CN211586590U - Novel reaction device for gefitinib nitration process - Google Patents
Novel reaction device for gefitinib nitration process Download PDFInfo
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- CN211586590U CN211586590U CN201922371171.6U CN201922371171U CN211586590U CN 211586590 U CN211586590 U CN 211586590U CN 201922371171 U CN201922371171 U CN 201922371171U CN 211586590 U CN211586590 U CN 211586590U
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Abstract
The utility model provides a novel reaction unit of gefitinib nitration technology, includes the outer cauldron body, the outer cauldron body is including outer cauldron body and outer cauldron lid, and outer cauldron body is open-top's container, and its bottom is provided with the base and is used for supporting, and outer cauldron body lateral wall is hollow structure, is provided with inlet and liquid outlet on the outer cauldron body, and outer cauldron lid is for covering outer cauldron body open-ended lid, and outer cauldron covers swing joint and has the puddler, and in the puddler stretched into outer cauldron body, the puddler rotated under power device drives, the internal interior cauldron body that still is provided with of outer cauldron. The novel reaction device for the gefitinib nitration process is provided with the replaceable inner kettle body, the inner kettle body can be made of different materials and can be replaced according to process requirements, the equipment cost is greatly reduced, and the equipment utilization rate is improved.
Description
Technical Field
The utility model relates to a nitrify reactor equipment field, especially relate to a novel reaction unit of gefitinib nitration technology.
Background
Gefitinib is an oral epidermal growth factor receptor tyrosine kinase inhibitor. The preparation process comprises a nitration process and needs to use a nitration reaction kettle. Different acid liquids are needed in the nitration process, and reaction kettles made of different materials are needed to be used as reactors for different acid liquids. Because the reaction kettle body comprises a plurality of functional structures such as a heating structure, the whole kettle body structure is complex, the cost for preparing a plurality of reaction kettles made of different materials is high, and meanwhile, the utilization rate of the reaction kettles made of individual special materials is not high, so that the waste of equipment resources is caused.
Disclosure of Invention
In order to solve the problem, the utility model provides a novel reaction unit of gefitinib nitration technology is provided with removable interior cauldron body, and interior cauldron body can use different materials to make, changes according to the technology needs, reduces equipment cost greatly, lifting means utilization ratio.
To achieve the purpose, the utility model provides a novel reaction device for gefitinib nitration process, which comprises an outer kettle body, wherein the outer kettle body comprises an outer kettle body and an outer kettle cover, the outer kettle body is a container with an open top, the bottom of the outer kettle body is provided with a base for supporting, the outer kettle cover is a cover body for covering the opening of the outer kettle body, the outer kettle cover is movably connected with a stirring rod, the stirring rod extends into the outer kettle body, the stirring rod rotates under the driving of a power device, the reaction device is characterized in that the outer kettle body is also internally provided with an inner kettle body, the inner kettle body comprises an inner kettle body and an inner kettle cover, the inner kettle body is a container with an open top, the outer wall of the inner kettle body is attached to the inner wall of the outer kettle body, the inner kettle cover is of a disc-shaped structure with the same thickness as the wall thickness of the inner kettle body, the inner kettle cover covers the opening of the inner kettle body, the inner kettle cover is provided with an acid inlet and a feed, through holes are arranged on the outer kettle cover corresponding to the acid inlet and the feed inlet, and the acid inlet and the feed inlet penetrate through the through holes on the outer kettle cover and extend to the outside of the outer kettle cover; the outer kettle body, the outer kettle cover, the inner kettle body and the inner kettle cover are connected through flanges; the stirring rod comprises a power rod and a movable rod, the power rod is movably connected to the outer kettle cover and is driven to rotate by a power device, the lower end of the power rod extends into the outer kettle body, the power rod is detachably connected to the movable rod, and blades for stirring are arranged on the movable rod; the inner kettle cover is provided with a position yielding port corresponding to the position of the power rod, the position yielding port is a through hole, and the power rod penetrates through the position yielding port.
The utility model discloses a further improvement, the movable rod top is provided with the constant head tank, the power pole lower extreme corresponds the constant head tank and is provided with matched with location arch, the location is protruding to stretch into the constant head tank in the back, closes soon through at least two sets of fixing bolt and fixation nut and fixes.
The utility model discloses a further improvement, be provided with the sealing member between interior cauldron body and the interior cauldron lid, interior cauldron body abdication mouth department and the outer cauldron lid between be provided with the sealing member, the sealing member is acidproof sealed the pad.
The utility model discloses a further improvement, outer cauldron body lateral wall is hollow structure, is provided with inlet and liquid outlet on one's body to outer cauldron, and outer cauldron body lateral wall inner cavity is all connected to inlet and liquid outlet, pours into the fluid realization heating that has the temperature, keeps warm or the function of cooling through the outside cauldron body lateral wall inner cavity of inlet.
