CN211461682U - Low-frequency acousto-optic synergistic Alzheimer disease prevention and treatment device - Google Patents
Low-frequency acousto-optic synergistic Alzheimer disease prevention and treatment device Download PDFInfo
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Abstract
The utility model discloses a low-frequency acousto-optic synergistic Alzheimer disease prevention and treatment device, which comprises a device body, the device body is internally provided with a microprocessor, an acousto-optic stimulation and induction module, a power supply module, a key and display module, a storage module and an acousto-optic alarm module, the output end of the power supply module is connected with the input end of the microprocessor, the output end of the microprocessor is respectively connected with the storage module and the sound-light alarm module, the acousto-optic stimulating and sensing module, the key and the display module are connected with the microprocessor, the utility model cooperates with the control signal of the microprocessor according to the input signal of the key module, send reputation cooperative signal through reputation amazing and response module and realize prevention and treatment function, the utility model discloses a device provides music treatment and phototherapy simultaneously, and effectual and stability is good, but wide application in medical instrument technical field.
Description
Technical Field
The utility model belongs to the technical field of the medical instrument technique and specifically relates to a synergistic alzheimer's disease prevention and treatment device of low frequency reputation.
Background
Alzheimer's Disease (AD): namely senile dementia, is a progressive degenerative disease of the nervous system with hidden disease.
Alzheimer disease is a nervous system degenerative disease with progressive development with hidden diseases, the pathological changes can affect multiple systems such as nerves, movement, urinary system and the like, cognitive function is reduced, behavior disorder, life ability is reduced and the like, and depression, anxiety, psychosis and the like are frequently complicated, so that patients gradually lose self-care ability, and families are greatly affected. At present, the examination mainly comprises neuropsychological test, hematology examination, neuroimaging examination, electroencephalogram, cerebrospinal fluid detection, gene detection and the like. The diagnosis is mainly carried out according to the signs of the symptoms of the patients, magnetic resonance display, abnormal cerebrospinal fluid biomarkers, definite gene mutation in relatives and the like. The core diagnostic criteria include: 1. early and significant episodic memory impairment; 2. atrophy of the medial temporal gyrus; 3. an abnormal cerebrospinal fluid biomarker, an elevated β amyloid 1-42(a β 1-42) concentration, an elevated total Tau protein concentration, or an elevated phosphorylated Tau protein concentration, or a combination of the three; specific imaging of PET functional nerve images, bilateral temporal and apical lobe glucose metabolic rate reduction; 5. there are clear AD-associated autosomal dominant mutations in the orthotopic relatives. The treatment policy is to control the accompanying psychopathological symptoms, improve the cognitive function and delay the disease progress.
At present, the treatment modes for senile dementia patients at home and abroad are drug treatment and behavioral correction. The treatment requires symptomatic treatment, with the aim of controlling the accompanying psychopathological symptoms, the use of anxiolytics, antidepressants, antipsychotics, nootropic or cognitive function-improving drugs: drugs acting on neurotransmitters, and drugs that activate brain metabolism. In addition to drug therapy, there is a need for scientific correction of the patient's behavior, i.e. non-drug therapy, mainly including mediterranean diet, exercise therapy, phototherapy, acupuncture therapy, music therapy, stress reduction, increased socialization, attention to sleep hygiene and training to receive knowledge of dementia. At present, the disease cannot be cured.
Research and clinical findings show that although the drug therapy is used as a main treatment method, no radical drug exists, all drugs can only improve the cognitive condition of patients in a short term, the post-treatment of patients with severe dementia is troublesome, and the curative effect of the drug is weakened or even ineffective. The treatment with antipsychotics is not helpful in improving cognitive function, but it can control the mental symptoms of the patient, such as anxiety, irritability, emotional instability, hallucinations, etc., which are troublesome to the care of the subjects and require the use of such drugs to control the mental symptoms. The non-drug therapy plays an important auxiliary role in treating the senile dementia, such as supporting the elderly to participate in social activities, work which can be achieved by more participation, or professional cognitive training and intelligence-promoting activities, and simultaneously needing auxiliary diet, nutrition and other exercises, and aiming at hopefully slowing down the cognitive decline.
The existing music therapy or phototherapy has a certain relieving effect on senile dementia symptoms, but no special treatment equipment for simultaneous music therapy and phototherapy exists.
SUMMERY OF THE UTILITY MODEL
In view of this, the embodiment of the present invention provides an effective device for preventing and treating alzheimer's disease with low frequency acousto-optic synergy.
