CN211410738U

CN211410738U - Neutron capture therapy system

Info

Publication number: CN211410738U
Application number: CN201921763620.5U
Authority: CN
Inventors: 江涛; 柏松龄; 陈韦霖
Original assignee: China Boron Xiamen Medical Equipment Co ltd
Current assignee: China Boron Xiamen Medical Equipment Co ltd
Priority date: 2019-10-21
Filing date: 2019-10-21
Publication date: 2020-09-04
Anticipated expiration: 2029-10-21

Abstract

The utility model provides a neutron capture treatment system, including neutron generating device and beam integer, the beam quality of the neutron line that neutron generating device produced is adjusted to beam integer, neutron capture treatment system is still including the concrete wall that forms the space that holds neutron generating device and beam integer, set up the support module in the concrete wall, the support module can support the beam integer and be used for adjusting the position of beam integer, neutron capture treatment system is still including the protective frame who is used for holding beam integer and support module, protective frame is used for the transportation or the installation of beam integer and support module. The neutron capture treatment system support structure of the utility model is modularized, so that the beam shaping body can be locally adjusted, the precision requirement is met, the beam quality is improved, and the assembly tolerance of the target is met; by providing a protective frame, the risk of the beam shaper tipping over during the transport of the fill material or the beam shaper and its support module is reduced.

Description

Neutron capture therapy system

Technical Field

The present invention relates to a radiation therapy system, and more particularly to a neutron capture therapy system.

Background

With the development of atomic science, radiation therapy such as cobalt sixty, linacs, electron beams, etc. has become one of the main means of cancer treatment. However, the traditional photon or electron therapy is limited by the physical conditions of the radiation, and can kill tumor cells and damage a large amount of normal tissues in the beam path; in addition, due to the difference in the sensitivity of tumor cells to radiation, conventional radiotherapy is often ineffective in treating malignant tumors with relatively high radiation resistance, such as multiple glioblastoma multiforme (glioblastoma multiforme) and melanoma (melanoma).

In order to reduce the radiation damage of normal tissues around tumor, the target therapy concept in chemotherapy (chemotherapy) is applied to radiotherapy; for tumor cells with high radiation resistance, radiation sources with high Relative Biological Effect (RBE) are also actively developed, such as proton therapy, heavy particle therapy, neutron capture therapy, etc. Wherein, the neutron capture treatment combines the two concepts, such as boron neutron capture treatment, and provides better cancer treatment selection than the traditional radioactive rays by the specific accumulation of boron-containing drugs in tumor cells and the precise neutron beam regulation.

The beam shaper is used for improving the flux and quality of a neutron source, is a core component of a neutron capture treatment system, and needs the center of a high-energy beam tube and the center of the beam shaper to be coincident as much as possible in order to ensure the beam quality and improve the treatment effect. Thus, the beam shaper is supported by concrete support modules, but the beam shaper as a whole and its concrete support part have a relatively high weight and a relatively high center of gravity, which may risk tipping during filling of the beam shaper material or during transport of the beam shaper as a whole and its support modules.

Therefore, a new technical solution is needed to solve the above problems.

SUMMERY OF THE UTILITY MODEL

In order to solve the above problem, the present invention provides a neutron capture treatment system, including neutron generating device and beam shaping body, the beam shaping body adjusts the beam quality of the neutron line produced by the neutron generating device, the neutron capture treatment system further includes a concrete wall forming a space for accommodating the neutron generating device and the beam shaping body, a support module is arranged in the concrete wall, the support module can support the beam shaping body and is used for adjusting the position of the beam shaping body, the neutron capture treatment system further includes a protection frame for accommodating the beam shaping body and the support module, and the protection frame is used for transportation or installation of the beam shaping body and the support module. The support structure is modularized, so that the beam shaping body can be locally adjusted, the precision requirement is met, the beam quality is improved, and the assembly tolerance of the target is met; by providing a protective frame, the risk of the beam shaper tipping over during the transport of the fill material or the beam shaper and its support module is reduced.

Preferably, the material of the protective frame is mild steel, and the protective frame is further provided with a support piece and a lifting lug. The supporting piece is used for supporting the protective frame and the beam shaping body and the supporting module which are arranged in the protective frame, so that the beam shaping body and the supporting module thereof are further prevented from overturning, and the stability is improved. The lifting lug is used to lift the guard frame to transfer the guard frame and the beam shaper and support module within the guard frame.

Preferably, the protection frame comprises an upper cover plate, a lower cover plate, a left side cover plate, a right side cover plate, a front side cover strip and a rear side cover strip, wherein the upper cover plate and the lower cover plate are respectively arranged at two ends of the left side cover plate and the right side cover plate and are detachably connected with the left side cover plate and the right side cover plate, and the front side cover strip and the rear side cover strip are respectively detachably connected with the left side cover plate and the right side cover plate. The protective frame is detachably connected, the structure is ingenious, the stability of the frame-type structure is improved, and the risk of overturning of the beam shaper during the process of filling materials or transporting the beam shaper and the supporting module thereof is further reduced.

