CN211675381U - Microsystem treatment device - Google Patents
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- CN211675381U CN211675381U CN202020144256.0U CN202020144256U CN211675381U CN 211675381 U CN211675381 U CN 211675381U CN 202020144256 U CN202020144256 U CN 202020144256U CN 211675381 U CN211675381 U CN 211675381U
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Abstract
The utility model provides a microsystem treatment device, microsystem treatment device include array micropin chip, and array micropin chip includes matrix type micropin array, and the micropin array is arranged by many micropins and is formed, and the micropin is the non-conical columnar structure, and the treatment end of micropin is the round face. The microneedle array formed by arranging a plurality of microneedles can massage and stimulate the whole acupoint area, and compared with single-point stimulation, the microneedle array has larger area for stimulating the acupoint area, and can stimulate the acupoint treatment area more accurately. The micro-needle is in a non-conical columnar structure, and the treatment end of the micro-needle is a round surface, so that the micro-needle is in a non-pointed structure, and the treatment end of the micro-needle is not easy to puncture the skin of a patient, so that the micro-needle array can massage and stimulate the acupuncture points of the patient for a long time, and the risk of skin infection caused by puncturing the skin is effectively reduced.
Description
Technical Field
The utility model relates to a traditional chinese medical science field of treating outward, in particular to microsystem treatment device.
Background
Research shows that the temperature of acupuncture points of a human body is different from that of non-acupuncture points, the temperature of acupuncture points of most healthy individuals is higher than that of non-acupuncture points, the temperature of acupuncture points in a disease state is different from that of acupuncture points in a health state, and temperature difference points different from the temperature of surrounding skin easily appear at the acupuncture points of meridians and collaterals. The blood flow is larger at the local part, the tissue metabolism is vigorous, the heat production is larger, and the temperature is higher because the acupuncture points have denser blood vessels and nerve distribution than non-acupuncture points, the temperature of the body surface is mainly determined by the amount of local blood flow and the local tissue metabolism, and the acupuncture points are used as the infusion points of qi and blood on the body surface, so that the local blood flow is larger, the tissue metabolism is stronger, and the heat production is larger. The temperature of the acupoints can reflect the physiological and pathological conditions inside the body and the correlation between the acupoints and the zang-fu organs. Through the connection of meridians and collaterals, the pathological changes of internal organs can be reflected on the body surface, so that whether the internal organs have pathological changes or not can be judged through the temperature change of meridians and collaterals and acupoints, and a basis is provided for the diagnosis of clinical diseases.
The research of modern Chinese medicine acupuncture mechanism shows that the acupoint function activity is a dynamic concept, mainly 'silence' in physiological state, and weak activity even no feeling of its existence, while in pathological state, it has different characteristics from physiological state, and the acupoint reaction and disease treatment functions are greatly enhanced, and the area size can also produce corresponding change.
The most common response to sensitization of acupoints (acupoints) is force sensitivity. Force sensitivity is one of the most common manifestations of sensitization of acupoints in acupuncture.
One of the common treatment modes of the traditional Chinese medicine external treatment apparatus is acupuncture treatment, single-point stimulation is carried out on the acupuncture points of a patient by adopting single acupuncture, the treatment time is short, the stimulation area is small, the stimulation intensity is weak, and the acupuncture treatment is single-point stimulation and needs manual positioning because the acupuncture points are dynamic areas, so that the precision of the inevitable acupuncture point treatment is poor. Another common external treatment apparatus for traditional Chinese medicine is a roller needle, which is pushed to roll to stimulate a part of acupuncture point regions, but the treatment mode of the roller needle is easy to puncture the skin of a patient, thereby causing skin infection, the retention time is short, the continuous stimulation intensity is weak, and although the stimulation area of the roller needle is large, the roller needle can stimulate the whole acupuncture point region, but not only the acupuncture point region but also non-acupuncture point regions during the rolling process, thereby easily causing discomfort of the non-acupuncture point regions.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to provide a microsystem treatment device in order to overcome that acupuncture treatment can only carry out single-point stimulation and fix a position and easily produce the deviation among the prior art to and traditional chinese medical science external treatment utensil punctures skin easily and causes the defect of infection.
The utility model discloses an above-mentioned technical problem is solved through following technical scheme:
a microsystem treatment device comprises an array microneedle chip and is characterized in that the array microneedle chip comprises a matrix microneedle array, the microneedle array is formed by arranging a plurality of microneedles, the microneedles are of non-conical columnar structures, and the treatment ends of the microneedles are round surfaces.
In this scheme, the microneedle array that forms by many microneedle array can massage amazing whole acupuncture point region, compares in single-point stimulation, and the area that microneedle array amazing acupuncture point region is bigger, can stimulate acupuncture point treatment region more accurately. The microneedle is a non-conical columnar structure, and the treatment end of the microneedle is a round surface, so that the microneedle is of a non-pointed structure, the risk of breakage of the microneedle in the use process can be effectively reduced, the treatment end of the microneedle is not easy to puncture the skin of a patient in the massage stimulation process of the acupuncture point of the patient, the acupuncture point of the patient can be stimulated by massaging the microneedle array for a long time, the treatment strength is enhanced, and the risk of skin infection caused by puncturing the skin can be effectively reduced.
