CN211562903U - Multifunctional microfluid impinging stream nanoparticle preparation device - Google Patents
Multifunctional microfluid impinging stream nanoparticle preparation device Download PDFInfo
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- CN211562903U CN211562903U CN201921840875.7U CN201921840875U CN211562903U CN 211562903 U CN211562903 U CN 211562903U CN 201921840875 U CN201921840875 U CN 201921840875U CN 211562903 U CN211562903 U CN 211562903U
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- 239000002105 nanoparticle Substances 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 230000001105 regulatory effect Effects 0.000 claims description 27
- 239000002904 solvent Substances 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 19
- 238000007789 sealing Methods 0.000 claims description 10
- 238000003860 storage Methods 0.000 claims description 8
- 238000004321 preservation Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 abstract description 5
- 238000009434 installation Methods 0.000 abstract 1
- 239000012296 anti-solvent Substances 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
The utility model provides a multifunctional microfluid impinging stream nanoparticle preparation device, which consists of a raw material supply part, a reaction part and a product collection part; the advantages are as follows: the device has the functions of three different microfluid reaction devices, namely a cross impinging stream reactor, a sleeve impinging stream reactor and a rotational flow impinging stream reactor, and can meet the preparation requirements of nanoparticles with different particle sizes; the device has the advantages of compact structure, high automation degree, convenient installation and use and wide popularization and application prospect.
Description
Technical Field
The utility model relates to a nanoparticle preparation facilities especially relates to a multi-functional microfluid striking flows nanoparticle preparation facilities.
Background
In recent years, the gradual development of micro-technology is beginning to be applied to various fields, and the preparation of nano-particles by microfluid is an important application. Currently, microfluid preparation of nanoparticles mainly exists in three forms of a cross impinging stream reactor, a rotational flow impinging stream reactor and a sleeve impinging stream reactor. Kunstmann-Olsen C et al (Microfluidics and nanofluorinics, 2012,12(5): 795-; shing Long Chow et al (European Journal of pharmaceuticals and Biopharmaceutics,2014,88(2): 462-; limin and the like (Beijing university of chemical industry, journal of Nature science, 2008,35(3):14-18) prepare spherical calcium carbonate nanoparticles by using a sleeve type microreactor, and a sleeve impinging stream reactor is suitable for large inlet flow and can meet the preparation of nanoparticles with the same and different solution and solvent flow rates by adjusting a filter screen. At present, a nanoparticle preparation device which meets different flow rates and different liquid inlet ratios is lacked.
SUMMERY OF THE UTILITY MODEL
The utility model aims at the preparation of nano-particle, provide a multi-functional preparation facilities. The system realizes the comprehensive use of the cross impinging stream reactor, the rotational flow impinging stream reactor and the sleeve impinging stream reactor, changes the use condition of a single device, improves the production efficiency and simultaneously realizes the automatic control of the device.
A multifunctional microfluidic impinging stream nanoparticle production apparatus, comprising: a raw material supply part, a reaction part and a product collection part.