Furthermore, the protection frame is further provided with a supporting piece, the supporting piece is detachably connected with the left side cover plate and the right side cover plate, and the lower surface of the supporting piece after being installed and the lower surface of the lower cover plate after being installed are on the same plane. The support further prevents the beam shaper and the support module thereof from overturning, thereby increasing the stability; the detachable connection is adopted, the supporting piece can be detached when interference is generated in the transportation process, the use convenience is improved, and the supporting piece can be installed or detached at any time.

Furthermore, the protective frame is further provided with lifting lugs, the lifting lugs are used for lifting the protective frame so as to transfer the protective frame and the beam shaping body and the support module in the protective frame, and the lifting lugs are bosses with through holes, which extend in the left and right directions from the middle positions of the upper parts of the left and right side cover plates respectively.

Preferably, the beam shaper comprises a support frame and a body part filled in the support frame, the body part being at least partially filled into the support frame before the support frame of the beam shaper is fixed to the support module; or fixing the support frame of the beam shaper to the support module, and filling the main body into the support frame. Preferably, the main body comprises a retarder and a reflector, and the retarder and/or the reflector of the specially shaped portion is filled into the support frame before the support frame of the beam shaper is fixed to the support module due to size, shape limitations or mounting accuracy requirements of the retarder.

Further, the support module and the beam shaper fixed to the support module are placed in the protective frame in their entirety before at least part of the body portion is filled, and the beam shaper and the support module are placed in the protective frame in their entirety before at least part of the body portion, in particular the portion with the greater weight, is filled, preventing overturning when the body portion is filled; or after the body portion is filled, the support module and the beam shaper fixed to the support module are placed in their entirety within the protective frame.

Preferably, the support module is provided with a detachably connected adjusting part, and the positions of the support module and the beam shaper are adjusted by an adjusting device acting on the adjusting part, so that the coincidence degree of the center of the beam shaper and the center of the beam line is improved, and the target can be placed in the central hole of the beam shaper. The protective frame can also be mounted by means of an adjusting device acting on the adjusting element.

Preferably, the neutron capture treatment system further includes an irradiation chamber and a charged particle beam generation chamber, the irradiation chamber and the charged particle beam generation chamber are a space surrounded by the concrete wall, the neutron capture treatment system includes a treatment table disposed in the irradiation chamber, an irradiated object on the treatment table performs treatment of irradiation with the neutron beam in the irradiation chamber, the neutron production device includes an accelerator and a target, the charged particle beam generated by acceleration of the accelerator acts on the target to generate a neutron beam, the charged particle beam generation chamber at least partially accommodates the accelerator, and the support module and the beam shaping body are at least partially accommodated in a partition wall between the irradiation chamber and the charged particle beam generation chamber.

Further, a shielding body is filled between the partition wall and the support module and the beam shaping body, the material of the shielding body comprises at least one of photon shielding material and neutron shielding material, the shielding body comprises at least one of rigid solid, flexible solid, liquid and powder, and a shielding plate is arranged on one side of the partition wall close to the irradiation chamber to shield the shielding body, so that the radiation is further reduced.

The neutron capture treatment system of the utility model has a modularized support structure, so that the beam shaping body can be locally adjusted, the precision requirement is met, the beam quality is improved, and the assembly tolerance of a target is met; by providing a protective frame, the risk of the beam shaper tipping over during the transport of the fill material or the beam shaper and its support module is reduced.

Drawings

Fig. 1 is a schematic structural diagram of a neutron capture therapy system according to an embodiment of the present invention;

fig. 2 is a schematic view of an installation of a beam shaper support module of a neutron capture therapy system according to an embodiment of the present invention;

fig. 3 is a schematic structural view of the beam shaper support module of fig. 2;

FIG. 4 is a schematic view of FIG. 3 taken at section A-A;

fig. 5 is a schematic diagram of a beam shaper of a neutron capture therapy system according to an embodiment of the present invention;

fig. 6 is a schematic view of a protective frame of a neutron capture treatment system according to an embodiment of the present invention;

FIG. 7 is a schematic view of the protective frame of FIG. 6 in another orientation;

FIG. 8 is a schematic view of a left side cover plate of the protective frame of FIG. 6;

FIG. 9 is a schematic view of the left side cover plate of FIG. 8 in another orientation;

FIG. 10 is a schematic view of a support member of the protective frame of FIG. 6;

fig. 11 is a schematic view of an adjustment member of a beam shaper support module in accordance with an embodiment of the present invention;

fig. 12 is a schematic view of the adjustment member of fig. 11 in another orientation.

Detailed Description

Embodiments of the present invention will be described in further detail with reference to the accompanying drawings so that those skilled in the art can implement the embodiments with reference to the description.