Preferably, the circular surface of the treatment end of the microneedle is a plane or a spherical surface.
In the scheme, the treatment end of the microneedle, which is used for touching the patient, adopts a plane or a spherical surface to puncture the skin of the patient more easily, so that the skin infection caused by the skin puncture is reduced, the microsystem treatment device can be ensured to stimulate the corresponding acupuncture points for a long time, and the treatment intensity is enhanced.
Preferably, the area of the array microneedle chip is 0.2cm2-0.3cm2。
In the scheme, the size of the microneedle array for stimulating the acupuncture points is limited by limiting the size of the array microneedle chip, so that the microneedle array can stimulate the acupuncture point region as far as possible without stimulating non-acupuncture point regions, and discomfort of the non-acupuncture point regions is avoided.
Preferably, the area of the array microneedle chip is 0.2cm2。
Preferably, the microneedle is a MEMS (micro electro mechanical system) microneedle, and the diameter of the microneedle is 80-160 μm, and the height of the microneedle is 120-220 μm.
Preferably, the microneedles are 100 μm in diameter and 200 μm in height.
Preferably, the microneedles are 160 μm in diameter and 220 μm in height.
Preferably, the microneedles are 80 μm in diameter and 160 μm in height.
In the scheme, the micro-needle formed by the MEMS (micro electro mechanical system) technology can reach smaller size, the size of the micro-needle can meet the requirement of sufficient treatment effect on one hand, and on the other hand, the micro-needle is ensured not to be broken easily and not to puncture the skin of a patient easily in the use process.
Preferably, the microsystem treatment device further comprises a fixing surface, and the array microneedle chip is arranged on the fixing surface.
In the scheme, the time for treating the patient for one time is generally between 6 hours and 72 hours, and the fixing surface can ensure that the array microneedle chip is stably fixed at the acupuncture point of the patient needing massage stimulation in the treatment period, so that the acupuncture point of the patient is continuously stimulated.
Preferably, an acupuncture point sensor is further arranged on the fixing surface, and the acupuncture point sensor and the array microneedle chip are located on the same end face of the fixing surface.
In the scheme, the pressure, the temperature and the pain valve of the acupuncture points, the non-acupuncture points, the healthy acupuncture points and the sick acupuncture points have specificity, whether the array microneedle chip is just positioned in the acupuncture point region or not can be judged according to the data detection result of the pressure and/or the temperature, and whether the treatment on a patient is relieved or improved or not is judged, so that accurate treatment is realized, the treatment time is shortened, and the treatment effect is improved.
Preferably, the acupoint sensors include an acupoint temperature sensor and/or an acupoint pressure sensor.
In the scheme, the temperature and the pressure of the acupuncture points and non-acupuncture points, healthy acupuncture points and sick acupuncture points have specificity, the change conditions of the temperature and/or the pressure of the acupuncture points before and after treatment can be detected by adopting the acupuncture point temperature sensor and/or the acupuncture point pressure sensor, treatment evaluation is carried out, and the final detection result can be more accurate due to various detection data.
Preferably, the acupuncture point sensor is arranged around the array microneedle chip.
In the scheme, the arrangement position of the acupuncture point sensor is required to ensure that the acupuncture point sensor does not influence the stimulation of the array microneedle chip to the acupuncture point region, and can accurately detect corresponding acupuncture point data.
Preferably, the fixing surface is a medical adhesive plaster.
In the scheme, the medical adhesive plaster is a fixed structure commonly used in the medical field, is low in price and easy to obtain, has qualified sanitary standard, and reduces the risk of skin infection of patients.
Preferably, the fixing surface is a film sensor with a wearable film display screen.
In the scheme, the acupuncture point data detected by the film sensor can be directly displayed by the corresponding film display screen, and a display screen specially used for displaying the detection data of the acupuncture point sensor is not required to be configured, so that the detection data is more visual and is easy to obtain.
The utility model discloses an actively advance the effect and lie in: the microneedle array formed by arranging a plurality of microneedles can massage and stimulate the whole acupoint area, and compared with single-point stimulation, the microneedle array has larger area for stimulating the acupoint area, and can stimulate the acupoint treatment area more accurately. The microneedle is a non-conical columnar structure, and the treatment end of the microneedle is a round surface, so that the microneedle is of a non-pointed structure, the risk of breakage of the microneedle in the use process can be effectively reduced, the treatment end of the microneedle is not easy to puncture the skin of a patient in the massage stimulation process of the acupuncture point of the patient, the acupuncture point of the patient can be stimulated by massaging the microneedle array for a long time, the treatment strength is enhanced, and the risk of skin infection caused by puncturing the skin can be effectively reduced.