The raw material supply section includes: the device comprises a first solvent tank (1), a first stop valve (3), a second solvent tank (2), a second stop valve (4), a first flat flow pump (5), a first flow regulating valve (6), a first one-way valve (7), a third stop valve (8), a second one-way valve (9), a fourth stop valve (10), a third one-way valve (11), a fifth stop valve (12), a fourth one-way valve (13), a sixth stop valve (14), a first solution tank (15), a seventh stop valve (17), a second solution tank (16), an eighth stop valve (18), a second flat flow pump (19), a second flow regulating valve (20), a fifth one-way valve (21), a ninth stop valve (22), a sixth one-way valve (23), a tenth stop valve (24), a seventh one-way valve (25), an eleventh stop valve (26), an eighth one-way valve (27), a twelfth stop valve (28), Ninth check valve (29), thirteenth stop valve (30), the reaction portion includes: a cross impinging stream part (31), a sleeve impinging stream part (32), a rotational flow impinging stream part (33) and a heat preservation box (39); the product collection section includes: a fourteenth stop valve (34), a fifteenth stop valve (35), a sixteenth stop valve (36), a seventeenth stop valve (37) and a liquid storage tank (38);
the raw material supply part, the reaction part and the product collection part are sequentially connected: an outlet pipe of a first solvent tank (1) is connected with an inlet pipe of a first stop valve (3), an outlet pipe of a second solvent tank (2) is connected with an inlet pipe of a second stop valve (4), an outlet pipe of the first stop valve (3) is connected with an outlet pipe of the second stop valve (4) in parallel and then connected with an inlet pipe of a first flat-flow pump (5) in series, an outlet pipe of the first flat-flow pump (5) is connected with an inlet pipe of a first flow regulating valve (6), an outlet pipe of a first check valve (7) is connected with an inlet pipe of a third stop valve (8), an outlet pipe of a second check valve (9) is connected with an inlet pipe of a fourth stop valve (10), an outlet pipe of the third check valve (11) is connected with an inlet pipe of a fifth stop valve (12), an outlet pipe of the fourth check valve (13) is connected with an inlet pipe of a sixth stop valve (14), an inlet pipe of the first check valve (7), an, An inlet pipe of a fourth one-way valve (13) is connected with an outlet pipe of the first flow regulating valve (6) after being connected in parallel, an outlet pipe of a first solution tank (15) is connected with an inlet pipe of a seventh stop valve (17), an outlet pipe of a second solution tank (16) is connected with an inlet pipe of an eighth stop valve (18), an outlet pipe of the seventh stop valve (17) is connected with an outlet pipe of the eighth stop valve (18) after being connected in parallel and then connected with an inlet pipe of a second flat-flow pump (19), an outlet pipe of the second flat-flow pump (19) is connected with an inlet pipe of a second flow regulating valve (20), an outlet pipe of a fifth one-way valve (21) is connected with an inlet pipe of a ninth stop valve (22), an outlet pipe of a sixth one-way valve (23) is connected with an inlet pipe of a tenth stop valve (24), an outlet pipe of a seventh one-way valve (25) is connected, an outlet pipe of a ninth check valve (29) is connected with an inlet pipe of a thirteenth check valve (30), an inlet pipe of a fifth check valve (21), an inlet pipe of a sixth check valve (23), an inlet pipe of a seventh check valve (25), an inlet pipe of an eighth check valve (27) and the inlet pipe of the ninth check valve (29) are connected in parallel and then connected with an outlet pipe of a second flow regulating valve (20), an outlet pipe of a third check valve (8) is connected with an inlet pipe (31-1) of a cross impinging stream component (31), an outlet pipe of a fourth check valve (10) is connected with an inlet pipe (32-4) of a sleeve impinging stream component (32), a fifth check valve (12) is connected with an inlet pipe (33-1) of a rotational impinging stream component (33), a sixth check valve (14) is connected with an inlet pipe (33-3) of the rotational impinging stream component (33), an outlet pipeline of the ninth check valve (22) is connected with an inlet pipe (31-2) of the cross impinging, an outlet pipeline of a tenth stop valve (24) is connected with an inlet pipe (31-4) of a cross impinging stream component (31), an outlet pipe of an eleventh stop valve (26) is connected with an inlet pipe (32-1) of a sleeve impinging stream component (32), an outlet pipe of a twelfth stop valve (28) is connected with an inlet pipe (33-2) of a rotational impinging stream component (33), an outlet pipe of a thirteenth stop valve (30) is connected with an inlet pipe (33-4) of the rotational impinging stream component (33), the cross impinging stream component (31) and the sleeve impinging stream component (32) are connected with the rotational impinging stream component (33) in parallel in a heat insulation box (39), an outlet pipe (31-3) of the cross impinging stream component (31) is connected with an inlet pipe of a fourteenth stop valve (34), an outlet pipe (32-7) of the sleeve impinging stream component (32) is connected with an inlet pipe of a fifteenth stop, an outlet pipe (33-8) of the rotational flow impinging stream component (33) is connected with an inlet pipe of a sixteenth stop valve (36), an outlet pipe of the fourteenth stop valve (34), an outlet pipe of the fifteenth stop valve (35) and an outlet pipe of the sixteenth stop valve (36) are connected in parallel and then connected with an inlet pipe of a seventeenth stop valve (37), and an outlet pipe of the seventeenth stop valve (37) is connected with an inlet pipe of a liquid storage tank (38).