The utility model discloses a further improvement, interior cauldron body wall thickness is no longer than 5 mm.
The application provides a novel reaction unit of gefitinib nitration technology, its technical effect who realizes as follows:
the outer cauldron body sets up with the separation of the interior cauldron body, and both can dismantle the connection, and the structure that is used for functions such as heating, stirring is gone up to the outer cauldron body, and the interior cauldron body is only for the thin containment structure of thickness, according to the technology demand, the interior cauldron body of removable different materials, because interior cauldron body material quality is less than the reactor of equal material greatly, and the internal manufacturing degree of difficulty of cauldron is less than the reactor of equal material greatly in the while, adopts cauldron body structure in the disconnect-type, the equipment cost that can significantly reduce. And the same outer cauldron body of cauldron body all can be used to the different inner cauldron bodies and work, promotes equipment utilization greatly, reduces the vacant reactor.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic diagram of the structure of an inner kettle body;
FIG. 3 is an enlarged view at A;
description of the drawings:
1. an outer kettle body; 2. a base; 3. an outer kettle cover; 4. a power rod; 5. a liquid inlet; 6. a liquid outlet; 7. an inner kettle body; 8. a movable rod; 9. a seal member; 10. fixing the bolt; 11. fixing a nut; 401. positioning the projection; 701. an inner kettle body; 702. an inner kettle cover; 703. an acid inlet; 704. a feed inlet; 705. a let position port; 801. positioning a groove; 802. and (4) countersinking.
Detailed Description
The invention will be described in further detail with reference to the following detailed description and accompanying drawings:
the novel reaction device for the gefitinib nitration process, as shown in fig. 1, comprises an outer kettle body, wherein the outer kettle body comprises an outer kettle body 1 and an outer kettle cover 3, the outer kettle body 1 is a container with an open top, a base 2 is arranged at the bottom of the outer kettle body and is used for supporting, the side wall of the outer kettle body 1 is of a hollow structure, the outer kettle body 1 is provided with a liquid inlet 5 and a liquid outlet 6, the liquid inlet 5 and the liquid outlet 6 are both connected with the inner cavity of the side wall of the outer kettle body 1, and fluid with temperature is injected into the inner cavity of the side wall of the outer kettle body 1 through the liquid inlet 5 to realize heating.
As shown in fig. 2, the inner kettle body 7 includes an inner kettle body 701 and an inner kettle cover 702, the inner kettle body 701 is a container with an open top, the outer wall of the inner kettle body 701 is attached to the inner wall of the outer kettle body 1, the inner kettle cover 702 is a disc-shaped structure with the same thickness as the wall thickness of the inner kettle body 701, the inner kettle cover 702 covers the opening of the inner kettle body 701, the inner kettle cover 702 is provided with an acid inlet 703 and a feed inlet 704, the acid inlet 703 and the feed inlet 704 are tubular structures, the outer kettle cover 3 is provided with through holes corresponding to the acid inlet 703 and the feed inlet 704, and the acid inlet 703 and the feed inlet 704 penetrate through holes in the outer kettle cover 3 and extend to the outside of the outer kettle cover 3. The inner kettle cover 702 is provided with a yielding port 705 corresponding to the position of the power rod 4, the yielding port 705 is a through hole, and the power rod 4 penetrates through the yielding port 705. As shown in fig. 1, an inner kettle body 7 is further arranged in the outer kettle body, and the outer kettle body 1, the outer kettle cover 3, the inner kettle body 701 and the inner kettle cover 702 are connected through flanges. A sealing element 9 is arranged between the inner kettle body 701 and the inner kettle cover 702, the sealing element 9 is arranged between the abdicating port 705 of the inner kettle body 701 and the outer kettle cover 3, and the sealing element 9 is an acid-proof sealing gasket.
As shown in fig. 3, a positioning groove 801 is formed at the top end of the movable rod 8, a positioning protrusion 401 matched with the positioning groove 801 is arranged at the lower end of the power rod 4, the positioning protrusion extends into the positioning groove 801 and then is fixed by screwing three groups of fixing bolts 10 and fixing nuts 11, countersunk holes 802 are formed at the positions where the fixing bolts 10 and the fixing nuts 11 are installed, and the heads and the nuts of the fixing bolts 10 are completely located in the countersunk holes 802, so that the outer wall of the movable rod 8 is smooth.