Drawings
Fig. 1 is a schematic front view of a microsystem treatment device according to embodiment 1 of the present invention.
Fig. 2 is a schematic side view of the microsystem treatment device according to embodiment 1 of the present invention.
Fig. 3 is a schematic side view of the microsystem treatment device according to embodiment 2 of the present invention.
Fig. 4 is a schematic front view of a microsystem treatment device according to embodiment 3 of the present invention.
Fig. 5 is a schematic side view of the microsystem treatment device according to embodiment 3 of the present invention.
Fig. 6 is a surface view of skin treated by the microsystem treatment device according to effect embodiment 5 of the present invention.
Fig. 7 is an enlarged view of the area a of fig. 6.
Fig. 8 is a diagram showing the surface of the skin of the present invention without being treated by the microsystem treatment apparatus according to effect example 5.
Fig. 9 is an enlarged view of the region C of fig. 8.
Fig. 10 is a statistical chart showing the mast cell degranulation rate in effect example 6 of the present invention.
Description of reference numerals:
1 array micro-needle chip
11 microneedle
2 fixed surface
3 acupoint sensor
Detailed Description
The present invention is further illustrated by way of the following examples, which are not intended to limit the scope of the invention.
Example 1
The embodiment provides a microsystem treatment device, as shown in fig. 1-2, the microsystem treatment device includes an array microneedle chip 1, the array microneedle chip 1 includes a microneedle array formed by arranging a plurality of microneedles 11, a center distance between two adjacent microneedles 11 is 500 μm, and multi-target-point precise treatment of skin and acupuncture points is realized through the array microneedle chip 1. A plurality of microneedles 11 are arranged in a matrix type, and photolithography is performed on a silicon wafer to form an array microneedle chip 1. In other alternative embodiments, the center distance between two neighboring microneedles 11 may also be designed to be other sizes, preferably 300 μm to 500 μm.
In order to allow the micro-needle array to stimulate the entire acupoint region of the patient and to stimulate only the acupoint region of the patient as much as possible without stimulating the non-acupoint region of the patient, the area of the array micro-needle chip 1 should be equal to or slightly larger than the size of the acupoint to be stimulated, preferably 0.2cm2-0.3cm2Therefore, the stimulation area of the microneedle array to the acupoint area can be ensured to be large enough, and discomfort of non-acupoint areas can be avoided as far as possible.
The microneedle array formed by arranging the microneedles 11 can massage and stimulate the whole acupoint area, and compared with single-point stimulation, the microneedle array has a larger area for stimulating the acupoint area, and can stimulate the acupoint treatment area more accurately. The size of the microneedle array for stimulating the acupuncture points is further limited by limiting the size of the array microneedle chip 1, so that the microneedle array can only stimulate the acupuncture point region and not stimulate the non-acupuncture point region, and the discomfort of the non-acupuncture point region is avoided.
The micro-needle 11 is of a cylindrical structure, the treatment end of the micro-needle 11 is a circular plane, the treatment end of the micro-needle 11 is in contact with the skin of a patient, the acupuncture point region of the patient is further stimulated, the skin of the patient is not easily punctured by the circular plane shape, the risk of skin infection is reduced, and long-term continuous massage stimulation of the micro-needle array on the acupuncture point region of the patient can be realized. The treatment end of the microneedle 11 is the end of the microneedle 11 that contacts the skin of the patient.
In other alternative embodiments, the structure of the microneedle 11 is not limited to a cylindrical shape, and may be designed into other non-conical columnar structures, but in order to ensure that the treatment end of the microneedle 11 does not pierce the skin of the patient, the treatment end preferably has a circular surface, and for example, the microneedle 11 may be designed into a truncated cone-shaped columnar structure.
The micro-needle 11 is of a non-pointed structure, so that the risk of breakage of the micro-needle 11 in the using process can be effectively reduced, and the treatment end of the micro-needle 11 is not easy to puncture the skin of a patient in the massage stimulation process of the acupuncture point of the patient, so that the acupuncture point of the patient can be massaged and stimulated by the micro-needle array for a long time, the treatment strength is enhanced, and the risk of skin infection caused by puncturing the skin can be effectively reduced.
The micro-needle 11 is an MEMS (micro electro mechanical system) micro-needle, the micro-needle 11 formed by the MEMS (micro electro mechanical system) technology can reach smaller size, and a larger number of micro-needles 11 can be arranged under the condition that the areas of the array micro-needle chips 1 are the same, so that a stronger stimulation effect is generated on a patient, the height of the micro-needle 11 can be smaller, and the skin of the patient is not easy to puncture in the treatment process. The diameter of the micro-needle 11 is 100 μm, the height is 200 μm, which can not only stimulate the skin and acupuncture point region to produce sufficient treatment effect, but also the micro-needle 11 is not easy to break and puncture the skin of the patient during the use process, thereby reducing the risk of skin infection. For pediatric patients, the height of the microneedles 11 may also be reduced accordingly, for example, using microneedles 11 having a diameter of 100 μm and a height of 160 μm. In alternative embodiments, the microneedles 11 may also be of other sizes, preferably 80 μm to 160 μm in diameter and 120 μm to 220 μm in height for use in adults; for children, the diameter is preferably 80 μm to 100 μm, and the height is preferably 120 μm to 160 μm.
