CN211581373U

CN211581373U - Clinical biological tissue sample preservation cryopreserving box

Info

Publication number: CN211581373U
Application number: CN201922130355.3U
Authority: CN
Inventors: 盛正平; 钟召赟; 黄颖瑜; 刘志鹏
Original assignee: Shanghai Biotree Biomedical Technology Co ltd
Current assignee: Shanghai Biotree Biomedical Technology Co ltd
Priority date: 2019-11-30
Filing date: 2019-11-30
Publication date: 2020-09-29
Anticipated expiration: 2029-11-30

Abstract

The utility model discloses a clinical biological tissue sample preservation cryopreservation box, which relates to the technical field of clinical biological tissue sample preservation equipment and comprises a cryopreservation box, a collet and a cover plate, wherein the cryopreservation box comprises an upper box body and a lower box body which are detachably connected, the upper box body is set into a box structure with two unsealed ends, the lower box body is set into a box structure with one unsealed end, the upper box body is rotatably connected with a box cover, the collet and the cover plate are sequentially arranged in the upper box body along the height direction of the collet, and the outer side wall of the collet and the cover plate are matched and contacted with the inner side wall of the upper box body; the inner bottom plate of the lower box body is provided with a refrigerator. The utility model discloses have and can dismantle the last box body and the lower box body of connection through the setting, conveniently change the refrigerator, need not to change the new cryopreserved box, just can realize guaranteeing to cryopreserve the effect of freezing of box for a long time, easy operation, effect that facilitates the use.

Description

Clinical biological tissue sample preservation cryopreserving box

Technical Field

The utility model relates to a clinical biological tissue sample preservation equipment technical field, more specifically say, it relates to a clinical biological tissue sample preserves cryopreserved box.

Background

The plant wide target metabolome perfectly combines the advantages of high resolution and wide coverage of non-target technology with the high sensitivity and accurate quantitative capability of target MRM technology: firstly, scanning a secondary mass spectrum with ultrahigh coverage rate of a sample inlet by using a high-resolution mass spectrum to obtain a spectrogram of all metabolites; then accurate substance identification is carried out by combining a BiotreeDB high-resolution secondary spectrum library; and then extracting MRM ion pair information from the mass spectrogram to specifically build a library for the sample, and then accurately quantifying by using a triple quadrupole mass spectrometry (MRM) technology. The comprehensive technology has the technical advantages of more identification substances, accurate qualitative and quantitative determination, wide dynamic range, high sensitivity, good repeatability and the like. Provides a more efficient method for detecting the complex metabolites of the plants.

When the wide target metabolome research of plants is carried out, samples need to be collected firstly, the collected samples need to be preserved, and the existing living tissue preservation generally adopts a freezing box for freezing. However, when the existing cryopreservation box is used, the cryopreservation aging is certain, and after the cryopreservation aging of the cryopreservation box is passed, if the cryopreservation is to be continued, all samples in the cryopreservation box need to be taken out, and then the samples are put into a new cryopreservation box again, so that the operation is very inconvenient and needs to be improved.

SUMMERY OF THE UTILITY MODEL

To this problem in the practical application, the utility model aims to provide a clinical biological tissue sample preserves cryopreserved box, concrete scheme is as follows:

a clinical biological tissue specimen preservation cryopreservation box is used for preserving biological tissues in a cryopreservation test tube and comprises a cryopreservation box, a bottom support and a cover plate, wherein the cryopreservation box comprises an upper box body and a lower box body which are detachably connected, the upper box body is of a box body structure with two unsealed ends, the lower box body is of a box body structure with one unsealed end,

the upper box body is rotatably connected with a box cover, the inside of the upper box body is sequentially provided with the bottom support and the cover plate along the height direction of the upper box body, and the outer side walls of the bottom support and the cover plate are matched and contacted with the inner side wall of the upper box body;

a refrigerator is arranged on the inner bottom plate of the lower box body;

the bottom support is uniformly provided with a plurality of placing holes, and the cover plate is uniformly provided with a plurality of limiting holes matched with the placing holes;

the internal diameter in spacing hole be in freeze the external diameter of depositing the test tube with freeze between the external diameter of depositing the test tube bottleneck.

