CN211584306U - A hand-held type coating extrusion device for depositing individualized pharmaceutical preparation - Google Patents
A hand-held type coating extrusion device for depositing individualized pharmaceutical preparation Download PDFInfo
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- CN211584306U CN211584306U CN201922404785.XU CN201922404785U CN211584306U CN 211584306 U CN211584306 U CN 211584306U CN 201922404785 U CN201922404785 U CN 201922404785U CN 211584306 U CN211584306 U CN 211584306U
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Abstract
The utility model relates to a hand-held type coating and extrusion device for depositing individualized pharmaceutical preparation utilizes the utility model discloses individualized medicine preparation equipment provides the medicine of accurate quantity according to patient's physiological characteristics and demand and patient's health data. The excipient is in pre-rolled form and the soluble drug (API) is deposited on the roll of excipient material by a drug dispenser mechanism. Before rolling into a coil, a ceramic heater is used for heating a final formula, then a stepping motor rolls again, and the API with a specific amount of the medicine and an auxiliary material coil are extruded into a coil together to be used as a normal oral medicine for administration and swallowing, so that the customized medicine is customized, and the device is compact in size and can be operated by hands.
Description
Technical Field
The utility model relates to a hand-held type coating extrusion device for depositing individualized pharmaceutical preparation belongs to medicine preparation technical field.
Background
Typically, when making pharmaceutical products, there are pre-formulated drugs available as pills, which cannot be personalized to some extent, as they are integers of concentration and fractional amounts of concentration will be lost in the manufacturer's product line. To this end, the present invention provides an apparatus for producing personalized pharmaceutical preparations.
SUMMERY OF THE UTILITY MODEL
To the deficiencies of the prior art, the utility model provides a hand-held type coating extrusion device for depositing individualized pharmaceutical preparation. The device produces a personalized pharmaceutical formulation based on the input of patient health data and calculates the final formulation by varying the rotation speed, deposition (coating) flow rate and heating intensity. The utility model provides the possibility of avoiding drug abuse, portability and individualized drug formulation, also helps to improve the therapeutic efficacy of the excavation itself.
The technical scheme of the utility model as follows:
a handheld coating extrusion device for storing personalized pharmaceutical preparations comprises an auxiliary material coil mechanism, a supporting mechanism, a heating mechanism, a pharmaceutical dispensing mechanism and a stepping motor;
the auxiliary material roll mechanism is used for providing an auxiliary material roll, the supporting mechanism comprises a conveyor belt, one end of the conveyor belt is provided with the auxiliary material roll mechanism, and the auxiliary material roll is arranged above the conveyor belt;
the drug dispensing mechanism comprises a drug dispenser and a micro-fluid device, the drug dispenser is used for conveying drug fluid to be manufactured to the micro-fluid device, and the micro-fluid device is used for uniformly paving the drug fluid to be manufactured on the auxiliary material roll to form a drug coating;
the heating mechanism is positioned below the conveying belt and used for heating the medicine coating to make the medicine coating amorphous; the stepping motor is positioned at the tail end of the advancing direction of the conveyor belt and is used for controlling the moving speed of the auxiliary material roll.
The rolls of adjuncts having a defined thickness and width are fed onto a conveyor belt, then the drug is coated onto the rolls using a drug dispenser and microfluidic device, heated by a heating mechanism, then a stepper motor is rolled again, extruding the rolls of adjuncts with a specified amount of drug API into a roll for normal oral drug administration and swallowing.
Preferably, the auxiliary material roll is a film made of excipient or a commercially available film, the auxiliary material roll is uniform in thickness, and the excipient comprises a plasticizer, a film forming agent and additional additives. The bottom of the blanket roll is an electrospun fiber or nonwoven fabric or a wet cast polymer matrix rolled into a cylindrical shape with a number of layers (about 3-5 meters depending on the application).
Preferably, the medicament dispenser is a syringe pump, one end of which is connected to the medicament fluid reservoir and the other end of which is connected to the microfluidic device. The drug fluid is delivered to the microfluidic device by a syringe pump.
It is further preferred that the number of medicament dispensers is at least one. Multiple drug dispensers may be connected to multiple drug cartridges, different drug cartridges may contain different drugs, and different drug fluids are delivered together to the microfluidic device via different drug dispensers.
