CN211284202U - New salt forming system for high-purity loxoprofen sodium - Google Patents
New salt forming system for high-purity loxoprofen sodium Download PDFInfo
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- CN211284202U CN211284202U CN201922083089.3U CN201922083089U CN211284202U CN 211284202 U CN211284202 U CN 211284202U CN 201922083089 U CN201922083089 U CN 201922083089U CN 211284202 U CN211284202 U CN 211284202U
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Abstract
The utility model provides a new salification system of high-purity loxoprofen sodium, which comprises a decoloration filtering device, a salification reaction device and a crystallization device which are sequentially communicated; the decoloring filtering device, the salifying reaction device and the crystallization device are communicated with the heat exchange device and the medium circulating device; the decoloring filtering device comprises a decoloring tank body, decoloring stirring equipment, a medium insulating layer and decoloring filtering equipment; the salifying reaction device comprises a salifying reaction tank body, a medium heat-insulating layer and a salifying reaction tank cover for sealing the salifying reaction tank body, and the crystallization device comprises a crystallization tank body, solvent spraying equipment, crystallization stirring equipment, pressurizing equipment, a medium heat-insulating layer and crystal filtering equipment, wherein the solvent spraying equipment, the crystallization stirring equipment, the pressurizing equipment, the medium heat-insulating layer and the crystal filtering equipment are arranged in the crystallization tank body. Through setting up decoloration filter equipment, salify reaction unit and crystallization device system as an organic whole, realize the reaction and accomplish in a set of device, avoid the loss, also reduce crude crystallization and air contact time, avoid influencing finished product quality.
Description
Technical Field
The utility model relates to a preparation equipment of compound especially relates to a new salification system of high-purity loxoprofen sodium.
Background
Loxoprofen sodium belongs to phenylpropionic acid non-steroidal anti-inflammatory drugs, is firstly developed by three co-located companies in Japan, is the first variety of non-steroidal anti-inflammatory drugs to be sold in Japan, is already collected by the Japanese pharmacopoeia and is imported in China. The product is listed in one of the new product development recommended trial varieties in nine five countries and 2010. Compared with the similar clinical medicines, the loxoprofen sodium has the characteristics that: stronger (good clinical effect), quicker (the peak value can be reached after the oral administration for 30 minutes), safer (little side effect). The other characteristic is wide adaptation diseases, and can be widely used for anti-inflammatory and analgesic treatment of rheumatoid arthritis, lumbago, scapulohumeral periarthritis, neck, shoulder and wrist syndrome, etc., analgesic and anti-inflammatory treatment after operation, trauma and tooth extraction, antipyretic and analgesic treatment of acute upper respiratory inflammation, etc.
The technical literature disclosed at present is improved from the aspects of synthesis process conditions, post-treatment solvents and the like, and the yield and purity are improved. In particular to a key step of obtaining a qualified finished product by further recrystallization after crystallization of a crude loxoprofen sodium product. The contact time of the crude loxoprofen sodium crystal and the air is long, which affects the quality of the finished product. In order to solve the problem, the improvement of the existing system is urgently needed, and the integration of processes such as filtration, washing and dissolution is realized, so that the quality of finished products is improved.
SUMMERY OF THE UTILITY MODEL
The utility model provides a not enough to prior art, the utility model provides a new salification system of high-purity loxoprofen sodium realizes the synchronous completion of technologies such as filtration, washing, dissolution in same system, and the product purity of preparation is high.