Through the technical scheme, when biological tissues are frozen and stored, the lower box body is firstly installed on the upper box body, the bottom support is installed in the upper box body, then the frozen test tubes storing the biological tissues are inserted into the placing holes and are placed in the frozen box, the bottoms of the frozen test tubes are contacted with the refrigerator, then the cover plate is covered, the bottleneck of the frozen test tubes is positioned in the limiting holes, finally the cover plate is covered, the biological tissues can be frozen and stored, when the freezing and storing aging of the frozen and stored box fails, the lower box body is directly disassembled from the upper box body, a new refrigerator is replaced, the lower box body is installed on the upper box body again, the freezing and storing can be continuously realized, the process does not need to take out a plurality of frozen and stored test tubes from the failed frozen and replace the new frozen and stored box one by one, the freezing and storing effect can be kept, the biological tissues in the frozen and stored test tubes are very convenient and simple to operate, when the biological tissues in the frozen and stored test tubes need to be taken, open the lid, take out the apron, close the lid, dismantle down the box body, can take out the cryopreserved test tube of needs one by one, take the convenience, the practicality is strong.

Furthermore, the refrigerator is formed by combining a plurality of layers of concentric ring structures and is spirally arranged on the inner bottom plate of the lower box body.

Through above-mentioned technical scheme, help guaranteeing that the refrigerator can freeze with each and deposit the test tube contact, guarantee to freeze and deposit the effect.

Furthermore, the four corners of the bottom support in the placing hole are provided with elastic pieces, the elastic pieces and the bottom support are obliquely arranged, and the elastic pieces are of a semi-tubular structure with an annular cross section.

Through above-mentioned technical scheme, when placing the cryopreserved test tube, cryopreserved test tube extrusion elastic component, the elastic component applies reaction force to cryopreserved test tube, can not only make the cryopreserved box be applicable to the cryopreserved test tube of different specifications, has improved the stability when cryopreserved test tube preserves simultaneously, helps guaranteeing the security that cryopreserved the test tube in the transportation.

Further, the angle between the elastic piece and the bottom support is set to be 30-45 degrees.

Furthermore, one end of the upper box body, which is far away from the box cover, is connected with a connecting ring which is of an integrated structure, bulges are arranged on the outer side wall of the connecting ring, and the outer side wall of the connecting ring is matched with the inner side wall of the lower box body, so that the lower box body is connected with the connecting ring.

Through above-mentioned technical scheme, utilize the arch to play the effect of fixed box body down, help guaranteeing the stability of box body and box body connection back down.

Further, the refrigeration mode of the refrigerator adopts liquid nitrogen refrigeration.

Compared with the prior art, the beneficial effects of the utility model are as follows: in the utility model, the upper box body and the lower box body which are detachably connected are arranged, so that the refrigerator is convenient to replace, the freezing effect of the freezing box can be ensured for a long time without replacing a new freezing box, the operation is simple, and the use is convenient;

simultaneously, all set up the elastic component through four corners that lie in on the collet and place downthehole, can not only make to freeze the box of depositing and be applicable to the cryopreserved test tube of different specifications, improved the stability when cryopreserving the test tube simultaneously, help guaranteeing the security that freezes the test tube in the transportation.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention;

FIG. 2 is a schematic view of the working state of the present invention (when the cover plate is removed);

fig. 3 is an exploded view of the present invention.

Reference numerals: 1. freezing and storing the box; 11. an upper box body; 12. a lower box body; 2. a bottom support; 3. a cover plate; 4. a box cover; 5. a refrigerator; 6. placing holes; 7. a limiting hole; 8. an elastic member; 9. a connecting ring; 10. and (4) protruding.

Detailed Description

The present invention will be described in further detail with reference to the following examples and drawings, but the embodiments of the present invention are not limited thereto.