Referring to fig. 1, the neutron capture therapy system in the present embodiment is preferably a boron neutron capture therapy system 100, which includes a neutron production device 10, a beam shaper 20, a collimator 30, and a treatment table 40. The neutron generating apparatus 10 includes an accelerator 11 and a target T, and the accelerator 11 accelerates charged particles (such as protons, deuterons, and the like) to generate a charged particle beam P such as a proton beam, and the charged particle beam P irradiates the target T and reacts with the target T to generate a neutron beam (neutron beam) N, and the target T is preferably a metal target. The appropriate nuclear reactions are selected based on the desired neutron yield and energy, the available energy and current for accelerating charged particles, the physical properties of the metal target, and the like, and the nuclear reactions in question include⁷Li(p,n)⁷Be and⁹Be(p,n)⁹b, both reactions are endothermic. The energy thresholds of the two nuclear reactions are 1.881MeV and 2.055MeV, respectively, since the ideal neutron source for boron neutron capture therapy is epithermal neutrons at keV energy levels, theoretically if the metal is bombarded with protons whose energy is only slightly above the thresholdLithium targets can produce neutrons with relatively low energy and can Be used clinically without too much slowing treatment, however, the action cross section of the lithium metal (Li) target and the beryllium metal (Be) target and protons with threshold energy is not high, and in order to produce a sufficiently large neutron flux, the protons with higher energy are usually selected to initiate nuclear reaction. The ideal target material should possess high neutron yield, the neutron energy distribution that produces is close to super-heat neutron energy region (will be described in detail below), not too much strong penetrating radiation produces, safe cheap easily operation and characteristics such as high temperature resistant, actually can't find the nuclear reaction that accords with all requirements, the embodiment of the utility model adopts the target material that lithium metal made. However, as is well known to those skilled in the art, the material of the target T may be made of a metal material other than lithium or beryllium, such as tantalum (Ta) or tungsten (W); the target T may be in the form of a disk, may be in the form of other solid, or may be in the form of a liquid (liquid metal). The accelerator 11 may be a linear accelerator, a cyclotron, a synchrotron, or a synchrocyclotron, and the neutron generating apparatus 10 may also be a nuclear reactor without using an accelerator and a target. Whether the neutron source of boron neutron capture therapy comes from a nuclear reactor or from the nuclear reaction of charged particles of an accelerator and a target, the generated radiation field is actually mixed, i.e. the beam contains neutrons, photons from low energy to high energy. For boron neutron capture therapy of deep tumors, the greater the amount of radiation other than epithermal neutrons, the greater the proportion of non-selective dose deposition in normal tissue, and therefore the unnecessary dose of radiation that these would cause should be minimized. In addition, for normal tissue of the irradiated subject, the various radiation rays should be prevented from being excessive, also resulting in unnecessary dose deposition.

The neutron beam N generated by the neutron generator 10 passes through the beam shaper 20 and the collimator 30 in order and is irradiated on the irradiation target 200 on the treatment table 40. The beam shaper 20 can adjust the beam quality of the neutron beam N generated by the neutron generator 10, the collimator 30 is used for converging the neutron beam N, so that the neutron beam N has high targeting performance in the treatment process, the collimator 30 can be adjusted to adjust the direction of the beam and the position relation between the beam and the irradiated object 200 on the treatment table 40, and the positions of the treatment table 40 and the irradiated object 200 can also be adjusted to enable the beam to be directed at the tumor cells M in the irradiated object 200. These adjustments may be manually made or may be automatically made through a series of control mechanisms. It is to be understood that the present invention may be used without a collimator, and the beam may be emitted from the beam shaper 20 and directly irradiated to the irradiated object 200 on the treatment table 40.

The beam shaping body 20 further comprises a reflector 21, a retarder 22, a thermal neutron absorber 23, a radiation shield 24 and a beam outlet 25, neutrons generated by the neutron generating device 10 need to reduce the content of neutrons and photons of other types as much as possible to avoid injury to operators or irradiated bodies besides epithermal neutrons meeting treatment requirements due to wide energy spectrum, so that the fast neutron energy (> 40keV) of the neutrons from the neutron generating device 10 needs to be adjusted to an epithermal neutron energy region (0.5eV-40keV) and the thermal neutrons (< 0.5eV) are reduced as much as possible through the retarder 22, the retarder 22 is made of a material with a large fast neutron action section and a small epithermal neutron action section, and as a preferred embodiment, the retarder 22 is made of a material with a D₂O、AlF₃、Fluental、CaF₂、 Li₂CO₃、MgF₂And Al₂O₃At least one of (a); the reflector 21 surrounds the retarder 22, reflects neutrons diffused to the periphery through the retarder 22 back to the neutron beam N to improve the utilization rate of the neutrons, and is made of a material having a strong neutron reflection capability, and as a preferred embodiment, the reflector 21 is made of at least one of Pb or Ni; the rear part of the retarder 22 is provided with a thermal neutron absorber 23 which is made of a material with a large cross section for reacting with thermal neutrons, as a preferred embodiment, the thermal neutron absorber 23 is made of Li-6, and the thermal neutron absorber 23 is used for absorbing the thermal neutrons passing through the retarder 22 so as to reduce the content of the thermal neutrons in the neutron beam N and avoid causing excessive dose with shallow normal tissues during treatment; the radiation shield 24 is used for shielding neutrons and photons leaking from a portion other than the beam outlet 25, the material of the radiation shield 24 includes at least one of a photon shielding material and a neutron shielding material, and as a preferred embodiment, the material of the radiation shield 24 includes lead (Pb) and lead (Pb) which are photon shielding materialsThe neutron shielding material Polyethylene (PE). The collimator 30 is disposed behind the beam outlet 25, and the hyperthermo neutron beam emitted from the collimator 30 irradiates the irradiated object 200, passes through a shallow normal tissue, and is slowed down to be a thermal neutron to reach the tumor cell M. It will be appreciated that the beam shaper 20 may have other configurations as long as the desired hyperthermal neutron beam for the treatment is obtained.