In order to solve the technical problem, the utility model provides a following technical scheme:
on the one hand, the utility model provides a new salification system of high-purity loxoprofen sodium, which comprises a decoloration filtering device, a salification reaction device and a crystallization device which are sequentially communicated;
the decoloring filtering device, the salifying reaction device and the crystallization device are all communicated with the heat exchange device and the medium circulating device;
the decoloring filtering device comprises a decoloring tank body, decoloring stirring equipment, a medium insulating layer coated outside the decoloring tank body and decoloring filtering equipment;
a solvent inlet and a material inlet are formed in the upper part of the decoloring tank body;
the solvent inlet is communicated with solvent spraying equipment;
the solvent spraying equipment is arranged in the decoloring tank body;
the decoloring stirring equipment comprises a decoloring speed reducer and a decoloring stirring shaft; the top end of the decoloring stirring shaft passes through a decoloring reaction tank cover and is installed with a decoloring speed reducer;
the tail end of the decoloring stirring shaft extends into the decoloring tank body and is close to the decoloring filtering device, the tail end of the decoloring stirring shaft is provided with a decoloring stirring paddle, and the bottom end of the decoloring stirring paddle is close to the decoloring filtering device;
the decolorizing and filtering equipment comprises an impurity collecting filter bag, a decolorizing filter bag pressing plate and a decolorizing and filtering supporting plate; the impurity collecting filter bag is fixedly arranged on the decoloring filtering supporting plate through a decoloring filter bag pressing plate; the upper part of the impurity collecting filter bag is fixed in the decoloring tank body through a filter bag hanging ring; the impurity collection filter bag is arranged, so that the blockage of the decoloration filter support plate can be avoided, and the impurity-active carbon collection treatment is realized by replacing the impurity collection filter bag;
the decolorizing and filtering support plate is provided with a first filtering hole which is cylindrical;
a solution outlet is formed in the bottom of the decoloring tank body and communicated with the salt forming reaction device through a pipeline;
the salt-forming reaction device comprises a salt-forming reaction tank body, a medium insulating layer coated on the periphery of the salt-forming reaction tank body and a salt-forming reaction tank cover used for sealing the salt-forming reaction tank body,
the salt-forming reaction tank cover is provided with a spraying solvent inlet and a salt-forming material adding port, and the cover at the salt-forming material adding port is provided with a salt-forming observation port for observation;
the salification reaction tank is internally provided with: salifying spraying equipment, salifying stirring equipment and salifying filtering equipment;
the salifying spraying equipment comprises a salifying spraying pipe;
the salifying spray pipes are arranged in the salifying reaction tank cover and are uniformly arranged in a grid shape, and a solvent of the salifying spray pipes is added through a spray solvent inlet;
the salification stirring equipment comprises a salification speed reducer and a salification stirring shaft; the top end of the salification stirring shaft passes through a salification reaction tank cover and is mounted with a salification speed reducer;
the tail end of the salification stirring shaft extends into the salification reaction tank body and is close to salification filtering equipment, and a stirring paddle is mounted at the tail end of the salification stirring shaft;
the salifying filter equipment is arranged at the bottom of the salifying reaction tank body and comprises a salifying filter bag, a salifying filter bag pressing plate and a salifying filter supporting plate; the salifying filter bag is fixed on the salifying filter support plate through a salifying filter bag pressing plate, and the upper part of the salifying filter bag is fixed through a filter bag hanging ring;
the salifying and filtering support plate is provided with a second filtering hole which is in an inverted frustum shape;
the salifying reaction tank body is conical, and an outlet at the bottom of the tank body is communicated with a crystallization device through a pipeline;
the crystallization device comprises a crystallization tank body, solvent spraying equipment, crystallization stirring equipment, pressurizing equipment, a medium insulating layer and crystal filtering equipment, wherein the solvent spraying equipment, the crystallization stirring equipment, the pressurizing equipment, the medium insulating layer and the crystal filtering equipment are arranged in the crystallization tank body;
a solvent inlet, a material inlet and an air inlet are formed in the upper part of the crystallization tank body; an observation port for observation is arranged on the cover of the material inlet; a pressure relief opening is formed in the lower part of the crystallization tank body;
the solvent inlet is communicated with solvent spraying equipment; the solvent spraying equipment comprises spraying pipelines which are arranged in a crystallization tank body in a net shape;
the crystallization stirring equipment is arranged in the crystallization tank body and comprises a crystallization speed reducer and a crystallization stirring shaft; the top end of the crystallization stirring shaft passes through the crystallization tank cover and is installed with a crystallization speed reducer;
the tail end of the crystallization stirring shaft extends into the crystallization tank body and is close to the crystal filtering equipment, a crystallization stirring paddle is mounted at the tail end of the crystallization stirring shaft, and the bottom end of the crystallization stirring paddle is close to the crystal filtering equipment;
the pressurizing equipment comprises a pressurizing air source, a pressure gauge and a pressurizing valve;
the pressurized gas source is connected with the pressure gauge, the pressurized valve and the gas inlet through pipelines;
the crystal filtering equipment comprises a crystal collecting filter bag, a crystal filter bag pressing plate and a crystal filtering supporting plate; the upper part of the crystal collection filter bag is fixed through a crystal filter bag hanging ring;
the crystal filtering support plate is provided with a third filtering hole which is in an inverted frustum shape;
a solvent outlet is formed in the bottom of the crystallization tank body and communicated with a waste liquid collecting device through a pipeline;
the medium insulating layer is communicated with the heat exchange device through a pipeline;
the heat exchange device is communicated with the medium circulating device through a pipeline; the medium circulating device is communicated with the medium heat-insulating layer through a pump.
