonic amplitude and the phase information by using the existing inversion model and displays the information on a display through a human-computer interaction interface.
The utility model discloses can realize that different kind magnetic nanoparticle samples are at direct current magnetic field or single-frequency alternating magnetic field or dual-frequency alternating magnetic field or the above-mentioned thermophysical characteristic parameter (concentration, temperature and particle size distribution information) accurate measurement under the excitation of combination magnetic field.
Example 2: a magnetic nanoparticle-based thermophysical parameter measurement system, as shown in FIG. 1, realizes measurement of the temperature and concentration of magnetic nanoparticles, and comprises the following operation steps: (1) a user sets parameters such as a system constant temperature, the type of a test sample, a magnetic field excitation mode and the like on a computer through a human-computer interaction module according to the requirement of the user; (2) placing magnetic nano solid powder particles or magnetic nano colloid or magnetic nano liquid samples in a sample test tube 5; (3) the magnetic field excitation module 10 is turned on, and applies an excitation magnetic field to the area where the sample tube 5 is located: according to a magnetic field excitation mode set by a user, a data acquisition card outputs signals, the signals are subjected to power amplification through a direct current power amplifier or an alternating current power amplifier, then the signals are conditioned through a power filter and input to a solenoid to generate an excitation magnetic field, the magnetic field is a direct current magnetic field or a single-frequency alternating magnetic field or a double-frequency alternating magnetic field or a mixed magnetic field, the frequency of the excitation magnetic field is less than 20KHz, and the magnetic field intensity is 0-100 gauss.
(4) A pair of coaxial reversely wound solenoids I1 is adopted to measure the magnetization response signal of the magnetic nano sample under the excitation of the excitation magnetic field in real time; (5) performing signal conditioning such as pre-amplification, filtering and the like on the magnetization response signal in the step (4) by adopting a low-noise pre-positioned signal amplification circuit and a filter, and acquiring a discrete signal after signal conditioning by using a data acquisition card; (6) a signal conditioning unit in the computer extracts and stores harmonic amplitude and phase information of the obtained discrete signal by adopting the existing harmonic amplitude detection algorithm, and simultaneously extracts each harmonic amplitude and phase information of the magnetization response signal by adopting a digital phase-sensitive detection algorithm or a fast Fourier transform algorithm or a least square system identification algorithm; (7) according to the temperature requirement set by the user, performing constant temperature work of other temperature points, and skipping to the step (3) to finish measurement of the set temperature point; (8) the thermophysical parameter inversion unit respectively inverts the magnetic nanoparticle temperature and concentration information according to the temperature inversion model described in the invention patent (refer to patent ZL 201610399156.0) previously developed by the team of the invention. Namely, the thermal physical parameter inversion unit inverts the temperature and concentration information of the magnetic nanoparticles according to the existing calculation program.
Temperature inversion model: x = AY, X being harmonic amplitudeValue information, a is a matrix constant, and Y is temperature information. By A-1The concentration information can be obtained by calculating the temperature information by X = Y and then substituting the calculated temperature information into any one of the harmonic wave equations in the matrix equation. And finally, displaying the inverted information on a display.
The other structure is the same as embodiment 1.
Example 3: a thermal physical parameter measuring system based on magnetic nanoparticles realizes the measurement of the particle size distribution of the magnetic nanoparticles, and comprises the following operation steps: (1) the user sets parameters such as the constant temperature of the system, the type of a test sample, a magnetic field excitation mode and the like through the human-computer interaction module according to the requirement; (2) placing magnetic nano solid powder particles or magnetic nano colloid or magnetic nano liquid samples in a sample test tube 5; (3) applying an excitation magnetic field to the area of the sample:
according to a magnetic field excitation mode set by a user, a data acquisition card outputs a signal, the signal is amplified through a power amplifier, then the signal is conditioned through a power filter and input to a solenoid to generate an excitation magnetic field, the magnetic field is a direct current magnetic field or a single-frequency alternating magnetic field or a double-frequency alternating magnetic field or a mixed magnetic field, the frequency of the excitation magnetic field is less than 20KHz, and the magnetic field intensity is 0-100 gauss.
(4) A pair of coaxial reversely wound measuring solenoids is adopted to measure the magnetization response signal of the magnetic nano sample under the excitation of the excitation magnetic field in real time; (5) performing signal conditioning such as pre-amplification, filtering and the like on the magnetization response signal in the step (4) by adopting a low-noise pre-amplifier and a filter; (6) extracting and storing harmonic amplitude and phase information of the discrete signals obtained in the step (5) by adopting a harmonic amplitude detection algorithm; and extracting amplitude and phase information of each subharmonic of the magnetization response signal by adopting a digital phase-sensitive detection algorithm or a fast Fourier transform algorithm or a least square system identification algorithm. (7) Changing the intensity of the excitation magnetic field, skipping to the step (3) to continue measurement, and completing the measurement of the particle size distribution at a single temperature point;
(8) and (4) carrying out constant temperature work according to the temperature set by the user, and skipping to the step (3) to continue measurement until the temperature point set by the user is finished. (9) The thermal physical parameter inversion unit respectively obtains the particle size distribution information under different temperatures according to the model disclosed in the patent application number CN 201910543170.7.
The other structure is the same as embodiment 1.
The utility model discloses based on the constant temperature basin of U type, coaxial multilayer structure apply the thermal physical parameter measurement system of one set of magnetic nano particle of subassembly design such as solenoid of solenoid and a pair of coaxial reverse coiling, can realize multiple magnetic field excitation mode, can set for different constant temperature environment according to user's demand, realize the accurate measurement of magnetic nano particle thermal physical parameter developments. The utility model discloses greatly expand the measurement field of the hot physical parameter dynamic characteristic of magnetic nano particle, provide basis and support in fields such as spin electron device, drug transport, magnetic particle imaging and magnetic nano temperature measurement for magnetic nano particle.