After the irradiated body 200 is administered or injected with the boron-containing (B-10) drug, the boron-containing drug selectively accumulates in the tumor cells M, and then the boron-containing (B-10) drug has a high capture cross section for thermal neutrons¹⁰B(n,α)⁷Li neutron capture and nuclear fission reaction generation⁴He and⁷the average Energy of the two charged particles is about 2.33MeV, the two charged particles have high Linear Energy Transfer (LET) and short-range characteristics, and the Linear Energy Transfer and the range of the α short particles are 150 keV/mum and 8μm respectively⁷The Li-heavily-charged particles are 175 keV/mum and 5μm, and the total range of the two particles is about equal to the size of a cell, so that the radiation damage to organisms can be limited at the cell level, and the aim of locally killing tumor cells can be achieved on the premise of not causing too much damage to normal tissues.

In this embodiment, a radiation shielding device 50 is further disposed between the irradiated object 200 and the beam outlet 25 to shield the normal tissue of the irradiated object from the beam emitted from the beam outlet 25, but it should be understood that the radiation shielding device 50 may not be disposed.

The boron neutron capture therapy system 100 is entirely housed in a building having a concrete structure, and specifically, the boron neutron capture therapy system 100 further includes an irradiation chamber 101 and a charged particle beam generation chamber 102, the object 200 on the therapy table 40 performs therapy in which the neutron beam N is irradiated in the irradiation chamber 101, the charged particle beam generation chamber 102 at least partially houses the accelerator 11, and the beam shaper 20 is at least partially housed in a partition wall 103 between the irradiation chamber 101 and the charged particle beam generation chamber 102. It is understood that the partition wall 103 may be a wall that completely separates the irradiation chamber 101 and the charged particle beam generation chamber 102; the irradiation chamber 101 and the charged particle beam generation chamber 102 may be partially isolated from each other, and the irradiation chamber 101 and the charged particle beam generation chamber 102 may be communicated with each other. The target material T can have one or more, and the charged particle beam P can selectively act with one or more of the target materials T or simultaneously act with a plurality of the target materials T to generate one or more therapeutic neutron beams N. One or more beam shapers 20, collimators 30 and treatment tables 40 can be provided corresponding to the number of targets T; the treatment tables can be arranged in the same irradiation chamber, or a separate irradiation chamber can be arranged for each treatment table.

The irradiation chamber 101 and the charged particle beam generation chamber 102 are spaces formed by being surrounded by a concrete wall W (including a partition wall 103), and the concrete structure can shield neutrons and other radiation rays leaking during the operation of the boron neutron capture treatment system 100. Referring to fig. 2, the beam shaper 20 is supported by the support module 60 disposed in the partition wall 103, a receiving groove 1031 for at least partially receiving the support module 60 is disposed on a side of the partition wall 103 close to the irradiation chamber 102, and a slot 1032 for passing a transport tube of an accelerator or the like is disposed on a side close to the charged particle beam generation chamber 101, so that the receiving groove 1031 and the slot 1032 penetrate the partition wall in the traveling direction of the neutron beam N, which is a plane surface of the partition wall 103 and perpendicular to the wall surface of the partition wall 103 in this embodiment. The support structure is modularized, so that the beam shaping body can be locally adjusted, the precision requirement is met, the beam quality is improved, and the assembly tolerance of the target is met. The cross-sectional profile of the support module 60 is located between the cross-sectional profiles of the receiving

grooves

1031 and 1032 in a plane perpendicular to the direction of propagation of the neutron beam N, thereby avoiding through-slits in the direction of propagation of the beam, further reducing radiation, and facilitating adjustment of the support module 60. In this embodiment, the support module 60 is a rectangular parallelepiped, the cross sections of the receiving grooves 1031 and the grooves 1032 perpendicular to the transmission direction of the neutron beam N are both "Jiong", and the side walls of the receiving grooves 1031 and the grooves 1032 are parallel to the transmission direction of the neutron beam N. The shielding plate 70 is further disposed on one side of the partition wall 103 close to the irradiation chamber 102, and the shielding plate 70 can enhance the shielding effect of the partition wall and suppress the secondary radiation generated by the partition wall, thereby avoiding the radiation to the normal tissue of the patient. The shielding plate 70 may match the cross-sectional profile of the support module 60 in a plane perpendicular to the direction of propagation of the neutron beam N, thereby shielding neutrons leaking from between the support module and the partition wall. The shielding plate is a PE plate, and it is understood that the shielding plate may be provided on the side of the partition wall 103 close to the charged particle beam generating chamber 102 and on the side of the support module 60 close to the irradiation chamber 101, and the shielding plate may be made of other neutron or photon shielding material such as lead, or may not be provided.