The cross impinging stream component (31) is formed by connecting four pipelines which are mutually vertical, namely a pipeline (31-1), a pipeline (31-2), a pipeline (31-3) and a pipeline (31-4) (figure 2).
The sleeve impinging stream component (32) comprises an inner sleeve (32-6), an outer sleeve (32-3), a fixed sleeve (32-2), a sealing ring (32-5) and a filter screen (32-8), wherein the inner sleeve (32-6) is connected with the outer sleeve (32-3) after the sealing ring (32-5) is added, the outer sleeve (32-3) is fixedly connected with the fixed sleeve (32-2) by threads, and the filter screen (32-8) is wrapped at two ends outside the annular cavity and is compressed and fixed (figure 3).
The cyclone impinging stream component (33) consists of an upper liquid inlet part (33-5), a lower liquid outlet part (33-7), a sealing ring (33-6) and a fixing bolt (33-9), wherein the sealing ring (33-6) is placed between the upper liquid inlet part (33-5) and the lower liquid outlet part (33-7) and is fixed by the bolt (33-9) after being connected (figure 4).
The utility model has the advantages that:
the utility model discloses use cross impinging stream reactor, whirl impinging stream reactor and sleeve impinging stream reactor multipurposely, can satisfy the preparation of the nano-particle under the different flow and the nano-particle preparation of different particle diameters.
Drawings
FIG. 1 is a flow chart of the multifunctional nanoparticle preparation device system by an anti-solvent method.
In the figure: 1. a first solvent tank 2, a second solvent tank 3, a first stop valve 4, a second stop valve 5, a first flat flow pump 6, a first flow rate regulating valve 7, a first check valve 8, a third stop valve 9, a second check valve 10, a fourth stop valve 11, a third check valve 12, a fifth stop valve 13, a fourth check valve 14, a sixth stop valve 15, a first solution tank 16, a seventh stop valve 17, a second solution tank 18, an eighth stop valve 19, a second flat flow pump 20, a second flow rate regulating valve 21, a fifth check valve 22, a ninth stop valve 23, a sixth check valve 24, a tenth stop valve 25, a seventh check valve 26, an eleventh stop valve 27, an eighth check valve 28, a twelfth stop valve 29, a ninth check valve 30, a thirteenth stop valve 31, a crossflow reactor 32, a crossflow impinging stream reactor 32, a second impinging stream control valve, a second flow rate regulating valve 17, a third, A sleeve impinging stream reactor 33, a rotational flow impinging stream reactor 34, a fourteenth stop valve 35, a fifteenth stop valve 36, a sixteenth stop valve 37, a seventeenth stop valve 38, a liquid storage tank 39 and a heat preservation box
FIG. 2 is a cross impinging stream component of the multi-functional anti-solvent nanoparticle preparation device system.
31-1, inlet pipe 31-2, inlet pipe 31-3, outlet pipe 31-4, inlet pipe
FIG. 3 is a sleeve type impinging stream component of the multi-functional anti-solvent nanoparticle preparation device system.
32-1, an inlet pipe 32-2, a fixed sleeve 32-3, an outer sleeve 32-4 and an inlet pipe
32-5 parts, a sealing ring 32-6 parts, an inner sleeve 32-7 part, an outlet pipe 32-8 part and a filter screen
FIG. 4 is a diagram illustrating a swirling impinging stream component of the multi-functional anti-solvent nanoparticle preparation apparatus system.
33-1, 33-2, 33-3, 33-4, and
33-5 parts of upper liquid inlet part 33-6 parts, 33-7 parts of sealing ring, 33-8 parts of lower liquid outlet part and outlet pipe
33-9, bolt
The specific implementation mode is as follows:
the present invention will be described in further detail by way of examples with reference to the accompanying drawings, which are illustrative of the present invention and are not intended to limit the present invention.
