CN211613077U

CN211613077U - High-efficient centrifugal equipment of bispecific antibody

Info

Publication number: CN211613077U
Application number: CN202020145016.2U
Authority: CN
Inventors: 张扬
Original assignee: Zhongkebaocheng Biomedical Technology Co ltd
Current assignee: Zhongkebaocheng Biomedical Technology Co ltd
Priority date: 2020-01-23
Filing date: 2020-01-23
Publication date: 2020-10-02
Anticipated expiration: 2030-01-23

Abstract

The utility model discloses a high-efficient centrifugal equipment of bispecific antibody, include centrifuge tube, pneumatic cylinder, bear frame, motor, rotation axis, gear one, connecting plate, driven shaft, loading board and sealed lid, its characterized in that: the centrifugal cylinder is arranged on the support, the hydraulic cylinder is arranged at the bottom of the centrifugal cylinder, the bearing frame is arranged on the piston rod, the motor is arranged on the bearing frame, one end of the rotating shaft is connected with the motor, the first gear is provided with a connecting ring, the connecting plate is arranged on the bearing frame, and the driven shaft vertically penetrates through the second bearing. The utility model discloses be provided with the fastening pad on the bearing groove inner wall on the loading board, the vertical bearing groove that penetrates of test tube that will be equipped with the bispecific antibody can play the fixed action to the test tube through the fastening pad, avoids the test tube to take place vertical rocking in centrifugal process, improves the stability of test tube in bispecific antibody centrifugal process, reinforcing bispecific antibody centrifugation effect.

Description

High-efficient centrifugal equipment of bispecific antibody

Technical Field

The utility model relates to a bispecific antibody production technical field specifically is a high-efficient centrifugal equipment of bispecific antibody.

Background

The bispecific antibody needs to be centrifuged at a certain rotating speed at a specific temperature in the production process, so that the active ingredients of the bispecific antibody can be separated, the quality of the bispecific antibody can be ensured, the structural denaturation of the bispecific antibody can be avoided, and the binding capacity of the bispecific antibody can be ensured.

Disclosure of Invention

The utility model aims at providing a inconvenient putting into centrifugal device and taking out the bispecific antibody from centrifugal device, work efficiency is low, the not good problem of bispecific antibody centrifugation effect to the bispecific antibody that present bispecific antibody centrifugal device exists, provide a structural design is reasonable, be convenient for bispecific antibody put into centrifugal device and take out the bispecific antibody from centrifugal device, work efficiency is high, the high-efficient centrifugal equipment of bispecific antibody that the bispecific antibody centrifugation is effectual.

The utility model provides a technical scheme that technical problem taken does:

the utility model provides a high-efficient centrifugal equipment of bispecific antibody, includes centrifuge tube, pneumatic cylinder, bears frame, motor, rotation axis, gear one, connecting plate, driven shaft, loading board and sealed lid, its characterized in that: the centrifugal cylinder is arranged on the bracket, the centrifugal cylinder is connected with the bracket through welding, the connection strength between the centrifugal cylinder and the bracket is enhanced, the structural strength of centrifugal equipment is improved, the hydraulic cylinder is arranged at the bottom of the centrifugal cylinder, the piston rod is arranged on the hydraulic cylinder, the piston rod vertically penetrates into the centrifugal cylinder, the hydraulic cylinder is connected with the centrifugal cylinder through a bolt, the stability of the hydraulic cylinder on the centrifugal cylinder is improved, and the stability of the hydraulic cylinder in the working process can also be enhanced, the bearing frame is arranged on the piston rod, the bearing I is arranged on the bearing frame, the bearing frame is connected with the piston rod through welding, the connection strength between the bearing frame and the piston rod is improved, the stability of the bearing frame in the up-and-down moving process under the action of the hydraulic cylinder and the piston rod is enhanced, so that a test tube provided with a bispecific antibody can be conveniently taken, the labor intensity of operators is reduced, the motor is arranged on the bearing frame through bolts, the installation efficiency and the stability after installation of the motor are improved, the stability of the motor in the working process is enhanced, one end of the rotating shaft is connected with the motor, the other end of the rotating shaft extends into the first bearing, the first gear is provided with a connecting ring, the connecting ring is sleeved on the rotating shaft through a fastening bolt, the connecting plate is arranged on the bearing frame and provided with a second bearing, the driven shaft vertically penetrates through the second bearing, the bottom end of the driven shaft is provided with a second gear, the bearing plate is provided with an installation ring, a bearing groove is arranged on the bearing plate and connected with the top end of the driven shaft, a test tube provided with the bispecific antibody vertically penetrates through the bearing groove on the bearing plate, and the motor drives the rotating shaft to rotate, the rotating shaft drives the first gear to rotate, the second gear drives the second gear to rotate, the second gear drives the driven shaft to rotate in the second bearing, the driven shaft drives the bearing plate and the bispecific antibody placed on the bearing plate to rotate, thereby carrying out centrifugal treatment on the bispecific antibody, improving the centrifugal efficiency and the centrifugal quality of the bispecific antibody, reducing the labor intensity of operators, wherein the sealing cover is movably connected with the top end of the centrifugal cylinder, be provided with the baffle through the spring in sealed lid, sealed lid promotes the baffle through the spring and descends, and the baffle plays limiting displacement to the test tube of the rotatory centrifugal process of bispecific antibody, and the test tube of centrifugal process can be at the inslot rebound of bearing the weight of under the effect of centrifugal force, and the elasticity of spring promotes the baffle downwards, makes the baffle block the test tube and rises, improves the stability of test tube in bispecific antibody centrifugal process.