The embodiment of the utility model provides a synergistic Alzheimer's disease prevention and treatment device of low frequency reputation, the device comprises a device body, this internal microprocessor, reputation amazing and response module, power module, button and display module, storage module and audible-visual alarm module of being equipped with of device, microprocessor's input is connected to power module's output, storage module and audible-visual alarm module are connected respectively to microprocessor's output, microprocessor is connected with response module, button and display module to reputation amazing.
Further, an arc-shaped handle is arranged on the device body.
Further, an LED lamp source window is arranged on the device body, an LED lamp source is arranged in the LED lamp source window, and the input end of the LED lamp source is connected with the output end of the microprocessor through a control circuit.
Further, the display module in button and the display module is liquid crystal display, liquid crystal display sets up in the shell face of device body.
Further, the key module in the key and display module comprises a down-moving key, an up-moving key and a review function key, and the down-moving key, the up-moving key and the review function key are all arranged below the liquid crystal display screen.
Further, an alarm lamp is arranged below the arc-shaped handle.
Further, a buzzer window is arranged between the arc-shaped handle and the alarm lamp.
Furthermore, an audio window is arranged on the device body.
Further, the lower end of the device body is a pedestal, and a power indicator, a power switch, a digital key, a USB power supply socket and a power adapter socket are arranged on the pedestal; the storage module is a built-in SD card which is arranged at the bottom of the pedestal.
Further, the acousto-optic stimulation and induction module is composed of a sound induction circuit, a sound stimulation circuit, a light induction circuit and a light stimulation circuit.
Above-mentioned the utility model discloses technical scheme in the embodiment has following advantage: the utility model discloses a microprocessor, reputation amazing and response module, power module, button and display module, storage module and audible-visual alarm module, according to the input signal of button module, cooperation microprocessor's control signal sends reputation cooperative signal through reputation amazing and response module and realizes prevention and treatment function, the utility model discloses a device provides music treatment and phototherapy simultaneously, and is effectual and stable good.
Drawings
FIG. 1 is a block diagram of the overall structure of a low-frequency acousto-optic cooperative Alzheimer's disease prevention and treatment device of the present invention;
fig. 2 is a schematic structural diagram of a low-frequency acousto-optic synergistic alzheimer disease prevention and treatment device of the present invention;
FIG. 3 is a schematic diagram of the optical stimulation circuit of the present invention;
fig. 4 is a schematic diagram of a photo-sensing circuit according to the present invention;
fig. 5 is a schematic diagram of the sound stimulation circuit of the present invention;
fig. 6 is a schematic diagram of the sound sensing circuit of the present invention.
Detailed Description
Referring to fig. 1, the embodiment of the utility model provides a synergistic alzheimer's disease prevention and treatment device of low frequency reputation, the device comprises a device body, this internal microprocessor, reputation amazing and response module, power module, button and display module, storage module and audible-visual alarm module of being equipped with of device, microprocessor's input is connected to power module's output, storage module and audible-visual alarm module are connected respectively to microprocessor's output, reputation amazing and response module, button and display module connect microprocessor.
Referring to fig. 2, further as a preferred embodiment, the device body is provided with an arc-shaped handle 1.
Referring to fig. 2, as a further preferred embodiment, an LED light source window 3 is provided on the device body, an LED light source 2 is provided in the LED light source window 3, and an input end of the LED light source is connected to an output end of the microprocessor through a control circuit.
Referring to fig. 2, as a further preferred embodiment, the display module in the keys and the display module is a liquid crystal display, and the liquid crystal display 4 is disposed on the outer surface of the device body.
Referring to fig. 2, as a further preferred embodiment, the key module in the key and display module includes a down key 5, an up key 13, and a review function key 6, and the down key 5, the up key 13, and the review function key 6 are all disposed below the liquid crystal display 4.
Referring to fig. 2, in a further preferred embodiment, a warning lamp 11 is arranged below the arc-shaped handle 1.
Referring to fig. 2, in a further preferred embodiment, a buzzer window 10 is arranged between the arc-shaped handle 1 and the alarm lamp 11.
Referring to fig. 2, in a further preferred embodiment, an audio window 12 is provided on the apparatus body.
Referring to fig. 2, in a further preferred embodiment, a pedestal 16 is provided at the lower end of the device body, and a power indicator 7, a power switch 15, a numeric key, a USB power supply socket 8 and a power adapter socket 9 are provided on the pedestal 16; the storage module is a built-in SD card 17, and the built-in SD card 17 is arranged at the bottom of the pedestal.