Advantageous effects
Compared with the prior art, the utility model, following beneficial effect has:
the utility model provides a new salification system of high-purity loxoprofen sodium has following advantage:
through setting up decoloration filter equipment, salify reaction unit and crystallization device system as an organic whole, realize the reaction and accomplish in a set of device, avoid the loss, also reduce crude crystallization and air contact time, avoid influencing finished product quality.
Various types of filter equipment are arranged according to different reactions in each step, so that the retention of filtrate is avoided, the product quality is improved, and the product loss in the leaching process is reduced; by arranging the leaching device, the waste of the solvent is reduced; through setting up the filter bag, can realize the filtration to impurity, also be favorable to the collection of crystal, can also avoid follow-up because the jam causes influence etc. to filtration equipment.
Drawings
FIG. 1 is a schematic structural view of an integrated device;
FIG. 2 is a schematic view of a decolorizing filter device.
FIG. 3 is a schematic view of the structure of a salt-forming reaction apparatus.
FIG. 4 is a schematic view of a structure of a crystallization apparatus.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments, but it should not be construed that the scope of the subject matter of the present invention is limited to the following examples.
The process equipment or devices not specifically noted in the following examples are conventional in the art; all reagents are commercially available.
Example 1
The utility model provides a new salification system of high-purity loxoprofen sodium, which comprises a decoloration filtering device 1, a salification reaction device 2 and a crystallization device 3 which are communicated in sequence;
the decoloring and filtering device 1, the salifying reaction device 2 and the crystallization device 3 are all communicated with a heat exchange device 4 and a medium circulating device 5;
the decoloring filtering device 1 comprises a decoloring tank body 11, decoloring stirring equipment, a medium insulating layer coated outside the decoloring tank body and decoloring filtering equipment;
the upper part of the decoloring tank body 11 is provided with a solvent inlet 111 and a material inlet 112;
the solvent inlet 111 is communicated with a solvent spraying device 113;
the solvent spraying equipment 113 is arranged in the decoloring tank body 11;
the decoloring stirring equipment is arranged in the decoloring tank body 11;
the decoloring stirring equipment comprises a decoloring speed reducer 121 and a decoloring stirring shaft 122; the top end of the decoloring stirring shaft 122 passes through a decoloring reaction tank cover and is installed with a decoloring speed reducer 121;
the tail end of the decoloring stirring shaft 122 extends into the decoloring tank body 11 and is close to decoloring filtering equipment, the tail end of the decoloring stirring shaft 122 is provided with a decoloring stirring paddle 123, and the bottom end of the decoloring stirring paddle 123 is close to the decoloring filtering equipment;
the decoloring filtering apparatus includes an impurity collecting filter bag 132, a decoloring filter bag pressing plate 131, and a decoloring filtering supporting plate 133; the impurity collecting filter bag 132 is fixedly arranged on a decoloring filtering support plate 133 through a decoloring filter bag pressure plate 131; the upper part of the impurity collecting filter bag 132 is fixed in the decolorizing tank body 11 through a filter bag hanging ring 134; the impurity collection filter bag 132 is arranged, so that the blockage of the decoloration filter support plate can be avoided, and the impurity-active carbon collection treatment is realized by replacing the impurity collection filter bag;
the decolorizing and filtering support plate 131 is provided with a first filtering hole 1311, and the first filtering hole 1311 is cylindrical;
a solution outlet 14 is formed in the bottom of the decoloring tank body 11, and the solution outlet 14 is communicated with the salt forming reaction device 2 through a pipeline;
the salt-forming reaction device 2 comprises a salt-forming reaction tank body 22, a medium insulating layer 15 coated on the periphery of the salt-forming reaction tank body and a salt-forming reaction tank cover 21 used for sealing the salt-forming reaction tank body,