Preferably, the motor is a servo motor, the motor drives the rotating shaft to rotate in the forward direction or the reverse direction, the rotating shaft drives the gear I to rotate in the forward direction or the reverse direction, the gear drives the gear II to rotate in the forward direction or the reverse direction, the gear II drives the driven shaft to rotate in the forward direction or the reverse direction in the bearing II, and the driven shaft drives the bearing plate and the bispecific antibody placed on the bearing plate to rotate in the forward direction or the reverse direction, so that the bispecific antibody is subjected to centrifugal treatment, the centrifugal efficiency and the centrifugal quality of the bispecific antibody are improved, and the labor intensity of operators is reduced.

Preferably, the first gear is arranged to be replaceable on the rotating shaft through the connecting ring and the fastening bolt, the first gear with the proper size is selected according to centrifugal rotating speed requirements of different bispecific antibodies, the first gear is sleeved on the rotating shaft through the connecting ring and the fastening bolt, the motor drives the rotating shaft to rotate, the rotating shaft drives the first gears to rotate, the rotating speeds of the first gears are different due to different sizes of the first gears, the ratio between the first gears and the second gears is different, the rotating speeds of the second gears are different due to the fact that the first gears drive the second gears, further the rotating speeds of the driven shaft and the bearing plates on the driven shaft are different, the proper rotating speed of the bispecific antibodies can be subjected to centrifugal treatment, the centrifugal effect of the bispecific antibodies is improved, the universality of the centrifugal equipment can be improved, and the application range of the centrifugal equipment is expanded.

Preferably, the cross sections of the first gear and the second gear are both of an isosceles trapezoid structure, the first gear is connected with the second gear, the motor drives the rotating shaft to rotate, the rotating shaft drives the first gear to rotate, the gear drives the second gear to rotate, the second gear drives the driven shaft to rotate in the second bearing, and the driven shaft drives the bearing plate and the bispecific antibody placed on the bearing plate to rotate, so that the bispecific antibody is subjected to centrifugal treatment, the centrifugal efficiency and the centrifugal quality of the bispecific antibody are improved, and the labor intensity of operators is reduced.

Preferably, the loading board pass through the collar and set up the structure that can change on the driven shaft, pass through the screw thread with the collar on the loading board and be connected with the driven shaft, improve the installation effectiveness of loading board on the driven shaft, the change of loading board on the driven shaft of being convenient for, the test tube that will be equipped with bispecific antibody is vertical to be passed the bearing groove on the loading board, the loading board is rotatory under the drive of driven shaft, drive test tube and the bispecific antibody in the test tube and rotate, carry out centrifugal treatment to bispecific antibody in the test tube, the centrifugal effect of work efficiency and bispecific antibody has been improved, bispecific antibody centrifugal equipment's application scope has been enlarged.

Preferably, the loading board on be provided with the fastening pad on the bearing groove inner wall, the vertical bearing groove that penetrates of test tube that will be equipped with the bispecific antibody can play the fixed action to the test tube through the fastening pad, avoid the test tube to take place vertical rocking in centrifugal process, improve the stability of test tube in bispecific antibody centrifugal process, reinforcing bispecific antibody centrifugation effect.