As shown in fig. 1 to 3, a clinical biological tissue specimen preservation cryopreservation box for preserving biological tissues in a cryopreservation test tube comprises a cryopreservation box 1, a bottom support 2 and a cover plate 3, wherein the cryopreservation box 1 comprises an upper box body 11 and a lower box body 12 which are detachably connected, the upper box body 11 is set into a box body structure with two unsealed ends, the lower box body 12 is set into a box body structure with one unsealed end, a box cover 4 is rotatably connected to the upper box body 11, the bottom support 2 and the cover plate 3 are sequentially arranged in the upper box body 11 along the height direction of the upper box body, and the outer side walls of the bottom support 2 and the cover plate 3 are in matched contact with the inner side wall of the upper box body 11; a refrigerator 5 is arranged on the inner bottom plate of the lower box body 12; a plurality of placing holes 6 are uniformly formed in the bottom support 2, and a plurality of limiting holes 7 matched with the placing holes 6 for use are uniformly formed in the cover plate 3; the internal diameter of spacing hole 7 is between the external diameter of freezing the test tube and the external diameter of freezing the test tube bottleneck of depositing. Alternatively, the refrigerator 5 is detachably attached to the inner bottom plate of the lower case 12. Thus, when the biological tissue is frozen, firstly, the lower box body 12 is arranged on the upper box body 11, the bottom support 2 is arranged in the upper box body 11, then the frozen test tube with the biological tissue is inserted into the placing hole 6 and is placed in the frozen box 1, the bottom of the frozen test tube is contacted with the refrigerator 5, then the cover plate 3 is covered, the bottleneck of the frozen test tube is positioned in the limiting hole 7, finally, the cover 4 is covered, the biological tissue can be frozen, when the frozen time of the frozen box 1 is invalid, the lower box body 12 is directly detached from the upper box body 11, a new refrigerator 5 is replaced, then the lower box body 12 is arranged on the upper box body 11 again, the frozen storage can be continuously realized, the process does not need to take out a plurality of frozen test tubes from the invalid frozen box 1 one by one, the frozen storage box 1 does not need to be replaced, the frozen storage effect can be kept, and convenience is achieved, easy operation when the biological tissue in the cryopreserved test tube is taken to needs, opens lid 4, takes out apron 3, closes lid 4, dismantles box body 12 down, can take out the cryopreserved test tube of needs one by one, and it is convenient to take, and the practicality is strong.

The refrigerator 5 is formed by combining a plurality of layers of concentric ring structures and is spirally arranged on the inner bottom plate of the lower box body 12. The refrigerating mode of the refrigerator 5 adopts liquid nitrogen refrigeration. Thus, the refrigerator 5 can be contacted with each freezing test tube, and the freezing effect is guaranteed.

Four corners that lie in placing in the hole 6 on collet 2 all are provided with elastic component 8, establish to the slope setting between elastic component 8 and collet 2, and elastic component 8 establishes to be annular half tubular structure for the cross-section. The angle between the elastic element 8 and the shoe 2 is set to 30-45 deg.. Like this, when placing the cryopreserved test tube, cryopreserved test tube extrusion elastic component 8, elastic component 8 exerts reaction force to cryopreserved test tube, can not only make cryopreserved box 1 be applicable to the cryopreserved test tube of different specifications, has improved the stability when cryopreserved test tube preserves simultaneously, helps guaranteeing the security that cryopreserved test tube in the transportation.

One end of the upper box body 11, which is far away from the box cover 4, is connected with a connecting ring 9 which is of an integrated structure, the outer side wall of the connecting ring 9 is provided with protrusions 10, and the outer side wall of the connecting ring 9 is matched with the inner side wall of the lower box body 12, so that the lower box body 12 is connected with the connecting ring 9. In this way, the protrusion 10 is used to fix the lower case 12, which helps to ensure the stability of the upper case 11 after connecting with the lower case 12.