a spraying solvent inlet 211 and a salt forming material adding port 212 are arranged on the salt forming reaction tank cover 21, and a salt forming observation port for observation is arranged on a cover at the salt forming material adding port;
the salification reaction tank is internally provided with: salifying spraying equipment, salifying stirring equipment and salifying filtering equipment;
the salt-forming spraying equipment comprises a salt-forming spraying pipe 221;
the salt-forming spray pipes 221 are arranged in the salt-forming reaction tank cover 21 and are uniformly arranged in a grid shape, and the solvent of the salt-forming spray pipes 221 enters the salt-forming reaction tank through the spray solvent inlet 211;
the salification stirring equipment comprises a salification speed reducer 231 and a salification stirring shaft 232; the top end of the salification stirring shaft 232 passes through a salification reaction tank cover 21 and is mounted with a salification speed reducer 231;
the tail end of the salifying stirring shaft 232 extends into the salifying reaction tank body 22 and is close to salifying filtering equipment, and the tail end of the salifying stirring shaft 232 is provided with a stirring paddle 233;
the salifying filter equipment is arranged at the bottom of the salifying reaction tank body 22 and comprises a salifying filter bag 241, a salifying filter bag pressing plate 242 and a salifying filter supporting plate 243; the salifying filter bag is fixed on a salifying filter support plate 243 through a salifying filter bag pressing plate 242, and the upper part of the salifying filter bag is fixed through a filter bag hanging ring 244;
the salifying and filtering support plate 243 is provided with a second filtering hole 2431, and the second filtering hole 2431 is in an inverted frustum shape;
the salifying reaction tank body is conical, and a tank bottom outlet 25 is communicated with a crystallization device through a pipeline;
the crystallization device comprises a crystallization tank body 31, solvent spraying equipment, crystallization stirring equipment, pressurizing equipment, a medium insulating layer 15 and crystal filtering equipment, wherein the solvent spraying equipment, the crystallization stirring equipment and the pressurizing equipment are arranged in the crystallization tank body 31;
the upper part of the crystallization tank body 31 is provided with a solvent inlet 33, a material inlet 34 and an air inlet 35; an observation port for observation is arranged on the cover of the material inlet; a pressure relief port 36 is formed in the lower part of the crystallization tank body;
the solvent inlet 33 is communicated with a solvent spraying device 37; the solvent spraying equipment comprises spraying pipelines which are arranged in a crystallization tank body in a net shape;
the crystallization stirring equipment is arranged in the crystallization tank body 31 and comprises a crystallization speed reducer 381 and a crystallization stirring shaft 382; the top end of the crystallization stirring shaft 382 passes through the crystallization tank cover and is installed with a crystallization speed reducer 381;
the tail end of the crystallization stirring shaft 382 extends into the crystallization tank body 31 and is close to the crystal filtering equipment, a crystallization stirring paddle 383 is installed at the tail end of the crystallization stirring shaft 382, and the bottom end of the crystallization stirring paddle 383 is close to the crystal filtering equipment;
the pressurizing equipment comprises a pressurizing air source, a pressure gauge and a pressurizing valve;
the pressurized gas source is connected with the pressure gauge, the pressurized valve and the gas inlet 35 through pipelines;
the crystal filtering device comprises a crystal collecting filter bag 391, a crystal filter bag pressing plate 392 and a crystal filtering supporting plate 393; the upper part of the crystal collection filter bag is fixed by a crystal filter bag hanging ring 394;
the crystal filtering support plate 393 is provided with a third filtering hole 3931, and the third filtering hole 3931 is in an inverted circular truncated cone shape;
a solvent outlet 37 is formed in the bottom of the crystallization tank body, and the solvent outlet 37 is communicated with a waste liquid collecting device through a pipeline;
the medium insulating layer 15 is communicated with the heat exchange device 4 through a pipeline;
the heat exchange device 4 is communicated with the medium circulating device 5 through a pipeline; the medium circulating device is communicated with the medium heat-insulating layer through a pump.