Preferably, the sealed back of covering on be provided with the connecting rod perpendicularly, the baffle on seted up the connecting hole, and pass the connecting hole with the connecting rod is vertical, it installs on the centrifuge tube through the screw thread to seal the lid, sealed lid promotes the baffle through the spring and descends, the baffle plays limiting displacement to the test tube of the rotatory centrifugation in-process of bispecific antibody, the test tube of centrifugation in-process can be at the inslot rebound that bears under the effect of centrifugal force, the elasticity of spring promotes the baffle downwards, make the baffle block the test tube and rise, improve the stability of test tube in bispecific antibody centrifugation, pass the connecting hole with the connecting rod is vertical, make the baffle can reciprocate along the connecting rod, avoid the baffle to take place transversely to rock along with rotatory test tube, further improve the stability of test tube in bispecific antibody centrifugation.

Has the advantages that: the utility model discloses pass through the collar with the loading board and set up the structure that can change on the driven shaft, pass through the screw thread with the collar on the loading board and be connected with the driven shaft, improve the installation effectiveness of loading board on the driven shaft, the change of loading board on the driven shaft of being convenient for, the test tube that will be equipped with the bispecific antibody is vertical to be passed the bearing groove on the loading board, the loading board is rotatory under the drive of driven shaft, it rotates to drive the test tube and the bispecific antibody in the test tube, carry out centrifugal treatment to the bispecific antibody in the test tube, the centrifugal effect of work efficiency and bispecific antibody has been improved, bispecific antibody centrifugal equipment's application scope has been enlarged.

Drawings

Fig. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a schematic view of a part of the structure of the present invention, illustrating a connection structure of the first gear and the second gear.

Fig. 3 is a schematic view of a part of the structure of the present invention, illustrating the connection structure of the bearing plate and the bearing groove.

Fig. 4 is a bottom view of fig. 3 according to the present invention.

Fig. 5 is a schematic view of a part of the structure of the present invention, illustrating the connection structure of the sealing cover and the baffle.

Fig. 6 is a schematic view of a part of the structure of the present invention, illustrating the connection structure of the baffle and the spring.

Fig. 7 is a schematic diagram of another embodiment of the present invention.

In the figure: 1. the centrifugal cylinder comprises a centrifugal cylinder, 2 hydraulic cylinders, 3 bearing frames, 4 motors, 5 rotating shafts, 6 gears I, 7 connecting plates, 8 driven shafts, 9 bearing plates, 10 sealing covers, 11 supports, 12 piston rods, 13 bearings I, 14 connecting rings, 15 fastening bolts, 16 bearings II, 17 gears II, 18 mounting rings, 19 bearing grooves, 20 fastening pads, 21 springs, 22 baffles, 23 connecting rods, 24 connecting holes and 25 limiting rods.

Detailed Description

The present invention will be described in more detail with reference to the accompanying drawings.

The first embodiment is as follows:

as shown in fig. 1-6, a high-efficiency centrifugal apparatus with bispecific antibody comprises a centrifugal cylinder 1, a hydraulic cylinder 2, a bearing frame 3, a motor 4, a rotating shaft 5, a first gear 6, a connecting plate 7, a driven shaft 8, a bearing plate 9 and a sealing cover 10, and is characterized in that: the centrifugal cylinder 1 is arranged on the support 11, the centrifugal cylinder 1 is connected with the support 11 through welding, the connection strength between the centrifugal cylinder 1 and the support 11 is enhanced, the structural strength of centrifugal equipment is improved, the hydraulic cylinder 2 is arranged at the bottom of the centrifugal cylinder 1, the piston rod 12 is arranged on the hydraulic cylinder 2, the piston rod 12 vertically penetrates into the centrifugal cylinder 1, the hydraulic cylinder 2 is connected with the centrifugal cylinder 1 through a bolt, the stability of the hydraulic cylinder 2 on the centrifugal cylinder 1 is improved, the stability of the hydraulic cylinder 2 in the working process can also be enhanced, the bearing frame 3 is arranged on the piston rod 12, the bearing frame 3 is provided with the bearing I13, the bearing frame 3 is connected with the piston rod 12 through welding, the connection strength between the bearing frame 3 and the piston rod 12 is improved, and the stability of the bearing frame 3 in the up-down moving process under the action of the hydraulic cylinder 2 and the piston rod 12, thereby being convenient for taking and placing test tubes with the bispecific antibody, improving the centrifugal efficiency of the bispecific antibody and reducing the labor intensity of operators, the motor 4 is arranged on the bearing frame 3 through bolts, improving the installation efficiency of the motor 4 and the stability after installation, enhancing the stability of the motor 4 in the working process, one end of the rotating shaft 5 is connected with the motor 4, the other end extends into the bearing I13, the gear I6 is provided with the connecting ring 14, the connecting ring 14 is sleeved on the rotating shaft 5 through the fastening bolt 15, the connecting plate 7 is arranged on the bearing frame 3, the connecting plate 7 is provided with the bearing II 16, the driven shaft 8 vertically passes through the bearing II 16, the bottom end of the driven shaft 8 is provided with the gear II 17, the bearing plate 9 is provided with the installation ring 18, a bearing groove 19 is arranged on a bearing plate 9, a mounting ring 18 is connected with the top end of a driven shaft 8, a test tube filled with a bispecific antibody vertically penetrates through the bearing groove 19 on the bearing plate 9, a motor 4 drives a rotating shaft 5 to rotate, the rotating shaft 5 drives a gear I6 to rotate, the gear I6 drives a gear II 17 to rotate, the gear II 17 drives the driven shaft 8 to rotate in a bearing II 16, the driven shaft 8 drives the bearing plate 9 and the bispecific antibody placed on the bearing plate 9 to rotate, so that the bispecific antibody is centrifugally treated, the centrifugal efficiency and centrifugal quality of the bispecific antibody are improved, the labor intensity of operators is reduced, a sealing cover 10 is movably connected with the top end of a centrifugal cylinder 1, a baffle plate 22 is arranged in the sealing cover 10 through a spring 21, the sealing cover 10 pushes the baffle plate 22 to descend through the spring 21, and the baffle plate 22 plays a limiting role on the test tube in the process, the test tube in the centrifugation process can move upwards in the bearing groove 19 under the action of centrifugal force, the baffle 22 is pushed downwards by the elastic force of the spring 21, the baffle 22 prevents the test tube from rising, and the stability of the test tube in the bispecific antibody centrifugation process is improved.

Preferably, the motor 4 is set as a servo motor 4, the motor 4 drives the rotating shaft 5 to rotate forward or backward, the rotating shaft 5 drives the gear I6 to rotate forward or backward, the gear I6 drives the gear II 17 to rotate forward or backward, the gear II 17 drives the driven shaft 8 to rotate forward or backward in the bearing II 16, and the driven shaft 8 drives the bearing plate 9 and the bispecific antibody placed on the bearing plate 9 to rotate forward or backward, so that the bispecific antibody is centrifuged, the centrifugation efficiency and the centrifugation quality of the bispecific antibody are improved, and the labor intensity of operators is reduced.

Preferably, the first gear 6 is provided with a replaceable structure on the rotating shaft 5 through a connecting ring 14 and a fastening bolt 15, according to the centrifugal rotating speed requirements of different bispecific antibodies, gear I6 with the same size is selected, the gear I6 is sleeved on the rotating shaft 5 through a connecting ring 14 and a fastening bolt 15, the motor 4 drives the rotating shaft 5 to rotate, the rotating shaft 5 drives the gears I6 to rotate, the rotating speeds of the gears I6 are different due to different sizes of the gear I6, the rotating speeds of the gears I6 are different due to different proportions between the gear I6 and the gear II 17, the rotating speeds of the gears I6 driving the gear II 17 are different, and then make driven shaft 8 and bearing plate 9 rotational speed on the driven shaft 8 different, can carry out centrifugal treatment to bispecific antibody suitable rotational speed, improved bispecific antibody's centrifugal effect, also can improve centrifugal apparatus's commonality, enlarged centrifugal apparatus's application scope.

Preferably, the cross sections of the first gear 6 and the second gear 17 are both of an isosceles trapezoid structure, the first gear 6 is connected with the second gear 17, the motor 4 drives the rotating shaft 5 to rotate, the rotating shaft 5 drives the first gear 6 to rotate, the first gear 6 drives the second gear 17 to rotate, the second gear 17 drives the driven shaft 8 to rotate in the second bearing 16, and the driven shaft 8 drives the bearing plate 9 and the bispecific antibody placed on the bearing plate 9 to rotate, so that the bispecific antibody is centrifuged, the centrifugation efficiency and the centrifugation quality of the bispecific antibody are improved, and the labor intensity of operators is reduced.