The wall thickness of the inner kettle body 7 is not more than 5mm, and a plurality of inner kettle bodies 7 made of different materials can be prepared for replacement. In-service use, the outer cauldron body sets up with the separation of the interior cauldron body 7, both can dismantle the connection, set up on the outer cauldron body and be used for heating, the structure of functions such as stirring, interior cauldron body 7 is only for the thin containment structure of thickness, according to the technology demand, the interior cauldron body 7 of removable different materials, because the reactor of the equal material of the internal 7 material quality of cauldron is less than greatly, the reactor that the degree of difficulty is less than equal material greatly is made to the internal 7 of cauldron simultaneously, adopt the internal 7 structure of cauldron in the disconnect-type, equipment cost that can significantly reduce. And different inner kettle bodies 7 can work by using the same outer kettle body, so that the equipment utilization rate is greatly improved, and vacant reactors are reduced.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, but also to cover any modifications or equivalent changes made in the technical spirit of the present invention, which fall within the scope of the present invention.
Claims (5)
1. A novel reaction device for a gefitinib nitration process comprises an outer kettle body, wherein the outer kettle body comprises an outer kettle body and an outer kettle cover, the outer kettle body is a container with an open top, a base is arranged at the bottom of the outer kettle body for supporting, the outer kettle cover is a cover body for covering the opening of the outer kettle body, a stirring rod is movably connected on the outer kettle cover and extends into the outer kettle body, the stirring rod is driven by a power device to rotate, the reaction device is characterized in that an inner kettle body is also arranged in the outer kettle body, the inner kettle body comprises an inner kettle body and an inner kettle cover, the inner kettle body is a container with an open top, the outer wall of the inner kettle body is attached to the inner wall of the outer kettle body, the inner kettle cover is of a disc-shaped structure with the same thickness as the wall of the inner kettle body, the inner kettle cover covers the opening of the inner kettle body, an acid inlet and a feed inlet are arranged on the inner kettle cover, the acid inlet and the feed inlet are of a tubular structure, through holes are arranged on, the acid inlet and the feed inlet penetrate through the through hole on the outer kettle cover and extend to the outside of the outer kettle cover; the outer kettle body, the outer kettle cover, the inner kettle body and the inner kettle cover are connected through flanges; the stirring rod comprises a power rod and a movable rod, the power rod is movably connected to the outer kettle cover and is driven to rotate by a power device, the lower end of the power rod extends into the outer kettle body, the power rod is detachably connected to the movable rod, and blades for stirring are arranged on the movable rod; the inner kettle cover is provided with a position yielding port corresponding to the position of the power rod, the position yielding port is a through hole, and the power rod penetrates through the position yielding port.
2. The novel reaction device for the gefitinib nitration process according to claim 1, characterized in that: the utility model discloses a power pole, including the movable rod, power pole lower extreme, the movable rod top is provided with the constant head tank, the power pole lower extreme corresponds the constant head tank and is provided with matched with location arch, protruding back of stretching into in the constant head tank in the location is fixed through at least two sets of fixing bolt and fixation nut close soon.
3. The novel reaction device for the gefitinib nitration process according to claim 2, characterized in that: the interior cauldron body is provided with the sealing member between the cauldron lid in and, interior cauldron body abdication mouth department is provided with the sealing member between the outer cauldron lid, the sealing member is acidproof sealed pad.
4. The novel reaction device for the gefitinib nitration process according to any one of claims 1-3, wherein: outer cauldron body lateral wall is hollow structure, is provided with inlet and liquid outlet on one's body outer cauldron, and outer cauldron body lateral wall inner cavity is all connected to inlet and liquid outlet, pours into the fluid realization heating that has the temperature, keeps warm or the cooling function into through the inlet to outer cauldron body lateral wall inner cavity.
5. The novel reaction device for the gefitinib nitration process according to claim 4, characterized in that: the wall thickness of the inner kettle body is not more than 5 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922371171.6U CN211586590U (en) | 2019-12-25 | 2019-12-25 | Novel reaction device for gefitinib nitration process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922371171.6U CN211586590U (en) | 2019-12-25 | 2019-12-25 | Novel reaction device for gefitinib nitration process |
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| Publication Number | Publication Date |
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| CN211586590U true CN211586590U (en) | 2020-09-29 |
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| CN201922371171.6U Active CN211586590U (en) | 2019-12-25 | 2019-12-25 | Novel reaction device for gefitinib nitration process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116040138A (en) * | 2023-01-06 | 2023-05-02 | 重庆大学 | Ocean sealing method for carbon dioxide hydrate |
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2019
- 2019-12-25 CN CN201922371171.6U patent/CN211586590U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116040138A (en) * | 2023-01-06 | 2023-05-02 | 重庆大学 | Ocean sealing method for carbon dioxide hydrate |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221228 Address after: No. 8, Weiyi Road, Anqing Hi tech Industrial Development Zone, Anqing City, Anhui Province 246000 Patentee after: ANQING CHICO PHARMACEUTICAL CO.,LTD. Address before: Room 1017, building F6, No.9, Weidi Road, Xianlin University Town, Xianlin street, Qixia District, Nanjing City, Jiangsu Province, 210000 Patentee before: NANJING CHICO PHARMACEUTICAL CO.,LTD. |
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| TR01 | Transfer of patent right |