With reference to fig. 3-4, the support module 60 includes concrete and a reinforcement 61 (described in detail below) at least partially disposed in the concrete, and since the concrete has low tensile strength and is easy to crack, and the beam shaping body is very sensitive to deformation, and requires sufficient rigidity of the support structure, the reinforcement disposed in the concrete can increase rigidity, increase tensile strength, and increase load-bearing capacity, and the material modulus of elasticity of the reinforcement is not lower than 40GPa, the ultimate strength is not lower than 200MPa, and the yield strength is not lower than 100 MPa. Since neutrons are generated in the beam shaper, the material in the periphery is most severely activated, the material of the reinforcement is composed of an element having a small neutron interaction cross section or having a short half-life (less than 1 year) of the radioisotope generated after neutron activation, and for example, the material of the reinforcement is composed of at least one of C, H, O, N, Si, Al, Mg, Li, B, Mn, Cu, Zn, S, Ca, and Ti in 90 wt% or more. In the embodiment, at least part of the reinforcing part is made of aluminum alloy, and the half-life period of the aluminum after being activated by neutrons is shorter, namely only 2.2 minutes; in the traditional reinforced concrete structure, elements such as iron, cobalt, nickel and the like rich in the steel bar are activated by neutrons, and then the half-life period is longer, for example, the half-life period of cobalt 60 is 5.27 years; the radioactivity derived from neutron activation is greatly reduced in a limited time by adopting the aluminum alloy, so that the dosage caused by secondary radiation is reasonably inhibited, and the future equipment dismantling is facilitated. The material of the reinforcing portion may further be an aluminum magnesium alloy, or may be a carbon fiber composite material, a glass fiber composite material, or a combination thereof.

The reinforcement 61 includes formworks 611 and ribs 612 disposed between the formworks, and the formworks 611 are fixedly connected to the ribs 612. The template 611 comprises a lower template 6111, a left template 6112 and a right template 6113 which are arranged at two sides of the lower template 6111, and a circular template 6114 which is surrounded by the lower template and the left and right templates, wherein the template 611 is made of aluminum alloy and is used as an anchoring plate of the rib 612. In the present embodiment, the beam shaper 20 is generally cylindrical, and it will be appreciated that the annular die plate may be replaced with other shaped die plates when the beam shaper is configured in other shapes. The ribs 612 include horizontal transverse ribs 6121, horizontal longitudinal ribs 6122 and vertical ribs 6123, and are distributed among the concrete inner circular template, the left template, the right template and the lower template at preset intervals in the horizontal direction, the vertical direction and the thickness direction of the concrete, the intervals are determined according to specific conditions, the intervals are only schematically drawn in the figure, and the ribs are also made of aluminum alloy. In this embodiment, the horizontal transverse rib 6121 is welded and anchored with the left template 6112, the right template 6113 and the circular template 6114 from left to right, the vertical rib 6123 is welded and anchored with the lower template 6111, the circular template 6114 and the horizontal transverse rib 6121, and the horizontal longitudinal rib 6122 is welded and anchored with the horizontal transverse rib 6121 and the vertical rib 6123. It will be appreciated that the form and ribs may be arranged in other ways, and that the welding sequence and process may be performed in other ways known to those skilled in the art, and that other fastening means may be used.

During construction, a front template and a rear template (not shown in the figure) need to be erected, and the front side, the rear side and the upper side of the support module 60 have no anchoring requirements, so that concrete is poured into a containing cavity formed among the lower template 6111, the left template 6112, the right template 6113, the circular template 6114 and the front template and the rear template by adopting a traditional wood template, the upper side is not provided with a template, the concrete state can be observed conveniently during construction, and the upper side is scraped by a plate after the concrete is filled. After the concrete is poured and cured, the front and rear formworks are removed to form the support module 60. In this embodiment, the beam shaper 20 is placed within the support module 60, with the outer wall of the beam shaper 20 mating with the inner surface of the annular template 6114. In order to restrict the degree of freedom of the beam shaper 20 in forward and backward translation and rotation, the beam shaper 20 is fixedly connected to the support module 60, for example, a threaded hole is formed on the circular ring template 6114, a hole is formed at a position corresponding to an outer wall of the beam shaper 20 (for example, an outer wall of the support frame 20a of the beam shaper 20 described below), and the beam shaper 20 is connected to the circular ring template 6114 by a bolt. Before concrete is poured, the threaded holes of the circular ring template 6114 are filled with plastic protective sleeves, so that concrete is prevented from leaking out of the threaded holes and threads are protected. In order to ensure the compactness of the concrete under the circular ring formwork, an opening can be formed under the front formwork or the rear formwork, and the concrete can be poured from the opening. After the concrete is poured and cured, the plastic protective sleeve filled in the threaded hole of the circular template 6114 is taken out, the beam shaper is placed in the accommodating cavity formed on the inner surface of the circular template 6114, and then the beam shaper 20 and the support module 60 are connected by bolts. It is understood that the construction process may be performed in other ways known to those skilled in the art.