Preferably, the bearing plate 9 set up to the structure that can change on driven shaft 8 through collar 18, be connected bearing plate 9 on collar 18 through screw thread and driven shaft 8, improve the installation effectiveness of bearing plate 9 on driven shaft 8, be convenient for the change of bearing plate 9 on driven shaft 8, the test tube that will be equipped with bispecific antibody is vertical to pass bearing groove 19 on the bearing plate 9, bearing plate 9 is rotatory under driven shaft 8's drive, drive test tube and the interior bispecific antibody of test tube and rotate, carry out centrifugal treatment to the bispecific antibody in the test tube, the centrifugal effect of work efficiency and bispecific antibody has been improved, bispecific antibody centrifugal equipment's application scope has been enlarged.

Preferably, bearing plate 9 on be provided with fastening pad 20 on the 19 inner walls of bearing groove, the test tube that will be equipped with the bispecific antibody vertically penetrates bearing groove 19, can play the fixed action to the test tube through fastening pad 20, avoid the test tube to take place vertically to rock in centrifugal process, improve the stability of test tube in bispecific antibody centrifugal process, reinforcing bispecific antibody centrifugal effect.

Preferably, a connecting rod 23 is vertically arranged on the back surface of the sealing cover 10, a connecting hole 24 is arranged on the baffle plate 22, and pass connecting rod 23 is vertical connecting hole 24, pass through threaded mounting on centrifuge tube 1 with sealed lid 10, sealed lid 10 promotes baffle 22 through spring 21 and descends, baffle 22 plays limiting displacement to the test tube of the rotatory centrifugation in-process of bispecific antibody, the test tube in the centrifugation can upwards move in bearing groove 19 under the effect of centrifugal force, spring 21's elasticity promotes baffle 22 downwards, make baffle 22 block the test tube and rise, improve the stability of test tube in the centrifugation of bispecific antibody, pass connecting rod 23 is vertical connecting hole 24, make baffle 22 can reciprocate along connecting rod 23, avoid baffle 22 to take place transversely to rock along with rotatory test tube, further improve the stability of test tube in the centrifugation of bispecific antibody.

Example two:

as shown in the attached figure 7, the high-efficiency centrifugal equipment for the bispecific antibody comprises a centrifugal cylinder 1, a hydraulic cylinder 2, a bearing frame 3, a motor 4, a rotating shaft 5, a first gear 6, a connecting plate 7, a driven shaft 8, a bearing plate 9 and a sealing cover 10, and is characterized in that: the centrifugal cylinder 1 is arranged on the support 11, the centrifugal cylinder 1 is connected with the support 11 through welding, the connection strength between the centrifugal cylinder 1 and the support 11 is enhanced, the structural strength of centrifugal equipment is improved, the hydraulic cylinder 2 is arranged at the bottom of the centrifugal cylinder 1, the piston rod 12 is arranged on the hydraulic cylinder 2, the piston rod 12 vertically penetrates into the centrifugal cylinder 1, the hydraulic cylinder 2 is connected with the centrifugal cylinder 1 through a bolt, the stability of the hydraulic cylinder 2 on the centrifugal cylinder 1 is improved, the stability of the hydraulic cylinder 2 in the working process can also be enhanced, the bearing frame 3 is arranged on the piston rod 12, the bearing frame 3 is provided with the bearing I13, the bearing frame 3 is connected with the piston rod 12 through welding, the connection strength between the bearing frame 3 and the piston rod 12 is improved, and the stability of the bearing frame 3 in the up-down moving process under the action of the hydraulic cylinder 2 and the piston rod 12, thereby being convenient for taking and placing test tubes with the bispecific antibody, improving the centrifugal efficiency of the bispecific antibody and reducing the labor intensity of operators, the motor 4 is arranged on the bearing frame 3 through bolts, improving the installation efficiency of the motor 4 and the stability after installation, enhancing the stability of the motor 4 in the working process, one end of the rotating shaft 5 is connected with the motor 4, the other end extends into the bearing I13, the gear I6 is provided with the connecting ring 14, the connecting ring 14 is sleeved on the rotating shaft 5 through the fastening bolt 15, the connecting plate 7 is arranged on the bearing frame 3, the connecting plate 7 is provided with the bearing II 16, the driven shaft 8 vertically passes through the bearing II 16, the bottom end of the driven shaft 8 is provided with the gear II 17, the bearing plate 9 is provided with the installation ring 18, a bearing groove 19 is arranged on a bearing plate 9, a mounting ring 18 is connected with the top end of a driven shaft 8, a test tube filled with a bispecific antibody vertically penetrates through the bearing groove 19 on the bearing plate 9, a motor 4 drives a rotating shaft 5 to rotate, the rotating shaft 5 drives a gear I6 to rotate, the gear I6 drives a gear II 17 to rotate, the gear II 17 drives the driven shaft 8 to rotate in a bearing II 16, the driven shaft 8 drives the bearing plate 9 and the bispecific antibody placed on the bearing plate 9 to rotate, so that the bispecific antibody is centrifugally treated, the centrifugal efficiency and centrifugal quality of the bispecific antibody are improved, the labor intensity of operators is reduced, a sealing cover 10 is movably connected with the top end of a centrifugal cylinder 1, a baffle plate 22 is arranged in the sealing cover 10 through a spring 21, the sealing cover 10 pushes the baffle plate 22 to descend through the spring 21, and the baffle plate 22 plays a limiting role on the test tube in the process, the test tube in the centrifugation process can move upwards in the bearing groove 19 under the action of centrifugal force, the baffle 22 is pushed downwards by the elastic force of the spring 21, the baffle 22 prevents the test tube from rising, and the stability of the test tube in the bispecific antibody centrifugation process is improved.