The utility model overcomes in the past the unicity of magnetism nano particle physical parameter system measurement condition, the physical parameter under the unable accurate measurement dynamic parameter intercoupling can realize multiple magnetic field excitation mode, and the physical parameter accurate measurement under the many physics intercoupling states under the alternating temperature environment can realize physical parameter developments deduction.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. The utility model provides a thermal physics parameter measurement system based on magnetic nano particle, includes computer and data acquisition card, and computer and data acquisition card are connected, its characterized in that, data acquisition card is connected with constant temperature control module, magnetic field excitation module (10) and weak magnetism measuring module (9) respectively, and constant temperature control module is connected with basin (6), is equipped with sample test tube (5) that hold the magnetic nano particle sample in the basin, and magnetic field excitation module (10) are connected with weak magnetism measuring module, and weak magnetism measuring module sets up the outside at sample test tube (5).
2. The system for the measurement of thermophysical parameters based on magnetic nanoparticles according to claim 1, characterized in that the weak magnetic measurement module comprises a measurement solenoid, a signal amplification circuit and a filter, the measurement solenoid is connected with the magnetic field excitation module (10), the measurement solenoid is arranged outside the sample tube (5), the measurement solenoid is connected with the signal amplification circuit, the signal amplification circuit is connected with the filter, the filter is connected with the data acquisition card; the measuring solenoid is a pair of coaxial reverse-phase wound solenoids I (1), and the solenoids I (1) are connected with a signal amplifying circuit.
3. The magnetic nanoparticle-based thermophysical parameter measurement system according to claim 1 or 2, characterized in that the magnetic field excitation module (10) comprises a direct current excitation unit, a single frequency alternating excitation unit and/or a dual frequency alternating excitation unit, all connected with an application solenoid.
4. The magnetic nanoparticle-based thermophysical parameter measurement system of claim 3, wherein the applying solenoid comprises a high frequency solenoid (2), a low frequency solenoid (3), and a direct current solenoid (4), the high frequency solenoid (2), the low frequency solenoid (3), and the direct current solenoid (4) all matching solenoid I (1); the direct current excitation unit is connected with the direct current solenoid (4), the single-frequency alternating excitation units are connected with the low-frequency solenoid (3) and the high-frequency solenoid (2), and the double-frequency alternating excitation units are connected with the low-frequency solenoid (3) and the high-frequency solenoid (2); the high-frequency solenoid (2) is sleeved on the outer side of the solenoid I (1), the low-frequency solenoid (3) is sleeved on the outer side of the high-frequency solenoid (2), and the direct-current solenoid (4) is sleeved on the outer side of the low-frequency solenoid (3).
5. The system for measuring thermophysical parameters based on magnetic nanoparticles according to claim 4, characterized in that the DC excitation unit comprises a DC power amplifier respectively connected with the data acquisition card and the DC solenoid (4); the single-frequency alternating excitation unit and the double-frequency alternating excitation unit both comprise an alternating current power amplifier and a power filter, the alternating current power amplifier is connected with the data acquisition card, the alternating current power amplifier is connected with the power filter, and the power filter is connected with the low-frequency solenoid (3) or the high-frequency solenoid (2).
6. The system for measuring the thermophysical parameters based on the magnetic nanoparticles as recited in claim 1 or 5, characterized in that the thermostatic control module comprises a thermostatic water tank, a temperature sensor (8) and a communication module, wherein a water pump is arranged in the thermostatic water tank, the water pump is connected with a water tank (6) through a water supply pipeline, and the water tank is connected with the thermostatic water tank through a water return pipeline; a temperature sensor (8) is arranged in the water tank (6), the temperature sensor (8) is connected with a data acquisition card through a temperature transmitter, the data acquisition card is connected with a communication module, and the communication module is connected with a constant-temperature water tank.
7. The magnetic nanoparticle-based thermophysical parameter measurement system according to claim 6, wherein the water tank (6) is a U-shaped water tank, a water supply pipeline and a water return pipeline of the thermostatic water tank are respectively connected with two ends of the U-shaped water tank, the sample test tube (5) is arranged at an upper part of one end of the U-shaped water tank, and the solenoid structure is fixed outside the upper part of one end of the U-shaped water tank.
8. The magnetic nanoparticle-based thermophysical parameter measurement system of claim 7, wherein the temperature sensor (8) is fixed at the upper part of the other end of the U-shaped water tank by an O-ring (7).
9. The system according to claim 1 or 8, wherein the computer is connected to a display, and a human-computer interaction module is provided on the display; the computer is internally provided with a signal conditioning unit and a thermal physical parameter inversion unit, the signal conditioning unit is connected with the thermal physical parameter inversion unit, and the signal conditioning unit is connected with a filter of the weak magnetic measurement module.
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| CN112577995A (en) * | 2020-12-22 | 2021-03-30 | 包头稀土研究院 | Gradient magnetic field magnetocaloric effect measuring device and control method |
| CN117662100A (en) * | 2024-02-02 | 2024-03-08 | 中国石油大学(华东) | Fractured reservoir plugging control system and method of magnetic microspheres under multiple magnetic control |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112577995A (en) * | 2020-12-22 | 2021-03-30 | 包头稀土研究院 | Gradient magnetic field magnetocaloric effect measuring device and control method |
| CN117662100A (en) * | 2024-02-02 | 2024-03-08 | 中国石油大学(华东) | Fractured reservoir plugging control system and method of magnetic microspheres under multiple magnetic control |
| CN117662100B (en) * | 2024-02-02 | 2024-04-26 | 中国石油大学(华东) | Fractured reservoir plugging control system and method of magnetic microspheres under multiple magnetic control |
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