Microsystem treatment device still includes stationary plane 2, array micropin chip 1 is located and can be pasted on the one side of patient's skin in stationary plane 2, under the general condition, the time of carrying out a treatment to the patient generally is between 6 hours to 72 hours, stationary plane 2 can guarantee that array micropin chip 1 fixes stably in the treatment period in patient need massage amazing acupuncture point department, make array micropin chip 1 keep somewhere in the region that the patient needs to carry out the treatment for a long time, the realization is amazing to patient's acupuncture point continuously, strengthen treatment intensity, the treatment effect is improved, overcome the defect that traditional chinese medical science external treatment utensil treatment time is shorter.
The area of the fixing surface 2 is preferably 2cm2-4cm2The size of the fixing surface 2 is designed into a smaller shape, the patient can only expose the skin at the corresponding acupuncture point in the treatment process, and the size of the fixing surface 2 is smaller, so that the whole occupied area of the microsystem treatment device is smaller, the microsystem treatment device is easier to hide, and the influence on the image of the patient is reduced. Moreover, since the fixing surface 2 is usually made of a thin material, the excessive area of the fixing surface 2 tends to cause adhesion of parts of the fixing surface 2, which affects the application effect.
The fixing surface 2 is made of medical adhesive plaster commonly used in the medical field, is low in price and easy to obtain, has qualified sanitary standard, and reduces the risk of skin infection of patients.
Example 2
The structure of the present embodiment is substantially the same as that of embodiment 1, except that the structure of the treatment end of the microneedle 11 and the center distance between two neighboring microneedles 11 are different.
The present embodiment provides a cylindrical microneedle 11, the treatment end of the microneedle 11 is a spherical surface with a circular shape, and the center distance between two adjacent microneedles 11 is 300 μm. The spherical structure can effectively reduce the risk of breakage of the micro-needle 11 in the using process, and can not easily puncture the skin of a patient while enhancing the stimulation to the acupuncture point area of the patient, thereby realizing the long-time massage stimulation of the acupuncture point of the patient by the micro-needle array, enhancing the treatment intensity and effectively reducing the risk of skin infection caused by puncturing the skin.
Example 3
The structure of this embodiment is basically the same as that of embodiment 1, except that an acupuncture point sensor 3 is further provided on the fixing surface 2.
The acupuncture point sensor 3 and the array micro-needle chip 1 are positioned on the same end face of the fixed face 2, namely the acupuncture point sensor 3 is also arranged in the fixed face 2 and can be pasted on one face of the skin of a patient. The pressure, the temperature and the pain valve of the acupuncture points and non-acupuncture points have specificity, and whether the array micro-needle chip 1 is exactly positioned in the acupuncture point area can be judged according to the data detection result of the pressure and/or the temperature, so that accurate treatment is carried out.
For example, the acupoint sensor 3 may detect changes of temperature and/or pressure of an acupoint by using an acupoint temperature sensor for detecting temperature of the acupoint and/or an acupoint pressure sensor for detecting pressure of the acupoint, and determine whether the array microneedle chip 1 is exactly positioned in the acupoint region by detecting changes of temperature, pressure, pain valve, and the like of the acupoint.
In order to ensure that the acupuncture point sensors 3 do not influence the stimulation of the array microneedle chip 1 to acupuncture point regions and can accurately detect corresponding acupuncture point data, the acupuncture point sensors 3 are arranged around the array microneedle chip 1, and one or more acupuncture point sensors 3 can be arranged to acquire different detection data, so that the final detection result is more accurate.
Example 4
The structure of this embodiment is basically the same as that of embodiment 1, except that the function of the acupuncture point sensor 3 is different.
The pressure, temperature and pain valve of the healthy acupuncture points and the sick acupuncture points have specificity, and in the treatment process, the treatment of the patient can be evaluated by detecting the change of data of the acupuncture point sensors 3 in the microsystem treatment device, and whether the treatment relieves or improves the disease state of the patient is judged.
For example, the acupoint sensor 3 may detect changes in temperature and/or pressure of the acupoints by using an acupoint temperature sensor for detecting temperature of the acupoints and/or an acupoint pressure sensor for detecting pressure of the acupoints, and determine whether the treatment on the patient is effective by detecting changes in temperature, pressure, pain valve, etc. of the acupoints, and various detection data may make the final detection result more accurate.
Example 5
The structure of this example is substantially the same as that of example 1, except that the microneedles 11 are different in size.