Preferably, the bottom in the centrifuge bowl 1 is vertically provided with a limiting rod 25, and the limiting rod 25 vertically penetrates through the bearing frame 3, so that the stability of the bearing frame 3 in the ascending or descending process can be improved through the limiting rod 25, the transverse deviation of the bearing frame 3 in the ascending or descending process is avoided, the stability of the bispecific antibody in the centrifugation treatment process is further improved, and the centrifugation treatment effect of the bispecific antibody is enhanced.

The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

The utility model discloses the part that does not relate to all is the same with prior art or can adopt prior art to realize.

Claims

1. The utility model provides a high-efficient centrifugal equipment of bispecific antibody, includes centrifuge tube, pneumatic cylinder, bears frame, motor, rotation axis, gear one, connecting plate, driven shaft, loading board and sealed lid, its characterized in that: the centrifugal cylinder is arranged on the bracket, the hydraulic cylinder is arranged at the bottom of the centrifugal cylinder, a piston rod is arranged on the hydraulic cylinder, the piston rod vertically penetrates into the centrifugal cylinder, the bearing frame is arranged on the piston rod, a bearing is arranged on the bearing frame, the motor is arranged on the bearing frame, one end of the rotating shaft is connected with the motor, the other end of the rotating shaft extends into the bearing I, the gear I is provided with a connecting ring, the connecting ring is sleeved on the rotating shaft through a fastening bolt, the connecting plate is arranged on the bearing frame, a bearing II is arranged on the connecting plate, the driven shaft vertically penetrates through the bearing II, a gear II is arranged at the bottom end of the driven shaft, the bearing plate is provided with a mounting ring, a bearing groove is arranged on the bearing plate, the mounting ring is connected with the top end of the driven shaft, and the sealing cover is movably connected with the top, a baffle is arranged in the sealing cover through a spring.

2. The bispecific antibody high-efficiency centrifugation device according to claim 1, characterized in that: the motor is set as a servo motor.

3. The bispecific antibody high-efficiency centrifugation device according to claim 1, characterized in that: the first gear is arranged to be replaceable on the rotating shaft through a connecting ring and a fastening bolt.

4. The bispecific antibody high-efficiency centrifugation device according to claim 1, characterized in that: the cross sections of the first gear and the second gear are both of isosceles trapezoid structures, and the first gear is connected with the second gear.

5. The bispecific antibody high-efficiency centrifugation device according to claim 1, characterized in that: the bearing plate is arranged to be a structure which can be replaced on the driven shaft through the mounting ring.

6. The bispecific antibody high-efficiency centrifugation device according to claim 1, characterized in that: and fastening pads are arranged on the inner wall of the bearing groove on the bearing plate.

7. The bispecific antibody high-efficiency centrifugation device according to claim 1, characterized in that: the back of the sealing cover is vertically provided with a connecting rod, the baffle is provided with a connecting hole, and the connecting rod vertically penetrates through the connecting hole.