Preferably, the microfluidic device comprises at least two channels, each channel having the same width. For uniform application of the drug fluid to the roll of the secondary material over a period of time.
Further preferably, the microfluidic device is an L-shaped plate, the lateral wall of the plate is transversely provided with an inlet, the plate is vertically provided with a channel, the outlet of the channel is downward, and the inlet is connected with the medicament dispenser. The medicament fluid in the medicament dispenser enters the channel from the inlet and flows down the channel onto the auxiliary roll.
Further preferably, the channel outlet is provided with an end plug. The coated width of the microfluidic channel can be controlled by varying the outlet of the microfluidic device.
Further preferably, a temperature sensor is arranged in the channel of the microfluidic device, and a temperature adjusting device is arranged on the side wall of the plate. Delivering a temperature settable drug fluid.
Preferably, the heating mechanism is a ceramic heater.
Preferably, the supporting mechanism further comprises a supporting frame, a conveying wheel is arranged on the supporting frame and connected with the conveying belt, and the conveying wheel is controlled by a motor to rotate. The conveying belt is driven by the conveying wheel to move horizontally. The driving of the transfer wheel can be realized by using a 6v28BYJ 48 single-stage motor with small volume.
Preferably, the hand-held coating extrusion device for storing personalized pharmaceutical preparations further comprises a microcontroller, the microcontroller being connected to the drug dispenser, the heating mechanism, the motor, and the stepper motor. The flow rate, heating temperature and motor speed of the injection pump are controlled by the microcontroller.
Preferably, the rotation speed of the stepping motor is the same as the rotation speed of the support mechanism motor. Both motors rotate at the same speed as the feed and the rotation should be synchronized otherwise a perfect roll will not be formed.
The device is used for formulating the personalized medicine dosage, and the final concentration of the medicine is defined as follows:
concentration of drug in the drug dispenser (to be applied)
Speed of drug dispensing
Volume of drug dispensed
-the rotation speed of the auxiliary roll
Dispensed drug (final formulation) RPM (speed of stepper motor) surface area of dispensed blanket (length width (constant)) flow rate dispensed amount of drug.
The beneficial effects of the utility model reside in that:
the device can be used together with 2 5v stepping motors, is controlled by a microcontroller, draws the relation between API flow and rotating speed, and fits an equation for a final formula. Utilize the utility model discloses a device, the final product that makes comprises the film book that contains specific quantity medicine, can regard as normal oral drug to administer and swallow, the individualized medicine of customization, but device compact, handheld operation will bring the innovation in the pharmaceutical industry field.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2-1 is a schematic top perspective view of the support mechanism;
FIG. 2-2 is a schematic side view of the support mechanism;
2-3 are schematic views of the back side of the support mechanism;
FIGS. 2-4 are schematic top views of the support mechanism;
FIGS. 2-5 are schematic end views of the support mechanism;
FIG. 3 is a schematic diagram of a microcontroller connection;
FIG. 4-1 is a schematic front view of a microfluidic device configuration;
FIG. 4-2 is a schematic left view of the structure of the microfluidic device;
FIGS. 4-3 are right side schematic views of microfluidic device structures;
FIGS. 4-4 are schematic top views of microfluidic device structures;
FIGS. 4-5 are schematic bottom views of the microfluidic device structure;
FIG. 5-1 is a schematic front view of the syringe pump;
FIG. 5-2 is a schematic bottom view of the syringe pump;
FIGS. 5-3 are schematic top views of syringe pump configurations;
FIGS. 5-4 are schematic left side views of syringe pump configurations;
5-5 are schematic diagrams of the syringe pump configuration from the right;
FIGS. 5-6 are perspective views of the syringe pump;
FIG. 6 is a schematic view of the structure of an auxiliary material roll;
FIG. 7 is a schematic view of an unwind layer of the wrapper;
wherein: 1. the device comprises an auxiliary material roll mechanism, 2 a supporting mechanism, 3 a medicine distributor, 4 a microfluid device, 4-1 an inlet, 4-2 a channel, 4-3 an outlet, 5 a heating mechanism, 6 a supporting mechanism and 7 a stepping motor.
Detailed Description
The present invention will be further described, but not limited to, by the following examples in conjunction with the accompanying drawings.
Example 1:
a handheld coating extrusion device for storing personalized medicine preparations is shown in figure 1 and comprises an auxiliary material roll mechanism 1, a supporting mechanism 2, a heating mechanism 5, a medicine distribution mechanism and a stepping motor 7.