After the beam shaper 20 and the support module 60 have been machined, they need to be transported to the partition 103, either the beam shaper 20 is transported together after being mounted to the support module 60, or the beam shaper 20 is mounted to the support module 60 after the beam shaper 20 and the support module 60 are transported separately to the partition 103. Referring to fig. 5, in the present embodiment, the beam shaper 20 includes a support frame 20a and a main body 20b (including a reflector 21, a retarder 22, a thermal neutron absorber 23, a radiation shield 24, etc.) filled in the support frame 20a, where the main body 20b may be at least partially filled into the support frame 20a, and then the support frame 20a of the beam shaper 20 is fixed to the support module 60; the support frame 20a of the beam shaper 20 may be fixed to the support module 60, and the main body 20b may be filled in the support frame 20 a. In one embodiment, due to size, shape limitations or mounting accuracy requirements of the retarders, the retarder 22 and/or the reflector 21 of a special-shaped portion (e.g., a non-rectangular cross-sectional portion in fig. 5) is first filled into the support frame 20a and encapsulated (e.g., by the end plate 20c), the support frame 20a of the beam shaper 20 is then fixed to the support module 60, the rest of the body portion 20b and the encapsulated body portion 20b are filled into the support frame 20a, and the beam shaper 20 and the support module 60 are then transported together to the partition wall 103 and mounted to the receiving cavity 1031. In this process, since the beam shaper 20 and its concrete support module 60 are relatively heavy and have a relatively high center of gravity, which risks overturning during transport, a protective frame 80 (described in detail below) is provided, and the support module 60 and the whole of the beam shaper 20 fixed to the support module 60 are transported while being placed in the protective frame 80. At the same time, the support module 60 and the entirety of the beam shaper 20 fixed to the support module 60 can be placed into the protective frame 80 before filling at least part of the body section 20b, in particular the heavier part (such as the lead block as reflector 21 and at least part of the radiation shield 24), refilling this part of the body section 20b, preventing overturning when filling the body section 20 b. After the beam shaper 20 and the support module 60 have been transported to the partition wall 103, the protection frame 80 is removed.

Referring to fig. 6 and 7, the protective frame 80 is a rectangular parallelepiped, and includes an upper cover plate 81, a lower cover plate 82, a left cover plate 83, a right cover plate 84, a front cover strip 85, and a rear cover strip 86, and the protective frame 80 forms an integral accommodating cavity of the beam shaper 20 and the support module 60. The up, down, left, right, front, and rear are the same as the up, down, left, right, front, and rear of the support module 60. The upper and

lower cover plates

81, 82 are flat plates, are provided at both ends of the left and right

side cover plates

83, 84, respectively, and are detachably connected thereto. Referring to fig. 8 and 9, in one embodiment, the left side cover plate 83 is provided at upper and lower ends thereof with a first flange 831 extending leftward, the right side cover plate 84 is provided at upper and lower ends thereof with a second flange 841 extending rightward, the first and

second flanges

831 and 841 are provided with first and second screw holes S1 and S2, respectively, left and right edges of the upper and

lower cover plates

81 and 82 are flush with ends of the first and

second flanges

831 and 841, respectively, and third and fourth screw holes S3 and S4 are provided at positions of the upper and

lower cover plates

81 and 82 corresponding to the first and second screw holes S1 and S2, respectively, through which bolts are passed to connect the upper and

lower cover plates

81 and 82 with the left side cover plate 83 and the right side cover plate 84, respectively. The front side cover strip 85 and the rear side cover strip 86 are detachably connected with the left side cover plate 83 and the right side cover plate 84 respectively, and the number and the shape of the front side cover strip 85 and the rear side cover strip 86 can be set according to actual conditions. In one embodiment, the number of the front cover strip 85 and the number of the rear cover strip 86 are 2, the front and rear cover strips 85, 86 are rectangular in cross section parallel to the plate surfaces of the left and right side covers 83, 84 and extend linearly in the left-right direction, the left side cover 83 is provided with a first boss 832 extending leftwards at the edge in the front-back direction, the right side cover 84 is provided with a second boss 842 (not shown) extending rightwards at the edge in the front-back direction, the number of the first and second bosses 832, 842 corresponds to the total number of the front and rear cover strips 85, 86, the first and second bosses 832, 842 are provided with fifth and sixth threaded holes S5, S6, the left edges of the front and rear cover strips 85, 86 are flush with the end of the first boss 832, the right edges of the front and rear cover strips 85, 86 are flush with the end of the second boss 842, and the front and rear cover strips 85, 86 are flush with the fifth and sixth threaded holes S5, S5, And seventh and eighth threaded holes S7 and S8 are formed in the positions corresponding to S6, and bolts penetrate through the threaded holes to connect the front and rear side cover bars 85 and 86 with the left and right side cover plates 83 and 84 respectively. The number of the bolts and the threaded holes is not required, and the requirement on connection strength is met.

In connection with fig. 10, the protection frame 80 may also be provided with a support 87, further preventing the beam shaper and its supporting module from overturning, increasing stability. In one embodiment, there are 4 supporting members 87 respectively disposed at the bottom of the left and right

side cover plates

83, 84, two connecting

portions

833, 843 respectively extend from the front and rear bottom edges of the left and right

side cover plates

83, 84 in the front and rear direction, and the supporting members 87 are detachably connected to the left and right

side cover plates

83, 84 through the connecting

portions

833, 843 respectively. The lower surfaces of the connecting

portions

833, 843 are flush with the lower surface of the lower cover plate 82 after mounting, and the lower surface of the supporting member 87 after mounting is also flush with the lower surface, so as to ensure that the supporting surfaces of the protection frame 80 are on the same plane and have a larger supporting surface. The detachable connection is adopted, the supporting piece can be detached when interference is generated in the transportation process, the use convenience is improved, and the supporting piece can be installed or detached at any time. In one embodiment, threaded holes are respectively formed at corresponding positions of the supporting member 87 and the connecting

portions

833 and 843, and bolts are inserted through the threaded holes to connect the supporting member 87 and the left and right

side cover plates

83 and 84, it is to be understood that other detachable connection methods can be adopted, and the supporting member 87 and the left and right

side cover plates

83 and 84 can also be integrated.