This example provides a microneedle array consisting of microneedles 11 having a diameter of 100 μm and a height of 200 μm, and a transdermal test was performed on a patient. The micro-needle array in the micro-system treatment device is aligned to the acupuncture point of a patient, the micro-system treatment device is fixed on the skin surface of the patient through the fixing surface 2, and the micro-needle 11 continuously stimulates the acupuncture point to achieve the purpose of treatment.
Example 6
The structure of this example is substantially the same as that of example 1, except that the microneedles 11 are different in size.
The present embodiment provides a microneedle array comprising microneedles 11 having a diameter of 160 μm and a height of 220 μm for targeted drug delivery to a patient. The micro needle 11 is coated with medicine for treating corresponding diseases, and the microsystem treatment device is attached to the corresponding acupuncture point of a patient, so that the acupuncture point targeted medicine penetration treatment is promoted, and the purpose of treating diseases is achieved.
Example 7
The structure of this example is substantially the same as that of example 1, except that the microneedles 11 are different in size.
This example provides a microneedle array consisting of microneedles 11 having a diameter of 80 μm and a height of 200 μm for stimulating acupuncture points on the face of a patient. The whole face of the patient is small in size, the micro-needle array is suitable for the micro-needles 11 and the micro-needle array with small sizes, the micro-needle array is prevented from stimulating other non-treatment areas to cause discomfort of the patient, and the size of the corresponding fixing surface 2 is preferably designed to be small when the micro-system treatment device is applied to the face.
Example 8
The structure of this example is substantially the same as that of example 7, except that the microneedles 11 are different in size.
This example provides a microneedle array comprising microneedles 11 having a diameter of 80 μm and a height of 160 μm for stimulating the acupuncture point region of the eye of a patient. The whole size of the eye of the patient is smaller, the micro-needle array is suitable for the micro-needles 11 and the micro-needle arrays with smaller sizes, the micro-needle arrays are prevented from stimulating other non-treatment areas to cause discomfort of the patient, and the size of the corresponding fixing surface 2 is preferably designed to be smaller when the micro-system treatment device is used for the eye.
Example 9
The structure of this example is substantially the same as that of example 1, except that the size of the array microneedle chip 1 is different.
This example provides a dimension of 0.2cm2The size of the microneedle array in the microneedle array chip 1 is approximately the same as the size of an acupuncture point region which needs to be treated and stimulated, so that the microneedle array can stimulate the complete acupuncture point region and can not stimulate a non-acupuncture point region, and discomfort of the non-acupuncture point region is caused.
Example 10
The structure of this embodiment is substantially the same as that of embodiment 1, except that the size of the fixing surface 2 is different.
This example provides a size of 2cm2The fixing surface 2 and the microsystem treatment device are used for carrying out pain easing tests on patients, and pain of the patients is relieved through stimulation of the micro-needles 11 to acupuncture points.
Example 11
The structure of this embodiment is basically the same as that of embodiment 3, except that the types and the number of the acupuncture point sensors 3 are different.
This example provides a dimension of 2.5cm 22 and 0.2cm of the fixing surface2The array microneedle chip 1, the fixed surface 2 adopts medical rubberized fabric, set up an acupuncture point pressure sensor respectively in the left and right sides of array microneedle chip 1 for detect the pressure data in acupuncture point region, judge whether array microneedle chip 1 just in time fixes a position in acupuncture point region. The acupoint pressure sensor canAs a MEMS (micro electro mechanical system) sensor.
In other alternative embodiments, the acupuncture point pressure sensors are not limited to be respectively arranged on the left side and the right side of the array microneedle chip 1, and the acupuncture point pressure sensors can be respectively arranged on the upper side and the lower side of the array microneedle chip 1; or one acupuncture point pressure sensor is respectively arranged on the left side and the upper side of the array micro-needle chip 1. The positions and the number of the acupuncture point pressure sensors can be adjusted according to actual requirements, but in order to enable the detection result to be more accurate, the acupuncture point pressure sensors are preferably arranged around the array microneedle chip 1.
The microsystem treatment device in this embodiment can also be used for precise external treatment in traditional Chinese medicine and timely evaluation of treatment effect, as in embodiment 4.
Example 12
The structure of this embodiment is basically the same as that of embodiment 11, except that the type of the acupuncture point sensor 3 is different.
This example provides a dimension of 2.5cm 22 and 0.2cm of the fixing surface2The array microneedle chip 1, the fixed surface 2 adopts medical rubberized fabric, set up an acupuncture point temperature sensor respectively in the left and right sides of array microneedle chip 1 for detect the temperature data in acupuncture point region, judge whether array microneedle chip 1 just in time fixes a position in acupuncture point region. The acupoint temperature sensor may be a MEMS (micro electro mechanical system) sensor.
In other alternative embodiments, the acupuncture point temperature sensors are not limited to be respectively arranged on the left side and the right side of the array microneedle chip 1, and the acupuncture point temperature sensors can be respectively arranged on the upper side and the lower side of the array microneedle chip 1; or one acupoint temperature sensor is respectively arranged on the left side and the upper side of the array microneedle chip 1. The positions and the number of the acupuncture point temperature sensors can be adjusted according to actual requirements, but in order to enable the detection result to be more accurate, the acupuncture point temperature sensors are preferably arranged around the array microneedle chip 1.