The auxiliary material rolling mechanism is used for providing an auxiliary material roll, the supporting mechanism comprises a conveying belt and a supporting frame, a conveying wheel is arranged on the supporting frame and connected with the conveying belt, and the conveying wheel is controlled by a motor to rotate. The conveying belt is driven by the conveying wheel to move horizontally. The driving of the conveying wheel can be realized by using a 6v28BYJ 48 single-stage motor with small volume, as shown in figures 2-1 to 2-5, one end of the conveying belt is provided with an auxiliary material roll mechanism, and the auxiliary material roll is arranged above the conveying belt.
The medicament dispensing mechanism comprises a medicament dispenser 3 and a microfluidic device 4, the medicament dispenser 3 being for delivering a medicament fluid to be produced to the microfluidic device 4, the microfluidic device 4 being for laying the medicament fluid to be produced evenly on a roll of web material to form a medicament coating. The drug dispenser is a syringe pump, as shown in fig. 5-1 to 5-6, one end of the syringe pump is connected to the drug fluid reservoir, the other end is connected to the microfluidic device, and the drug fluid is delivered to the microfluidic device through the syringe pump.
The heating mechanism 5 is positioned below the conveying belt, is a ceramic heater and is used for heating the medicine coating to make the medicine coating amorphous; the stepping motor 7 is located at the end of the direction of belt travel, as the belt travels from left to right in fig. 1, and is used to control the speed of movement of the rolls of the supplement material.
The rolls of adjuncts having a defined thickness and width are fed onto a conveyor belt, then the drug is coated onto the rolls using a drug dispenser and microfluidic device, heated by a heating mechanism, then a stepper motor is rolled again, extruding the rolls of adjuncts with a specified amount of drug API into a roll for normal oral drug administration and swallowing.
The auxiliary material roll is a film made of an excipient or a commercially available film, the thickness of the auxiliary material roll is uniform and consistent, and the excipient comprises a plasticizer, a film forming agent and an additional additive. The bottom of the blanket roll is an electrospun fiber or nonwoven fabric or a wet cast polymer matrix 1a, 1b, 1c, as shown in fig. 7, rolled into a cylindrical shape, as shown in fig. 6, with a number of layers (about 3-5 meters depending on the application).
Example 2:
a hand-held coating extrusion device for storing individualized pharmaceutical preparations is constructed as described in example 1, except that the number of medicament dispensers is two. Multiple medication dispensers may be connected to multiple medication barrels, e.g., barrel a may contain medication a, barrel b may contain medication b, and so on. Different cartridges may contain different medicaments and different medicament fluids are delivered together to the microfluidic device via different medicament dispensers.
Example 3:
a hand-held coating extrusion device for storing individualized pharmaceutical preparations is constructed as described in example 1, except that the microfluidic device is an L-shaped plate with an inlet opening in the lateral wall of the plate, nine channels in the plate are vertically arranged, each channel has the same width, the outlet opening of the channel is downward, and the inlet opening is connected to a pharmaceutical dispenser, as shown in fig. 4-1 to 4-5. The medicament fluid in the medicament dispenser enters the channel from the inlet and flows down the channel onto the auxiliary roll. For uniform application of the drug fluid to the roll of the secondary material over a period of time.
Example 4:
a hand-held coating extrusion device for storing individualized pharmaceutical preparations is constructed as described in example 3, except that the channel outlet is provided with an end plug. The coated width of the microfluidic channel can be controlled by varying the outlet of the microfluidic device.
Example 5:
a hand-held coating extrusion device for storing personalized pharmaceutical preparations, constructed as described in example 3, except that a temperature sensor is provided in the channel of the microfluidic device and a temperature regulating device is provided on the side wall of the plate. Delivering a temperature settable drug fluid.
Example 6:
a hand-held coating extrusion device for storing personalized pharmaceutical preparations, having the structure as described in example 1, except that the hand-held coating extrusion device for storing personalized pharmaceutical preparations further comprises a microcontroller, the microcontroller being connected to the drug dispenser, the heating mechanism, the motor, and the stepper motor, as shown in fig. 3. The flow rate, heating temperature and motor speed of the injection pump are controlled by the microcontroller. The rotating speed of the stepping motor is the same as that of the supporting mechanism motor. Both motors rotate at the same speed as the feed and the rotation should be synchronized otherwise a perfect roll will not be formed.