In addition, as shown in fig. 2, the pedestal of the present embodiment is further provided with 0-3 numeral keys 14.
Referring to fig. 2, further as a preferred embodiment, the acousto-optic stimulation and sensing module is composed of a sound sensing circuit, a sound stimulation circuit, a light sensing circuit and a light stimulation circuit.
Specifically, the utility model provides a device is through regularly adding 40Hz low frequency reputation costimulation to the senile dementia patient, makes brain central nervous system's main component part microglia increase, makes the cell diameter increase, clears away the beta amyloid in AD patient's pathology brain for pathological plaque quantity reduces, and the treatment effect is judged through the gamma wave frequency and the cognitive function of beta amyloid content and brain vision cortex (AC) in the periodic detection patient brain in the treatment process.
The utility model discloses a device mainly includes microprocessor, reputation amazing and response module, power module, button and display module, storage module, 6 parts of audible-visual alarm module, and wherein the microprocessor circuit has advantages such as small, with low costs, stability is good, portable convenience as the main control unit.
The microprocessor module is an embedded system main control unit and is responsible for processing and calculating signals, prompting a patient to treat by timing voice, sending out a 40Hz low-frequency pulse signal, and controlling the on-off of the triode BD245-25 to control the operation of the acousto-optic stimulation module, thereby realizing the accurate control of acousto-optic frequency and working time and ensuring the periodicity and timeliness of treatment; and meanwhile, the signal of the acousto-optic induction module is collected, and the acousto-optic fault voice alarm circuit is controlled according to the signal. The microprocessor of the embodiment adopts an Atmega168 singlechip as the microprocessor, sends out voice prompts of treatment start and end at regular time, outputs a 40Hz PWM signal and controls a triode Q2The LED1, the LED2 (shown in figure 3) and the voice chip GBG40 (shown in figure 5) of the LED lamp are switched on or off (shown in figure 3), so that acousto-optic cooperative stimulation is realized, meanwhile, an acousto-optic sensing signal is received to realize abnormal alarm control, and effective treatment is ensured; while also controlling the display and storage circuitry.
The acousto-optic stimulation and sensing module integrates acousto-optic synergetic generation and detection functions and mainly comprises an acousto-optic stimulation circuit consisting of an LED lamp, a voice chip, a microphone and a photosensitive diode and a sensing circuit for sound detection and light intensity detection. As shown in fig. 4, the present invention obtains the light sensing signal through D1, and then outputs the corresponding sensing signal to the microprocessor. As shown in FIG. 6, the utility model discloses an XF-18D acquires the sound sensing signal, then exports the Audio signal to microprocessor after circuit processing. Under the control signal of 40Hz low-frequency pulse sent by the microprocessor, the acousto-optic cooperation of the LED lamp and the audio device is realized. Meanwhile, the sound detection circuit detects the intensity change of the sound and feeds the change back to the microprocessor, and the light detection circuit detects the background light change and feeds the change back to the microprocessor. The sound and light stimulation and induction module of the embodiment can be controlled by the MCU voice chip GBG40 to receive the language prompt sent by the main control chip and send 40Hz low frequency sound, and the XF-18D microphone detection sound detection module is adopted to realize the voice detection and feed back the detection result to the MCU; a low-energy 12V power supply is adopted to simultaneously supply a constant current source circuit and 2 white 20W LED lamps, a PWM signal sent by a main control chip is received to stably control the flicker and brightness of the white energy-saving lamps, and the change frequency of background light in the environment detected by a photosensitive diode is fed back to an MCU to judge whether the light flicker is normal or not.
The power supply module is a 5V rechargeable direct current power supply, is connected with a 220V and 50Hz to 5V power supply adapter through a round port during charging to directly supply power to the microprocessor module and the light stimulation and induction circuit, and supplies power to the sound stimulation and induction circuit after the voltage is reduced to 3V; the charger with 5V and 1A output can also be used for directly supplying power to the microprocessor module and the light stimulation and induction circuit through the USB port through a USB wire; in the power module of this embodiment, a 5V dc power converted from a 220V mains adapter supplies power to a control tube such as a microprocessor and a triode, an SX1318 chip is used in an internal booster circuit to raise the voltage to 12V to supply power to an LED1 and an LED2 (as shown in fig. 3) low-voltage energy-saving bulb, and the internal booster circuit converts the voltage to 3V dc voltage through an AMS1117-3.3 chip to supply power to a voice chip GBG40 (as shown in fig. 5).