The microsystem treatment device in this embodiment can also be used for precise external treatment in traditional Chinese medicine and timely evaluation of treatment effect, as in embodiment 4.
Example 13
The structure of this embodiment is basically the same as that of embodiment 3, except that the types and the number of the acupuncture point sensors 3 are different.
This example provides a size of 3cm 22 and 0.2cm of the fixing surface2The array micro-needle chip 1, the fixed surface 2 adopts medical adhesive plaster, the left and right sides of the array micro-needle chip 1 are respectively provided with an acupuncture point temperature sensor and an acupuncture point pressure sensor, for the region with obvious tenderness, the acupuncture point pressure sensors are respectively arranged above and below the region, and for the region with skin temperature of the acupuncture point lower than the temperature of the surrounding skin, the acupuncture point temperature sensors are respectively arranged above and below the region. Whether the array microneedle chip 1 is exactly positioned in the acupoint area is judged by detecting the temperature and pressure data of the acupoint area. The acupoint temperature sensor and the acupoint pressure sensor can be MEMS (micro electro mechanical system) sensors.
In other alternative embodiments, the acupuncture point temperature sensor and the acupuncture point pressure sensor are not limited to be respectively arranged on the left side and the right side of the array microneedle chip 1, and can also be respectively arranged on the upper side and the lower side of the array microneedle chip 1; or the microneedle chip 1 is respectively arranged on the left side and the upper side, and the specific arrangement position and number can be adjusted according to the actual situation.
The microsystem treatment device in this embodiment can also be used for precise external treatment in traditional Chinese medicine and timely evaluation of treatment effect, as in embodiment 4.
Example 14
The structure of this embodiment is basically the same as that of embodiment 13, except that the number of the acupuncture point sensors 3 is different.
This example provides a size of 3cm 22 and 0.2cm of the fixing surface2The array microneedle chip 1, the fixed surface 2 adopts medical rubberized fabric, the left and right sides of the array microneedle chip 1 are respectively provided with an acupuncture point temperature sensor, and the upper and lower sides of the array microneedle chip 1 are respectively provided with an acupuncture point pressure sensor. Whether the array microneedle chip 1 is exactly positioned in the acupoint area is judged by detecting the temperature and pressure data of the acupoint area. In other alternative embodiments, the cavitiesThe positions of the position temperature sensor and the position of the acupuncture point pressure sensor can be interchanged, or the position temperature sensor and the position of the acupuncture point pressure sensor are arranged in a staggered mode.
The microsystem treatment device in this embodiment can also be used for precise external treatment in traditional Chinese medicine and timely evaluation of treatment effect, as in embodiment 4.
Example 15
The structure of this embodiment is substantially the same as that of embodiment 3, except that the structure of the fixing surface 2 is different.
The embodiment provides a film pressure sensor of wearing formula film display screen in area as stationary plane 2, and stationary plane 2 has included acupuncture point sensor 3 this moment, need not to set up in addition again and is used for detecting acupuncture point sensor 3 of acupuncture point data. The area is 0.2cm2The array microneedle chip 1 is arranged at one end, used for being attached to the skin, of the film pressure sensor and used for detecting pressure changes of the acupuncture point region, monitoring the pressure changes of the acupuncture point region and the skin region in real time through the film display screen and evaluating the effect of meridian treatment. The acupuncture point data detected by the film pressure sensor can be directly displayed by the film display screen, and a display screen specially used for displaying the detection data of the acupuncture point sensor 3 is not required to be configured, so that the detection data is more visual and is easy to obtain.
The film pressure sensor in this embodiment may also be used to determine the accuracy of positioning the array microneedle chip 1, perform precise external treatment in traditional Chinese medicine, and evaluate the treatment condition of the patient in time, as in embodiments 3 and 4.
Example 16
The structure of this embodiment is substantially the same as that of embodiment 15, except that the structure of the fixing surface 2 is different.
The embodiment provides a film temperature sensor of area wearing formula film display screen as stationary plane 2, and stationary plane 2 has included acupuncture point sensor 3 this moment, need not to set up in addition again and is used for detecting acupuncture point sensor 3 of acupuncture point data. The area is 0.2cm2The array microneedle chip 1 is arranged at one end, used for being attached to the skin, of the film temperature sensor and used for detecting the temperature change of an acupuncture point region, monitoring the pressure change of the acupuncture point region and a skin region in real time through the film display screen and evaluating the effect of meridian treatment. Film(s)The acupuncture point data detected by the temperature sensor can be directly displayed by the thin film display screen, and a display screen specially used for displaying the detection data of the acupuncture point sensor 3 is not required to be configured, so that the detection data is more visual and is easy to obtain.