Example 1
In the example, a first flat-flow pump (5) and a second flat-flow pump (19) are opened, the solvent in a first solvent tank (1) or a second solvent tank (2) passes through the first flat-flow pump (5), a first flow regulating valve (6), a first check valve (7) and a third stop valve (8) are opened, the solvent enters a cross impinging stream reactor (31) with the heat preservation temperature of 80 ℃ through the first flow regulating valve (6), the first check valve (7) and the third stop valve (8), meanwhile, the solution in a first solution tank (15) or a second solution tank (16) passes through the second flat-flow pump (19), the second flow regulating valve (19), a fifth check valve (21), an eighth stop valve (22), a sixth check valve (23) and a ninth stop valve (24) are opened, and the solution passes through the second flow regulating valve (19), the fifth check valve (21), the eighth stop valve (22), the sixth check valve (23), The ninth stop valve (24) enters a cross impinging stream reactor (31) with the temperature of 80 ℃ for impinging reaction, the fourteenth stop valve (34) and the seventeenth stop valve (37) are opened, and the product after the solution and the solvent are impinged is nano-particles with the particle size of 60-300nm and enters a liquid storage tank (38) through the fourteenth stop valve (34) and the seventeenth stop valve (37).
Example 2
In the example, a first flat-flow pump (5) and a second flat-flow pump (19) are opened, the solvent in a first solvent tank (1) or a second solvent tank (2) passes through the first flat-flow pump (5), a first flow regulating valve (6), a second one-way valve (9) and a fourth stop valve (10) are opened, the solvent enters a sleeve-type impinging stream reactor (32) with the heat preservation temperature of 80 ℃ through the first flow regulating valve (6), the second one-way valve (9) and the fourth stop valve (10), meanwhile, the solution in a first solution tank (15) or a second solution tank (16) passes through the second flat-flow pump (19), the second flow regulating valve (19), a seventh one-way valve (25) and an eleventh stop valve (26) are opened, the solution enters the sleeve-type impinging stream reactor (32) with the heat preservation temperature of 80 ℃ through the second flow regulating valve (19), the fifteenth stop valve (35) is opened, And a seventeenth stop valve (37), wherein the product after the solution and the solvent are collided is a nanoparticle with the particle size of 400-1400 nm, and enters the liquid storage tank (38) through a fifteenth stop valve (35) and the seventeenth stop valve (37).
Example 3
In the example, a first flat-flow pump (5) and a second flat-flow pump (19) are opened, the solvent in a first solvent tank (1) or a second solvent tank (2) passes through the first flat-flow pump (5), a first flow regulating valve (6), a third check valve (11), a fifth check valve (12), a fourth check valve (13) and a sixth check valve (14) are opened, the solvent passes through the first flow regulating valve (6), the third check valve (11), the fifth check valve (12), the fourth check valve (13) and the sixth check valve (14) and enters a rotational flow type impinging stream reactor (33) with the heat preservation temperature of 80 ℃, meanwhile, the solution in a first solution tank (15) or a second solution tank (16) passes through the second flat-flow pump (19), and a second flow regulating valve (19), an eighth check valve (27), a twelfth check valve (28), a ninth check valve (29) and a thirteenth check valve (30) are opened, the solution enters a rotational flow impinging stream reactor (33) with the temperature of 80 ℃ through a second flow regulating valve (19), an eighth one-way valve (27), a twelfth stop valve (28), a ninth one-way valve (29) and a thirteenth stop valve (30), a sixteenth stop valve (36) and a seventeenth stop valve (37) are opened, and the product after the solution and the solvent are impinged is nano-particles with the particle size of 30-100 nm and enters a liquid storage tank (38) through the sixteenth stop valve (36) and the seventeenth stop valve (37).