The key and display module is provided with 4 keys, wherein the starting and the shutdown are one key, the stored data access playback function is one key, and the up/down selection is one key respectively; and a liquid crystal display interface (displaying treatment time and times); as shown in fig. 2, the key and display module of this embodiment is composed of 1 power switch key 15, 1 playback function key 6, 1 up-shift key 13 and down- shift key 5, 4 numeric keys 14, 1 LED lamp 7 and a liquid crystal display (LCD12864) 4. The power supply key 15 realizes the on-off of the power supply (short-press starting and long-press 1s shutdown); 1 playback function key 6 for playing back and viewing the treated patient information and number of times; 1 up-shift key 13 and down-shift key 5 for moving up and down information items; the LED lamp 7 is used to display the power-on state (red); 4 number keys of 0-3 are used for inputting the ID number of the patient, and the liquid crystal screen 4 is used for displaying the ID number of the patient, the treatment time and the treated times in real time.
And the storage module is used for storing the treatment course, times (days) and each treatment time of the AD patient, and directly storing by adopting an SD card so as to be checked by doctors or family members of the AD patient and arrange to detect cerebrospinal fluid, MRI or cognitive function. The memory module of the present embodiment stores data by 1 16G custodon SD card 17. The microprocessor sends the patient information and the treatment times and time to be displayed in real time and simultaneously writes the patient information and the treatment times and time into the SD card to be stored for the family members of the patient or medical personnel to check the treatment times and time of the patient so as to arrange to carry out cognitive function detection and other evaluation modes to detect the treatment effect of the patient, and the collected data can be used for scientific research and analysis.
And the sound-light alarm module consists of an LED lamp, a buzzer and a control circuit and is used for giving an alarm by sensing abnormity in sound and light. The sound and light alarm module of the present embodiment is composed of an LED lamp 11, 1 buzzer 10 and a control circuit thereof. The LED lamp 11 is used to reflect light sensing abnormality alarm (red flashing), and the buzzer 10 is used to reflect sound detection abnormality alarm.
The specific working principle of the circuit of the utility model is as follows: firstly, the power supply of the equipment is switched on, after a power key 15 is turned on, a power lamp 7 is turned on to be red, a microprocessor is initialized, and a patient is prompted to prepare for treatment, so that accompanying family members or medical staff can lose people or select patient information; then the microprocessor sends out 40Hz low-frequency PWM signals to control the acousto-optic stimulation and induction module to send out white light flicker and sound stimulation, and simultaneously receives the comparison of the change frequency of the photosensitive diode to the ambient light and the change frequency of the audio frequency with 40Hz, if the change frequency is abnormal, the acousto-optic alarm circuit 11 is started to reflect the light induction abnormal alarm (red flicker), the buzzer 10 rings and shuts down, and the acousto-optic synergy and the therapeutic effectiveness are ensured. During normal treatment, the microprocessor also stores the patient information, the treatment times and the time in the storage SD card 17 in real time and displays the patient information, the treatment times and the treatment time on the display screen 4; after normal treatment for 1 hour, the microprocessor sends out a treatment ending voice prompt, stores data in the SD card 17, ends treatment and enters a low-power consumption standby state, if a power switch is not turned off, the voice prompt treatment is carried out within a fixed time on the next day, and if the power switch is turned off, the power switch needs to be turned on to start the treatment process on the next day.
The utility model discloses a low frequency reputation prevention in coordination with AD and treatment amazing device working process does: in a white wall sound-free space, under the condition that the low-frequency sound-light collaborative AD prevention and treatment stimulation device is powered by an adapter or a charger or a rechargeable battery, a power switch is turned on, a power lamp is in red, ID information of a patient to be treated is input or selected according to prompt of a display screen after voice prompt treatment, sound-light collaborative stimulation is started after confirmation, 40Hz music is sent out by audio, 20W white energy-saving lamps of 2 low-voltage LEDs flicker according to 40Hz PWM signals, if the device is normal, the duration lasts for 1 hour (if the sound-light collaborative abnormality can make a buzzer sound, meanwhile, a warning lamp flashes for red for 3S, and then the device is automatically turned off), and the treated times and the treated time can be displayed by the display screen in the process. When 1 hour is full, the device will send out a voice prompt for the end of treatment, and then the power can be turned off (if not, the device will enter a low power consumption timing mode, and prompt treatment at the same time in the next day, and if the same patient is treated 7 times continuously, the device will send out a voice prompt for examination or a new treatment cycle can be started.