The guard frame 80 is also provided with lifting lugs 88 for lifting the guard frame 80 to transfer the guard frame 80 and the beam shaper 20 and its support module 60 within the guard frame 80, such as by a crane placing the guard frame 80 and the beam shaper 20 and its support module 60 within the guard frame 80 onto a vehicle via the lifting lugs 88 to the divider wall 103. The form, number and position of the lifting lugs 88 can be various, in an embodiment, the lifting lugs 88 are bosses with through holes respectively extending to the left and right in the middle positions of the upper parts of the left and right

side cover plates

83, 84, 2 lifting lugs are respectively arranged on the left and right

side cover plates

83, 84, and the lifting lugs 88 and the left and right

side cover plates

83, 84 can be integrated or fixedly connected.

It will be appreciated that the guard frame may have other configurations depending on the shape and size of the beam shaper and support module. The protective frame is made of a steel structure, low-carbon steel Q235 is selected as a material, the strength and the rigidity are high, and the protective frame can be understood as other materials. The protective frame is detachably connected, the structure is ingenious, the stability of the frame-type structure is improved, and the risk of overturning of the beam shaper during the process of filling materials or transporting the beam shaper and the supporting module thereof can be reduced.

The installation method of the protection frame 80 is as follows:

1. the supporting module 60 and the beam shaper 20 fixed to the supporting module 60 are separated from the ground to a certain height by an adjusting member 62 provided on the supporting module 60 and an adjusting device (described in detail below) acting on the adjusting member 62;

2. the lower cover plate 82 is placed on the bottom of the support module 60 in alignment therewith;

3. the left and right

side cover plates

83, 84 are respectively connected with the lower cover plate 82;

4. the beam shaper 20 and its support modules 60 are perfectly attached to the lower cover plate 82 and the left and right

side cover plates

83, 84 by the adjustment means;

5. the front and rear side cover strips 85, 86 are respectively connected with the left and right

side cover plates

83, 84;

6. the upper cover 81 is connected to left and right side covers 83, 84.

It can be understood that the above steps 5 and 6 are not in sequence, and in the case that the main body part needs to be filled after the support frame is installed, the side cover strips of step 5 can be connected with the left and right side cover plates after the main body part is filled and the main body part is packaged.

Then adjusting the positions of the support module 60 and the beam shaper 20, and referring to fig. 11-12, a detachably connected adjusting member 62 is provided on the support module 60, and an adjusting device (not shown) such as a jack acts on the adjusting member 62 to adjust the positions of the support module 60 and the beam shaper 20, so that the beam shaper 20 moves between a first position in which the central axis of the beam shaper 20 substantially coincides with the central axis of the transport tube of the accelerator and a second position; in the second position, the central axis of the beam shaper 20 is not coincident with the central axis of the transport tube of the accelerator. Thereby improving the contact ratio of the center of the beam shaper and the center of the beam pipeline and enabling the target to be placed in the central hole of the beam shaper. The adjusting member 62 is disposed at a lower portion of a sidewall of the support module 60 facing the irradiation chamber 101, and it is understood that other positions are possible; the adjusting piece can also be arranged on the beam shaping body, and the beam shaping body is directly driven by the adjusting piece to carry out position adjustment. Since the jack acts on the adjusting member in the form of concentrated force, a torsion bar may be provided at a corresponding position of the reinforcing portion 61 to increase strength. In this embodiment, the adjusting member 62 is an L-shaped bracket having a first side plate 621 and a second side plate 622 perpendicular to each other, the first side plate 621 is fixed to a lower portion of a side wall of the support module 60 facing the irradiation chamber 101 by bolts or the like, the jack acts on the second side plate 622, the adjusting member 62 further includes a reinforcing rib 623 connecting the first side plate and the second side plate to increase strength, and the bracket is made of a steel plate.

After adjustment, the support module 60 is fixed (e.g. by placing a steel plate or the like in the gap between the support module and the floor, fixing the support module to the floor by bolts or the like, fixing a baffle in the area of the partition wall near the upper end of the support module, further preventing the support module from falling over), and a shield (not shown) is filled between the partition wall 103 and the support module 60 and the beam shaper 20 to maintain the position of the support module and the beam shaper and to prevent radiation from passing through the gap between the partition wall and the support module. The material of the shield includes at least one of photon shielding material and neutron shielding material, and may be a rigid solid cut to a suitable size, such as lead, lead-antimony alloy, teflon, graphite, paraffin, PE containing boron carbide or lithium carbonate or lithium fluoride, PMMA (acrylic), PMMA containing boron carbide or lithium carbonate or lithium fluoride; or a powder filled in a rigid container or a flexible container cut into an appropriate size, such as a powder of boron carbide or lithium carbonate or lithium fluoride; or a liquid filled in a rigid container or a flexible container cut into an appropriate size, such as water, heavy water, boric acid, in which boron carbide or lithium carbonate or lithium fluoride powder is dissolved; but also flexible solids such as rubber or silicone. The adjustment member 62 can be removed and then a shield plate 70 can be installed to shield the shield to further reduce radiation.