The working process of the system is as follows:
and (3) decoloring and filtering: dissolving loxoprofen acid in ethyl acetate (the molar ratio of loxoprofen acid to ethyl acetate is 1: 50) with a metered volume, adding the loxoprofen acid into a decoloring tank body, adding active carbon with the mass of loxoprofen acid and the like through a material inlet, controlling the medium temperature of a medium insulating layer under the stirring of a decoloring stirring device, heating the decoloring tank body to 45.0-50.0 ℃, decoloring for 30min, and performing primary filtration after the decoloring reaction is completed; in the filtering process, leaching and decolorizing the tank body by using solvent spraying equipment, and cleaning the materials in the tank body; after cleaning, removing impurities, collecting a filter bag, and entering the next reaction flow;
salt forming reaction: the filtrate obtained from the upper part enters a salt-forming reaction tank body through a material inlet, the temperature of the materials in the salt-forming reaction tank body is reduced to 0.0-5.0 ℃ through a medium heat-insulating layer, purified water, sodium bicarbonate and methanol are added through a salt-forming material adding port and a salt-forming solvent inlet, the materials are stirred at the temperature of 0.0-5.0 ℃ and react for 3.0-4.0 hours (the molar ratio of loxoprofen acid to purified water to sodium bicarbonate to methanol is 1: 80-100: 1.0-1.2: 10-50), and the PH value is measured to be 7.0; heating the materials in the salt-forming reaction tank to 20.0-25.0 ℃ by using a medium heat-insulating layer, observing the material solution from a salt-forming observation port, and filtering for the second time;
and (3) crystallization reaction: discharging the filtrate into a crystallization tank, spraying and adding new ethyl acetate (the added ethyl acetate is 1/2 volume amount of ethyl acetate used in the step 1) through a solvent inlet), cooling to 0.0-5.0 ℃ through a medium heat-insulating layer under stirring, stopping stirring, carrying out heat-insulating crystallization for 5.0 hours, filtering after crystallization is completed, washing two sides of solids in a filter bag through spraying and adding solvent, closing each inlet and outlet after filtering is completed, pressurizing the tank body through a pressurized gas source, introducing nitrogen and pressurizing until the pressure in the crystallization tank body is 0.2-0.3 MPa, and drying recrystallization crystals. After being pressed to be dry, the solid is collected and dried for 1.0h at the temperature of 40.0 ℃ to obtain the loxoprofen sodium, the yield is 91.6 percent, and the purity is 99.95 percent.
The medium heat-insulating layer, the heat exchange device and the medium circulating device belong to a conventional temperature control system, and can meet the temperature control requirement of each step in a salt forming system, and the method is not limited to any form.
In this application, all kinds of agitated vessel, temperature control system etc. all communicate with the power, the not important guard point of power, and technical personnel in the field can carry out the erection joint according to specific device needs. The valve of the utility model can be added according to specific needs. The temperature control system also belongs to a conventional system, as long as the heating and the refrigeration of the medium can be controlled.
It is to be understood that the above embodiments are merely exemplary embodiments that have been employed to illustrate the principles of the present invention, and that the present invention is not limited thereto. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit and substance of the invention, and these modifications and improvements are also considered to be included in the scope of the invention.
Claims (3)
1. A new salt forming system of high-purity loxoprofen sodium is characterized by comprising a decoloring and filtering device, a salt forming reaction device and a crystallization device which are sequentially communicated;
the decoloring filtering device, the salifying reaction device and the crystallization device are all communicated with the heat exchange device and the medium circulating device;
the decoloring filtering device comprises a decoloring tank body, decoloring stirring equipment, a medium insulating layer coated outside the decoloring tank body and decoloring filtering equipment;
a solvent inlet and a material inlet are formed in the upper part of the decoloring tank body;
the solvent inlet is communicated with solvent spraying equipment;
the solvent spraying equipment is arranged in the decoloring tank body;
the decoloring stirring equipment comprises a decoloring speed reducer and a decoloring stirring shaft; the top end of the decoloring stirring shaft passes through a decoloring reaction tank cover and is installed with a decoloring speed reducer;
the tail end of the decoloring stirring shaft extends into the decoloring tank body and is close to the decoloring filtering device, the tail end of the decoloring stirring shaft is provided with a decoloring stirring paddle, and the bottom end of the decoloring stirring paddle is close to the decoloring filtering device;
the decolorizing and filtering equipment comprises an impurity collecting filter bag, a decolorizing filter bag pressing plate and a decolorizing and filtering supporting plate; the impurity collecting filter bag is fixedly arranged on the decoloring filtering supporting plate through a decoloring filter bag pressing plate; the upper part of the impurity collecting filter bag is fixed in the decoloring tank body through a filter bag hanging ring;
the decolorizing and filtering support plate is provided with a first filtering hole which is cylindrical;
a solution outlet is formed in the bottom of the decoloring tank body and communicated with the salt forming reaction device through a pipeline;
the salt-forming reaction device comprises a salt-forming reaction tank body, a medium insulating layer coated on the periphery of the salt-forming reaction tank body and a salt-forming reaction tank cover used for sealing the salt-forming reaction tank body,
the salt-forming reaction tank cover is provided with a spraying solvent inlet and a salt-forming material adding port, and the cover at the salt-forming material adding port is provided with a salt-forming observation port for observation;
the salification reaction tank is internally provided with: salifying spraying equipment, salifying stirring equipment and salifying filtering equipment;
the salifying spraying equipment comprises a salifying spraying pipe;
the salifying spray pipes are arranged in the salifying reaction tank cover and are uniformly arranged in a grid shape, and a solvent of the salifying spray pipes is added through a spray solvent inlet;
the salification stirring equipment comprises a salification speed reducer and a salification stirring shaft; the top end of the salification stirring shaft passes through a salification reaction tank cover and is mounted with a salification speed reducer;
the tail end of the salification stirring shaft extends into the salification reaction tank body and is close to salification filtering equipment, and a stirring paddle is mounted at the tail end of the salification stirring shaft;
the salifying filter equipment is arranged at the bottom of the salifying reaction tank body and comprises a salifying filter bag, a salifying filter bag pressing plate and a salifying filter supporting plate; the salifying filter bag is fixed on the salifying filter support plate through a salifying filter bag pressing plate, and the upper part of the salifying filter bag is fixed through a filter bag hanging ring;
the salifying and filtering support plate is provided with a second filtering hole which is in an inverted frustum shape;
the salification reaction tank body is conical, and an outlet at the bottom of the tank is communicated with the crystallization device through a pipeline.