Claims (4)
1. A multifunctional microfluidic impinging stream nanoparticle production apparatus, comprising: a raw material supply part, a reaction part and a product collection part;
the raw material supply section includes: the device comprises a first solvent tank (1), a first stop valve (3), a second solvent tank (2), a second stop valve (4), a first flat flow pump (5), a first flow regulating valve (6), a first one-way valve (7), a third stop valve (8), a second one-way valve (9), a fourth stop valve (10), a third one-way valve (11), a fifth stop valve (12), a fourth one-way valve (13), a sixth stop valve (14), a first solution tank (15), a seventh stop valve (17), a second solution tank (16), an eighth stop valve (18), a second flat flow pump (19), a second flow regulating valve (20), a fifth one-way valve (21), a ninth stop valve (22), a sixth one-way valve (23), a tenth stop valve (24), a seventh one-way valve (25), an eleventh stop valve (26), an eighth one-way valve (27), a twelfth stop valve (28), Ninth check valve (29), thirteenth stop valve (30), the reaction portion includes: a cross impinging stream part (31), a sleeve impinging stream part (32), a rotational flow impinging stream part (33) and a heat preservation box (39); the product collection section includes: a fourteenth stop valve (34), a fifteenth stop valve (35), a sixteenth stop valve (36), a seventeenth stop valve (37) and a liquid storage tank (38);
the raw material supply part, the reaction part and the product collection part are sequentially connected: an outlet pipe of a first solvent tank (1) is connected with an inlet pipe of a first stop valve (3), an outlet pipe of a second solvent tank (2) is connected with an inlet pipe of a second stop valve (4), an outlet pipe of the first stop valve (3) is connected with an outlet pipe of the second stop valve (4) in parallel and then connected with an inlet pipe of a first flat-flow pump (5) in series, an outlet pipe of the first flat-flow pump (5) is connected with an inlet pipe of a first flow regulating valve (6), an outlet pipe of a first check valve (7) is connected with an inlet pipe of a third stop valve (8), an outlet pipe of a second check valve (9) is connected with an inlet pipe of a fourth stop valve (10), an outlet pipe of the third check valve (11) is connected with an inlet pipe of a fifth stop valve (12), an outlet pipe of the fourth check valve (13) is connected with an inlet pipe of a sixth stop valve (14), an inlet pipe of the first check valve (7), an, An inlet pipe of a fourth one-way valve (13) is connected with an outlet pipe of the first flow regulating valve (6) after being connected in parallel, an outlet pipe of a first solution tank (15) is connected with an inlet pipe of a seventh stop valve (17), an outlet pipe of a second solution tank (16) is connected with an inlet pipe of an eighth stop valve (18), an outlet pipe of the seventh stop valve (17) is connected with an outlet pipe of the eighth stop valve (18) after being connected in parallel and then connected with an inlet pipe of a second flat-flow pump (19), an outlet pipe of the second flat-flow pump (19) is connected with an inlet pipe of a second flow regulating valve (20), an outlet pipe of a fifth one-way valve (21) is connected with an inlet pipe of a ninth stop valve (22), an outlet pipe of a sixth one-way valve (23) is connected with an inlet pipe of a tenth stop valve (24), an outlet pipe of a seventh one-way valve (25) is connected, an outlet pipe of a ninth check valve (29) is connected with an inlet pipe of a thirteenth check valve (30), an inlet pipe of a fifth check valve (21), an inlet pipe of a sixth check valve (23), an inlet pipe of a seventh check valve (25), an inlet pipe of an eighth check valve (27) and the inlet pipe of the ninth check valve (29) are connected in parallel and then connected with an outlet pipe of a second flow regulating valve (20), an outlet pipe of a third check valve (8) is connected with an inlet pipe (31-1) of a cross impinging stream component (31), an outlet pipe of a fourth check valve (10) is connected with an inlet pipe (32-4) of a sleeve impinging stream component (32), a fifth check valve (12) is connected with an inlet pipe (33-1) of a rotational impinging stream component (33), a sixth check valve (14) is connected with an inlet pipe (33-3) of the rotational impinging stream component (33), an outlet pipeline of the ninth check valve (22) is connected with an inlet pipe (31-2) of