To sum up, the utility model discloses a device has following advantage:
the utility model utilizes the physiological characteristics that the accumulation of beta amyloid protein and Tau protein in the brain of the Alzheimer's disease patient is closely related to the disease of the senile dementia patient, and the gamma wave frequency of the brain visual cortex (AC) of the AD patient can be disturbed, has certain effect on the treatment of the AD patient based on the music therapy and the light therapy, adopts the PWM signal of 40Hz to control the acousto-optic stimulation module, realizes the acousto-optic co-stimulation to the AD patient, through testing senile dementia mouse patients, cerebral spinal fluid, MRI images and electroencephalogram analysis are adopted to discover that microglia of main components of a central nervous system of a brain can be increased, the cell diameter can be increased, amyloid beta in pathological brains of AD mouse patients is reduced, the number of pathological plaques of temporal frontals in the MRI images is reduced, an electroencephalogram shows that the frequency of gamma waves of visual cortex (AC) of the brains is improved, and cognitive function detection also discovers that cognition of the AD mouse is improved. The device is portable and convenient, is suitable for carrying, provides a new treatment mode and special equipment for the old and difficult problem of treating AD patients at present, and breaks through the problems of the characteristics of music and light which are not used clearly in the current music therapy and light stimulation therapy and the diversity and ineffectiveness of the equipment.
While the preferred embodiments of the present invention have been described, the present invention is not limited to the above embodiments, and those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present invention, and such equivalent modifications or substitutions are intended to be included within the scope of the present invention as defined by the appended claims.
Claims (10)
1. A low-frequency acousto-optic synergistic Alzheimer disease prevention and treatment device is characterized in that: the device comprises a device body, wherein a microprocessor, an acousto-optic stimulation and induction module, a power supply module, a key, a display module, a storage module and an acousto-optic alarm module are arranged in the device body, the output end of the power supply module is connected with the input end of the microprocessor, the output end of the microprocessor is respectively connected with the storage module and the acousto-optic alarm module, and the acousto-optic stimulation and induction module, the key and the display module are connected with the microprocessor.
2. The device for preventing and treating Alzheimer's disease with low frequency acousto-optic synergy according to claim 1, wherein: the device body is provided with an arc-shaped handle.
3. The device for preventing and treating Alzheimer's disease with low frequency acousto-optic synergy according to claim 1, wherein: the LED lamp is characterized in that an LED lamp source window is arranged on the device body, an LED lamp source is arranged in the LED lamp source window, and the input end of the LED lamp source is connected with the output end of the microprocessor through a control circuit.
4. The device for preventing and treating Alzheimer's disease with low frequency acousto-optic synergy according to claim 1, wherein: the display module in button and the display module is liquid crystal display, liquid crystal display sets up in the shell face of device body.
5. The device for the prevention and treatment of Alzheimer's disease with low frequency acousto-optic synergy according to claim 4, wherein: the key module in the key and display module comprises a downward moving key, an upward moving key and a review function key, and the downward moving key, the upward moving key and the review function key are all arranged below the liquid crystal display screen.
6. The device for preventing and treating Alzheimer's disease with low frequency acousto-optic synergy according to claim 2, wherein: and an alarm lamp is arranged below the arc-shaped handle.
7. The device for the prevention and treatment of Alzheimer's disease with low frequency acousto-optic synergy according to claim 6, wherein: and a buzzer window is arranged between the arc-shaped handle and the alarm lamp.
8. The device for preventing and treating Alzheimer's disease with low frequency acousto-optic synergy according to claim 1, wherein: an audio window is arranged on the device body.
9. The device for preventing and treating Alzheimer's disease with low frequency acousto-optic synergy according to claim 1, wherein: the lower end of the device body is a pedestal, and a power indicator lamp, a power switch, a digital key, a USB power supply socket and a power adapter socket are arranged on the pedestal; the storage module is a built-in SD card which is arranged at the bottom of the pedestal.
10. The device for preventing and treating Alzheimer's disease with low frequency acousto-optic synergy according to claim 1, wherein: the acousto-optic stimulation and induction module is composed of a sound induction circuit, a sound stimulation circuit, a light induction circuit and a light stimulation circuit.
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| CN113262372A (en) * | 2021-04-02 | 2021-08-17 | 西安交通大学医学院第二附属医院 | Rehabilitation device based on big data senile dementia patient |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113262372A (en) * | 2021-04-02 | 2021-08-17 | 西安交通大学医学院第二附属医院 | Rehabilitation device based on big data senile dementia patient |
| CN113262372B (en) * | 2021-04-02 | 2022-10-11 | 西安交通大学医学院第二附属医院 | Rehabilitation equipment based on big data senile dementia patient |
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