The device is used for formulating the personalized medicine dosage, and the final concentration of the medicine is defined as follows:
concentration of drug in the drug dispenser (to be applied)
Speed of drug dispensing
Volume of drug dispensed
-the rotation speed of the auxiliary roll
Dispensed drug (final formulation) RPM (speed of stepper motor) surface area of dispensed blanket (length width (constant)) flow rate dispensed amount of drug.
Claims (10)
1. A handheld coating extrusion device for storing personalized pharmaceutical preparations is characterized by comprising an auxiliary material coil mechanism, a supporting mechanism, a heating mechanism, a pharmaceutical distribution mechanism and a stepping motor;
the auxiliary material roll mechanism is used for providing an auxiliary material roll, the supporting mechanism comprises a conveyor belt, one end of the conveyor belt is provided with the auxiliary material roll mechanism, and the auxiliary material roll is arranged above the conveyor belt;
the drug dispensing mechanism comprises a drug dispenser and a micro-fluid device, the drug dispenser is used for conveying drug fluid to be manufactured to the micro-fluid device, and the micro-fluid device is used for uniformly paving the drug fluid to be manufactured on the auxiliary material roll to form a drug coating;
the heating mechanism is positioned below the conveying belt and used for heating the medicine coating to make the medicine coating amorphous; the stepping motor is positioned at the tail end of the advancing direction of the conveyor belt and is used for controlling the moving speed of the auxiliary material roll.
2. The handheld, coated extrusion device for holding personalized medicine formulations according to claim 1, wherein the medicine dispenser is a syringe pump, one end of which is connected to the medicine fluid reservoir and the other end of which is connected to the microfluidic device;
the number of medicament dispensers is at least one.
3. The handheld, coated extrusion device for storing personalized pharmaceutical preparations according to claim 1, wherein the microfluidic device comprises at least two channels, each channel having the same width.
4. A hand-held coating extrusion device for storing personalized pharmaceutical preparations according to claim 1, characterized in that the microfluidic device is an L-shaped plate with inlet openings in the lateral walls of the plate and vertically in the plate with channels with outlet openings downwards, the inlet openings being connected to the pharmaceutical dispenser.
5. A hand-held coating extrusion device for storing personalized pharmaceutical preparations according to claim 4, wherein the channel outlet is provided with an end plug.
6. A handheld, coated extrusion device for storing personalized pharmaceutical preparations according to claim 4, characterized in that a temperature sensor is provided in the channel of the microfluidic device and a temperature regulating device is provided on the side wall of the plate.
7. The handheld, coating-extrusion device for storing personalized medicine preparations according to claim 1, wherein the heating mechanism is a ceramic heater.
8. The handheld, coated extrusion device of claim 1, wherein the support mechanism further comprises a support frame, the support frame having a transfer wheel, the transfer wheel coupled to a conveyor belt, the transfer wheel being rotated by a motor.
9. The handheld coating extrusion device of claim 8, wherein the handheld coating extrusion device for storing a personalized pharmaceutical formulation further comprises a microcontroller, the microcontroller being connected to the drug dispenser, the heating mechanism, the motor, and the stepper motor.
10. The hand-held coating extrusion device for storing personalized pharmaceutical preparations according to claim 9, wherein the rotational speed of the stepper motor is the same as the rotational speed of the support mechanism motor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922404785.XU CN211584306U (en) | 2019-12-27 | 2019-12-27 | A hand-held type coating extrusion device for depositing individualized pharmaceutical preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922404785.XU CN211584306U (en) | 2019-12-27 | 2019-12-27 | A hand-held type coating extrusion device for depositing individualized pharmaceutical preparation |
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| CN211584306U true CN211584306U (en) | 2020-09-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113041149A (en) * | 2019-12-27 | 2021-06-29 | 山东钛铖医疗器械有限公司 | A hand-held type coating extrusion device for depositing individualized pharmaceutical preparation |
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- 2019-12-27 CN CN201922404785.XU patent/CN211584306U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113041149A (en) * | 2019-12-27 | 2021-06-29 | 山东钛铖医疗器械有限公司 | A hand-held type coating extrusion device for depositing individualized pharmaceutical preparation |
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