The utility model discloses a concrete implementation principle does: when the biological tissue is frozen, firstly, the lower box body 12 is arranged on the upper box body 11, the bottom support 2 is arranged in the upper box body 11, then the frozen test tubes with the biological tissue are inserted into the placing holes 6 to be placed in the frozen box 1, the bottoms of the frozen test tubes are contacted with the refrigerator 5, then the cover plate 3 is covered, the bottleneck of the frozen test tubes are positioned in the limiting holes 7, finally, the cover 4 is covered, the biological tissue can be frozen, when the freezing aging of the frozen box 1 fails, the lower box body 12 is directly detached from the upper box body 11, a new refrigerator 5 is replaced, then the lower box body 12 is arranged on the upper box body 11 again, the freezing can be continuously taken out, the process does not need to take out a plurality of frozen test tubes from the failed frozen box 1 one by one, the frozen box 1 does not need to be replaced, the freezing effect can be kept, the operation is convenient and simple, when the biological tissue in the cryopreserved test tube needs to be taken, the box cover 4 is opened, the cover plate 3 is taken out, the box cover 4 is closed, the box body 12 is disassembled, the cryopreserved test tubes can be taken out one by one, the taking is convenient, and the practicability is high.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and to simplify the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.

It is above only the utility model discloses a preferred embodiment, the utility model discloses a scope of protection does not only confine above-mentioned embodiment, the all belongs to the utility model discloses a technical scheme under the thinking all belongs to the utility model discloses a scope of protection. It should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A clinical biological tissue specimen preservation cryopreservation box is used for preserving biological tissues in a cryopreservation test tube and is characterized by comprising a cryopreservation box (1), a bottom support (2) and a cover plate (3), wherein the cryopreservation box (1) comprises an upper box body (11) and a lower box body (12) which are detachably connected, the upper box body (11) is of a box body structure with two unsealed ends, the lower box body (12) is of a box body structure with one unsealed end, and the lower box body (12) is of a box body structure with one unsealed end,

the upper box body (11) is rotatably connected with a box cover (4), the bottom support (2) and the cover plate (3) are sequentially arranged in the upper box body (11) along the height direction of the upper box body, and the outer side walls of the bottom support (2) and the cover plate (3) are matched and contacted with the inner side wall of the upper box body (11);

a refrigerator (5) is arranged on the inner bottom plate of the lower box body (12);

a plurality of placing holes (6) are uniformly formed in the bottom support (2), and a plurality of limiting holes (7) matched with the placing holes (6) for use are uniformly formed in the cover plate (3);

the internal diameter of spacing hole (7) is in freeze the external diameter of depositing the test tube with freeze between the external diameter of depositing the test tube bottleneck.

2. The clinical biological tissue specimen preservation cryopreservation box of claim 1, wherein the refrigerator (5) is arranged in a multi-layer concentric ring structure and is spirally arranged on the inner bottom plate of the lower box body (12).

3. The clinical biological tissue specimen preservation cryopreservation box according to claim 1, wherein elastic members (8) are arranged on four corners of the bottom support (2) in the placing hole (6), the elastic members (8) and the bottom support (2) are arranged in an inclined manner, and the elastic members (8) are arranged in a semi-tubular structure with an annular section.

4. The clinical biological tissue specimen preservation cryopreservation box of claim 3, wherein the angle between the elastic member (8) and the bottom tray (2) is set to be 30-45 °.

5. The clinical biological tissue specimen preservation and cryopreservation box according to claim 1, wherein one end of the upper box body (11) far away from the box cover (4) is connected with a connecting ring (9) which is of an integrated structure with the box cover, the peripheral outer side wall of the connecting ring (9) is provided with a protrusion (10), the outer side wall of the connecting ring (9) is matched with the inner side wall of the lower box body (12), so that the lower box body (12) is connected with the connecting ring (9).

6. The clinical biological tissue specimen preservation cryopreservation box of claim 1, wherein the refrigeration mode of the refrigerator (5) adopts liquid nitrogen refrigeration.