The boron neutron capture treatment system 100 can further comprise a preparation room, a control room and other spaces for auxiliary treatment, each irradiation room can be provided with a preparation room for fixing the irradiated object to the treatment table, injecting boron medicine, simulating a treatment plan and the like before irradiation treatment, a connecting channel is arranged between the preparation room and the irradiation room, and the irradiated object is directly pushed into the irradiation room after the preparation is completed or automatically enters the irradiation room under the control of the control mechanism through a track. The control room is used for controlling the accelerator, the beam transmission part, the treatment table and the like, the whole irradiation process is controlled and managed, and a manager can simultaneously monitor a plurality of irradiation rooms in the control room.

The concrete wall in the embodiment is a boron-containing barite concrete wall with the thickness of more than 1m and the density of 3g/c.c., the boron-containing concrete has better neutron absorption performance, the radiation shielding effect of the concrete is enhanced, and the neutron exposure amount of metal materials in the concrete can be reduced. It will be appreciated that other thicknesses or densities are possible or other materials may be substituted and that different portions of the concrete wall may differ in thickness, density or material. It is to be understood that the present invention may also be applied to other types of neutron irradiation systems; the neutron generating device can be replaced by other radiation generating devices, and the materials of the concrete and the supporting module can be replaced according to the requirements.

Although illustrative embodiments of the invention have been described above to facilitate the understanding of the invention by those skilled in the art, it should be understood that the invention is not limited to the scope of the embodiments, and that various changes may be apparent to those skilled in the art without departing from the spirit and scope of the invention as defined and defined in the appended claims.

Claims

1. A neutron capture therapy system comprising a neutron production device and a beam shaper, the beam shaper adjusting the beam quality of neutron lines produced by the neutron production device, the neutron capture therapy system further comprising a concrete wall forming a space to accommodate the neutron production device and the beam shaper, characterized in that a support module is arranged within the concrete wall, the support module being capable of supporting the beam shaper and for adjusting the position of the beam shaper, the neutron capture therapy system further comprising a protective frame for accommodating the beam shaper and the support module, the protective frame being used for transport or installation of the beam shaper and the support module.

2. The neutron capture therapy system of claim 1, wherein the material of the guard frame is mild steel, the guard frame further provided with supports for supporting the guard frame and the beam shaper and support module disposed within the guard frame and lifting lugs for lifting the guard frame to displace the guard frame and the beam shaper and support module within the guard frame.

3. The neutron capture therapy system of claim 1, wherein the protective frame comprises an upper cover plate, a lower cover plate, a left cover plate, a right cover plate, a front cover bar, and a rear cover bar, wherein the upper and lower cover plates are respectively disposed at two ends of the left and right cover plates and detachably connected thereto, and the front and rear cover bars are respectively detachably connected to the left and right cover plates.

4. The neutron capture therapy system of claim 3, wherein the protective frame is further provided with a support member, the support member is detachably connected to the left and right side cover plates, and the lower surface of the support member after being mounted is on the same plane as the lower surface of the lower cover plate after being mounted.

5. The neutron capture therapy system of claim 3, wherein the protective frame is further provided with lifting lugs, and the lifting lugs are bosses with through holes, which extend in the left and right directions from the middle positions of the upper parts of the left and right side cover plates respectively.

6. The neutron capture therapy system of claim 1, wherein the beam shaper comprises a support frame and a body portion stuffed within the support frame, the body portion stuffed at least partially into the support frame prior to securing the support frame of the beam shaper to the support module; or fixing the support frame of the beam shaper to the support module, and filling the main body into the support frame.

7. The neutron capture therapy system of claim 6, wherein an entirety of the support module and a beam shaper secured to the support module are placed within the protective frame prior to at least partial filling of the body portion; or after the body portion is filled, the support module and the beam shaper fixed to the support module are placed in their entirety within the protective frame.

8. The neutron capture therapy system of claim 1, wherein a detachably connected adjustment member is provided on the support module, and the position of the support module and the beam shaper are adjusted and the protective frame is mounted by an adjustment device acting on the adjustment member.

9. The neutron capture therapy system according to claim 1, further comprising an irradiation chamber and a charged particle beam generation chamber, wherein the irradiation chamber and the charged particle beam generation chamber form a space surrounded by the concrete wall, the neutron capture therapy system comprises a treatment table disposed in the irradiation chamber, an irradiated body on the treatment table performs the treatment of the neutron beam irradiation in the irradiation chamber, the neutron production device comprises an accelerator and a target, the charged particle beam generated by the accelerator is accelerated to react with the target to generate a neutron beam, the charged particle beam generation chamber at least partially accommodates the accelerator, and the support module and the beam shaper are at least partially accommodated in a partition wall between the irradiation chamber and the charged particle beam generation chamber.

10. The neutron capture therapy system of claim 9, wherein a shield is filled between the dividing wall and the support module and beam shaper, a side of the dividing wall near the irradiation chamber being provided with a shield plate to shield the shield.