the cross impinging, an outlet pipeline of a tenth stop valve (24) is connected with an inlet pipe (31-4) of a cross impinging stream component (31), an outlet pipe of an eleventh stop valve (26) is connected with an inlet pipe (32-1) of a sleeve impinging stream component (32), an outlet pipe of a twelfth stop valve (28) is connected with an inlet pipe (33-2) of a rotational impinging stream component (33), an outlet pipe of a thirteenth stop valve (30) is connected with an inlet pipe (33-4) of the rotational impinging stream component (33), the cross impinging stream component (31) and the sleeve impinging stream component (32) are connected with the rotational impinging stream component (33) in parallel in a heat insulation box (39), an outlet pipe (31-3) of the cross impinging stream component (31) is connected with an inlet pipe of a fourteenth stop valve (34), an outlet pipe (32-7) of the sleeve impinging stream component (32) is connected with an inlet pipe of a fifteenth stop, an outlet pipe (33-8) of the rotational flow impinging stream component (33) is connected with an inlet pipe of a sixteenth stop valve (36), an outlet pipe of the fourteenth stop valve (34), an outlet pipe of the fifteenth stop valve (35) and an outlet pipe of the sixteenth stop valve (36) are connected in parallel and then connected with an inlet pipe of a seventeenth stop valve (37), and an outlet pipe of the seventeenth stop valve (37) is connected with an inlet pipe of a liquid storage tank (38).
2. The multifunctional microfluidic impinging stream nanoparticle preparation device according to claim 1, characterized by comprising a cross impinging stream component (31), characterized in that: is formed by connecting four pipelines which are mutually vertical, namely a pipeline (31-1), a pipeline (31-2), a pipeline (31-3) and a pipeline (31-4).
3. The multifunctional microfluidic impinging stream nanoparticle preparation device according to claim 1, characterized by comprising a sleeve impinging stream component (32), characterized by: the filter is composed of an inner sleeve (32-6), an outer sleeve (32-3), a fixed sleeve (32-2), a sealing ring (32-5) and a filter screen (32-8), wherein the inner sleeve (32-6) is connected with the outer sleeve (32-3) after the sealing ring (32-5) is added, the outer sleeve (32-3) is fixedly connected with the fixed sleeve (32-2) through threads, and the filter screen (32-8) is wrapped at two ends outside a ring cavity and is pressed and fixed.
4. The multifunctional microfluidic impinging stream nanoparticle preparation device according to claim 1, characterized by comprising a swirling impinging stream component (33), characterized by: the device consists of an upper liquid inlet part (33-5), a lower liquid outlet part (33-7), a sealing ring (33-6) and a fixing bolt (33-9), wherein the sealing ring (33-6) is placed between the upper liquid inlet part (33-5) and the lower liquid outlet part (33-7) and is fixed by the bolt (33-9) after being connected.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921840875.7U CN211562903U (en) | 2019-10-30 | 2019-10-30 | Multifunctional microfluid impinging stream nanoparticle preparation device |
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| CN201921840875.7U CN211562903U (en) | 2019-10-30 | 2019-10-30 | Multifunctional microfluid impinging stream nanoparticle preparation device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110756135A (en) * | 2019-10-30 | 2020-02-07 | 青岛科技大学 | Multifunctional microfluid impinging stream nanoparticle preparation device |
| CN113617312A (en) * | 2021-08-06 | 2021-11-09 | 温州大学新材料与产业技术研究院 | High-temperature steam-microwave-assisted impinging stream reaction device and composite material preparation method |
-
2019
- 2019-10-30 CN CN201921840875.7U patent/CN211562903U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110756135A (en) * | 2019-10-30 | 2020-02-07 | 青岛科技大学 | Multifunctional microfluid impinging stream nanoparticle preparation device |
| CN113617312A (en) * | 2021-08-06 | 2021-11-09 | 温州大学新材料与产业技术研究院 | High-temperature steam-microwave-assisted impinging stream reaction device and composite material preparation method |
| CN113617312B (en) * | 2021-08-06 | 2022-09-23 | 温州大学新材料与产业技术研究院 | High-temperature steam-microwave-assisted impinging stream reaction device and composite material preparation method |
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Granted publication date: 20200925 Termination date: 20211030 |