2. The new salt formation system of high-purity loxoprofen sodium as claimed in claim 1, wherein the crystallization device comprises a crystallization tank, a solvent spraying device, a crystallization stirring device, a pressurizing device, a medium insulating layer and a crystal filtering device, wherein the solvent spraying device, the crystallization stirring device, the pressurizing device, the medium insulating layer and the crystal filtering device are arranged in the crystallization tank;
a solvent inlet, a material inlet and an air inlet are formed in the upper part of the crystallization tank body; an observation port for observation is arranged on the cover of the material inlet; a pressure relief opening is formed in the lower part of the crystallization tank body;
the solvent inlet is communicated with solvent spraying equipment; the solvent spraying equipment comprises spraying pipelines which are arranged in a crystallization tank body in a net shape;
the crystallization stirring equipment is arranged in the crystallization tank body and comprises a crystallization speed reducer and a crystallization stirring shaft; the top end of the crystallization stirring shaft passes through the crystallization tank cover and is installed with a crystallization speed reducer;
the tail end of the crystallization stirring shaft extends into the crystallization tank body and is close to the crystal filtering equipment, a crystallization stirring paddle is mounted at the tail end of the crystallization stirring shaft, and the bottom end of the crystallization stirring paddle is close to the crystal filtering equipment;
the pressurizing equipment comprises a pressurizing air source, a pressure gauge and a pressurizing valve;
the pressurized gas source is connected with the pressure gauge, the pressurized valve and the gas inlet through pipelines;
the crystal filtering equipment comprises a crystal collecting filter bag, a crystal filter bag pressing plate and a crystal filtering supporting plate; the upper part of the crystal collection filter bag is fixed through a crystal filter bag hanging ring;
the crystal filtering support plate is provided with a third filtering hole which is in an inverted frustum shape;
and a solvent outlet is formed in the bottom of the crystallization tank body and is communicated with a waste liquid collecting device through a pipeline.
3. The system for forming new salt of high-purity loxoprofen sodium as claimed in claim 2, wherein the medium insulating layer is communicated with the heat exchange device through a pipeline;
the heat exchange device is communicated with the medium circulating device through a pipeline; the medium circulating device is communicated with the medium heat-insulating layer through a pump.
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| CN201922083089.3U CN211284202U (en) | 2019-11-28 | 2019-11-28 | New salt forming system for high-purity loxoprofen sodium |
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| CN201922083089.3U CN211284202U (en) | 2019-11-28 | 2019-11-28 | New salt forming system for high-purity loxoprofen sodium |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114195770A (en) * | 2021-12-30 | 2022-03-18 | 连云港贵科药业有限公司 | Preparation method and device of posaconazole |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114195770A (en) * | 2021-12-30 | 2022-03-18 | 连云港贵科药业有限公司 | Preparation method and device of posaconazole |
| CN114195770B (en) * | 2021-12-30 | 2023-08-08 | 连云港贵科药业有限公司 | Preparation method and device of posaconazole |
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Effective date of registration: 20220303 Address after: 264400 Zhuhai Road North Jiaochang Road East, economic development zone, Wendeng District, Weihai City, Shandong Province Patentee after: Chenghong Pharmaceutical (Weihai) Co.,Ltd. Address before: 264200-132f-09009, Qingdao Middle Road, Weihai Economic and Technological Development Zone, Shandong Province Patentee before: Weihai Houpu Biotechnology Co.,Ltd. |
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