The film pressure sensor in this embodiment may also be used to determine the accuracy of positioning the array microneedle chip 1, perform precise external treatment in traditional Chinese medicine, and evaluate the treatment condition of the patient in time, as in embodiments 3 and 4.
Effect example 1
This effect example uses the microsystem treatment device of example 1.
1. Subject: patients with neck pain.
2. The number of experimental people: 45 people.
3. Selecting a standard:
(1) the patient with neck pain is confirmed by the diagnosis of the traditional Chinese medicine and the western medicine;
(2) adult males or females between the ages of 18-65;
(3) repeated attacks of neck pain and neck stiffness discomfort, more than 1 attack per month and more than 3 months of continuous attack time;
(4) the current visit visual analogue rating (VAS) pain score is between 4 and 7 points (4. ltoreq. VAS. ltoreq.7);
(5) no other treatment was received for the last 3 months;
(6) no skin damage is locally generated;
(7) promise not to receive other relevant treatment methods (including drug treatment) during treatment;
(8) sign an informed consent and agree.
4. Exclusion criteria:
(1) patients with cervical spine trauma and in the acute phase;
(2) patients who have been treated with acupuncture or other treatments (including medication) that may affect the determination of efficacy in the last 3 months;
(3) the prior patients with cervical trauma operation history or thoracic vertebra trauma history, neurological deficit, congenital spinal abnormality and systemic bone or joint diseases;
(4) patients with diabetes or hyperglycemia;
(5) the local treatment of patients is affected by skin ulceration or contusion and laceration;
(6) patients with serious diseases (such as cardiovascular and cerebrovascular diseases, nervous system, liver, kidney, endocrine system, hemopoietic system, etc.), infectious diseases such as tuberculosis, tumor, etc.), psychosis patients, and postoperative patients;
(7) pregnant or lactating women.
5. Rejection standard:
(1) finding those that do not meet inclusion criteria during treatment;
(2) other serious complications or sudden deterioration of the disease.
6. The treatment method comprises the following steps: sterilizing the acupoint and microsystem treatment device conventionally, fixing the microsystem treatment device on the acupoint to be treated, slightly pressing for fixing, and taking down after 6-24 hr. During the period of needle retention, the buried part is pressed by hands for 1-2min every 4 hours to enhance stimulation and improve curative effect.
7. The treatment time is as follows: the treatment is carried out every other day, and 3 times is a treatment course.
8. Observation indexes are as follows: NPQ neck pain scale.
TABLE 1 data sheet of experimenters
| Detecting data | |
| Body temperature (. degree. C.) | 36.75±0.04 |
| Systolic pressure (mmHg) | 111.8±1.65 |
| Diastolic blood pressure (mmHg) | 74.02±0.94 |
| Heart rate (times/minutes) | 74.67±1.62 |
| Respiration (times/minutes) | 18.51±0.27 |
| Age (year of old) | 38.69±1.83 |
| Sex (male/female) | 5/40 |
| Occupation (physical/brain/physical) | 14/28/3 |
| Course of disease | 4(2，6) |
| Long term low head (Yes/No) | 39/6 |
TABLE 2 NPQ neck pain Scale
| Detecting data | |
| Before treatment (neck pain value) | 0.2202±0.0140 |
| For once treatment (neck pain value/P value) | 0.1929±0.0131/0.1581 |
| The treatment course is over (neck pain value/P value) | 0.138±0.0114/<0.0001 |
As can be seen from Table 2, the more the number of treatments, the smaller the value of the amount of neck pain, and the P value was less than 0.05, so that the differences examined were statistically significant, and it was concluded that the microsystem treatment device had the effect of treating the patient with neck pain.
Effect example 2
In this embodiment, the microsystem treatment apparatus in embodiment 1 is used, and the subjects, the number of experimental subjects, the selection criteria, the exclusion criteria, the treatment methods, and the treatment time in this embodiment are the same as those in embodiment 1, except that the observation indexes are different.
The observation criteria in this example are the McGill pain scale.
TABLE 3 McGill pain Scale
The more the treatment times are, the smaller the detection result of each numerical value is, and the P value after the treatment course is finished is less than 0.05, so the detected difference has statistical significance, and the microsystem treatment device can be inferred to have the treatment effect on the patient with the neck pain.
Effect example 3
The embodiment with the effect uses the microsystem treatment device in the embodiment 8, the microsystem treatment device is applied to an eye acupoint after being sterilized, the microneedle arrays are respectively aligned to Jingming acupoint, Zanzhu acupoint, Taiyang acupoint, Sibai acupoint, Chengzhu acupoint and Chengzhu acupoint, and are left for 12 hours, 1 time every other day, and 10 days is a treatment course, so that the asthenopia can be effectively relieved.
Effect example 4
In the embodiment with the effects, the microsystem treatment device in the embodiment 7 is used, and after being sterilized, the microsystem treatment device is pasted on the nebula acupoint and the dialectic facial acupoint, so that the symptom of facial paralysis can be effectively relieved.
Effect example 5
In this effective example, the transdermal test as in example 5 was performed, and after aligning the microneedle array in the microsystem treatment device to the tsusanli acupoint region of the rat, the microsystem treatment device was fixed to the rat for 6 hours, the microsystem treatment device was removed, and the skin of the rat tsusanli acupoint region stimulated by the microsystem treatment device and the skin of the rat tsusanli acupoint region not stimulated by the microsystem treatment device were sampled, respectively. Two groups of skin were paraffin sectioned and stained with toluidine blue.
Observing two groups of skins by a microscope, wherein, fig. 6-7 are rat tsusanli acupoint areas skins after being stimulated by a microsystem treatment device, fig. 7 is an enlarged view of an area A in fig. 6, and an area B in fig. 6-7 is an acupoint area stimulated by a micro needle array; fig. 8 to 9 show the skin of the rat tsusanli acupoint region without being stimulated by the microsystem treatment device, fig. 9 is an enlarged view of the region C in fig. 8, and the region D in fig. 8 to 9 shows the acupoint region without being stimulated by the microneedle array in the normal state. Through comparison of fig. 6 to 7 and fig. 8 to 9, it can be seen that the microneedles 11 do not form a visible pore size on the skin surface nor a distinct regular indentation on the skin surface. Therefore, the microsystem treatment device does not puncture the skin and is safer in the aspect of traditional Chinese medicine external treatment.
Effect example 6
Rats were divided into three groups and three different experiments were performed.
Experiment 2 a smooth silicon wafer was used, i.e. no microneedle array was placed on the wafer, which was soaked and evenly coated with histamine (2mg/mL), aimed at the plantar trillionic region of the rat, and was fixed on the rat.
After histamine in the three experiments stagnates in the foot three-acupoint region of the rat for the same period of time, the skin and subcutaneous tissues in the foot three-acupoint region of the rat in the three experiments are respectively taken, paraffin section and toluidine blue staining are carried out, the degranulation rate of each group of mast cells is observed and counted, and the influence on the penetration effect of histamine under different conditions is analyzed.
The statistical results are shown in fig. 10, the leftmost dotted histogram is the statistical data of experiment 1, the middle latticed histogram is the statistical data of experiment 2, and the rightmost striped histogram is the statistical data of experiment 3, wherein the statistical method adopts one-factor analysis of variance. According to data statistics, experiment 1 had a significant statistical difference (P <0.001) compared to experiment 3, and experiment 2 also had a significant statistical difference (P <0.01) compared to experiment 3.
Both the microsystem treatment device of experiment 1 and the smooth silicon wafer of experiment 2 enhanced the penetration of histamine by statistical analysis of the mast cell degranulation rate, wherein the microsystem treatment device of experiment 1 was more effective than the smooth silicon wafer of experiment 2.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like are used in the orientation or positional relationship indicated in the drawings, which are for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, are not to be construed as limiting the present invention unless otherwise indicated herein.
Although specific embodiments of the present invention have been described above, it will be understood by those skilled in the art that this is by way of example only and that the scope of the invention is defined by the appended claims. Various changes and modifications to these embodiments may be made by those skilled in the art without departing from the spirit and the principles of the present invention, and these changes and modifications are all within the scope of the present invention.
Claims (10)
1. A microsystem treatment device comprises an array microneedle chip and is characterized in that the array microneedle chip comprises a matrix microneedle array, the microneedle array is formed by arranging a plurality of microneedles, the microneedles are of non-conical columnar structures, and the treatment ends of the microneedles are round surfaces.
2. The microsystem treatment device of claim 1, wherein the circular face of the treatment end of the microneedle is planar or spherical.
3. The microsystem treatment device of claim 1, wherein the array microneedle chip has an area of 0.2cm2-0.3cm2。
4. The microsystem treatment device according to claim 1, wherein the microneedle is a MEMS (micro electro mechanical system) microneedle, the microneedle having a diameter of 80 μ ι η to 160 μ ι η and a height of 120 μ ι η to 220 μ ι η.
5. The microsystem treatment device of claim 1, further comprising a mounting surface on which the array microneedle chip is disposed.
6. The microsystem treatment device according to claim 5, wherein an acupoint sensor is further provided on the fixing surface, and the acupoint sensor and the array microneedle chip are located on the same end surface of the fixing surface.
7. The microsystem treatment device according to claim 6, wherein the acupoint sensor comprises an acupoint temperature sensor and/or an acupoint pressure sensor.
8. The microsystem treatment device of claim 6, wherein the acupoint sensor is disposed around the array microneedle chip.
9. The microsystem treatment device according to claim 5, wherein the fastening surface is a medical adhesive tape.
10. The microsystem treatment device of claim 5, wherein the fixed surface is a thin film sensor with a wearable thin film display screen.
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| CN113058152A (en) * | 2021-03-15 | 2021-07-02 | 优微智点(北京)生物科技有限公司 | Reversible thermochromic microcapsule biological identification type soluble microneedle acupoint plaster |
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